Ethical aspects of aging research

Biogerontology

Volumn 12, Issue 6, 2011, Pages 491-502

  Seppet, Enn ^a   Pääsuke, Mati ^a   Conte, Maria ^b   Capri, Miriam ^b   Franceschi, Claudio ^b  

^a UNIVERSITY OF TARTU   (Estonia)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Ethical issues; Human aging; Informed consent; Older population; Recruitment of subjects; Stem cells; Tissue samples

Indexed keywords

ACCESS TO INFORMATION; AGING; ALZHEIMER DISEASE; CLINICAL PRACTICE; EMBRYONIC STEM CELL; HUMAN; INFORMED CONSENT; PARTICIPATORY RESEARCH; PRIORITY JOURNAL; RESEARCH ETHICS; REVIEW; STANDARDIZATION; STEM CELL RESEARCH;

AGED; AGING; ANIMALS; BIOMEDICAL RESEARCH; GERIATRICS; GUIDELINES AS TOPIC; HUMANS; INFORMED CONSENT; LONGEVITY; PATIENT SELECTION; SPECIMEN HANDLING; STEM CELL RESEARCH; TISSUE BANKS;

EID: 83555161518     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-011-9340-9     Document Type: Review

References (54)

1. V Árnason 2010 Bioethics in Iseland Camb Q Healtc Ethics 19 299 309 10.1017/S0963180110000071
2. C Auray-Blais J Patenaude 2006 A biobank management model applicable to biomedical research BMC Med Ethics 7 1 9 10.1186/1472-6939-7-4 (Pubitemid 43863309)
3. S Beccafico C Puglielli T Pietrangelo R Bellomo G Fanò S Fulle 2007 Age-dependent effects on functional aspects in human satellite cells Ann N Y Acad Sci 1100 345 352 17460197 10.1196/annals.1395.037 1:CAS:528: DC%2BD2sXlslOit7c%3D (Pubitemid 47092671)
4. A Bigot V Jacquemin F Debacq-Chainiaux G Buttler-Browne O Toussaint D Furling V Mouly 2008 Replicative aging down-regulates the myogenic regulatory factors in human myoblasts Biol Cell 100 189 199 17988214 10.1042/BC20070085 1:CAS:528:DC%2BD1cXitVKqtrg%3D (Pubitemid 351372677)
5. J Blair McCormick HA Huso 2010 Stem cells and ethics: current issues J Cardiovasc Trans Res 3 122 127 10.1007/s12265-009-9155-0
6. AC Bringnier AM Gewirtz 2010 Embryonic and adult stem cell therapy J Allergy Clin Immunol 125 S336 S344 10.1016/j.jaci.2009.09.032
7. Council of Europe (2005) Additional protocol to the convention on human rights and biomedicine concerning biomedical research, Strasbourg, 2005. European treaty series no. 195
8. RM Doerflinger 2010 Old and new ethics in the stem cell debate J Law Med Ethics 38 2 212 319 20579244 10.1111/j.1748-720X.2010.00481.x
9. R Dresser 2010 Stem cell research as innovation: expanding the ethical ad policy conversation J Law Med Ethics 38 2 332 341 20579255 10.1111/j.1748-720X. 2010.00492.x
10. K Duff JW Mold Y Gidron 2009 Cognitive functioning predicts survival in the elderly J Clin Exp Neuropsychol 31 90 95 18608698 10.1080/13803390801998664
11. BS Elger AL Caplan 2006 Consent and anonymization in research involving biobanks EMBO Reports 7 661 666 16819458 10.1038/sj.embor.7400740 1:CAS:528:DC%2BD28XmsVanu70%3D (Pubitemid 43986258)
12. Ezzat H, Ross S, von Dadelzen P, Morris T, Liston R, Magee LA (2010) Ethics review as a component of institutional approval for a multicentre continuous quality improvement project: the investigator's perspective. Health Service Res 10:223 http://www.biomedcentral.com/1472-6963/10/223
13. C Franceschi L Motta S Valensin R Rapisarda A Franzone M Berardelli M Motta D Monti M Bonafè L Ferrucci L Deiana GM Pes C Carru MS Desole C Barbi G Sartoni C Gemelli F Lescai F Olivieri F Marchegiani M Cardelli L Cavallone P Gueresi A Cossarizza L Troiano G Pini P Sansoni G Passeri R Lisa L Spazzafumo L Amadio S Giunta R Stecconi R Morresi C Viticchi R Mattace G De Benedictis G Baggio 2000 Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians (IMUSCE) Aging (Milano) 12 77 84 1:STN:280:DC%2BD3M%2FgvV2hsw%3D%3D (Pubitemid 30407459)
14. JF Fries 2000 Compression of morbidity in the elderly Vaccine 18 1584 1589 10689132 10.1016/S0264-410X(99)00490-9 1:STN:280:DC%2BD3c7ls1OqtQ%3D%3D (Pubitemid 30109512)
