The neuroprotective effects of tocotrienol rich fraction and alpha tocopherol against glutamate injury in astrocytes

Bosnian Journal of Basic Medical Sciences

Volumn 14, Issue 4, 2014, Pages 195-204

  Selvaraju, Thilaga Rati ^a   Khaza’ai, Huzwah ^a   Vidyadaran, Sharmili ^a   Mutalib, Mohd Sokhini Abd ^a   Vasudevan, Ramachandran ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Alpha tocopherol; Astrocytes; Glutamate; Tocotrienol rich fraction; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ALPHA TOCOTRIENOL; ANTIOXIDANT; GLUTAMIC ACID; NEUROPROTECTIVE AGENT; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ASTROCYTE; CELL CYCLE; CELL DEATH; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; HUMAN; LIPID PEROXIDATION; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PATHOLOGY; SCANNING ELECTRON MICROSCOPY;

ALPHA-TOCOPHEROL; ANTIOXIDANTS; ASTROCYTES; CELL CYCLE; CELL DEATH; CELL LINE; CELL SURVIVAL; GLUTAMIC ACID; HUMANS; LIPID PEROXIDATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON, SCANNING; NEUROPROTECTIVE AGENTS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TOCOTRIENOLS;

EID: 84916887817     PISSN: 15128601     EISSN: 18404812     Source Type: Journal    
DOI: 10.17305/bjbms.2014.4.91     Document Type: Article

References (40)

