메뉴 건너뛰기




Volumn 79, Issue 10, 2011, Pages 4122-4130

Pneumolysin with low hemolytic activity confers an early growth advantage to streptococcus pneumoniae in the blood

Author keywords

[No Author keywords available]

Indexed keywords

PNEUMOLYSIN;

EID: 80855127655     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05418-11     Document Type: Article
Times cited : (40)

References (36)
  • 1
    • 0028028168 scopus 로고
    • Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae
    • Alexander, J. E., et al. 1994. Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae. Infect. Immun. 62:5683-5688.
    • (1994) Infect. Immun. , vol.62 , pp. 5683-5688
    • Alexander, J.E.1
  • 2
    • 62149092818 scopus 로고    scopus 로고
    • Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects against Streptococcus pneumoniae infection in the lung
    • Arévalo, M. T., et al. 2009. Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects against Streptococcus pneumoniae infection in the lung. FEMS Immunol. Med. Microbiol. 55:346-351.
    • (2009) FEMS Immunol. Med. Microbiol. , vol.55 , pp. 346-351
    • Arévalo, M.T.1
  • 3
    • 0028924974 scopus 로고
    • A pneumolysinnegative mutant of Streptococcus pneumoniae causes chronic bacteremia rather than acute sepsis in mice
    • Benton, K. A., M. P. Everson, and D. E. Briles. 1995. A pneumolysinnegative mutant of Streptococcus pneumoniae causes chronic bacteremia rather than acute sepsis in mice. Infect. Immun. 63:448-455.
    • (1995) Infect. Immun. , vol.63 , pp. 448-455
    • Benton, K.A.1    Everson, M.P.2    Briles, D.E.3
  • 4
    • 0028934267 scopus 로고
    • Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae
    • Berry, A. M., et al. 1995. Effect of defined point mutations in the pneumolysin gene on the virulence of Streptococcus pneumoniae. Infect. Immun. 63:1969-1974.
    • (1995) Infect. Immun. , vol.63 , pp. 1969-1974
    • Berry, A.M.1
  • 5
    • 0024355265 scopus 로고
    • Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae
    • Berry, A. M., J. Yother, D. E. Briles, D. Hansman, and J. C. Paton. 1989. Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae. Infect. Immun. 57:2037-2042.
    • (1989) Infect. Immun. , vol.57 , pp. 2037-2042
    • Berry, A.M.1    Yother, J.2    Briles, D.E.3    Hansman, D.4    Paton, J.C.5
  • 6
    • 0032768658 scopus 로고    scopus 로고
    • Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces nitric oxide production from macrophages
    • Braun, J. S., R. Novak, G. Gao, P. J. Murray, and J. L. Shenep. 1999. Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces nitric oxide production from macrophages. Infect. Immun. 67:3750-3756.
    • (1999) Infect. Immun. , vol.67 , pp. 3750-3756
    • Braun, J.S.1    Novak, R.2    Gao, G.3    Murray, P.J.4    Shenep, J.L.5
  • 7
    • 0242593825 scopus 로고    scopus 로고
    • Geographic distribution and clonal diversity of Streptococcus pneumoniae serotype 1 isolates
    • Brueggemann, A. B., and B. G. Spratt. 2003. Geographic distribution and clonal diversity of Streptococcus pneumoniae serotype 1 isolates. J. Clin. Microbiol. 41:4966-4970.
    • (2003) J. Clin. Microbiol. , vol.41 , pp. 4966-4970
    • Brueggemann, A.B.1    Spratt, B.G.2
  • 8
    • 0035865826 scopus 로고    scopus 로고
    • Proinflammatory interactions of pneumolysin with human neutrophils
    • Cockeran, R., et al. 2001. Proinflammatory interactions of pneumolysin with human neutrophils. J. Infect. Dis. 183:604-611.
    • (2001) J. Infect. Dis. , vol.183 , pp. 604-611
    • Cockeran, R.1
  • 9
    • 77949657612 scopus 로고    scopus 로고
