Role of UV in cutaneous melanoma

Photochemistry and Photobiology

Volumn 84, Issue 2, 2008, Pages 528-536

  Maddodi, Nityanand ^a   Setaluri, Vijayasaradhi ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELANOMA; RADIATION INJURY; REVIEW; SKIN TUMOR; ULTRAVIOLET RADIATION;

MELANOMA; NEOPLASMS, RADIATION-INDUCED; SKIN NEOPLASMS; ULTRAVIOLET RAYS;

EID: 41149159261     PISSN: 00318655     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1751-1097.2007.00283.x     Document Type: Review

References (142)

1. Ferguson, K. (2005) Clinical updates. Melanoma. J. Contin. Educ. Nurs. 36, 242 243.
2. Sue, N. S. Roberta (2002) The management of high-risk melanoma: Staging, treatment, and nursing issues. Dermatol. Nurs. 14, 363.
3. Hall, H. I., D. R. Miller, J. D. Rogers B. Bewerse (1999) Update on the incidence and mortality from melanoma in the United States. J. Am. Acad. Dermatol. 40, 35 42.
4. Boscoe, F. M. Schymura (2006) Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993-2002. BMC Cancer 6, 264.
5. American Cancer Society (2007) Cancer facts and figures. Available at http://www.cancer.org/downloads/STT/CAFF2007PWSecured.pdf.
6. Strouse, J. J., T. R. Fears, M. A. Tucker A. S. Wayne (2005) Pediatric melanoma: Risk factor and survival analysis of the surveillance, epidemiology and end results database. J. Clin. Oncol. 23, 4735 4741.
7. Hu, S., F. Ma, F. Collado-Mesa R. S. Kirsner (2004) UV radiation, latitude, and melanoma in US Hispanics and blacks. Arch. Dermatol. 140, 819 824.
8. Jemal, A., S. S. Devesa, T. R. Fears P. Hartge (2000) Cancer surveillance series: Changing patterns of cutaneous malignant melanoma mortality rates among whites in the United States. J. Natl Cancer Inst. 92, 811 818.
9. Caldwell, M. M., J. F. Bornman, C. L. Ballare, S. D. Flint G. Kulandaivelu (2007) Terrestrial ecosystems, increased solar ultraviolet radiation, and interactions with other climate change factors. Photochem. Photobiol. Sci. 6, 252 266.
10. Hader, D. P., H. D. Kumar, R. C. Smith R. C. Worrest (2007) Effects of solar UV radiation on aquatic ecosystems and interactions with climate change. Photochem. Photobiol. Sci. 6, 267 285.
11. Zepp, R. G., D. J. E. Iii, N. D. Paul B. Sulzberger (2007) Interactive effects of solar UV radiation and climate change on biogeochemical cycling. Photochem. Photobiol. Sci. 6, 286 300.
12. McKenzie, R. L., P. J. Aucamp, A. F. Bais, L. O. Bjorn M. Ilyas (2007) Changes in biologically-active ultraviolet radiation reaching the earth's surface. Photochem. Photobiol. Sci. 6, 218 231.
13. Madronich, S., R. B. McKenzie, L. Björn M. Caldwell (1998) Changes in biologically active ultraviolet radiation reaching the earth's surface. J. Photochem. Photobiol. B, Biol. 46, 5 19.
14. Jhappan, C., F. P. Noonan G. Merlino (2003) Ultraviolet radiation and cutaneous malignant melanoma. Oncogene 22, 3099 3112.
15. Cadet, J., E. Sage T. Douki (2005) Ultraviolet radiation-mediated damage to cellular DNA. Mutat. Res. 571, 3 17.
16. Pfeifer, G. P., Y.-H. You A. Besaratinia (2005) Mutations induced by ultraviolet light. Mutat. Res. 571, 19 31.
17. Lee, D.-H. G. P. Pfeifer (2003) Deamination of 5-methylcytosines within cyclobutane pyrimidine dimers is an important component of UVB mutagenesis. J. Biol. Chem. 278, 10314 10321.
18. Mitchell, D. L. (2000) Effects of cytosine methylation on pyrimidine dimer formation in DNA. Photochem. Photobiol. 71, 162 165.
19. Tommasi, S., M. F. Denissenko G. P. Pfeifer (1997) Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases. Cancer Res. 57, 4727 4730.
