메뉴 건너뛰기




Volumn 14, Issue 3, 2014, Pages 169-181

The multimodal treatment of acromegaly: Current status and future perspectives

Author keywords

Acromegaly; Cabergoline; Dopamine agonists; GH; IGF 1; Lanreotide; Octreotide; Pegvisomant; Radiation therapy; Somatostatin analogs

Indexed keywords

CHOLECYSTOKININ; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; GROWTH HORMONE RELEASING FACTOR; KI 67 ANTIGEN; PEGVISOMANT; PEPTIDE HORMONE RECEPTOR BLOCKING AGENT; SECRETIN; SOMATOMEDIN C; SOMATOSTATIN DERIVATIVE; SOMATOSTATIN RECEPTOR 1; SOMATOSTATIN RECEPTOR 2; SOMATOSTATIN RECEPTOR 3; SOMATOSTATIN RECEPTOR 4; SOMATOSTATIN RECEPTOR 5;

EID: 84916612073     PISSN: 18715303     EISSN: 22123873     Source Type: Journal    
DOI: 10.2174/1871530314666140609110308     Document Type: Article
Times cited : (11)

References (139)
  • 1
    • 70449366466 scopus 로고    scopus 로고
    • Acromegaly: Pathogenesis and treatment
    • Melmed, S. (2009) Acromegaly: Pathogenesis and treatment. J. Clin. Invest, 119, 3189-3200.
    • (2009) J. Clin. Invest , vol.119 , pp. 3189-3200
    • Melmed, S.1
  • 2
    • 49349112415 scopus 로고    scopus 로고
    • Acromegaly
    • Melmed, S. (2006) Acromegaly. N Engl. J. Med., 335, 2258-2273.
    • (2006) N Engl. J. Med , vol.335 , pp. 2258-2273
    • Melmed, S.1
  • 3
    • 79955093923 scopus 로고    scopus 로고
    • Pathogenesis of pituitary tumors
    • Melmed, S. (2011) Pathogenesis of pituitary tumors. Nat. Rev. Endocrinol., 7, 257-266.
    • (2011) Nat. Rev. Endocrinol , vol.7 , pp. 257-266
    • Melmed, S.1
  • 4
    • 0033139863 scopus 로고    scopus 로고
    • Epidemiology of acromegaly
    • Holdaway, I.M. and Rajasoorya, C. (1999) Epidemiology of acromegaly. Pituitary, 2, 29-41.
    • (1999) Pituitary , vol.2 , pp. 29-41
    • Holdaway, I.M.1    Rajasoorya, C.2
  • 8
    • 0031769360 scopus 로고    scopus 로고
    • The outcome of surgery for acromegaly: The need for a specialist pituitary surgeon for all types of GH-secreting adenomas
    • Lissett, C.A.; Peacey, S.R.; Laing, I.; Tetlow, R.; Davis, J.R. and Shalet, S.M. (1998) The outcome of surgery for acromegaly: the need for a specialist pituitary surgeon for all types of GH-secreting adenomas. Clin. Endocrinol., 49, 653-7.
    • (1998) Clin. Endocrinol , vol.49 , pp. 653-657
    • Lissett, C.A.1    Peacey, S.R.2    Laing, I.3    Tetlow, R.4    Davis, J.R.5    Shalet, S.M.6
  • 9
    • 84863011100 scopus 로고    scopus 로고
    • Acromegaly surgery in Manchester revisited-the impact of reducing surgeon numbers and the 2010 consensus guidelines for disease remission
    • Wang, Y.Y.; Higham, C.; Kearney, T.; Davis, J.R.; Trainer, P. and Gnanalingham, K.K. (2012) Acromegaly surgery in Manchester revisited-the impact of reducing surgeon numbers and the 2010 consensus guidelines for disease remission. Clin. Endocrinol., 76, 399-406.
    • (2012) Clin. Endocrinol , vol.76 , pp. 399-406
    • Wang, Y.Y.1    Higham, C.2    Kearney, T.3    Davis, J.R.4    Trainer, P.5    Gnanalingham, K.K.6
  • 11
    • 15944401695 scopus 로고    scopus 로고
    • The outcome of surgery in 668 patients with acromegaly using current criteria of biochemical cure
    • Nomikos, P.; Buchfelder, M. and Fahlbusch, R. (2005) The outcome of surgery in 668 patients with acromegaly using current criteria of biochemical cure. Eur. J. Endocrinol., 152, 379-387.
    • (2005) Eur. J. Endocrinol , vol.152 , pp. 379-387
    • Nomikos, P.1    Buchfelder, M.2    Fahlbusch, R.3
  • 14
    • 84881482571 scopus 로고    scopus 로고
    • Endoscopic vs. microscopic transsphenoidal surgery for acromegaly: Outcomes in a concurrent series of patients using modern criteria for remission
    • Starke, R.M.; Raper, D.M.; Payne, S.C.; Vance, M.L.; Oldfield, E.J. and Jane, J.A. Jr. (2013) Endoscopic vs. microscopic transsphenoidal surgery for acromegaly: outcomes in a concurrent series of patients using modern criteria for remission. J. Clin. Endocrinol. Metab., 98, 3190-3198.
    • (2013) J. Clin. Endocrinol. Metab , vol.98 , pp. 3190-3198
    • Starke, R.M.1    Raper, D.M.2    Payne, S.C.3    Vance, M.L.4    Oldfield, E.J.5    Jane, J.A.6
  • 15
    • 84858150033 scopus 로고    scopus 로고
    • Clinical factors involved in the recurrence of pituitary adenomas after surgical remission: A structured review and meta-analysis
    • Roelfsema, F.; Biermasz, N.R. and Pereira, A.M. (2012) Clinical factors involved in the recurrence of pituitary adenomas after surgical remission: a structured review and meta-analysis. Pituitary, 15, 71-83.
    • (2012) Pituitary , vol.15 , pp. 71-83
    • Roelfsema, F.1    Biermasz, N.R.2    Pereira, A.M.3
  • 17
    • 84888204414 scopus 로고    scopus 로고
    • Repeat endoscopic transsphenoidal surgery for acromegaly: Remission and complications
    • Wilson, T.J; McKean, E.L; Barkan, A.L; Chandler, W.F; and Sullivan, S.E. (2013) Repeat endoscopic transsphenoidal surgery for acromegaly: remission and complications. Pituitary, 16, 459-464.