1. Tabrizi S. Neurodegenerative diseases neurobiology pathogenesis and therapeutics. J Neurol Neurosurg and Psychiatry. 2006;77(2):284. http://dx.doi.org/10.1136/jnnp.2005.072710.
2. Dibble LE, Lange M. Predicting falls in individuals with Parkinson disease: a reconsideration of clinical balance measures. J Neurol Phys Ther. 2006;30(2):60-7. http://dx.doi.org/10.1097/01. NPT.0000282569.70920.dc.
3. Shukla V, Mishra SK, Pant HC. Oxidative stress in neurodegeneration. Adv Pharmacol Sci. 2011; 2011:572-634.
4. Rock RB, Gekker G, Hu S, Sheng WS, Cheeran M, Lokensgard JR, et al. Role of microglia in central nervous system infections. Clin Microbiol Rev. 2004;17(4):942-64, table of contents. http://dx.doi. org/10.1128/CMR.17.4.942-964.2004.
5. Wang Y, Qin ZH. Molecular and cellular mechanisms of excitotoxic neuronal death. Apoptosis. 2010;15(11):1382-402. http://dx.doi. org/10.1007/s10495-010-0481-0
6. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr. 2000;130(4S Suppl):1007S-15S. Epub 2000/03/29.
7. Higuchi Y. Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis. J Cell Mol Med. 2004;8(4):455-64. http://dx.doi.org/10.1111/j.1582-4934.2004. tb00470.x
8. Scandalios JG. Oxidative stress responses--what have genomescale studies taught us? Genome Biol. 2002;3(7):1019. http://dx.doi. org/10.1186/gb-2002-3-7-reviews1019.
9. Emerit J, Edeas M, Bricaire F. Neurodegenerative diseases and oxidative stress. Biomed Pharmacother. 2004;58(1):39-46. http:// dx.doi.org/10.1016/j.biopha.2003.11.004.
10. Sen CK, Khanna S, Roy S, Packer L. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c- Src) kinase activation and death of HT4 neuronal cells. J Biol Chem. 2000;275(17):13049-55. http://dx.doi.org/10.1074/jbc.275.17.13049.
11. Saito Y, Nishio K, Akazawa YO, Yamanaka K, Miyama A, Yoshida Y, et al. Cytoprotective eff ects of vitamin E homologues against glutamate- induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar eff ects by antioxidant function. Free Radic Biol Med. 2010;49(10):1542-9. http:// dx.doi.org/10.1016/j.freeradbiomed.2010.08.016.
12. Maniam S, Mohamed N, Shuid AN, Soelaiman IN. Palm tocotrienol exerted better antioxidant activities in bone than alpha-tocopherol. Basic Clin Pharmacol Toxicol. 2008;103(1):55-60. http://dx.doi. org/10.1111/j.1742-7843.2008.00241.x.
13. Serbinova E, Kagan V, Han D, Packer L. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic Biol Med. 1991;10(5):263-75. http://dx.doi.org/10.1016/0891-5849(91)90033-Y
14. Wu SJ, Liu PL, Ng LT. Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells. Molecular nutrition & food research. 2008;52(8):921-9. http://dx.doi. org/10.1002/mnfr.200700418.
15. Wu SJ, Ng LT. Antioxidant and antihepatoma activities of palm oil extract. Journal of Food Lipids. 2007;14(2):122-37. http://dx.doi. org/10.1111/j.1745-4522.2007.00075.x.
16. Takahashi K, Loo G. Disruption of mitochondria during tocotrienol- induced apoptosis in MDA-MB-231 human breast cancer cells. Biochem Pharmacol. 2004;67(2):315-24. http://dx.doi.org/10.1016/j. bcp.2003.07.015.
17. Goh SH, Hew NF, Norhanom AW, Yadav M. Inhibition of tumour promotion by various palm-oil tocotrienols. Int J Cancer. 1994;57(4):529-31. http://dx.doi.org/10.1002/ijc.2910570415
18. Osakada F, Hashino A, Kume T, Katsuki H, Kaneko S, Akaike A. Alpha-tocotrienol provides the most potent neuroprotection among Vitamin E analogs on cultured striatal neurons. Neuropharmacology. 2004;47(6):904-15. http://dx.doi. org/10.1016/j.neuropharm.2004.06.029.
19. Minhajuddin M, Beg ZH, Iqbal J. Hypolipidemic and antioxidant properties of tocotrienol rich fraction isolated from rice bran oil in experimentally induced hyperlipidemic rats. Food Chem Toxicol. 2005;43(5):747-53. http://dx.doi.org/10.1016/j.fct.2005.01.015.
20. Mutalib MSA, Khaza'ai H, Wahle KWJ. Palm-tocotrienol rich fraction (TRF) is a more eff ective inhibitor of LDL oxidation and endothelial cell lipid peroxidation than α-tocopherol in vitro. Food Research International. 2003;36(5):405-13. http://dx.doi. org/10.1016/S0963-9969(02)00173-4.