20. You, Y.-H., P. E. Szabo G. P. Pfeifer (2000) Cyclobutane pyrimidine dimers form preferentially at the major p53 mutational hotspot in UVB-induced mouse skin tumors. Carcinogenesis 21, 2113 2117.
21. Jiang, Y., C. Ke, P. A. Mieczkowski P. E. Marszalek (2007) Detecting ultraviolet damage in single DNA molecules by atomic force microscopy. Biophys. J. 93, 1758 1767.
22. Horikawa-Miura, M., N. Matsuda, M. Yoshida, Y. Okumura, T. Mori M. Watanabe (2007) The greater lethality of UVB radiation to cultured human cells is associated with the specific activation of a DNA damage-independent signaling pathway. Radiat. Res. 167, 655 662.
23. DeFedericis, H., H. Patrzyc, M. Rajecki, E. Budzinski, H. Iijima, J. Dawidzik, M. Evans, K. Greene H. Box (2006) Singlet oxygen-induced DNA damage. Radiat. Res. 165, 445 451.
24. Besaratinia, A., S. E. Bates, T. W. Synold G. P. Pfeifer (2004) Similar mutagenicity of photoactivated porphyrins and ultraviolet A radiation in mouse embryonic fibroblasts: Involvement of oxidative DNA lesions in mutagenesis. Biochemistry 43, 15557 15566.
25. Sinha, R. P. D. P. Hader (2002) Life under solar UV radiation in aquatic organisms. Adv. Space Res. 30, 1547 1556.
26. Mouret, S., C. Baudouin, M. Charveron, A. Favier, J. Cadet T. Douki (2006) From the cover: Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation. Proc. Natl Acad. Sci. USA 103, 13765 13770.
27. Ikehata, H., H. Kudo, T. Masuda T. Ono (2003) UVA induces C->T transitions at methyl-CpG-associated dipyrimidine sites in mouse skin epidermis more frequently than UVB. Mutagenesis 18, 511 519.
28. Krizek, D. T. (2004) Influence of PAR and UV-A in determining plant sensitivity and photomorphogenic responses to UV-B radiation. Photochem. Photobiol. 79, 307 315.
29. Wood, S. R., M. Berwick, R. D. Ley, R. B. Walter, R. B. Setlow G. S. Timmins (2006) UV causation of melanoma in Xiphophorus is dominated by melanin photosensitized oxidant production. Proc. Natl Acad. Sci. USA 103, 4111 4115.
30. Tadokoro, T., N. Kobayashi, B. Z. Zmudzka, S. Ito, K. Wakamatsu, Y. Yamaguchi, K. S. Korossy, S. A. Miller, J. Z. Beer V. J. Hearing (2003) UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin. FASEB J. 17, 1177 1179.
31. Sinha, R. P., M. Klisch, E. W. Helbling D.-P. Häder (2001) Induction of mycosporine-like amino acids (MAAs) in cyanobacteria by solar ultraviolet-B radiation. J. Photochem. Photobiol. B, Biol. 60, 129 135.
32. Landry, L. G., C. C. S. Chapple R. L. Last (1995) Arabidopsis mutants lacking phenolic sunscreens exhibit enhanced ultraviolet-B injury and oxidative damage. Plant Physiol. 109, 1159 1166.
33. Li, J., T. M. Ou-Lee, R. Raba, R. G. Amundson R. L. Last (1993) Arabidopsis flavonoid mutants are hypersensitive to UV-B irradiation. Plant Cell 5, 171 179.
34. Yaar, M. B. A. Gilchrest (2001) Ageing and photoageing of keratinocytes and melanocytes. Clin. Exp. Dermatol. 26, 583 591.
35. Reedy, M. V., C. D. Faraco C. A. Erickson (1998) Specification and migration of melanoblasts at the vagal level and in hyperpigmented silkie chickens. Dev. Dyn. 213, 476 485.
36. Lloyd, R. S. (2005) Investigations of pyrimidine dimer glycosylases - A paradigm for DNA base excision repair enzymology. Mutat. Res. 577, 77 91.
37. Thoma, F. (1999) Light and dark in chromatin repair: Repair of UV-induced DNA lesions by photolyase and nucleotide excision repair. EMBO J. 18, 6585 6598.
38. Lehmann, A. R. (1995) Nucleotide excision repair and the link with transcription. Trends Biochem. Sci. 20, 402 405.
39. Lindahl, T. R. D. Wood (1999) Quality control by DNA repair. Science 286, 1897 1905.
40. Fears, T. R., J. Scotto M. A. Schneiderman (1977) Mathematical models of age and ultraviolet effects on the incidence of skin cancer among whites in the United States. Am. J. Epidemiol. 105, 420 427.
