The immune receptor Tim-3 mediates activation of PI3 kinase/mTOR and HIF-1 pathways in human myeloid leukaemia cells

International Journal of Biochemistry and Cell Biology

Volumn 59, Issue , 2015, Pages 11-20

  Prokhorov, Alexandr ^a   Gibbs, Bernhard F ^a   Bardelli, Marco ^b   Rüegg, Laura ^a,c   Fasler Kan, Elizaveta ^c,d   Varani, Luca ^b   Sumbayev, Vadim V ^a  

^a UNIVERSITY OF KENT   (United Kingdom)

^b INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^c UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

^d UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

HIF 1; Mammalian target of rapamycin (mTOR) pathway; Myeloid leukaemia cells; Tim 3

Indexed keywords

GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1; MAMMALIAN TARGET OF RAPAMYCIN; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; RECEPTOR; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN 3; UNCLASSIFIED DRUG; CALCIUM; GALECTIN; HAVCR2 PROTEIN, HUMAN; LGALS9 PROTEIN, HUMAN; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; MTOR PROTEIN, HUMAN; PHOSPHOLIPASE C; PHOSPHOSERINE; PHOSPHOTYROSINE; PROTEIN BINDING; STEM CELL FACTOR; TARGET OF RAPAMYCIN KINASE; VASCULOTROPIN A;

ACUTE GRANULOCYTIC LEUKEMIA; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; GLYCOLYSIS; HUMAN; HUMAN CELL; MOUSE; MYELOID LEUKEMIA CELL LINE; NONHUMAN; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; UPREGULATION; BIOLOGICAL MODEL; CHEMISTRY; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; MYELOID LEUKEMIA; PATHOLOGY; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; TIME; TUMOR CELL LINE;

MAMMALIA;

CALCIUM; CELL LINE, TUMOR; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GALECTINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; LEUKEMIA, MYELOID; LIGANDS; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; STEM CELL FACTOR; TIME FACTORS; TOR SERINE-THREONINE KINASES; TYPE C PHOSPHOLIPASES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84917690962     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.11.017     Document Type: Article

References (29)