    • (2013) Pituitary , vol.16 , pp. 459-464
    • Wilson, T.J.1    McKean, E.L.2    Barkan, A.L.3    Chandler, W.F.4    Sullivan, S.E.5
  • 18
    • 0036312912 scopus 로고    scopus 로고
    • Assessment of disease activity in treated acromegalic patients using a sensitive GH assay: Should we achieve strict GH levels for a biochemical cure?
    • Costa, A.C.; Rossi, A.; Matinelli, C.E. Jr.; Manchado, H.R. and Moreira, A.C. (2002) Assessment of disease activity in treated acromegalic patients using a sensitive GH assay: should we achieve strict GH levels for a biochemical cure? J. Clin. Endocrinol. Metab., 87, 3142-3147.
    • (2002) J. Clin. Endocrinol. Metab , vol.87 , pp. 3142-3147
    • Costa, A.C.1    Rossi, A.2    Matinelli, C.E.3    Manchado, H.R.4    Moreira, A.C.5
  • 20
    • 42049103438 scopus 로고    scopus 로고
    • Divergence between growth hormone and insulin-like growth factor 1 concentrations in the follow up of acromegaly
    • Alexopoulou, O.; Bex, M.; Abs, R.; T'Sjoen, G.; Velkeniers, B. and Maiter, D. (2008) Divergence between growth hormone and insulin-like growth factor 1 concentrations in the follow up of acromegaly. J. Clin. Endocrinol. Metab., 93, 1324-1330.
    • (2008) J. Clin. Endocrinol. Metab , vol.93 , pp. 1324-1330
    • Alexopoulou, O.1    Bex, M.2    Abs, R.3    T'Sjoen, G.4    Velkeniers, B.5    Maiter, D.6
  • 22
    • 5544328189 scopus 로고    scopus 로고
    • Estrogen regulation of growth hormone action
    • Leung, K.C.; Johannsson, G.; Leung, G.M. and Ho, K.K. (2004) Estrogen regulation of growth hormone action. Endocr. Rev., 25, 693-721.
    • (2004) Endocr. Rev , vol.25 , pp. 693-721
    • Leung, K.C.1    Johannsson, G.2    Leung, G.M.3    Ho, K.K.4
  • 23
    • 84870362604 scopus 로고    scopus 로고
    • Estrogen treatment for acromegaly
    • Shimon, I. and Barkan, A. (2012) Estrogen treatment for acromegaly. Pituitary, 15, 601-607.
    • (2012) Pituitary , vol.15 , pp. 601-607
    • Shimon, I.1    Barkan, A.2
  • 24
    • 2342542387 scopus 로고    scopus 로고
    • Raloxifene decreases serum IGF-I in male patients with active acromegaly
    • Dimaraki, E.V.; Symons, K.V. and Barkan, A.L. (2004) Raloxifene decreases serum IGF-I in male patients with active acromegaly. Eur. J. Endocrinol., 150, 481-487.
    • (2004) Eur. J. Endocrinol , vol.150 , pp. 481-487
    • Dimaraki, E.V.1    Symons, K.V.2    Barkan, A.L.3
  • 25
    • 0017911785 scopus 로고
    • Acromegaly: Results of long-term treatment with bromocriptine
    • Besser, G.M.; Wass, J.A. and Thorner, M.O. (1978) Acromegaly: results of long-term treatment with bromocriptine. Acta. Endocrinol. Supplement., 216, 187-198.
    • (1978) Acta. Endocrinol. Supplement , vol.216 , pp. 187-198
    • Besser, G.M.1    Wass, J.A.2    Thorner, M.O.3
  • 28
    • 84898829018 scopus 로고    scopus 로고
    • A practical approach to acromegaly management in Latinamerica
    • suppl 1
    • Bronstein, M.; Bruno, O.D.; Abreu, A.; Mangupli, R. and Mercado, M. (2014) A practical approach to acromegaly management in Latinamerica. Pituitary, 17(suppl 1), 30-35.
    • (2014) Pituitary , vol.17 , pp. 30-35
    • Bronstein, M.1    Bruno, O.D.2    Abreu, A.3    Mangupli, R.4    Mercado, M.5
  • 29
    • 0015914428 scopus 로고
    • Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary GH
    • Brazeu, P.; Vale, W.; Burgus, R.; Ling, N.; Botheher, M.; Rivier, J. and Guillemin, R. (1973) Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary GH. Science, 179, 77-79.
    • (1973) Science , vol.179 , pp. 77-79
    • Brazeu, P.1    Vale, W.2    Burgus, R.3    Ling, N.4    Botheher, M.5    Rivier, J.6    Guillemin, R.7
  • 31
    • 0037372024 scopus 로고    scopus 로고
    • Interrelationship between the novel peptide ghrelin and somatostatin/GHRH in the regulation of pulsatile GH secretion
    • Tannenbaum, G.S.; Epelbaum, J. and Bowers, C.Y. (2003) Interrelationship between the novel peptide ghrelin and somatostatin/GHRH in the regulation of pulsatile GH secretion. Endocrinology, 144, 967-974.
    • (2003) Endocrinology , vol.144 , pp. 967-974
    • Tannenbaum, G.S.1    Epelbaum, J.2    Bowers, C.Y.3
  • 32
    • 0242343213 scopus 로고
    • Autonomic regulation of somatostatin release: Studies with primary cultures of canine fundic mucosal cells
    • Yamada, T.; Soll, A.H.; Park, J.; and Elashoff, J. (1984) Autonomic regulation of somatostatin release: Studies with primary cultures of canine fundic mucosal cells. Am. J. Physiol., 247, G567-G573.
    • (1984) Am. J. Physiol , vol.247 , pp. 567-573
    • Yamada, T.1    Soll, A.H.2    Park, J.3    and Elashoff, J.4
  • 33
    • 0018968278 scopus 로고
    • Processing of somatostatin precursors: Evidence of enzymatic cleavage by hypothalamic extract
    • Zingg, H.H. and Patel, Y.C. (1980) Processing of somatostatin precursors: evidence of enzymatic cleavage by hypothalamic extract. Biochem. Biophys. Res. Com., 93, 1274-1279.