21. Qureshi AA, Bradlow BA, Brace L, Manganello J, Peterson DM, Pearce BC, et al. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids. 1995;30(12):1171-7. http://dx. doi.org/10.1007/BF02536620.
22. Sen CK, Rink C, Khanna S. Palm oil-derived natural Vitamin E alpha-tocotrienol in brain health and disease. J Am Coll Nutr. 2010;29(3 Suppl):314S-23S. http://dx.doi.org/10.1080/07315724.20 10.10719846.
23. Mangialasche F, Kivipelto M, Mecocci P, Rizzuto D, Palmer K, Winblad B, et al. High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age. J Alzheimers Dis. 2010;20(4):1029-37.
24. Aggarwal BB, Sundaram C, Prasad S, Kannappan R. Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Biochem Pharmacol. 2010;80(11):1613-31. http://dx.doi.org/10.1016/j.bcp.2010.07.043.
25. Wang J, Rajakulendran N, Amirsadeghi S, Vanlerberghe GC. Impact of mitochondrial alternative oxidase expression on the response of Nicotiana tabacum to cold temperature. Physiol Plant. 2011;142(4):339-51. Epub 2011/03/16.
26. van Meerloo J, Kaspers GJ, Cloos J. Cell sensitivity assays: the MTT assay. Methods Mol Biol. 2011;731:237-45. http://dx.doi. org/10.1007/978-1-61779-080-5_20.
27. Nguyen HT, Olson J, DeVries C, Savage W, Holtzman D. Scanning electron microscopic study of lead eff ects on cerebral astrocytes in primary culture. Scan Electron Microsc. 1982(Pt 2):891-6.
28. Schubert D, Kimura H, Maher P. Growth factors and vitamin E modify neuronal glutamate toxicity. Proc Natl Acad Sci U S A. 1992;89(17):8264-7. http://dx.doi.org/10.1073/pnas.89.17.8264.
29. Khanna S, Roy S, Parinandi NL, Maurer M, Sen CK. Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. J Neurochem. 2006;98(5):1474-86. http://dx.doi. org/10.1111/j.1471-4159.2006.04000.x.
30. Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, et al. Malonaldehyde acts as a mitochondrial toxin: Inhibitory eff ects on respiratory function and enzyme activities in isolated rat liver mitochondria. Life Sci. 2006;79(15):1466-72. http://dx.doi.org/10.1016/j.lfs.2006.04.024.
31. Mazlan M, Sue Mian T, Mat Top G, Zurinah Wan Ngah W. Comparative eff ects of alpha-tocopherol and gamma-tocotrienol against hydrogen peroxide induced apoptosis on primary-cultured astrocytes. J Neurol Sci. 2006;243(1-2):5-12. http://dx.doi. org/10.1016/j.jns.2005.10.006.
32. Then SM, Mazlan M, Mat Top G, Wan Ngah WZ. Is Vitamin E toxic to neuron cells? Cell Mol Neurobiol. 2009;29(4):485-96. http://dx. doi.org/10.1007/s10571-008-9340-8.
33. S. M. Then WZWN, G. M. Top, and M. Mazlan. Comparison of the eff ects of α-tocopherol and γ-tocotrienol against oxidative stress in two diff erent neuronal cultures. Sains Malaysiana. 2010;39(1):145-56.
34. Hardej D, Trombetta LD. The eff ects of ebselen on cisplatin and diethyldithiocarbamate (DDC) cytotoxicity in rat hippocampal astrocytes. Toxicol Lett. 2002;131(3):215-26. http://dx.doi. org/10.1016/S0378-4274(02)00056-5.
35. Folch J, Junyent F, Verdaguer E, Auladell C, Pizarro JG, Beas-Zarate C, et al. Role of cell cycle re-entry in neurons: a common apoptotic mechanism of neuronal cell death. Neurotox Res. 2012;22(3):195-207. http://dx.doi.org/10.1007/s12640-011-9277-4.
36. Schwartz EI, Smilenov LB, Price MA, Osredkar T, Baker RA, Ghosh S, et al. Cell cycle activation in postmitotic neurons is essential for DNA repair. Cell Cycle. 2007;6(3):318-29. http://dx.doi.org/10.4161/ cc.6.3.3752.
37. Dringen R, Hirrlinger J. Glutathione pathways in the brain. Biol Chem. 2003;384(4):505-16. http://dx.doi.org/10.1515/BC.2003.059.
38. Iwata-Ichikawa E, Kondo Y, Miyazaki I, Asanuma M, Ogawa N. Glial cells protect neurons against oxidative stress via transcriptional up-regulation of the glutathione synthesis. J Neurochem. 1999;72(6):2334-44. http://dx.doi.org/10.1046/j.1471-4159.1999.0722334.x.
39. Gegelashvili G, Schousboe A. High afflnity glutamate transporters: regulation of expression and activity. Mol Pharmacol. 1997;52(1):6-15.
40. Szydlowska K, Gozdz A, Dabrowski M, Zawadzka M, Kaminska B. Prolonged activation of ERK triggers glutamate- induced apoptosis of astrocytes: neuroprotective eff ect of FK506. J Neurochem. 2010;113(4):904-18. http://dx.doi. org/10.1111/j.1471-4159.2010.06656.x.