Down-regulation of miRNA-106b inhibits growth of melanoma cells by promoting G1-phase cell cycle arrest and reactivation of p21/WAF1/Cip1 protein

Oncotarget

Volumn 5, Issue 21, 2014, Pages 10636-10649

  Prasad, Ram ^a   Katiyar, Santosh K ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

Cell cycle; Grape seed proanthocyanidins; Melanoma; MicroRNA 106b; Tumor xenograft growth

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; MICRORNA; MICRORNA 106B; PROANTHOCYANIDIN DERIVATIVE; UNCLASSIFIED DRUG; CYCLIN DEPENDENT KINASE INHIBITOR 1A; GRAPE SEED EXTRACT; GRAPE SEED PROANTHOCYANIDINS; MESSENGER RNA; MIRN106 MICRORNA, HUMAN; PROANTHOCYANIDIN; PROTEIN P53;

A375 CELL LINE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER TISSUE; CELL SPECIFICITY; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG TARGETING; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION REGULATION; GRAPE; HS294T CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MEL 1011 CELL LINE; MEL 1241 CELL LINE; MEL 928 CELL LINE; MELANOCYTE; MELANOMA; MELANOMA CELL LINE; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SK MEL 119 CELL LINE; SK MEL28 CELL LINE; TUMOR XENOGRAFT; ANIMAL; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; DRUG SCREENING; ENZYME IMMUNOASSAY; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL CULTURE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; FEMALE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINTS; GRAPE SEED EXTRACT; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION, FLUORESCENCE; MELANOMA; MICE; MICE, NUDE; MICRORNAS; PROANTHOCYANIDINS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84916912472     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2527     Document Type: Article

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