    • (1980) Biochem. Biophys. Res. Com , vol.93 , pp. 1274-1279
    • Zingg, H.H.1    Patel, Y.C.2
  • 34
    • 0024569197 scopus 로고
    • NIH Conference: Somatostatin and somatostatin analogue (SMS 201- 995) in treatment of hormone-secreting tumors of the pituitary and gastrointestinal tract and non-neoplastic diseases of the gut
    • Gorden, P.; Comi, R.J.; Maton, P.N. and Go, V.L. (1989) NIH Conference: Somatostatin and somatostatin analogue (SMS 201- 995) in treatment of hormone-secreting tumors of the pituitary and gastrointestinal tract and non-neoplastic diseases of the gut. Ann. Intern. Med., 110, 35-50.
    • (1989) Ann. Intern. Med , vol.110 , pp. 35-50
    • Gorden, P.1    Comi, R.J.2    Maton, P.N.3    Go, V.L.4
  • 35
    • 0029114410 scopus 로고
    • Molecular biology of somatostatin receptors
    • Reisine, T. and Bell, G.I. (1995) Molecular biology of somatostatin receptors. Endocr. Rev., 16, 427-442.
    • (1995) Endocr. Rev , vol.16 , pp. 427-442
    • Reisine, T.1    Bell, G.I.2
  • 36
    • 0030612281 scopus 로고    scopus 로고
    • Molecular pharmacology of somatostatin receptor subtypes
    • Patel, Y.C. (1997) Molecular pharmacology of somatostatin receptor subtypes. J. Endocrinol. Invest., 20, 348-367.
    • (1997) J. Endocrinol. Invest , vol.20 , pp. 348-367
    • Patel, Y.C.1
  • 37
    • 34249035476 scopus 로고    scopus 로고
    • Novel insights in somatostatin receptor physiology
    • Tulipano, G. and Schulz, S. (2007) Novel insights in somatostatin receptor physiology. Eur. J. Endocrinol., 153, S3-S11.
    • (2007) Eur. J. Endocrinol , vol.153 , pp. 3-11
    • Tulipano, G.1    Schulz, S.2
  • 38
    • 0035958027 scopus 로고    scopus 로고
    • Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst3 receptor function by heterodimerization with sst2a
    • Pfeiffer, M.; Koch, T.; Schröder, H.; Klutzny, M.; Kirscht, S.; Kreienkamp, H.J; Höllt, V. and Schulz, S. (2001) Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst3 receptor function by heterodimerization with sst2a. J. Biol. Chem., 276, 14027-14036.
    • (2001) J. Biol. Chem , vol.276 , pp. 14027-14036
    • Pfeiffer, M.1    Koch, T.2    Schröder, H.3    Klutzny, M.4    Kirscht, S.5    Kreienkamp, H.J.6    Höllt, V.7    Schulz, S.8
  • 39
    • 0037205489 scopus 로고    scopus 로고
    • Heterodimerization of somatostatin and opioid receptors modulates phosphorylation, internalization and desensitization
    • Pfeiffer, M.; Koch, T.; Schroder, H.; Laugsch, M.; Höllt, V. and Schulz, S. (2002) Heterodimerization of somatostatin and opioid receptors modulates phosphorylation, internalization and desensitization J. Biol. Chem., 277, 19762-19772.
    • (2002) J. Biol. Chem , vol.277 , pp. 19762-19772
    • Pfeiffer, M.1    Koch, T.2    Schroder, H.3    Laugsch, M.4    Höllt, V.5    Schulz, S.6
  • 42
    • 0027457177 scopus 로고
    • Pharmacokinetics of a long-acting formulation of the new somatostatin analog BIM 23014 in patients with acromegaly
    • Heron, I.; Thomas, F.; Dero, M.; Gancel, A.; Ruiz, J.M.; Schatz, B. and Kuhn, J.M. (1993) Pharmacokinetics of a long-acting formulation of the new somatostatin analog BIM 23014 in patients with acromegaly. J. Clin. Endocrinol. Metab., 76, 721-727.
    • (1993) J. Clin. Endocrinol. Metab , vol.76 , pp. 721-727
    • Heron, I.1    Thomas, F.2    Dero, M.3    Gancel, A.4    Ruiz, J.M.5    Schatz, B.6    Kuhn, J.M.7
  • 43
    • 17744378733 scopus 로고    scopus 로고
    • Human somatostatin receptor subtypes in acromegaly: Distinct patterns of messenger ribonucleic acid expression and hormone suppression identify different tumoral phenotypes
    • Jaquet, P.; Saveanu, A.; Gunz, G.; Fina, F.; Zamora, A.J.; Grino, M.; Culler, M.D.; Moreau, J.P.; Enjalbert, A. and Ouafik, L.H. (2000) Human somatostatin receptor subtypes in acromegaly: distinct patterns of messenger ribonucleic acid expression and hormone suppression identify different tumoral phenotypes. J. Clin. Endocrinol. Metab., 85, 781-792.
    • (2000) J. Clin. Endocrinol. Metab , vol.85 , pp. 781-792
    • Jaquet, P.1    Saveanu, A.2    Gunz, G.3    Fina, F.4    Zamora, A.J.5    Grino, M.6    Culler, M.D.7    Moreau, J.P.8    Enjalbert, A.9    Ouafik, L.H.10
  • 44
    • 34249108901 scopus 로고    scopus 로고
    • Preclinical and clinical experiences with the role of somatostatin receptors in the treatment of pituitary adenomas
    • Van der Hoek, J.; Lamberts, S.W.J. and Hofland, L.J. (2007) Preclinical and clinical experiences with the role of somatostatin receptors in the treatment of pituitary adenomas. Eur. J. Endocrinol., 156, S45-S61.
    • (2007) Eur. J. Endocrinol , vol.156 , pp. 45-61
    • Van der Hoek, J.1    Lamberts, S.W.J.2    Hofland, L.J.3
  • 46
    • 0030747124 scopus 로고    scopus 로고
    • 111-Indium-pentetreotide pituitary scintigraphy and hormonal responses to octreotide in acromegalic patients
    • Legovini, P.; De Menis, E.; Billeci, D.; Conti, B.; Zoli, P. and Conte, N. (1997) 111-Indium-pentetreotide pituitary scintigraphy and hormonal responses to octreotide in acromegalic patients. J. Endocrinol. Invest., 20, 424-428.