41. Williams, M. A. Ouhtit (2005) Towards a better understanding of the molecular mechanisms involved in sunlight-induced melanoma. J. Biomed. Biotechnol. 2005, 57 61.
42. Zanetti, R., S. Franceschi, S. Rosso, S. Colonna E. Bidoli (1992) Cutaneous melanoma and sunburns in childhood in a southern European population. Eur. J. Cancer 28, 1172 1176.
43. Whiteman, D., C. Whiteman A. Green (2001) Childhood sun exposure as a risk factor for melanoma: A systematic review of epidemiologic studies. Cancer Causes Control 12, 69 82.
44. Atillasoy, E. S., J. T. Seykora, P. W. Soballe, R. Elenitsas, M. Nesbit, D. E. Elder, K. T. Montone, E. Sauter M. Herlyn (1998) UVB induces atypical melanocytic lesions and melanoma in human skin. Am. J. Pathol. 152, 1179 1186.
45. Berking, C., R. Takemoto, R. L. Binder, S. M. Hartman, D. J. Ruiter, P. M. Gallagher, S. R. Lessin M. Herlyn (2002) Photocarcinogenesis in human adult skin grafts. Carcinogenesis 23, 181 187.
46. Wolnicka-Glubisz, A. F. P. Noonan (2006) Neonatal susceptibility to UV induced cutaneous malignant melanoma in a mouse model. Photochem. Photobiol. Sci. 5, 254 260.
47. Pfahlberg, A., D. Schneider, K. Kölmel O. Gefeller (2000) Ultraviolet exposure in childhood and in adulthood: Which life period modifies the risk of melanoma more substantially? Soz. Praventivmed. 45, 119 124.
48. Pfahlberg, A., K. F. Kolmel O. Gefeller Febim Study Group (2001) Timing of excessive ultraviolet radiation and melanoma: Epidemiology does not support the existence of a critical period of high susceptibility to solar ultraviolet radiation induced melanoma. Br. J. Dermatol. 144, 471 475.
49. Solomon, C. C., E. White, A. R. Kristal T. Vaughan (2004) Melanoma and lifetime UV radiation. Cancer Causes Control 15, 893 902.
50. Kennedy, C., C. Bajdik, R. Willemze, F. De Gruijl, B. J. Bouwes Leiden Skin Cancer Study (2003) The influence of painful sunburns and lifetime sun exposure on the risk of actinic keratoses, seborrheic warts, melanocytic nevi, atypical nevi, and skin cancer. J. Invest. Dermatol. 120, 1087 1093.
51. Beitner, H., S. Norell, U. Ringborg, G. Wennersten B. Mattson (1990) Malignant melanoma: Aetiological importance of individual pigmentation and sun exposure. Br. J. Dermatol. 122, 43 51.
52. Holman, C. B. Armstrong (1984) Cutaneous malignant melanoma and indicators of total accumulated exposure to the sun: An analysis separating histogenetic types. J. Natl Cancer Inst. 73, 75 82.
53. Dubin, N., B. Pasternack M. Moseson (1990) Simultaneous assessment of risk factors for malignant melanoma and non-melanoma skin lesions, with emphasis on sun exposure and related variables. Int. J. Epidemiol. 19, 811 819.
54. Rosso, S., R. Zanetti, M. Pippione H. Sancho-Garnier (1998) Parallel risk assessment of melanoma and basal cell carcinoma: Skin characteristics and sun exposure. Melanoma Res. 8, 573 583.
55. Mack, T. B. Floderus (1991) Malignant melanoma risk by nativity, place of residence at diagnosis, and age at migration. Cancer Causes Control 2, 401 411.
56. Costin, G.-E. V. J. Hearing (2007) Human skin pigmentation: Melanocytes modulate skin color in response to stress. FASEB J. 21, 976 994.
57. Miyamura, Y., S. G. Coelho, R. Wolber, S. A. Miller, K. Wakamatsu, B. Z. Zmudzka, S. Ito, C. Smuda, T. Passeron, W. Choi, J. Batzer, Y. Yamaguchi, J. Z. Beer V. J. Hearing (2007) Regulation of human skin pigmentation and responses to ultraviolet radiation. Pigment Cell Res. 20, 2 13.