1. M. Abooali, G.S. Lall, K. Coughlan, H.S. Lall, B.F. Gibbs, and V.V. Sumbayev Crucial involvement of xanthine oxidase in the intracellular signalling networks associated with human myeloid cell function Sci Rep 4 2014 6307
2. A.C. Anderson Tim-3, a negative regulator of anti-tumor immunity Curr Opin Immunol 24 2012 213 216
3. A.C. Anderson, D.E. Anderson, L. Bregoli, W.D. Hastings, N. Kassam, and C. Lei Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells Science 318 2007 1141 1143
4. C.E. Berry, and J.M. Hare Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications J Physiol 555 2004 589 606
5. V.C. Broudy Stem cell factor and hematopoiesis Blood 90 1997 1345 1364
6. R.M.C. Dawson, D.L. Elliot, W.H. Elliot, and K.M. Jones Data for biochemical research 1986 Clarendon Press Oxford 544
7. G.J. Freeman, J.M. Casasnovas, J.D.T. Umetsu, and R.H. DeKruyff TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity Immunol Rev 235 2010 172 189
8. J. George, and A.D. Struthers Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress Vasc Health Risk Manag 5 2009 265 272
9. B.F. Gibbs, I.M. Yasinska, A.E. Oniku, and V.V. Sumbayev Effects of stem cell factor on hypoxia-inducible factor 1 alpha accumulation in human acute myeloid leukaemia and LAD2 mast cells PLoS One 6 2011 e22502
10. G. Han, G. Chen, B. Shen, and Y. Li Tim-3: an activation marker and activation limiter of innate immune cells Front Immunol 4 2013 449
11. A.S. Hui, A.L. Bauer, J.B. Striet, P.O. Schnell, and M.F. Czyzyk-Krzeska Calcium signaling stimulates translation of HIF-alpha during hypoxia FASEB J 20 2006 466 475
12. M. Kapiszewska, A. Cierniak, M. Elas, and A. Lankoff Lifespan of etoposide-treated human neutrophils is affected by antioxidant ability of quercetin Toxicol In Vitro 21 2007 1020 1030
13. Y. Kikushige, and K. Akashi TIM-3 as a therapeutic target for malignant stem cells in acute myelogenous leukemia Ann NY Acad Sci 1266 2012 118 123
14. S.J. Lee, J.H. Yoon, and K.S. Song Chrysin inhibited stem cell factor (SCF)/c-Kit complex-induced cell proliferation in human myeloid leukemia cells Biochem Pharmacol 74 2007 215 225
15. S. Nakae, M. Iikura, H. Suto, H. Akiba, D.T. Umetsu, and R.H. Dekruyff TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells Blood 110 2007 2565 2568
16. S.F. Ngiow, M.W. Teng, and M.J. Smyth Prospects for TIM3-targeted antitumor immunotherapy Cancer Res 71 2011 6567 6571
17. S.A. Nicholas, and V.V. Sumbayev The involvement of hypoxia-inducible factor 1 alpha in Toll-like receptor 7/8-mediated inflammatory response Cell Res 19 2009 973 983
18. J. Patel, E.N. Bozeman, and P. Selvaraj Taming dendritic cells with TIM-3: another immunosuppressive strategy used by tumors Immunotherapy 4 2012 1795 1798
19. D. Pchejetski, J. Nunes, K. Coughlan, H. Lall, S.M. Pitson, and J. Waxman The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1alpha protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6 Immunol Cell Biol 89 2011 268 274
20. A. Sevanian, K.J. Davies, and P. Hochstein Serum urate as an antioxidant for ascorbic acid Am J Clin Nutr 54 1991 1129S 1134S
21. V.V. Sumbayev In vitro effects of corticosteroids DDT, and 4, 9-dichlorodibenzodioxin on rat liver xanthine oxidase activity. Interactions between xanthine oxidase and cytochrome P450 in rat liver in vivo Biochemistry (Mosc) 65 2000 972 975
22. V.V. Sumbayev LPS-induced Toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein FEBS Lett 582 2008 319 326
23. V.V. Sumbayev, and S.A. Nicholas Hypoxia-inducible factor 1 as one of the signaling drivers of Toll-like receptor-dependent and allergic inflammation Arch Immunol Ther Exp (Warsz) 58 2010 287 294
24. V.V. Sumbayev, S.A. Nicholas, C.L. Streatfield, and B.F. Gibbs Involvement of hypoxia-inducible factor-1 HIF(1alpha) in IgE-mediated primary human basophil responses Eur J Immunol 39 2009 3511 3519
25. C. Wang, J. Liu, L. Wang, and X. Geng Solubilization and refolding with simultaneous purification of recombinant human stem cell factor Appl Biochem Biotechnol 144 2008 181 189
26. I.M. Yasinska, B.F. Gibbs, G.S. Lall, and V.V. Sumbayev The HIF-1 transcription complex is essential for translational control of myeloid hematopoietic cell function by maintaining mTOR phosphorylation Cell Mol Life Sci 71 2014 699 710
27. Yokoyama WM, Christensen M, Santos GD, Miller D. Production of monoclonal antibodies. Curr Protoc Immunol 2006; Chapter 2, Unit 2.5. http://dx.doi.org/10.1002/0471142735.im0205s74.
28. M.K. Zafar, R. Mohsin, S. Hassen, R. Agarwal, H. Mumtaz, and N. Ali Detection of inositol phosphates by polyacrylamide gel electrophoresis (PAGE) under apoptotic conditions in cultured SW480 cells J Arkansas Acad Sci 64 2010 129 133
29. Y. Zhang, C.J. Ma, J.M. Wang, X.J. Ji, X.Y. Wu, J.P. Moorman, and Z.Q. Yao Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ monocytes J Leukoc Biol 91 2012 189 196