    • (1997) J. Endocrinol. Invest , vol.20 , pp. 424-428
    • Legovini, P.1    De Menis, E.2    Billeci, D.3    Conti, B.4    Zoli, P.5    Conte, N.6
  • 48
    • 42149145552 scopus 로고    scopus 로고
    • Correlation of in vitro and in vivo somatotrophic adenoma responsiveness to somatostatin analogues and dopamine agonists with immunohistochemical evaluation of somatostatin and dopamine receptors and electron microscopy
    • Ferone, G.; de Herder, W.W.; Pivonello, R.; Kros, J.M.; van Koetsveld, P.M.; de Jong, T.; Minuto, F.; Colao, A; Lamberts, S.W. and Hofland, L.J. (2008) Correlation of in vitro and in vivo somatotrophic adenoma responsiveness to somatostatin analogues and dopamine agonists with immunohistochemical evaluation of somatostatin and dopamine receptors and electron microscopy. J. Clin. Endocrinol. Metab., 93, 1412-1417.
    • (2008) J. Clin. Endocrinol. Metab , vol.93 , pp. 1412-1417
    • Ferone, G.1    de Herder, W.W.2    Pivonello, R.3    Kros, J.M.4    van Koetsveld, P.M.5    de Jong, T.6    Minuto, F.7    Colao, A.8    Lamberts, S.W.9    Hofland, L.J.10
  • 51
    • 84873603331 scopus 로고    scopus 로고
    • Low somatostatin receptor subtype 2, but not dopamine receptor subtype 2 expression predicts the lack of biochemical response of somatotropinomas to treatment with somatostatin analogs
    • Wildemberg, L.A.; Neto, L.V.; Costa, D.F.; Nasciuti, L.E.; Takiya, C.M.; Alves, L.M.; Rebora, A.; Minuto, F.; Ferone, D. and Gadelha, M.R. (2013) Low somatostatin receptor subtype 2, but not dopamine receptor subtype 2 expression predicts the lack of biochemical response of somatotropinomas to treatment with somatostatin analogs. J. Endocrinol. Invest., 36, 38-43.
    • (2013) J. Endocrinol. Invest , vol.36 , pp. 38-43
    • Wildemberg, L.A.1    Neto, L.V.2    Costa, D.F.3    Nasciuti, L.E.4    Takiya, C.M.5    Alves, L.M.6    Rebora, A.7    Minuto, F.8    Ferone, D.9    Gadelha, M.R.10
  • 52
  • 55
    • 35848933015 scopus 로고    scopus 로고
    • Analysis of GNAS mutations in 60 growth hormone secreting pituitary tumors: Correlation with clinical and pathological characteristics and surgical outcome based on highly sensitive GH and IGF-1 criteria for remission
    • Freda, P.U.; Chung, W.K.; Matsuoka, N.; Walsh, J.E.; Kanibir, M.N.; Kleinman, G.; Wang, Y.; Bruce, J.N. and Post, K.D. (2007) Analysis of GNAS mutations in 60 growth hormone secreting pituitary tumors: correlation with clinical and pathological characteristics and surgical outcome based on highly sensitive GH and IGF-1 criteria for remission. Pituitary, 10, 275-282.
    • (2007) Pituitary , vol.10 , pp. 275-282
    • Freda, P.U.1    Chung, W.K.2    Matsuoka, N.3    Walsh, J.E.4    Kanibir, M.N.5    Kleinman, G.6    Wang, Y.7    Bruce, J.N.8    Post, K.D.9
  • 56
    • 84875156034 scopus 로고    scopus 로고
    • Granulation pattern but no GSP or GHR mutation is associated with clinical characteristics in somatostatinnaïve patients with somatotroph adenomas
    • Larkin, S.; Reddy, R.; Karavitaki, R.; Cudlip, S.; Wass, J. And Ansorge, O. (2013) Granulation pattern but no GSP or GHR mutation is associated with clinical characteristics in somatostatinnaïve patients with somatotroph adenomas. European J. Endocrinol., 168, 491-499.
    • (2013) European J. Endocrinol , vol.168 , pp. 491-499
    • Larkin, S.1    Reddy, R.2    Karavitaki, R.3    Cudlip, S.4    Wass, J.5    Ansorge, O.6
  • 57
    • 27544470454 scopus 로고    scopus 로고
    • The implications of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly
    • Bhayana, S.; Booth, G.L.; Asa, S.L.; Kovacs, K. and Ezzat, S. (2005) The implications of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly. J. Clin. Endocrinol. Metab., 90, 6290-6299.
    • (2005) J. Clin. Endocrinol. Metab , vol.90 , pp. 6290-6299
    • Bhayana, S.1    Booth, G.L.2    Asa, S.L.3    Kovacs, K.4    Ezzat, S.5
  • 59
    • 84880952646 scopus 로고    scopus 로고
    • Ki-67 is a predictor of acromegaly control with octreotide LAR independent of SSTR2 status and relates to cytokeratin pattern
    • Kasuki, L; Wildemberg, L.E; Neto, L.V; Marcondes, J; Takiya, C.M. and Gadelha, M.R. (2013) Ki-67 is a predictor of acromegaly control with octreotide LAR independent of SSTR2 status and relates to cytokeratin pattern. European J. Endocrinol., 169, 217- 223.
    • (2013) European J. Endocrinol , vol.169 , pp. 217-223
    • Kasuki, L.1    Wildemberg, L.E.2    Neto, L.V.3    Marcondes, J.4    Takiya, C.M.5    Gadelha, M.R.6
  • 60
    • 84876036199 scopus 로고    scopus 로고
    • Familial isolated pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene
    • Beckers, A; Aaltonen L.A; Daly, A.F. and Karhu A. (2013) Familial isolated pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene. Endocr. Rev., 34, 239-277.
    • (2013) Endocr. Rev , vol.34 , pp. 239-277
    • Beckers, A.1    Aaltonen, L.A.2    Daly, A.F.3    Karhu, A.4
  • 62
    • 84862655105 scopus 로고    scopus 로고
    • AIP expression in sporadic somatotropinomas is a predictor of the response to octreotide LAR therapy independent of SSTR2 expression
    • Kasuki, L; Viera Neto, L; Wildemberg, L.E; Machado Colli, L; de Castro, M; Takiya, C.M; and Gadelha, M.R. (2012) AIP expression in sporadic somatotropinomas is a predictor of the response to octreotide LAR therapy independent of SSTR2 expression. Endocr. Rel. Cancer., 19, L25-L29.
    • (2012) Endocr. Rel. Cancer , vol.19 , pp. 25-29
    • Kasuki, L.1    Viera Neto, L.2    Wildemberg, L.E.3    Machado Colli, L.4    de Castro, M.5    Takiya, C.M.6    Gadelha, M.R.7
  • 63
    • 80052605110 scopus 로고    scopus 로고
    • Pharmacokinetic and technical comparison of sandostatin LAR and other formulations of long-acting octreotide
    • Peterssen, H.; Bizec, J.C.; Schuetz, H. and Delporte, M.L. (2011) Pharmacokinetic and technical comparison of sandostatin LAR and other formulations of long-acting octreotide. BMC Res. Notes, 4, 344.