58. Tsai, T., C. Vu D. Henson (2005) Cutaneous, ocular and visceral melanoma in African Americans and Caucasians. Melanoma Res. 15, 213 217.
59. Pennello, G., S. Devesa M. Gail (2000) Association of surface ultraviolet B radiation levels with melanoma and nonmelanoma skin cancer in United States blacks. Cancer Epidemiol. Biomarkers Prev. 9, 291 297.
60. Eide, M. J. M. A. Weinstock (2005) Association of UV index, latitude, and melanoma incidence in nonwhite populations - US Surveillance, Epidemiology, and End Results (SEER) Program, 1992 to 2001. Arch. Dermatol. 141, 477 481.
61. Tatalovich, Z., J. Wilson, T. Mack, Y. Yan M. Cockburn (2006) The objective assessment of lifetime cumulative ultraviolet exposure for determining melanoma risk. J. Photochem. Photobiol. B, Biol. 85, 198 204.
62. Gilchrest, B. A., M. S. Eller, A. C. Geller M. Yaar (1999) The pathogenesis of melanoma induced by ultraviolet radiation. N. Engl. J. Med. 340, 1341 1348.
63. Curtin, J. A., J. Fridlyand, T. Kageshita, H. N. Patel, K. J. Busam, H. Kutzner, K.-H. Cho, S. Aiba, E.-B. Brocker, P. E. LeBoit, D. Pinkel B. C. Bastian (2005) Distinct sets of genetic alterations in melanoma. N. Engl. J. Med. 353, 2135 2147.
64. Blankenburg, S., I. König, R. Moessner, P. Laspe, K. Thoms, U. Krueger, S. Khan, G. Westphal, M. Volkenandt, C. Neumann, A. Ziegler, K. Kraemer, K. Reich S. Emmert (2005) No association between three xeroderma pigmentosum group C and one group G gene polymorphisms and risk of cutaneous melanoma. Eur. J. Hum. Genet. 13, 253 255.
65. Blankenburg, S., I. R. Konig, R. Moessner, P. Laspe, K.-M. Thoms, U. Krueger, S. G. Khan, G. Westphal, C. Berking, M. Volkenandt, K. Reich, C. Neumann, A. Ziegler, K. H. Kraemer S. Emmert (2005) Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: A case-control study. Carcinogenesis 26, 1085 1090.
66. Sidwell, R. U., A. Sandison, J. Wing, H. D. Fawcett, J. E. Seet, C. Fisher, T. Nardo, M. Stefanini, A. R. Lehmann J. J. Cream (2006) A novel mutation in the XPA gene associated with unusually mild clinical features in a patient who developed a spindle cell melanoma. Br. J. Dermatol. 155, 81 88.
67. Lai, K., N. D. Girolamo, R. M. Conway, M. J. Jager M. C. Madigan (2007) The effect of ultraviolet radiation on choroidal melanocytes and melanoma cell lines: Cell survival and matrix metalloproteinase production. Graefes Arch. Clin. Exp. Ophthalmol. 245, 715 724.
68. Berking, C., R. Takemoto, K. Satyamoorthy, T. Shirakawa, M. Eskandarpour, J. Hansson, P. VanBelle, D. Elder M. Herlyn (2004) Induction of melanoma phenotypes in human skin by growth factors and ultraviolet B. Cancer Res. 64, 807 811.
69. Wang, L.-E., P. Xiong, S. S. Strom, L. H. Goldberg, J. E. Lee, M. I. Ross, P. F. Mansfield, J. E. Gershenwald, V. G. Prieto, J. N. Cormier, M. Duvic, G. L. Clayman, R. S. Weber, S. M. Lippman, C. I. Amos, M. R. Spitz Q. Wei (2005) In vitro sensitivity to ultraviolet B light and skin cancer risk: A case-control analysis. J. Natl Cancer Inst. 97, 1822 1831.
70. De Fabo, E. C., F. P. Noonan, T. Fears G. Merlino (2004) Ultraviolet B but not ultraviolet A radiation initiates melanoma. Cancer Res. 64, 6372 6376.
71. de Laat, A., J. C. van der Leun F. R. de Gruijl (1997) Carcinogenesis induced by UVA (365-nm) radiation: The dose-time dependence of tumor formation in hairless mice. Carcinogenesis 18, 1013 1020.
