Pathology of the human pituitary adenomas

Histochemistry and Cell Biology

Volumn 130, Issue 3, 2008, Pages 495-507

  Osamura, Robert Y ^a   Kajiya, Hanako ^a   Takei, Mao ^a,b   Egashira, Noboru ^a   Tobita, Maya ^a,c   Takekoshi, Susumu ^a   Teramoto, Akira ^b  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adenoma; Cell biology; Histochemistry; Pathology; Pituitary

Indexed keywords

AMYLOID; BROMOCRIPTINE; CORTICOTROPIN; FOLLITROPIN; GONADOTROPIN; GROWTH HORMONE; KERATIN; OCTREOTIDE; THYROTROPIN;

ACTH SECRETING ADENOMA; CARCINOMA; CELL DIFFERENTIATION; CLINICAL FEATURE; CROOKE CELL ADENOMA; CUSHING DISEASE; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; FOLLITROPIN SECRETING ADENOMA; GANGLIONEUROMA; GERM CELL TUMOR; GROWTH HORMONE SECRETING ADENOMA; HISTOCHEMISTRY; HORMONE SYNTHESIS; HUMAN; HYPERPROLACTINEMIA; HYPOPHYSIS; HYPOPHYSIS ADENOMA; HYPOPHYSIS CARCINOMA; IMMUNOHISTOCHEMISTRY; METASTASIS; MOLECULAR BIOLOGY; NONHUMAN; NULL CELL ADENOMA; PLURIHORMONAL ADENOMA; PRIORITY JOURNAL; PROLACTINOMA; RARE DISEASE; REVIEW; STELLATE CELL; THYROTROPIN SECRETING ADENOMA; TUMOR DIAGNOSIS;

ANIMALS; CELL DIFFERENTIATION; GONADOTROPINS; GROWTH HORMONE; HUMANS; LEUKEMIA; PITUITARY NEOPLASMS; PROLACTIN;

EID: 50249171121     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-008-0472-1     Document Type: Review

References (56)