    • (2011) BMC Res. Notes , vol.4 , pp. 344
    • Peterssen, H.1    Bizec, J.C.2    Schuetz, H.3    Delporte, M.L.4
  • 64
    • 57449121822 scopus 로고    scopus 로고
    • Population pharmacokinetic analysis of lanreotide autogel in healthy subjects: Evidence for injection interval of up to two months
    • Troconiz, I.F.; Cendros, J.M.; Peraire, C.; Ramis, J.; Garrido, M.J.; Boscani, P.F. and Obach, R. (2009) Population pharmacokinetic analysis of lanreotide autogel in healthy subjects: Evidence for injection interval of up to two months. Clin. Pharmacokinet., 48, 51-62.
    • (2009) Clin. Pharmacokinet , vol.48 , pp. 51-62
    • Troconiz, I.F.1    Cendros, J.M.2    Peraire, C.3    Ramis, J.4    Garrido, M.J.5    Boscani, P.F.6    Obach, R.7
  • 65
    • 39149133993 scopus 로고    scopus 로고
    • A 12-month, randomized cross-over study on the effects of lanreotide autogel and octreotide long acting repeatable on GH and IGF-1 levels in acromegaly
    • Andries, M.; Glintborg, D.; Kvistborg, A.; Hagen, C. and Andersen, M. (2008) A 12-month, randomized cross-over study on the effects of lanreotide autogel and octreotide long acting repeatable on GH and IGF-1 levels in acromegaly. Clin. Endocrinol., 68, 473-480.
    • (2008) Clin. Endocrinol , vol.68 , pp. 473-480
    • Andries, M.1    Glintborg, D.2    Kvistborg, A.3    Hagen, C.4    Andersen, M.5
  • 66
    • 84895076332 scopus 로고    scopus 로고
    • Lanreotide extended-release, aqueous gel formulation injected by patient, partner or health care provider in patients with acromegaly in the United States: 1-year data from the SODA registry
    • Salvatori, R.; Woodmansee, W.W.; Molitch, M.; Gordon, M.B. and Lomax, K.G. (2013) Lanreotide extended-release, aqueous gel formulation injected by patient, partner or health care provider in patients with acromegaly in the United States: 1-year data from the SODA registry. Pituitary, 17, 13-21.
    • (2013) Pituitary , vol.17 , pp. 13-21
    • Salvatori, R.1    Woodmansee, W.W.2    Molitch, M.3    Gordon, M.B.4    Lomax, K.G.5
  • 67
    • 77949274556 scopus 로고    scopus 로고
    • Rapid and sustained reductions of serum growth hormone and insulin-like growth factor 1 in patients with acromegaly receiving lanreotide autogel therapy: A randomized, placebo-controlled, multicenter study with a 52 week open extension
    • Melmed, S.; Cook, D.; Schopohl, J.; Goth, M.I.; Lam, K.S. and Marek, J. (2010) Rapid and sustained reductions of serum growth hormone and insulin-like growth factor 1 in patients with acromegaly receiving lanreotide autogel therapy: a randomized, placebo-controlled, multicenter study with a 52 week open extension. Pituitary, 13, 18-28.
    • (2010) Pituitary , vol.13 , pp. 18-28
    • Melmed, S.1    Cook, D.2    Schopohl, J.3    Goth, M.I.4    Lam, K.S.5    Marek, J.6
  • 68
    • 0031930952 scopus 로고    scopus 로고
    • Long-term therapy with long-acting octreotide (Sandostatin-LAR) for the management of acromegaly
    • Davies, P.H.; Stewart, S.E.; Lancranjan, L.; Sheppard, M.C. and Stewart, P.M. (1998) Long-term therapy with long-acting octreotide (Sandostatin-LAR) for the management of acromegaly. Clin. Endocrinol., 48, 311-316.
    • (1998) Clin. Endocrinol , vol.48 , pp. 311-316
    • Davies, P.H.1    Stewart, S.E.2    Lancranjan, L.3    Sheppard, M.C.4    Stewart, P.M.5
  • 71
    • 33644944535 scopus 로고    scopus 로고
    • First-line octreotide-LAR therapy induces tumor shrinkage and control hormone excess in patients with acromegaly: Results from an open, prospective, multicentre trial
    • Colao, A.; Pivonello, R.; Rosato, F.; Tita, P.; De Menis, E.; Barreca, A.; Ferrara, R.; Mainini, F.; Arosio, M. and Lombardi, G. (2002) First-line octreotide-LAR therapy induces tumor shrinkage and control hormone excess in patients with acromegaly: results from an open, prospective, multicentre trial. Clin. Endocrinol., 64, 342-352.
    • (2002) Clin. Endocrinol , vol.64 , pp. 342-352
    • Colao, A.1    Pivonello, R.2    Rosato, F.3    Tita, P.4    De Menis, E.5    Barreca, A.6    Ferrara, R.7    Mainini, F.8    Arosio, M.9    Lombardi, G.10
  • 73
    • 33646022576 scopus 로고    scopus 로고
    • Primary treatment of acromegaly with octreotide LAR: A long-term (up to nine years) prospective study of its efficacy in the control of disease activity and tumor shrinkage
    • Cozzi, R.; Montini, M.; Attanasio, R.; Albizzi, M.; Lasio, G.; Lodrini, S.; Doneda, P.; Cortesi, L. and Pagani, G. (2006) Primary treatment of acromegaly with octreotide LAR: a long-term (up to nine years) prospective study of its efficacy in the control of disease activity and tumor shrinkage. J. Clin. Endocrinol. Metab., 91, 1397-1403.
    • (2006) J. Clin. Endocrinol. Metab , vol.91 , pp. 1397-1403
    • Cozzi, R.1    Montini, M.2    Attanasio, R.3    Albizzi, M.4    Lasio, G.5    Lodrini, S.6    Doneda, P.7    Cortesi, L.8    Pagani, G.9
  • 75
    • 41349117707 scopus 로고    scopus 로고
    • Control of IGF-1 levels with titrated dose of lanreotide autogel over 48 weeks in patients with acromegaly
    • Chanson, P.; Borzon-Chazot, F.; Kuhn, J.M.; Blumberg, J.; Maisonobe, P. and Delemer, B. (2008) Control of IGF-1 levels with titrated dose of lanreotide autogel over 48 weeks in patients with acromegaly. Clin. Endocrinol., 69, 299-305.