72. Parisi, A. V. J. C. F. Wong (2000) An estimation of biological hazards due to solar radiation. J. Photochem. Photobiol. B, Biol. 54, 126 130.
73. Setlow, R. B., E. Grist, K. Thompson A. D. Woodhead (1993) Wavelengths effective in induction of malignant melanoma. Proc. Natl Acad. Sci. USA 90, 6666 6670.
74. Moan, J., A. Dahlback R. Setlow (1999) Epidemiological support for an hypothesis for melanoma induction indicating a role for UVA radiation. Photochem. Photobiol. 70, 243 247.
75. Kowalczuk, C. I., M. C. Priestner, A. J. Pearson, R. D. Saunders S. D. Bouffler (2006) Wavelength dependence of cellular responses in human melanocytes and melanoma cells following exposure to ultraviolet radiation. Int. J. Radiat. Biol. 82, 781 792.
76. Marrot, L., L. Marrot, J.-P. Belaïdi, C. Jones, P. Perez J.-R. Meunier (2005) Molecular responses to stress induced in normal human Caucasian melanocytes in culture by exposure to simulated solar UV. Photochem. Photobiol. 81, 367 375.
77. Hussein, M. R. (2005) Ultraviolet radiation and skin cancer: Molecular mechanisms. J. Cutan. Pathol. 32, 191 205.
78. Young, A. R. J. M. Sheehan (2001) UV-induced pigmentation in human skin. In Sun Protection in Man (Edited by P. U. Giacomoni pp. 357 375. Elsevier, Amsterdam.
79. Cripps, D. J. (1981) Natural and artificial photoprotection. J. Invest. Dermatol. 77, 154 157.
80. Halder, R. M. S. Bridgeman-Shah (1995) Skin cancer in African Americans. Cancer 75, 667 673.
81. Perry, P. N. Silverberg (2001) Cutaneous malignancy in albinism. Cutis 67, 427 430.
82. Streutker, C., D. McCready, K. Jimbow L. From (2000) Malignant melanoma in a patient with oculocutaneous albinism. J. Cutan. Med. Surg. 4, 149 152.
83. Christophers, A. J. (1998) Melanoma is not caused by sunlight. Mutat. Res. 422, 113 117.
84. Yakubu, A. O. Mabogunje (1993) Skin cancer in African albinos. Acta Oncol. 32, 621 622.
85. Lookingbill, D. P., G. L. Lookingbill B. Leppard (1995) Actinic damage and skin cancer in albinos in northern Tanzania: Findings in 164 patients enrolled in an outreach skin care program. J. Am. Acad. Dermatol. 32, 653 658.
86. Kromberg, J., D. Castle, E. Zwane T. Jenkins (1989) Albinism and skin cancer in Southern Africa. Clin. Genet. 36, 43 52.
87. Kripke, M. L. (1977) Latency, histology, and antigenicity of tumors induced by ultraviolet light in three inbred mouse strains. Cancer Res. 37, 1395 1400.
88. Kobayashi, N., A. Nakagawa, T. Muramatsu, Y. Yamashina, T. Shirai, M. W. Hashimoto, Y. Ishigaki, T. Ohnishi T. Mori (1998) Supranuclear melanin caps reduce ultraviolet induced DNA photoproducts in human epidermis. J. Invest. Dermatol. 110, 806 810.
89. Smit, N. P. M., A. A. Vink, R. M. Kolb, M.-J. S. T. Steenwinkel, P. T. M. van den Berg, F.v. Nieuwpoort, L. Roza S. Pavel (2001) Melanin offers protection against induction of cyclobutane pyrimidine dimers and 6-4 photoproducts by UVB in cultured human melanocytes. Photochem. Photobiol. 74, 424 430.
90. Barker, D., K. Dixon, E. E. Medrano, D. Smalara, S. Im, D. Mitchell, G. Babcock Z. A. Abdel-Malek (1995) Comparison of the responses of human melanocytes with different melanin contents to ultraviolet B irradiation. Cancer Res. 55, 4041 4046.
91. Nordlund, J. (1985) The pigmentary system: New interpretations of old data. J. Dermatol. 12, 105 116.
92. Yamaguchi, Y., M. Brenner V. J. Hearing (2007) The regulation of skin pigmentation. J. Biol. Chem. 282, 27557 27561.
93. Hennessy, A., C. Oh, B. Diffey, K. Wakamatsu, S. Ito J. Rees (2005) Eumelanin and pheomelanin concentrations in human epidermis before and after UVB irradiation. Pigment Cell Res. 18, 220 223.