15. S Fulle S Belia G Di Tano 2005 Sarcopenia is more than a muscular deficit Arch Ital Biol 143 229 234 16097500 1:STN:280:DC%2BD2MvjtFSguw%3D%3D (Pubitemid 41002629)
16. B Godard J Schmidtke J Cassiman S Ayme 2003 Data storage and DNA banking for biomedical research: informed consent, confidentiality, quality issues, ownership, return of benefits. A professional perspective Eur J Hum Gen 11 S88 S122 10.1038/sj.ejhg.5201114 (Pubitemid 38263570)
17. L Goldstein 2010 Why scientific details are important when novel technologies encounter law, politics, and ethics J Law Med Ethics 38 2 204 211 20579243 10.1111/j.1748-720X.2010.00480.x
18. Hawkins AK (2010) Biobanks: importance, implications and opportunities for genetic counsellors. J Genet Counsel. doi: 10.1007/s10897-010-9305-1
19. A Holdcroft 2007 Integrating the dimensions of sex and gender into basic life sciences research: methodological and ethical issues Gender Med 4 Suppl B S64 S74 10.1016/S1550-8579(07)80048-9 (Pubitemid 350286523)
20. O Hovatta M Stojkovic M Nogueira I Varela-Nieto 2010 European scientific, ethical, and legal issues on human stem cell research and regenerative medicine Stem Cells 28 1005 1007 20533567 10.1002/stem.436
21. K Hug 2005 Sources of human embryos for stem cell research: ethical problems and their possible solutions Medicina (Kaunas) 41 1002 1010
22. I Hyun 2010 The bioethics of stem cell research and therapy J Clin Invest 120 71 75 20051638 10.1172/JCI40435 1:CAS:528:DC%2BC3cXislWgug%3D%3D
23. I Hyun 2010 Allowing innovative stem cell-based therapies outside of clinical trials: ethical and policy challenges J Law Med Ethics 38 2 277 285 20579251 10.1111/j.1748-720X.2010.00488.x
24. I Ilkilic H Ertin 2010 Ethical aspects of human embryonic stem cell research in the Islamic world: positions and reflections Stem Cell Rev Rep 6 151 161 10.1007/s12015-010-9117-6
25. Y Ivashkov GA Van Norman 2009 Informed consent and the ethical management of older patient Anesthesiol Clin 27 569 580 19825493 10.1016/j.anclin.2009.07. 016
26. F Judd S Armstrong J Kulkarni 2009 Gender-sensitive mental health care Australas Psychiatry 17 105 111 19296270 10.1080/10398560802596108
27. MB Kapp 2006 Ethical and legal issues in research involving human subjects: do you want a piece of me? J Clin Pathol 59 335 339 16567467 10.1136/jcp.2005.030957 1:STN:280:DC%2BD287ntlylsg%3D%3D
28. J Karlawish 2008 Measuring decision-making capacity in cognitively impaired individuals Neurosignals 16 91 98 18097164 10.1159/000109763 1:CAS:528:DC%2BD1cXhs1WnsLw%3D (Pubitemid 350308325)
29. M Kawakami D Sipp K Kato 2010 Regulatory impacts on stem cell research in Japan Cell Stem cell 6 415 418 20452315 10.1016/j.stem.2010.04.010 1:CAS:528:DC%2BC3cXms1altrY%3D
30. SYH Kim PS Appelbaum DV Jeste JT Olin 2004 Proxy and surrogate consent in geriatric neuropsychiatric research: update and recommendations Am J Psychiatry 161 797 806 15121642 10.1176/appi.ajp.161.5.797 (Pubitemid 38625332)
31. MD Krynski AJ Tymchuk JG Ouslander 1994 How informed can consent be? New light on comprehension among elderly people making decisions about enteral tube feeding Gerontologist 34 36 43 8150306 10.1093/geront/34.1.36 1:STN:280:DyaK2c3gtVKhsw%3D%3D (Pubitemid 24072668)
32. S Kuang MA Rudnicki 2007 The emerging biology of satellite cells and their therapeutic potential Cell Press 14 81 91
33. K Lawrence A Rieder 2007 Methodologic and ethical ramifications of sex and gender differences in public health research Gender Med 4 S96 S105 10.1016/S1550-8579(07)80050-7
34. B Lo L Parham 2009 Ethical issues in stem cell research Endocrine Rev 30 204 213 10.1210/er.2008-0031
35. B Lo L Parham M Cedras S Fisher E Gates L Giudice D Gould Halme W Hershorn A Kriegstein R Rao C Roberst R Wagner 2010 Research ethics: NIH guidelines for stem cell research and gamete donors Science 372 962 963 10.1126/science.1180725