    • (2008) Clin. Endocrinol , vol.69 , pp. 299-305
    • Chanson, P.1    Borzon-Chazot, F.2    Kuhn, J.M.3    Blumberg, J.4    Maisonobe, P.5    Delemer, B.6
  • 76
    • 70349900717 scopus 로고    scopus 로고
    • Effects of initial therapy for five years with somatostatin analogs for acromegaly on growth hormone and insulin-like growth factor-1 leveles tumor shrinkage and cardiovascular disease: A prospective study
    • Colao, A.; Auriemma, R.S.; Galdiero, M.; Lombardi, G. and Pivonello, R. (2009) Effects of initial therapy for five years with somatostatin analogs for acromegaly on growth hormone and insulin-like growth factor-1 leveles tumor shrinkage and cardiovascular disease: a prospective study. J. Clin. Endocrinol. Metab., 94, 3746-3756.
    • (2009) J. Clin. Endocrinol. Metab , vol.94 , pp. 3746-3756
    • Colao, A.1    Auriemma, R.S.2    Galdiero, M.3    Lombardi, G.4    Pivonello, R.5
  • 77
    • 34347380169 scopus 로고    scopus 로고
    • A prospective, multicentre study to investigate the efficacy, safety and tolerability of octreotide LAR (long-acting repeatable octreotide) in the primary therapy of patients with acromegaly
    • Mercado, M.; Borges, F.; Bouterfa, H.; Chang, T.C.; Chervin, A.; Farrall, A.J.; Patocs, A.; Petersenn, S.; Podoba, J.; Safari, M. and Wardlaw, J. (2007) A prospective, multicentre study to investigate the efficacy, safety and tolerability of octreotide LAR (long-acting repeatable octreotide) in the primary therapy of patients with acromegaly. Clin. Endocrinol., 66, 859-868.
    • (2007) Clin. Endocrinol , vol.66 , pp. 859-868
    • Mercado, M.1    Borges, F.2    Bouterfa, H.3    Chang, T.C.4    Chervin, A.5    Farrall, A.J.6    Patocs, A.7    Petersenn, S.8    Podoba, J.9    Safari, M.10    Wardlaw, J.11
  • 78
    • 15944427116 scopus 로고    scopus 로고
    • The anti-tumoral effects of somatostatin analog therapy in acromegaly
    • Bevan, J.S. (2005) The anti-tumoral effects of somatostatin analog therapy in acromegaly. J. Clin. Endocrinol. Metab., 90, 1856-1863.
    • (2005) J. Clin. Endocrinol. Metab , vol.90 , pp. 1856-1863
    • Bevan, J.S.1
  • 83
    • 34447523623 scopus 로고    scopus 로고
    • Does partial surgical tumour removal influence the response to octreotide-LAR in acromegalic patients previously resistant to somatostatin analogue
    • Jallad, R.S.; Musolino, N.R.; Kodaira, S.; Cescato, V.A. and Bronstein, M.D. (2007) Does partial surgical tumour removal influence the response to octreotide-LAR in acromegalic patients previously resistant to somatostatin analogue. Clin. Endocrinol., 67, 310-315.
    • (2007) Clin. Endocrinol , vol.67 , pp. 310-315
    • Jallad, R.S.1    Musolino, N.R.2    Kodaira, S.3    Cescato, V.A.4    Bronstein, M.D.5
  • 85
    • 0037335063 scopus 로고    scopus 로고
    • Sandostatin LAR in acromegaly: A 6-week injection interval suppresses GH secretion as effectively as a 4-week interval
    • Biermasz, N.R.; van den Oever, N.C.; Frölich, M.; Arias, A.M.; Smit, J.W.; Romijn, J.A. and Roelfsema, F. (2003) Sandostatin LAR in acromegaly: a 6-week injection interval suppresses GH secretion as effectively as a 4-week interval. Clin. Endocrinol., 58, 288-295.
    • (2003) Clin. Endocrinol , vol.58 , pp. 288-295
    • Biermasz, N.R.1    van den Oever, N.C.2    Frölich, M.3    Arias, A.M.4    Smit, J.W.5    Romijn, J.A.6    Roelfsema, F.7
  • 86
    • 4143086978 scopus 로고    scopus 로고
    • Systematic dose-extension of octreotide LAR: The importance of individual tailoring of treatment in patients with acromegaly
    • Turner, H.E.; Thornton-Jones, V.A. and Wass, J.A. (2004) Systematic dose-extension of octreotide LAR: the importance of individual tailoring of treatment in patients with acromegaly. Clin. Endocrinol., 61, 224-231.
    • (2004) Clin. Endocrinol , vol.61 , pp. 224-231
    • Turner, H.E.1    Thornton-Jones, V.A.2    Wass, J.A.3
  • 87
    • 84919943074 scopus 로고    scopus 로고
    • Octreotide LAR treatment of acromegaly in "real life": Long-term outcome at a tertiary care center
    • [Epub ahead of print]
    • Espinosa-de-los-Monteros, A.L.; Gonzalez, B.; Vargas, G.; Sosa, E. and Mercado, M. (2014) Octreotide LAR treatment of acromegaly in "real life": Long-term outcome at a tertiary care center. Pituitary[Epub ahead of print].
    • (2014) Pituitary
    • Espinosa-de-los-Monteros, A.L.1    Gonzalez, B.2    Vargas, G.3    Sosa, E.4    Mercado, M.5
  • 89
    • 77950324692 scopus 로고    scopus 로고
    • Preoperative lanreotide treatment in acromegalic patients with macroadenomas increases sort-term postoperative cure rates: A prospective, randomized trial
    • Mao, Z.G.; Zhu, Y.H.; Wang, D.Y.; Zhou, J.; He, D.S.; Lan, H.; Luo, B.N. and Wang, H.J. (2010) Preoperative lanreotide treatment in acromegalic patients with macroadenomas increases sort-term postoperative cure rates: a prospective, randomized trial. Eur. J. Endocrinol., 162, 661-666.