    • Novel mucosal vaccines generated by genetic conjugation of heterologous proteins to pneumolysin (PLY) from Streptococcus pneumoniae
    • Douce, G., K. Ross, G. Cowan, J. Ma, and T. J. Mitchell. 2010. Novel mucosal vaccines generated by genetic conjugation of heterologous proteins to pneumolysin (PLY) from Streptococcus pneumoniae. Vaccine 28:3231-3237.
    • (2010) Vaccine , vol.28 , pp. 3231-3237
    • Douce, G.1    Ross, K.2    Cowan, G.3    Ma, J.4    Mitchell, T.J.5
  • 10
    • 0036785653 scopus 로고    scopus 로고
    • Role of RegM, a homologue of the catabolite repressor protein CcpA, in the virulence of Streptococcus pneumoniae
    • Giammarinaro, P., and J. C. Paton. 2002. Role of RegM, a homologue of the catabolite repressor protein CcpA, in the virulence of Streptococcus pneumoniae. Infect. Immun. 70:5454-5461.
    • (2002) Infect. Immun. , vol.70 , pp. 5454-5461
    • Giammarinaro, P.1    Paton, J.C.2
  • 11
    • 79955848787 scopus 로고    scopus 로고
    • A Variable region within the genome of Streptococcus pneumoniae contributes to strain-strain variation in virulence
    • Harvey, R. M., et al. 2011. A Variable region within the genome of Streptococcus pneumoniae contributes to strain-strain variation in virulence. PLoS One 6:e19650.
    • (2011) PLoS One , vol.6
    • Harvey, R.M.1
  • 12
    • 0027229928 scopus 로고
    • Gene splicing by overlap extension
    • Horton, R. M., et al. 1993. Gene splicing by overlap extension. Methods Enzymol. 217:270-279.
    • (1993) Methods Enzymol. , vol.217 , pp. 270-279
    • Horton, R.M.1
  • 13
    • 0028176663 scopus 로고
    • Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes
    • Houldsworth, S., P. W. Andrew, and T. J. Mitchell. 1994. Pneumolysin stimulates production of tumor necrosis factor alpha and interleukin-1 beta by human mononuclear phagocytes. Infect. Immun. 62:1501-1503.
    • (1994) Infect. Immun. , vol.62 , pp. 1501-1503
    • Houldsworth, S.1    Andrew, P.W.2    Mitchell, T.J.3
  • 14
    • 34548497122 scopus 로고    scopus 로고
    • Presence of nonhemolytic pneumolysin in serotypes of Streptococcus pneumoniae associated with disease outbreaks
    • Jefferies, J. M., et al. 2007. Presence of nonhemolytic pneumolysin in serotypes of Streptococcus pneumoniae associated with disease outbreaks. J. Infect. Dis. 196:936-944.
    • (2007) J. Infect. Dis. , vol.196 , pp. 936-944
    • Jefferies, J.M.1
  • 15
    • 0037378079 scopus 로고    scopus 로고
    • Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin
    • Jounblat, R., A. Kadioglu, T. J. Mitchell, and P. W. Andrew. 2003. Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin. Infect. Immun. 71:1813-1819.
    • (2003) Infect. Immun. , vol.71 , pp. 1813-1819
    • Jounblat, R.1    Kadioglu, A.2    Mitchell, T.J.3    Andrew, P.W.4
  • 16
    • 0033968726 scopus 로고    scopus 로고
    • Host cellular immune response to pneumococcal lung infection in mice
    • Kadioglu, A., et al. 2000. Host cellular immune response to pneumococcal lung infection in mice. Infect. Immun. 68:492-501.
    • (2000) Infect. Immun. , vol.68 , pp. 492-501
    • Kadioglu, A.1
  • 17
    • 30744464885 scopus 로고    scopus 로고
    • Identification of invasive serotype 1 pneumococcal isolates that express nonhemolytic pneumolysin
    • Kirkham, L. A., et al. 2006. Identification of invasive serotype 1 pneumococcal isolates that express nonhemolytic pneumolysin. J. Clin. Microbiol. 44:151-159.
    • (2006) J. Clin. Microbiol. , vol.44 , pp. 151-159
    • Kirkham, L.A.1
  • 18
    • 29644447798 scopus 로고    scopus 로고
    • Construction and immunological characterization of a novel nontoxic protective pneumolysin mutant for use in future pneumococcal vaccines