36. F Luna A Salles 2010 On moral incoherence and hidden battles: stem cell research in Argentina Dev World Bioethics 10 120 128 10.1111/j.1471-8847.2009. 00275.x
37. J Marshall 2006 Life extension research: an analysis of contemporary biological theories and ethical issues Med Health Care Philos 9 87 96 16645801 10.1007/s11019-005-2668-7 (Pubitemid 43632094)
38. E Matthews E Haimes A-M Duguet BFC Clark C Swine O Touissant 2005 Informed consent of very old patients and modern genomics Biogerontology 6 81 84 15834667 10.1007/s10522-004-7388-5 (Pubitemid 41583296)
39. Medical Research Council (2001) Human tissue and biological samples for use in research. Operational and ethical guidelines. MRC's website: www.mrc.ac.uk
40. L Mody DK Miller JM McGloin M Freeman ER Marcantonio J Maganizer S Studensky 2008 Recruitment and retention of older adults in aging research J Am Geriatr Soc 56 2340 2348 19093934 10.1111/j.1532-5415.2008.02015.x
41. CJ Moerman JA Haafkens M Soderstrom E Ràsky P Maguire U Maschewsky-Schneider M Norstedt D Hahn H Reinerth N McKevitt 2007 Gender equality in the work of local research ethics committees in Europe: a study of practice in five countries J Med Ethics 33 107 112 17264199 10.1136/jme.2005. 015206 1:STN:280:DC%2BD2s%2FlvFKmtw%3D%3D
42. KE Moore JF Mills MM Thornton 2006 Alternative sources of adult stem cells: a possible solution to the embryonic stem cell debate Gender Med 3 161 168 10.1016/S1550-8579(06)80204-4 (Pubitemid 44636943)
43. J Moye D Marson 2007 Assessment of decision-making capacity in older adults: an emerging area of practice and research J Gerontol 62B P3 P11
44. + muscle-derived stem cells: a quantitative study Mol Ther 17 1771 1778 19623164 10.1038/mt.2009.167 1:CAS:528:DC%2BD1MXoslymtL8%3D
45. PA Newton-Howes ND Bedford BR Dobbs FA Frizelle 1998 Informed consent: what do patients want to know? N Z Med J 111 340 342 9785548 1:STN:280:DyaK1M%2FgtFOhtQ%3D%3D (Pubitemid 128475934)
46. A Nyika 2009 Ethical and practical challenges surrounding genetic and genomic research in developing countries Acta Trop 112S S21 S31 10.1016/j.actatropica.2009.07.034
47. RM Sade 2002 Research on stored biological samples is still research Arch Int Med 162 1439 1440 10.1001/archinte.162.13.1439 (Pubitemid 34747473)
48. J Sugarman DC McCrory RC Hubal 1998 Getting meaningful informed consent from older adults: a structured literature review of empirical research J Am Geriatr Soc 46 517 524 9560079 1:STN:280:DyaK1c3hvFSjtA%3D%3D (Pubitemid 28188530)
49. The International Stem Cell Banking Initiative 2009 Consensus guidance for banking and supply of human embryonic stem cell lines for research purposes Stem Cell Rev Rep 5 301 314 10.1007/s12015-009-9085-x
50. AM Torke GC Alexander J Lantos 2008 Substituted judgement: the limitations of autonomy in surrogate decision making J Gen Intern Med 23 1514 1517 18618201 10.1007/s11606-008-0688-8
51. L Turner 2004 Biotechnology, bioethics and anti-aging interventions Trends Biotechnol 22 219 221 15109806 10.1016/j.tibtech.2004.03.008 1:CAS:528:DC%2BD2cXjtl2lt7w%3D (Pubitemid 38515737)
52. RWG Watson EW Kay D Smith 2010 Integrating biobanks: addressing the practical and ethical issues to deliver a valuable tool for cancer research Nature Rev 10 646 651 10.1038/nrc2913 1:CAS:528:DC%2BC3cXhtVSmurfF
53. Wizemann TM, Pardue ML (eds) (2001) For committee on understanding the biological contributions to human health: exploring the biological contributions to human health. Does sex matter? Institute of Medicine, National Academic Press, Washington DC, pp 17-19
54. M Yoshioka A Boivin C Bolduc J St-Amand 2007 Gender difference of androgen actions on skeletal muscle transcriptome J Mol Endocrinol 39 119 133 17693611 10.1677/JME-07-0027 1:CAS:528:DC%2BD1cXmslWmsL8%3D (Pubitemid 47337871)