    • (2010) Eur. J. Endocrinol , vol.162 , pp. 661-666
    • Mao, Z.G.1    Zhu, Y.H.2    Wang, D.Y.3    Zhou, J.4    He, D.S.5    Lan, H.6    Luo, B.N.7    Wang, H.J.8
  • 90
    • 0032922259 scopus 로고    scopus 로고
    • Clinical and biochemical response following withdrawal of a long-acting depot injection form of octreotide (Sandostatin LAR)
    • Stewart, P.M.; Stewart, S.E.; Clark, P.M. and Sheppard, M.C. (1999) Clinical and biochemical response following withdrawal of a long-acting depot injection form of octreotide (Sandostatin LAR). Clin. Endocrinol., 50, 295-299.
    • (1999) Clin. Endocrinol , vol.50 , pp. 295-299
    • Stewart, P.M.1    Stewart, S.E.2    Clark, P.M.3    Sheppard, M.C.4
  • 91
    • 0034433231 scopus 로고    scopus 로고
    • The course of GH and IGF-1 levels following withdrawal of long-acting octreotide in acromegaly
    • Lorcy, Y.; Dejarger, S. and Chanson, O.P. (2000) The course of GH and IGF-1 levels following withdrawal of long-acting octreotide in acromegaly. Pituitary, 3, 193-197.
    • (2000) Pituitary , vol.3 , pp. 193-197
    • Lorcy, Y.1    Dejarger, S.2    Chanson, O.P.3
  • 96
    • 11144353578 scopus 로고    scopus 로고
    • The novel somatostatin analog SOM230 is a potent inhibitor of hormone release of growth hormone- and prolacitn-secreting pituitary adenomas in vitro
    • Hofland, L.J.; van der Hoek, J. and van Koetsveld, P.M. (2004) The novel somatostatin analog SOM230 is a potent inhibitor of hormone release of growth hormone- and prolacitn-secreting pituitary adenomas in vitro. J. Clin. Endocrinol. Metab., 89, 1577- 1585.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , pp. 1577-1585
    • Hofland, L.J.1    van der Hoek, J.2    van Koetsveld, P.M.3
  • 104
    • 79955672862 scopus 로고    scopus 로고
    • Place of cabergoline in acromegaly: A meta-analysis
    • Sandret, L.; Maison, P. and Chanson, P. (2011) Place of cabergoline in acromegaly: A meta-analysis. J. Clin. Endocrinol. Metab., 96, 1327-1338.
    • (2011) J. Clin. Endocrinol. Metab , vol.96 , pp. 1327-1338
    • Sandret, L.1    Maison, P.2    Chanson, P.3
  • 106
  • 110
    • 0034616021 scopus 로고    scopus 로고
    • Receptors for dopamine and somatostatin: Formation of hetero-oligomers with enhanced functional activity
    • Rocheville, M.; Lange, D.C.; Kumar, U.; Patel, R.C. and Patel, Y.C. (2000) Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science, 288, 154-157.
    • (2000) Science , vol.288 , pp. 154-157
    • Rocheville, M.1    Lange, D.C.2    Kumar, U.3    Patel, R.C.4    Patel, Y.C.5
  • 111
    • 0344874253 scopus 로고    scopus 로고
    • Suppression of rat and human growth hormone and prolactin secretion by a novel somatostatin/ dopaminergic chimeric ligand
    • Ren, S.G.; Kim, S.; Taylor, J.; Dong, J.; Moreau, J.P.; Culler, M.D. and Melmed, S. (2003) Suppression of rat and human growth hormone and prolactin secretion by a novel somatostatin/ dopaminergic chimeric ligand. J. Clin. Endocrinol. Metab., 88, 5414-5421.
    • (2003) J. Clin. Endocrinol. Metab , vol.88 , pp. 5414-5421
    • Ren, S.G.1    Kim, S.2    Taylor, J.3    Dong, J.4    Moreau, J.P.5    Culler, M.D.6    Melmed, S.7
  • 112
    • 22744440925 scopus 로고    scopus 로고
    • Efficacy of chimeric molecules directed towards multiple somatostatin and dopamine receptors on inhibition of GH and prolactin secretion from GH-secreting pituitary adenomas classified as partially responsive to somatostatin analog therapy
    • Jaquet, P.; Gunz, G.; Saveanu, A.; Dufour, H.; Taylor, J.; Dong, J.; Kim, S.; Moreau, J.P.; Enjalbert, A. and Culler, M.D. (2005) Efficacy of chimeric molecules directed towards multiple somatostatin and dopamine receptors on inhibition of GH and prolactin secretion from GH-secreting pituitary adenomas classified as partially responsive to somatostatin analog therapy. Eur. J. Endocrinol., 153, 135-141.
    • (2005) Eur. J. Endocrinol , vol.153 , pp. 135-141
    • Jaquet, P.1    Gunz, G.2    Saveanu, A.3    Dufour, H.4    Taylor, J.5    Dong, J.6    Kim, S.7    Moreau, J.P.8    Enjalbert, A.9    Culler, M.D.10
  • 113
    • 0028266588 scopus 로고
    • Distribution of growth hormone receptor messenger ribonucleic acid containing and lacking exon 3 in human tissues
    • Mercado, M.; Davila, N.; McLeod, J.F. and Baumann, G. (1994) Distribution of growth hormone receptor messenger ribonucleic acid containing and lacking exon 3 in human tissues. J. Clin. Endocrinol. Metab., 78, 731-735.
    • (1994) J. Clin. Endocrinol. Metab , vol.78 , pp. 731-735
    • Mercado, M.1    Davila, N.2    McLeod, J.F.3    Baumann, G.4
  • 114
    • 0036800303 scopus 로고    scopus 로고
    • Growth hormone receptor antagonists: Discovery, development, and use in patients with acromegaly
    • Kopchick, J.J.; Parkinson, C.; Stevens, E.C. and Trainer, P.J. (2002) Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly. Endocr. Rev., 23, 623-646.
    • (2002) Endocr. Rev , vol.23 , pp. 623-646
    • Kopchick, J.J.1    Parkinson, C.2    Stevens, E.C.3    Trainer, P.J.4
  • 115
    • 16644401935 scopus 로고    scopus 로고
    • Discovery and development of a new class of drugs: GH antagonists
    • 10 Suppl
    • Kopchick, J.J. (2003) Discovery and development of a new class of drugs: GH antagonists. J. Endocrinol. Invest., 26(10 Suppl), 16-26.