    • Kirkham, L. A., et al. 2006. Construction and immunological characterization of a novel nontoxic protective pneumolysin mutant for use in future pneumococcal vaccines. Infect. Immun. 74:586-593.
    • (2006) Infect. Immun. , vol.74 , pp. 586-593
    • Kirkham, L.A.1
  • 19
    • 77952584658 scopus 로고    scopus 로고
    • Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression
    • Littmann, M., et al. 2009. Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression. EMBO Mol. Med. 1:211-222.
    • (2009) EMBO Mol. Med. , vol.1 , pp. 211-222
    • Littmann, M.1
  • 20
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods
    • Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408.
    • (2001) , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 21
    • 0030219032 scopus 로고    scopus 로고
    • Sequence variation in the Streptococcus pneumoniae pneumolysin gene affecting haemolytic activity and electrophoretic mobility of the toxin
    • Lock, R. A., Q. Y. Zhang, A. M. Berry, and J. C. Paton. 1996. Sequence variation in the Streptococcus pneumoniae pneumolysin gene affecting haemolytic activity and electrophoretic mobility of the toxin. Microb. Pathog. 21:71-83.
    • (1996) Microb. Pathog. , vol.21 , pp. 71-83
    • Lock, R.A.1    Zhang, Q.Y.2    Berry, A.M.3    Paton, J.C.4
  • 22
    • 0037452778 scopus 로고    scopus 로고
    • Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection
    • Malley, R., et al. 2003. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc. Natl. Acad. Sci. U. S. A. 100:1966-1971.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 1966-1971
    • Malley, R.1
  • 23
    • 0029438287 scopus 로고
    • The recA gene of Streptococcus pneumoniae is part of a competence-induced operon and controls an SOS regulon
    • Martin, B., P. Garcia, M. P. Castanie, B. Glise, and J. P. Claverys. 1995. The recA gene of Streptococcus pneumoniae is part of a competence-induced operon and controls an SOS regulon. Dev. Biol. Stand. 85:293-300.
    • (1995) Dev. Biol. Stand. , vol.85 , pp. 293-300
    • Martin, B.1    Garcia, P.2    Castanie, M.P.3    Glise, B.4    Claverys, J.P.5
  • 24
    • 3843125485 scopus 로고    scopus 로고
    • Molecular analysis of the psa permease complex of Streptococcus pneumoniae
    • McAllister, L. J., et al. 2004. Molecular analysis of the psa permease complex of Streptococcus pneumoniae. Mol. Microbiol. 53:889-901.
    • (2004) Mol. Microbiol. , vol.53 , pp. 889-901
    • McAllister, L.J.1
  • 25
    • 79251515144 scopus 로고    scopus 로고
    • Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4
    • McNeela, E. A., et al. 2010. Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. PLoS Pathog. 6:e1001191.
    • (2010) PLoS Pathog. , vol.6
    • McNeela, E.A.1
  • 26
    • 0025879875 scopus 로고
    • Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute-phase protein
    • Mitchell, T. J., P. W. Andrew, F. K. Saunders, A. N. Smith, and G. J. Boulnois. 1991. Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute-phase protein. Mol. Microbiol. 5:1883-1888.
    • (1991) Mol. Microbiol. , vol.5 , pp. 1883-1888
    • Mitchell, T.J.1    Andrew, P.W.2    Saunders, F.K.3    Smith, A.N.4    Boulnois, G.J.5
  • 27
    • 2442673903 scopus 로고    scopus 로고
    • The effect that mutations in the conserved capsular polysaccharide biosynthesis genes cpsA, cpsB, and cpsD have on virulence of Streptococcus pneumoniae
    • Morona, J. K., D. C. Miller, R. Morona, and J. C. Paton. 2004. The effect that mutations in the conserved capsular polysaccharide biosynthesis genes cpsA, cpsB, and cpsD have on virulence of Streptococcus pneumoniae . J. Infect. Dis. 189:1905-1913.
