Predictors of morbidity and mortality in acromegaly: An Italian survey

European Journal of Endocrinology

Volumn 167, Issue 2, 2012, Pages 189-198

  Arosio, M ^a   Reimondo, G ^b   Malchiodi, E ^a   Berchialla, P ^c   Borraccino, A ^c   De Marinis, L ^d   Pivonello, R ^e   Grottoli, S ^b   Losa, M ^f   Cannavo S ^g   Minuto, F ^h   Montini, M ⁱ   Bondanelli, M ^j   De Menis, E ^k   Martini, C ^l   Angeletti, G ^m   Velardo, A ⁿ   Peri, A ^o   Faustini Fustini, M ^p   Tita, P ^q   Pigliaru, F ^r   Borretta, G ^s   Scaroni, C ^l   Bazzoni, N ^t   Bianchi, A ^d   Appetecchia, M ^u   Cavagnini, F ^a   Lombardi, G ^e   Ghigo, E ^b   Beck Peccoz, P ^a   Colao, A ^e   Terzolo, M ^b   more..

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d CATHOLIC UNIVERSITY   (Italy)

^e UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^f VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^g UNIVERSITY OF MESSINA   (Italy)

^h UNIVERSITY OF GENOA   (Italy)

ⁱ Joined Hospitals of Bergamo   (Italy)

^j UNIVERSITY OF FERRARA   (Italy)

^k GENERAL HOSPITAL   (Italy)

^l UNIVERSITY OF PADOVA   (Italy)

^m UNIVERSITY OF PERUGIA   (Italy)

ⁿ UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^o UNIVERSITY OF FLORENCE   (Italy)

^p BELLARIA HOSPITAL   (Italy)

^q GARIBALDI HOSPITAL   (Italy)

^r DEPARTMENT OF RADIOLOGY   (Italy)

^s S CROCE E CARLE HOSPITAL   (Italy)

^t 'S Antonio Abate' Hospital   (Italy)

^u REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BROMOCRIPTINE; CABERGOLINE; DOPAMINE RECEPTOR STIMULATING AGENT; GROWTH HORMONE; GROWTH HORMONE RECEPTOR ANTAGONIST; HORMONE ANTAGONIST; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ACROMEGALY; ADULT; AGE; ARTICLE; CAUSE OF DEATH; COMORBIDITY; CONTROLLED STUDY; DEMOGRAPHY; DIABETES MELLITUS; DISEASE ACTIVITY; DISEASE CONTROL; FEMALE; FOLLOW UP; GAMMA KNIFE RADIOSURGERY; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE SECRETING ADENOMA; HUMAN; HYPERTENSION; ITALY; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; MEDICAL SOCIETY; MORBIDITY; MORTALITY; PREDICTION; PREVALENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RADIOTHERAPY; RETROSPECTIVE STUDY; TREATMENT RESPONSE; VASCULAR DISEASE;

ACROMEGALY; ADULT; DATA COLLECTION; FEMALE; FOLLOW-UP STUDIES; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; ITALY; MALE; MIDDLE AGED; MORBIDITY; MULTICENTER STUDIES AS TOPIC; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84864333824     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-12-0084     Document Type: Article

References (41)