94. Wakamatsu, K. S. Ito (2006) Evaluation of melanin-related metabolites as markers of solar ultraviolet-B radiation. Pigment Cell Res. 19, 460 464.
95. Yamaguchi, Y., K. Takahashi, B. Z. Zmudzka, A. Kornhauser, S. A. Miller, T. Tadokoro, W. Berens, J. Z. Beer V. J. Hearing (2006) Human skin responses to UV radiation: Pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. FASEB J. 20, 1486 1488.
96. De Leeuw, S., N. Smit, M. Van Veldhoven, E. Pennings, S. Pavel, J. Simons A. Schothorst (2001) Melanin content of cultured human melanocytes and UV-induced cytotoxicity. J. Photochem. Photobiol. B, Biol. 61, 106 113.
97. Kraus, L. M. Landthaler (1980) Malignant melanoma, leukoderma and vitiligo. Z. Hautkr. 55, 218 231.
98. Gregor, R. (1976) Vitiligo and malignant melanoma: A significant association? S. Afr. Med. 50, 1447 1449.
99. Cavallari, V., S. Cannavò, A. Ussia, G. Moretti A. Albanese (1996) Vitiligo associated with metastatic malignant melanoma. Int. J. Dermatol. 35, 738 740.
100. Gul, U., A. Kilic, O. Tulunay G. Kaygusuz (2007) Vitiligo associated with malignant melanoma and lupus erythematosus. J. Dermatol. 34, 142 145.
101. Buljan, M., M. Situm, L. Lugović M. Vucić (2006) Metastatic melanoma and vitiligo: A case report. Acta Dermatovenerol. Croat. 14, 100 103.
102. Nordlund, J., J. Kirkwood, B. Forget, G. Milton, D. Albert A. Lerner (1983) Vitiligo in patients with metastatic melanoma: A good prognostic sign. J. Am. Acad. Dermatol. 9, 689 696.
103. Kollias, N., R. Sayre, L. Zeise M. Chedekel (1991) Photoprotection by melanin. J. Photochem. Photobiol. B, Biol. 9, 135 160.
104. Hill, H. Z. (1992) The function of melanin or six blind people examine an elephant. Bioessays 14, 49 56.
105. Takeuchi, S., W. Zhang, K. Wakamatsu, S. Ito, V. J. Hearing, K. H. Kraemer D. E. Brash (2004) Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin. Proc. Natl Acad. Sci. USA 101, 15076 15081.
106. Garland, C., F. Garland E. Gorham (1993) Rising trends in melanoma. An hypothesis concerning sunscreen effectiveness. Ann. Epidemiol. 3, 103 110.
107. Wenczl, E., S. Pool, A. Timmerman, G. van der Schans, L. Roza A. Schothorst (1997) Physiological doses of ultraviolet irradiation induce DNA strand breaks in cultured human melanocytes, as detected by means of an immunochemical assay. Photochem. Photobiol. 66, 826 830.
108. Marrot, L., J. Belaidi, J. Meunier, P. Perez C. Agapakis-Causse (1999) The human melanocyte as a particular target for UVA radiation and an endpoint for photoprotection assessment. Photochem. Photobiol. 69, 686 693.
109. Wenczl, E., G. Van der Schans, L. Roza, R. Kolb, A. Timmerman, N. Smit, S. Pavel A. Schothorst (1998) (Pheo)melanin photosensitizes UVA-induced DNA damage in cultured human melanocytes. J. Invest. Dermatol. 111, 678 682.
110. Abdulla, F. R., S. R. Feldman, P. M. Williford, D. Krowchuk M. Kaur (2005) Tanning and skin cancer. Pediatr. Dermatol. 22, 501 512.
111. Swerdlow, A. J. M. A. Weinstock (1998) Do tanning lamps cause melanoma? An epidemiologic assessment. J. Am. Acad. Dermatol. 38, 89 98.
112. Gallagher, R. P., J. J. Spinelli T. K. Lee (2005) Tanning beds, sunlamps, and risk of cutaneous malignant melanoma. Cancer Epidemiol. Biomarkers Prev. 14, 562 566.
113. International Agency for Research on Cancer Working Group on Artificial Ultraviolet (UV) Light, Skin Cancer (2007) The association of use of sunbeds with cutaneous malignant melanoma and other skin cancers: A systematic review. Int. J. Cancer 120, 1116 1122.