1. NY Al-Brahim SL Asa 2006 My approach to pathology of the pituitary gland J Clin Pathol 59 1245 1253
2. SL Asa AM Bamberger B Cao M Wong KL Parker S Ezzat 1996 The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph J Clin Endocrinol Metab 81 2165 2170
3. M Bertholon-Gregoire J Trouillas MP Guigard B Loras J Tourniaire 1999 Mono- and plurihormonal thyrotropic pituitary adenomas: pathological, hormonal and clinical studies in 12 patients Eur J Endocrinol 140 519 527
4. S Bhayana GL Booth SL Asa K Kovacs S Ezzat 2005 The implication of somatotroph adenoma phenotype to somatostatin analog responsiveness in acromegaly J Clin Endocrinol Metab 90 6290 6295
5. M Bodner JL Castrillo LE Theill T Deerinck M Ellisman M Karin 1988 The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein Cell 55 505 518
6. SC Chandrasekharappa SC Guru P Manickam SE Olufemi FS Collins MR Emmert-Buck LV Debelenko Z Zhuang IA Lubensky LA Liotta JS Crabtree Y Wang BA Roe J Weisemann MS Boguski SK Agarwal MB Kester YS Kim C Heppner Q Dong AM Spiegel AL Burns SJ Marx 1997 Positional cloning of the gene for multiple endocrine neoplasia-type 1 Science 276 404 407
7. D Coss VG Thackray CX Deng PL Mellon 2005 Activin regulates luteinizing hormone beta-subunit gene expression through Smad-binding and homeobox elements Mol Endocrinol 19 2610 2623
8. C Cristina GS Diaz Torga RG Goya SS Kakar MI Perez-Millan VQ Passos D Giannella-Neto MD Bronstein D Becu-Villalobos 2007 PTTG expression in different experimental and human prolactinomas in relation to dopaminergic control of lactotropes Mol Cancer 6 4
9. AC Crooke 1935 A change in the basophil cells of the pituitary gland common to conditions which exhibit the syndrome attributed to basophil adenoma J Pathol Bacteriol 41 339 349
10. JS Dasen SM O'Connell SE Flynn M Treier AS Gleiberman DP Szeto F Hooshmand AK Aggarwal MG Rosenfeld 1999 Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types Cell 97 587 598
11. DeLellis RA, Lloyd RV, Heitz PU, Eng C (2004) Pathology and genetics of tumors of endocrine organs, World Health Organization Classification of Tumors. IARC Press, Lyon, pp 9-45
12. S Ezzat PJ Snyder WF Young LD Boyajy C Newman A Klibanski ME Molitch AE Boyd L Sheeler DM Cook 1992 Octreotide treatment of acromegaly. A randomized, multicenter study Ann Intern Med 117 711 718
13. S Ezzat G Kontogeorgos DA Redelmeier E Horvath AG Harris K Kovacs 1995 In vivo responsiveness of morphological variants of growth hormone-producing pituitary adenomas to octreotide Eur J Endocrinol 133 686 690
14. S Franscella CA Favrod-Coune G Pizzolato 1991 Pituitary corticotroph adenoma with Crooke's hyalinization Endocr Pathol 2 111 116
15. DH George BW Scheithauer K Kovacs E Horvath WF Young Jr RV Lloyd FB Meyer 2003 Crooke's cell adenoma of the pituitary: an aggressive variant of corticotroph adenoma Am J Surg Pathol 27 1330 1336
16. A Hagiwara Y Inoue K Wakasa T Haba T Tashiro T Miyamoto 2003 Comparison of growth hormone-producing and non-growth hormone-producing pituitary adenomas: imaging characteristics and pathologic correlation Radiology 228 533 538
17. E Horvath K Kovacs 1984 Gonadotroph adenomas of the human pituitary: sex-related fine-structural dichotomy. A histologic, immunocytochemical, and electron-microscopic study of 30 tumors Am J Pathol 117 429 440
18. E Horvath K Kovacs DW Killinger HS Smyth ME Platts W Singer 1980 Silent corticotropic adenomas of the human pituitary gland: a histologic, immunocytologic, and ultrastructural study Am J Pathol 98 617 638
19. E Horvath K Kovacs HS Smyth DW Killinger BW Scheithauer R Randall ER Laws Jr W Singer 1988 A novel type of pituitary adenoma: morphological features and clinical correlations J Clin Endocrinol Metab 66 1111 1118
20. Horvath E, Sheithauer BW, Kovacs K, Lloyd RV (1997) Pituitary adenomas. Oxford University Press, New York
21. E Horvath K Kovacs HS Smyth M Cusimano W Singer 2005 Silent adenoma subtype 3 of the pituitary-immunohistochemical and ultrastructural classification: a review of 29 cases Ultrastruct Pathol 29 511 524
22. K Kovacs E Horvath 1986 Pathology of growth hormone-producing tumors of the human pituitary Semin Diagn Pathol 3 18 33
23. K Kovacs E Horvath 2005 Effects of medical therapy on pituitary tumors Ultrastruct Pathol 29 163 167
24. M Kurosaki W Saeger DK Ludecke 2002 Intrasellar gangliocytomas associated with acromegaly Brain Tumor Pathol 19 63 67
25. B Lamolet AM Pulichino T Lamonerie Y Gauthier T Brue A Enjalbert J Drouin 2001 A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins Cell 104 849 859
26. CA Landis G Harsh J Lyons RL Davis F McCormick HR Bourne 1990 Clinical characteristics of acromegalic patients whose pituitary tumors contain mutant Gs protein J Clin Endocrinol Metab 71 1416 1420
27. EJ Lee T Russell L Hurley JL Jameson 2005 Pituitary transcription factor-1 induces transient differentiation of adult hepatic stem cells into prolactin-producing cells in vivo Mol Endocrinol 19 964 971
28. RV Lloyd L Jin X Qian E Kulig 1997 Aberrant p27kip1 expression in endocrine and other tumors Am J Pathol 150 401 407
29. A Matsuno H Katakami N Sanno Y Ogino RY Osamura S Matsukura N Shimizu T Nagashima 1999 Pituitary somatotroph adenoma producing growth hormone (GH)-releasing hormone (GHRH) with an elevated plasma GHRH concentration: a model case for autocrine and paracrine regulation of GH secretion by GHRH J Clin Endocrinol Metab 84 3241 3247