1. Orme SM, McNally RJQ, Cartwright RA & Belchetz PE. Mortality and cancer incidence in acromegaly: a retrospective cohort study. Journal of Clinical Endocrinology and Metabolism 1998 83 2730-2734. (doi:10.1210/jc.83.8. 2730)
2. Holdaway IM. Excess mortality in acromegaly. Hormone Research 2007 68 (Suppl 5) 166-172. (doi:10.1159/000110617)
3. Dekkers OM, Biermasz NR, Pereira AM, Romijn JA & Vandenbroucke JP. Mortality in acromegaly: a metaanalysis. Journal of Clinical Endocrinology and Metabolism 2008 93 61-67. (doi:10.1210/jc.2007-1191)
4. Sherlock M, Ayuk J, Tomlinson JW, Toogood AA, Aragon-Alonso A, Sheppard MC, Bates AS & Stewart PM. Mortality in patients with pituitary disease. Endocrine Reviews 2010 31 301-342. (doi:10.1210/er.2009-0033)
5. Wright AD, Hill DM, Lowy C & Fraser TR. Mortality in acromegaly. Quarterly Journal of Medicine 1970 39 1-16.
6. Bates AS, Van't Hoff W, Jones JM & Clayton RN. An audit of outcome of treatment in acromegaly. Quarterly Journal of Medicine 1993 86 293-299.
7. Sherlock M, Reulen RC, Alonso AA, Ayuk J, Clayton RN, Sheppard MC, Hawkins MM, Bates AS & Stewart PM. ACTH deficiency, higher doses of hydrocortisone replacement and radiotherapy are independent predictors of mortality in patients with acromegaly. Journal of Clinical Endocrinology and Metabolism 2009 94 4216-4223. (doi:10.1210/jc.2009-1097)
8. Beauregard C, Truong U, Hardy J & Serri O. Long-term outcome and mortality after transsphenoidal adenomectomy for acromegaly. Clinical Endocrinology 2003 58 86-91. (doi:10.1046/j.1365- 2265.2003.01679.x)
9. Ayuk J, Clayton RN, Holder G, Sheppard MC, Stewart PM & Bates AS. Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-1 concentrations, predict excess mortality in patients with acromegaly. Journal of Clinical Endocrinology and Metabolism 2004 89 1613-1617. (doi:10. 1210/jc.2003-031584)
10. Biermasz NR, Dekker FW, Pereira AM, van Thiel SW, Schutte PJ, van Dulken H, Romijn JA & Roelfsema F. Determinants of survival in treated acromegaly in a single center: predictive value of serial insulin-like growth factor I measurements. Journal of Clinical Endocrinology and Metabolism 2004 89 2789-2796. (doi:10. 1210/jc.2003-032041)
11. Kauppinen-Mäkelin R, Sane T, Reunanen A, Välimäki MJ, Niskanen L, Markkanen H, Löyttyniemi E, Ebeling T, Jaatinen P, Laine H, Nuutila P, Salmela P, Salmi J, Stenman UH, Viikari J & Voutilainen E. A nationwide survey of mortality in acromegaly. Journal of Clinical Endocrinology and Metabolism 2005 90 4081-4086. (doi:10.1210/jc.2004-1381)
12. Melmed S. Acromegaly and cancer: not a problem? Journal of Clinical Endocrinology and Metabolism 2001 86 2929-2934. (doi:10.1210/jc.86.7.2929)
13. Holdaway IM, Rajasoorya RC & Gamble GD. Factors influencing mortality in acromegaly. Journal of Clinical Endocrinology and Metabolism 2004 89 667-674. (doi:10.1210/jc.2003-031199)
14. Swearingen B, Barker FG II, Katznelson L, Biller BM, Grinspoon S, Klibanski A, Moayeri N, Black PM & Zervas NT. Long-term mortality after transsphenoidal surgery and adjunctive therapy for acromegaly. Journal of Clinical Endocrinology and Metabolism 1998 83 3419-3426. (doi:10.1210/jc.83.10. 3419)
15. Holdaway IM & Rajasoorya C. Epidemiology of acromegaly. Pituitary 1999 2 29-41. (doi:10.1023/A:1009965803750)
16. Giustina A, Barkan A, Casanueva FF, Cavagnini F, Frohman L, Ho K, Veldhuis J, Wass J, Von Werder K & Melmed S. Criteria for cure of acromegaly: a consensus statement. Journal of Clinical Endocrinology and Metabolism 2000 85 526-529. (doi:10.1210/ jc.85.2.526)
17. Aimaretti G, Boschetti M, Corneli G, Gasco V, Valle D, Borsotti M, Rossi A, Barreca A, Fazzuoli L, Ferone D, Ghigo E & Minuto M. Normal age-dependent values of serum insulin growth factor-I: results from a healthy Italian population. Journal of Endocrinological Investigation 2008 31 445-449.
18. Colombo P, Scarpino V, Zuccaro P, Apolone G, Gallus S & La Vecchia C. Smoking in Italian women and men, 2001. Tumori 2002 88 10-12.
19. Mestron A, Webb SM, Astorga R, Benito P, Catala M, Gaztambide S, Gomez JM, Halperin I, Lucas-Morante T, Moreno B, Obiols G, de Pablos P, Paramo C, Pico A, Torres E, Varela C, Vazquez JA, Zamora J, Albareda M & Gilabert M. Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry. European Journal of Endocrinology 2004 151 439-446. (doi:10.1530/eje.0.1510439)
20. Bex M, Abs R, T'Sjoen G, Mockel J, Velkeniers B, Muermans K & Maiter D. AcroBel - the Belgian registry on acromegaly: a survey of the 'real-life' outcome in 418 acromegalic subjects. European Journal of Endocrinology 2007 157 399-409. (doi:10.1530/EJE- 07-0358)