114. Kaidbey, K., P. Agin, R. Sayre A. Kligman (1979) Photoprotection by melanin - A comparison of black and Caucasian skin. J. Am. Acad. Dermatol. 1, 249 260.
115. Bech-Thomsen, N. H. Wulf (1996) Photoprotection due to pigmentation and epidermal thickness after repeated exposure to ultraviolet light and psoralen plus ultraviolet A therapy. Photodermatol. Photoimmunol. Photomed. 11, 213 218.
116. Gniadecka, M., H. Wulf, N. Mortensen T. Poulsen (1996) Photoprotection in vitiligo and normal skin. A quantitative assessment of the role of stratum corneum, viable epidermis and pigmentation. Acta Derm. Venereol. 76, 429 432.
117. Lock-Andersen, J., P. Therkildsen, F. de Fine Olivarius, M. Gniadecka, K. Dahlstrøm, T. Poulsen H. C. Wulf (1997) Epidermal thickness, skin pigmentation and constitutive photosensitivity. Photodermatol. Photoimmunol. Photomed. 13, 153 158.
118. Lock-Andersen, J., K. T. Drzewiecki H. C. Wulf (1998) The measurement of constitutive and facultative skin pigmentation and estimation of sun exposure in Caucasians with basal cell carcinoma and cutaneous malignant melanoma. Br. J. Dermatol. 139, 610 617.
119. Noonan, F. P., T. Otsuka, S. Bang, M. R. Anver G. Merlino (2000) Accelerated ultraviolet radiation-induced carcinogenesis in hepatocyte growth factor/scatter factor transgenic mice. Cancer Res. 60, 3738 3743.
120. Gandini, S., F. Sera, M. Cattaruzza, P. Pasquini, O. Picconi, P. Boyle C. Melchi (2005) Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure. Eur. J. Cancer 41, 45 60.
121. Gandini, S., F. Sera, M. Cattaruzza, P. Pasquini, D. Abeni, P. Boyle C. Melchi (2005) Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi. Eur. J. Cancer 41, 28 44.
122. Davies, H., G. R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M. J. Garnett, W. Bottomley, N. Davis, E. Dicks, R. Ewing, Y. Floyd, K. Gray, S. Hall, R. Hawes, J. Hughes, V. Kosmidou, A. Menzies, C. Mould, A. Parker, C. Stevens, S. Watt, S. Hooper, R. Wilson, H. Jayatilake, B. A. Gusterson, C. Cooper, J. Shipley, D. Hargrave, K. Pritchard-Jones, N. Maitland, G. Chenevix-Trench, G. J. Riggins, D. D. Bigner, G. Palmieri, A. Cossu, A. Flanagan, A. Nicholson, J. W. C. Ho, S. Y. Leung, S. T. Yuen, B. L. Weber, H. F. Seigler, T. L. Darrow, H. Paterson, R. Marais, C. J. Marshall, R. Wooster, M. R. Stratton A. P. Futreal (2002) Mutations of the BRAF gene in human cancer. Nature 417, 949 954.
123. Indsto, J. O., S. Kumar, L. Wang, K. A. Crotty, S. M. Arbuckle G. J. Mann (2007) Low prevalence of RAS-RAF-activating mutations in Spitz melanocytic nevi compared with other melanocytic lesions. J. Cutan. Pathol. 34, 448 455.
124. Poynter, J., J. Elder, D. Fullen, R. Nair, M. Soengas, T. Johnson, B. Redman, N. Thomas S. Gruber (2006) BRAF and NRAS mutations in melanoma and melanocytic nevi. Melanoma Res. 16, 267 273.
125. Pollock, P. M., U. L. Harper, K. S. Hansen, L. M. Yudt, M. Stark, C. M. Robbins, T. Y. Moses, G. Hostetter, U. Wagner, J. Kakareka, G. Salem, T. Pohida, P. Heenan, P. Duray, O. Kallioniemi, N. K. Hayward, J. M. Trent P. S. Meltzer (2002) High frequency of BRAF mutations in nevi. Nat. Genet. 33, 19 20.
126. Uribe, P., I. Wistuba S. González (2003) BRAF mutation: A frequent event in benign, atypical, and malignant melanocytic lesions of the skin. Am. J. Dermatopathol. 25, 365 370.