    • (2004) J. Infect. Dis. , vol.189 , pp. 1905-1913
    • Morona, J.K.1    Miller, D.C.2    Morona, R.3    Paton, J.C.4
  • 28
    • 0034020990 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of CpsD negatively regulates capsular polysaccharide biosynthesis in Streptococcus pneumoniae
    • Morona, J. K., J. C. Paton, D. C. Miller, and R. Morona. 2000. Tyrosine phosphorylation of CpsD negatively regulates capsular polysaccharide biosynthesis in Streptococcus pneumoniae. Mol. Microbiol. 35:1431-1442.
    • (2000) Mol. Microbiol. , vol.35 , pp. 1431-1442
    • Morona, J.K.1    Paton, J.C.2    Miller, D.C.3    Morona, R.4
  • 29
    • 69949111769 scopus 로고    scopus 로고
    • Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates
    • O'Brien, K. L., et al. 2009. Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet 374:893-902.
    • (2009) Lancet , vol.374 , pp. 893-902
    • O'Brien, K.L.1
  • 30
    • 0034114443 scopus 로고    scopus 로고
    • Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae
    • Ogunniyi, A. D., R. L. Folland, D. E. Briles, S. K. Hollingshead, and J. C. Paton. 2000. Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae. Infect. Immun. 68:3028-3033.
    • (2000) Infect. Immun. , vol.68 , pp. 3028-3033
    • Ogunniyi, A.D.1    Folland, R.L.2    Briles, D.E.3    Hollingshead, S.K.4    Paton, J.C.5
  • 31
    • 0036067905 scopus 로고    scopus 로고
    • The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo
    • Ogunniyi, A. D., P. Giammarinaro, and J. C. Paton. 2002. The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo. Microbiology 148:2045-2053.
    • (2002) Microbiology , vol.148 , pp. 2045-2053
    • Ogunniyi, A.D.1    Giammarinaro, P.2    Paton, J.C.3
  • 32
    • 0020638911 scopus 로고
    • Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae
    • Paton, J. C., R. A. Lock, and D. J. Hansman. 1983. Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae. Infect. Immun. 40:548-552.
    • (1983) Infect. Immun. , vol.40 , pp. 548-552
    • Paton, J.C.1    Lock, R.A.2    Hansman, D.J.3
  • 33
    • 0025779030 scopus 로고
    • Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide
    • Paton, J. C., et al. 1991. Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide. Infect. Immun. 59:2297-2304.
    • (1991) Infect. Immun. , vol.59 , pp. 2297-2304
    • Paton, J.C.1
  • 34
    • 0021363204 scopus 로고
    • Activation of human complement by the pneumococcal toxin pneumolysin
    • Paton, J. C., B. Rowan-Kelly, and A. Ferrante. 1984. Activation of human complement by the pneumococcal toxin pneumolysin. Infect. Immun. 43:1085-1087.
    • (1984) Infect. Immun. , vol.43 , pp. 1085-1087
    • Paton, J.C.1    Rowan-Kelly, B.2    Ferrante, A.3
  • 35
    • 0028307194 scopus 로고
    • Phase variation in pneumococcal opacity: relationship between colonial morphology and nasopharyngeal colonization
    • Weiser, J. N., R. Austrian, P. K. Sreenivasan, and H. R. Masure. 1994. Phase variation in pneumococcal opacity: relationship between colonial morphology and nasopharyngeal colonization. Infect. Immun. 62:2582-2589.
    • (1994) Infect. Immun. , vol.62 , pp. 2582-2589
    • Weiser, J.N.1    Austrian, R.2    Sreenivasan, P.K.3    Masure, H.R.4
  • 36
    • 79960408020 scopus 로고    scopus 로고
    • The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia
    • Witzenrath, M., et al. 2011. The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. J. Immunol. 187:434-440.
    • (2011) J. Immunol. , vol.187 , pp. 434-440
    • Witzenrath, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.