    • (2003) J. Endocrinol. Invest , vol.26 , pp. 16-26
    • Kopchick, J.J.1
  • 116
    • 0035040522 scopus 로고    scopus 로고
    • Binding and functional studies with the growth hormone receptor antagonist, B2036-PEG (pegvisomant), reveal effects of pegylation and evidence that it binds to a receptor dimer
    • Ross, R.J.; Leung, K.C.; Maamra, M.; Bennett, W.; Doyle, N.; Waters, M.J. and Ho, K.K. (2001) Binding and functional studies with the growth hormone receptor antagonist, B2036-PEG (pegvisomant), reveal effects of pegylation and evidence that it binds to a receptor dimer. J. Clin. Endocrinol. Metab., 86, 1716- 1723.
    • (2001) J. Clin. Endocrinol. Metab , vol.86 , pp. 1716-1723
    • Ross, R.J.1    Leung, K.C.2    Maamra, M.3    Bennett, W.4    Doyle, N.5    Waters, M.J.6    Ho, K.K.7
  • 117
    • 4544273108 scopus 로고    scopus 로고
    • Pegvisomant, a growth hormone-specific antagonist, undergoes cellular internalization
    • Maamra, M.; Kopchick, J.J.; Strasburger, C.J. and Ross, R.J. (2004) Pegvisomant, a growth hormone-specific antagonist, undergoes cellular internalization. J. Clin. Endocrinol. Metab., 89, 4532-4537.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , pp. 4532-4537
    • Maamra, M.1    Kopchick, J.J.2    Strasburger, C.J.3    Ross, R.J.4
  • 120
    • 33847700931 scopus 로고    scopus 로고
    • Tretament of acromegaly with the GH receptor antagonist pegvisomant in clinical practice: Safety and efficacy evaluation from the German Pegvisomant Observational Study
    • Schreiber, I.; Buchfelder, M.; Droste, M.; Forssmann, K.; Mann, K.; Saller, B. and Starsburger, C.J. (2006) Tretament of acromegaly with the GH receptor antagonist pegvisomant in clinical practice: safety and efficacy evaluation from the German Pegvisomant Observational Study. Eur. J. Endocrinol., 156, 75-82.
    • (2006) Eur. J. Endocrinol , vol.156 , pp. 75-82
    • Schreiber, I.1    Buchfelder, M.2    Droste, M.3    Forssmann, K.4    Mann, K.5    Saller, B.6    Starsburger, C.J.7
  • 121
    • 70449877776 scopus 로고    scopus 로고
    • Acrostudy: The first 5 years
    • Trainer, P.J. (2009) Acrostudy: The first 5 years. Eur. J. Endocrinol., 161, S19-S24.
    • (2009) Eur. J. Endocrinol , vol.161 , pp. 19-24
    • Trainer, P.J.1
  • 123
    • 33644594740 scopus 로고    scopus 로고
    • Elevated transaminases during medical treatment of acromegaly: A review of the German pegvisomant surveillance experience and a report of a patient with histologically proven chronic mild active hepatitis
    • German pegvisomant investigators
    • Biering, H.; Saller, B.; Bauditz, J.; Pirlich, M.; Rudolph, B.; Johne, A.; Buchfelder, M.; Mann, K.; Droste, M.; Schreiber, I.; Lochs, H.; Strasburger, C.J. and German pegvisomant investigators. (2006) Elevated transaminases during medical treatment of acromegaly: a review of the German pegvisomant surveillance experience and a report of a patient with histologically proven chronic mild active hepatitis. Eur. J. Endocrinol., 154, 213-220.
    • (2006) Eur. J. Endocrinol , vol.154 , pp. 213-220
    • Biering, H.1    Saller, B.2    Bauditz, J.3    Pirlich, M.4    Rudolph, B.5    Johne, A.6    Buchfelder, M.7    Mann, K.8    Droste, M.9    Schreiber, I.10    Lochs, H.11    Strasburger, C.J.12
  • 124
    • 0346728594 scopus 로고    scopus 로고
    • Insulin sensitivity and glucose tolerance improve in patients with acromegaly converted from depot octreotide to pegvisomant
    • Drake, W.M.; Rowles, S.V.; Roberts, M.E.; Fode, F.K.; Besser, G.M.; Monson, J.P. and Trainer, P.J. (2003) Insulin sensitivity and glucose tolerance improve in patients with acromegaly converted from depot octreotide to pegvisomant. Eur. J. Endocrinol., 149, 521-527.
    • (2003) Eur. J. Endocrinol , vol.149 , pp. 521-527
    • Drake, W.M.1    Rowles, S.V.2    Roberts, M.E.3    Fode, F.K.4    Besser, G.M.5    Monson, J.P.6    Trainer, P.J.7
  • 125
    • 15944375488 scopus 로고    scopus 로고
    • Alternate-day administration of pegvisomant maintains normal serum insulin-like growth factor-I levels in patients with acromegaly
    • Jehle, S.; Reyes, C.M.; Sundeen, R.E. and Freda, P.U. (2005) Alternate-day administration of pegvisomant maintains normal serum insulin-like growth factor-I levels in patients with acromegaly. J. Clin. Endocrinol. Metab., 90, 1588-1593.
    • (2005) J. Clin. Endocrinol. Metab , vol.90 , pp. 1588-1593
    • Jehle, S.1    Reyes, C.M.2    Sundeen, R.E.3    Freda, P.U.4
  • 132
    • 1942473114 scopus 로고    scopus 로고
    • Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor 1 concentrations predict excess mortality in patients with acromegaly
    • Ayuk, J.; Clayton, R.N.; Holder, G.; Sheppard, M.C.; Stewart, P.M. and Bates, A.S. (2004) Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor 1 concentrations predict excess mortality in patients with acromegaly. J. Clin. Endocrinol. Metab., 89, 1613-1617.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , pp. 1613-1617
    • Ayuk, J.1    Clayton, R.N.2    Holder, G.3    Sheppard, M.C.4    Stewart, P.M.5    Bates, A.S.6
  • 135
    • 33646060089 scopus 로고    scopus 로고
    • Conventional pituitary irradiation is effective in lowering serum growth hormone and insulin-like growth factor 1 in patients with acromegaly
    • Jenkins, P.J.; Bates, P.; Carson, M.N.; Stewart, P.M. and Wass, J.A. (2006) Conventional pituitary irradiation is effective in lowering serum growth hormone and insulin-like growth factor 1 in patients with acromegaly. J. Clin. Endocrinol. Metab., 91, 1239-1245.
    • (2006) J. Clin. Endocrinol. Metab , vol.91 , pp. 1239-1245
    • Jenkins, P.J.1    Bates, P.2    Carson, M.N.3    Stewart, P.M.4    Wass, J.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.