127. Yazdi, A., G. Palmedo, M. Flaig, U. Puchta, A. Reckwerth, A. Rütten, T. Mentzel, H. Hügel, M. Hantschke, M. Schmid-Wendtner, H. Kutzner C. Sander (2003) Mutations of the BRAF gene in benign and malignant melanocytic lesions. J. Invest. Dermatol. 121, 1160 1162.
128. Kumar, R., S. Angelini, E. Snellman K. Hemminki (2004) BRAF mutations are common somatic events in melanocytic nevi. J. Invest. Dermatol. 122, 342 348.
129. Wellbrock, C., L. Ogilvie, D. Hedley, M. Karasarides, J. Martin, D. Niculescu-Duvaz, C. J. Springer R. Marais (2004) V599EB-RAF is an oncogene in melanocytes. Cancer Res. 64, 2338 2342.
130. Patton, E., H. Widlund, J. Kutok, K. Kopani, J. Amatruda, R. Murphey, S. Berghmans, E. Mayhall, D. Traver, C. Fletcher, J. Aster, S. Granter, S. Look, C. Lee, D. Fisher L. Zon (2005) BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr. Biol. 15, 249 254.
131. Edwards, R. H., M. R. Ward, H. Wu, C. A. Medina, M. S. Brose, P. Volpe, S. Nussen-Lee, H. M. Haupt, A. M. Martin, M. Herlyn, S. R. Lessin B. L. Weber (2004) Absence of BRAF mutations in UV-protected mucosal melanomas. J. Med. Genet. 41, 270 272.
132. Thomas, N., M. Berwick M. Cordeiro-Stone (2006) Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation? J. Invest. Dermatol. 126, 1693 1696.
133. Thomas, N. E., S. N. Edmiston, A. Alexander, R. C. Millikan, P. A. Groben, H. Hao, D. Tolbert, M. Berwick, K. Busam, C. B. Begg, D. Mattingly, D. W. Ollila, C. K. Tse, A. Hummer, J. Lee-Taylor K. Conway (2007) Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma. Cancer Epidemiol. Biomarkers Prev. 16, 991 997.
134. Daya-Grosjean, L., C. Robert, C. Drougard, H. Suarez A. Sarasin (1993) High mutation frequency in ras genes of skin tumors isolated from DNA repair deficient xeroderma pigmentosum patients. Cancer Res. 53, 1625 1629.
135. Keijzer, W., M. P. Mulder, J. C. M. Langeveld, E. M. E. Smit, J. L. Bos, D. Bootsma J. H. J. Hoeijmakers (1989) Establishment and characterization of a melanoma cell line from a xeroderma pigmentosum patient: Activation of N-ras at a potential pyrimidine dimer site. Cancer Res. 49, 1229 1235.
136. van 't Veer, L. J., B. M. Burgering, R. Versteeg, A. J. Boot, D. J. Ruiter, S. Osanto, P. I. Schrier J. L. Bos (1989) N-ras mutations in human cutaneous melanoma from sun-exposed body sites. Mol. Cell. Biol. 9, 3114 3116.
137. Jiveskog, S., B. Ragnarsson-Olding, A. Platz U. Ringborg (1998) N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin. J. Invest. Dermatol. 111, 757 761.
138. Benjamin, C. L., V. O. Melnikova H. N. Ananthaswamy (2007) Models and mechanisms in malignant melanoma. Mol. Carcinog. 46, 671 678.
139. Pollock, P., F. Yu, L. Qiu, P. Parsons N. Hayward (1995) Evidence for u.v. induction of CDKN2 mutations in melanoma cell lines. Oncogene 11, 663 668.
140. Sarkar-Agrawal, P., I. Vergilis, N. E. Sharpless, R. A. DePinho T. M. Runger (2004) Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF. J. Natl Cancer Inst. 96, 1790 1793.
141. Choi, B., H. Choi, K. Ko, Y. Cho, F. Zhu, B. Kang, S. Ermakova, W. Ma, A. Bode Z. Dong (2005) The tumor suppressor p16(INK4a) prevents cell transformation through inhibition of c-Jun phosphorylation and AP-1 activity. Nat. Struct. Mol. Biol. 12, 699 707.
142. Recio, J. A., F. P. Noonan, H. Takayama, M. R. Anver, P. Duray, W. L. Rush, G. Lindner, E. C. De Fabo, R. A. DePinho G. Merlino (2002) Ink4a/Arf deficiency promotes ultraviolet radiation-induced melanomagenesis. Cancer Res. 62, 6724 6730.