30. T Minematsu S Miyai H Kajiya M Suzuki N Sanno S Takekoshi A Teramoto RY Osamura 2005 Recent progress in studies of pituitary tumor pathogenesis Endocrine 28 37 41
31. S Miyai S Yoshimura Y Iwasaki S Takekoshi RV Lloyd RY Osamura 2005 Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line Cell Tissue Res 322 269 277
32. H Mori Y Saitoh T Maeda Y Okada H Hirano M Tsuji 2001 Increased exocytosis of secretory granules in contrast to reduced serum hormone levels in pituitary adenomas of humans and rats treated with dopamine agonist Med Electron Microsc 34 123 133
33. H Naritaka T Kameya Y Sato S Furuhata M Otani T Kawase 1999 Morphological characterization and subtyping of silent somatotroph adenomas Pituitary 1 233 241
34. C Nelson VR Albert HP Elsholtz LI Lu MG Rosenfeld 1988 Activation of cell-specific expression of rat growth hormone and prolactin genes by a common transcription factor Science 239 1400 1405
35. PE Neumann JE Goldman DS Horoupian MA Hess 1985 Fibrous bodies in growth hormone-secreting adenomas contain cytokeratin filaments Arch Pathol Lab Med 109 505 508
36. N Onoda Y Kamezu S Takagi Y Shinohara RY Osamura 1992 An autopsy case of invasive pituitary adenoma (prolactinoma) with rapid fatal clinical course due to streptococcal meningitis Acta Pathol Jpn 42 832 836
37. RY Osamura 1988 Immunoelectron microscopic studies of GH and alpha subunit in GH secreting pituitary adenomas Pathol Res Pract 183 569 571
38. RY Osamura K Watanabe N Komatsu M Ohya N Kageyama 1982 Amorphous and stellate amyloid in functioning human pituitary adenomas: histochemical, immunohistochemical and electron microscopic studies Acta Pathol Jpn 32 605 611
39. RY Osamura N Egashira S Miyai M Yamazaki S Takekoshi N Sanno A Teramoto 2004 Molecular pathology of the pituitary. Development and functional differentiation of pituitary adenomas Front Horm Res 32 20 33
40. K Oyama N Sanno A Teramoto RY Osamura 2001 Expression of neuro D1 in human normal pituitaries and pituitary adenomas Mod Pathol 14 892 899
41. M Reincke B Allolio W Saeger D Kaulen W Winkelmann 1987 A pituitary adenoma secreting high molecular weight adrenocorticotropin without evidence of Cushing's disease J Clin Endocrinol Metab 65 1296 1300
42. F Robert J Hardy 1986 Human corticotroph cell adenomas Semin Diagn Pathol 3 34 41
43. W Saeger DK Ludecke M Buchfelder R Fahlbusch HJ Quabbe S Petersenn 2007 Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry Eur J Endocrinol 156 203 216
44. N Sanno A Teramoto A Matsuno K Inada J Itoh RY Osamura 1994 Clinical and immunohistochemical studies on TSH-secreting pituitary adenoma: its multihormonality and expression of Pit-1 Mod Pathol 7 893 899
45. N Sanno A Teramoto A Matsuno S Takekoshi RY Osamura 1995 GH and PRL gene expression by nonradioisotopic in situ hybridization in TSH-secreting pituitary adenomas J Clin Endocrinol Metab 80 2518 2522
46. N Sanno A Teramoto RY Osamura S Genka H Katakami L Jin RV Lloyd K Kovacs 1997 A growth hormone-releasing hormone-producing pancreatic islet cell tumor metastasized to the pituitary is associated with pituitary somatotroph hyperplasia and acromegaly J Clin Endocrinol Metab 82 2731 2737
47. N Sanno S Tahara R Kurotani A Matsuno A Teramoto RY Osamura 2001 Cytochemical and molecular biological aspects of the pituitary and pituitary adenomas-cell differentiation and transcription factors Prog Histochem Cytochem 36 263 299
48. MW Sornson W Wu JS Dasen SE Flynn DJ Norman SM O'Connell I Gukovsky C Carriere AK Ryan AP Miller L Zuo AS Gleiberman B Andersen WG Beamer MG Rosenfeld 1996 Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism Nature 384 327 333
49. M Sugiyama I Takumi Y Node N Sanno A Teramoto RY Osamura 1999 Neurohypophyseal germinoma with prolactinoma. Case illustration J Neurosurg 90 170
50. M Suzuki N Egashira H Kajiya T Minematsu S Takekoshi S Tahara N Sanno A Teramoto RY Osamura 2008 ACTH and alpha-subunit are co-expressed in rare human pituitary corticotroph cell adenomas proposed to originate from ACTH-committed early pituitary progenitor cells Endocr Pathol 19 17 26
51. S Tahara R Kurotani Y Ishii N Sanno A Teramoto RY Osamura 2002 A case of Cushing's disease caused by pituitary adenoma producing adrenocorticotropic hormone and growth hormone concomitantly: aberrant expression of transcription factors NeuroD1 and Pit-1 as a proposed mechanism Mod Pathol 15 1102 1105
52. M Takei M Suzuki H Kajiya Y Ishii S Tahara T Miyakoshi N Egashira S Takekoshi N Sanno A Teramoto RY Osamura 2007 Immunohistochemical detection of somatostatin receptor (SSTR) subtypes 2A and 5 in pituitary adenoma from acromegalic patients: good correlation with preoperative response to octreotide Endocr Pathol 18 208 216
53. A Teramoto N Sanno S Tahara YR Osamura 2004 Pathological study of thyrotropin-secreting pituitary adenoma: plurihormonality and medical treatment Acta Neuropathol 108 147 153
54. J Trouillas 2002 Pathology and pathogenesis of pituitary corticotroph adenoma Neurochirurgie 48 149 162
55. Vidal S, Horvath E, Kovacs K, Scheithauer BW (2004) Tumors of the Adenohypophysis. Humana Press, Totowa
56. R Yu S Melmed 2004 Pituitary tumor transforming gene: an update Front Horm Res 32 175 185