The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 49, 2014, Pages E5312-E5320

  Shewell, Lucy K ^a   Harvey, Richard M ^b   Higgins, Melanie A ^b   Day, Christopher J ^a   Hartley Tassell, Lauren E ^a   Chen, Austen Y ^b   Gillen, Christine M ^c   James, David B A ^d   Alonzo, Francis ^d   Torres, Victor J ^d   Walker, Mark J ^c   Paton, Adrienne W ^b   Paton, James C ^b   Jennings, Michael P ^a  

^a GRIFFITH UNIVERSITY   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cholesterol dependent cytolysin; Glycan binding; Pneumolysin; Streptococcus pneumoniae; Streptolysin O

Indexed keywords

CARBOHYDRATE; CHOLESTEROL DEPENDENT CYTOLYSIN; CYTOLYSIN; GLYCAN; GLYCOLIPID; LECTIN; MONOCLONAL ANTIBODY; PNEUMOLYSIN; SIALYL LEWIS X ANTIGEN; STREPTOLYSIN O; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CD15 ANTIGEN; LACTO-N-NEOTETRAOSE; OLIGOSACCHARIDE; PLY PROTEIN, STREPTOCOCCUS PNEUMONIAE; POLYSACCHARIDE; PROTEIN BINDING; STREPTOLYSIN;

ANTIGEN STRUCTURE; ARTICLE; BINDING SITE; BLOOD GROUP LEWIS SYSTEM; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; DOSE RESPONSE; ERYTHROCYTE; FLOW CYTOMETRY; HEMOLYSIS; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MUTAGENESIS; PROTEIN BINDING; PROTEIN DOMAIN; STREPTOCOCCUS PYOGENES; SURFACE PLASMON RESONANCE; WESTERN BLOTTING; AMINO ACID SEQUENCE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; TUMOR CELL LINE;

STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES;

AMINO ACID SEQUENCE; ANTIGENS, CD15; BACTERIAL PROTEINS; BINDING SITES; CARBOHYDRATES; CELL LINE, TUMOR; CELL MEMBRANE; ERYTHROCYTES; FLOW CYTOMETRY; GLYCOLIPIDS; HEMOLYSIS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; OLIGOSACCHARIDES; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; STREPTOLYSINS; SURFACE PLASMON RESONANCE;

EID: 84917694808     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1412703111     Document Type: Article

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