21. Petersenn S, Buchfelder M, Gerbert B, Franz H, Quabbe HJ, Schulte HM, Grussendorf M & Reincke M. Age and sex as predictors of biochemical activity in acromegaly: analysis of 1485 patients from the German Acromegaly Register. Clinical Endocrinology 2009 71 400-405. (doi:10.1111/j.1365-2265.2009. 03547.x)
22. Fieffe S, Morange I, Petrossians P, Chanson P, Rohmer V, Cortet C, Borson-Chazot F, Brue T & Delemer B. Diabetes in acromegaly, prevalence, risk factors and evolution; data from the French Acromegaly Registry. European Journal of Endocrinology 2011 164 877-884. (doi:10.1530/EJE-10-1050)
23. Nabarro JD. Acromegaly. Clinical Endocrinology 1987 26 481-512. (doi:10.1111/j.1365-2265.1987.tb00805.x)
24. Drange MS, Fram NR, Herman-Bonert V & Melmed S. Pituitary tumor registry: a novel clinical resource. Journal of Clinical Endocrinology and Metabolism 2000 85 168-174. (doi:10.1210/ jc.85.1.168)
25. Davidoff LM. Studies in acromegaly III. The anamnesis and symptomatology in one hundred cases. Endocrinology 1926 10 461-483. (doi:10.1210/endo-10-5-461)
26. Mccullagh EP, Beck JC & Schaffenburg CA. Control of diabetes and other features of acromegaly following treatment with estrogens. Diabetes 1955 4 13-23.
27. Cozzi R, Barausse M, Lodrini S, Lasio G & Attanasio R. Estroprogestinic pill normalizes IGF-I levels in acromegalic women. Journal of Endocrinological Investigation 2003 26 347-352.
28. Vallette S & Serri O. Oral estroprogestin: an alternative low cost therapy for women with postoperative persistent acromegaly? Pituitary 2010 13 311-314. (doi:10.1007/s11102-010-0236-5)
29. Roemmler J, Bidlingmaier M & Schopohl J. Endogenous estradiol may influence IGF-I levels in acromegalic women treated with pegvisomant. Pituitary 2010 13 89-93. (doi:10.1007/s11102- 008-0131-5)
30. Reid TJ, Post KD, Bruce JN, Nabi Kanibir M, Reyes-Vidal CM & Freda PU. Features at diagnosis of 324 patients with acromegaly did not change from 1981 to 2006: acromegaly remains underrecognized and under-diagnosed. Clinical Endocrinology 2010 72 203-208. (doi:10.1111/j.1365-2265.2009.03626.x)
31. Gordon DA, Hill FM & Ezrin C. Acromegaly: a review of 100 cases. Canadian Medical Association Journal 1962 87 1106-1109.
32. Beckers A. Higher prevalence of clinically relevant pituitary adenomas confirmed. Clinical Endocrinology 2010 72 290-291. (doi:10.1111/j.1365-2265. 2009.03726.x)
33. Cannavò S, Ferrau F, Ragonese M, Curtò L, Torre ML, Magistri M, Marchese A, Alibrandi A & Trimarchi F. Increased prevalence of acromegaly in a highly polluted area. European Journal of Endocrinology 2010 163 509-513. (doi:10.1530/EJE-10-0465)
34. Clemmons DR, VanWyk JJ, Ridgway EC, Kliman B, Kjellberg RN & Underwood LE. Evaluation of acromegaly by radioimmunoassay of somatomedin-C. New England Journal of Medicine 1979 301 1138-1142. (doi:10.1056/ NEJM197911223012102)
35. Schneider HJ, Friedrich N, Klotsche J, Schipf S, Nauck M, Völzke H, Sievers C, Pieper L, März W, Wittchen H, Stalla GK & Wallaschofski H. Prediction of incident 1 diabetes mellitus by baseline insulin like growth factor-I levels. European Journal of Endocrinology 2011 164 223-229. (doi:10.1530/EJE-10-0963)
36. Bondanelli M, Ambrosio MR & degli Uberti EC. Pathogenesis and prevalence of hypertension in acromegaly. Pituitary 2001 4 239-249. (doi:10.1023/A:1020798430884)
37. Vitale G, Pivonello R, Auriemma R, Guerra E, Milone F, Savastano S, Lombardi G & Colao A. Hypertension in acromegaly and in the normal population: prevalence and determinants. Clinical Endocrinology 2005 63 470-476. (doi:10.1111/j.1365- 2265.2005.02370.x)
38. Ohtsuka H, Komiya I, Aizawa T & Yamada T. Hypertension in acromegaly: hereditary hypertensive factor produces hypertension by enhancing IGF-I production. Endocrine Journal 1995 42 781-787. (doi:10.1507/endocrj.42.781)
39. Diez J. Insulin-like growth factor I in essential hypertension. Kidney International 1999 55 744-759. (doi:10.1046/j.1523- 1755.1999.00300.x)
40. Berg C, Petersenn S, Lahner H, Herrmann BL, Buchfelder M, Droste M, Stalla GK, Strasburger CJ, Roggenbuck U, Lehmann N, Moebus S, Jöckel KH, Möhlenkamp S, Erbel R, Saller B & Mann K. Cardiovascular risk factors in patients with uncontrolled and long-term acromegaly: comparison with matched data from the general population and the effect of disease control. Journal of Clinical Endocrinology and Metabolism 2010 95 3648-3656. (doi:10.1210/jc.2009- 2570)
41. Muller-Nordhorn J, Binting S, Roll S & Willich S. An update on regional variation in cardiovascular mortality within Europe. European Heart Journal 2008 29 1316-1326. (doi:10.1093/ eurheartj/ehm604)