Longevity mutants do not establish any "new science" of ageing

Biogerontology

Volumn 11, Issue 4, 2010, Pages 507-511

  Holliday, Robin ^a   Rattan, Suresh I S ^b  

^a Australian Academy of Sciences   (Australia)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Ageing; Evolution; Gerontogenes; Lifespan; Model systems

Indexed keywords

CATALASE; HEAT SHOCK PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR 1; KLOTHO PROTEIN; METHYLTRANSFERASE; SIRTUIN; SOMATOMEDIN C; TRANSCRIPTION FACTOR FOXO;

AGING; CAENORHABDITIS ELEGANS; DIET RESTRICTION; DROSOPHILA; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENE SILENCING; GENETIC TRANSCRIPTION; LIFESPAN; LONGEVITY; NONHUMAN; NOTE; PHENOTYPE; PRIORITY JOURNAL; REPRODUCTION; SURVIVAL; ANIMAL; GENETICS; HUMAN; MOLECULAR EVOLUTION; MUTATION;

AGING; ANIMALS; EVOLUTION, MOLECULAR; HUMANS; LONGEVITY; MUTATION; REPRODUCTION;

EID: 77954952870     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-010-9288-1     Document Type: Note

References (42)

1. Chen J, Senturk D, Wang JL, Müller HG, Carey JR, Caswell H, Caswell-Chen EP (2007) A demographic analysis of the fitness cost of extended longevity in Caenorhabditis elegans. J Gerontol Bio Sci 62A:126-135
2. Curran SP, Ruvkan G (2007) Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet 3:e56
3. Economos AC, Lints FA (1985) Growth rate, life span in Drosophila. V. The effect of prolongation of the period of growth on the total duration of life (J.H. Northrop, 1917). revisited. Mech Ageing Develop 33:103-113
4. Economos AC, Lints FA (1986) Developmental temperature and lifespan in Drosophila melanogaster. I. Constant developmental temperature: evidence for physiological adaptation in a wide temperature range. Gerontol 32: 18-27
5. Everitt AV, Rattan SIS, Le Couteur DG, de Cabo C (eds) (2010) Calorie restriction, aging and longevity. Springer, New York
6. Finch CE (2009) Update on slow aging and negligible senescence- a mini-review. Gerontology 55:307-313
7. Fontana L, Partridge L, Longo VD (2010) Extending healthy life span-from yeast to humans. Science 328:321-326
8. Friedman DB, Johnson TE (1988) A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118:75-86
9. Hayflick L (2007) Biological aging is no longer an unsolved problem. Ann NY Acad Sci 1100:1-13
10. Hipkiss A (2008) Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms? Biogerontology 9:49-55
11. Holliday R (1989) Food, reproduction and longevity: is the extended lifespan of calorie-restricted animals an evolutionary adaptation? BioEssays 10:125-127
12. Holliday R (1995) Understanding ageing. Cambridge University Press, Cambridge
13. Holliday R (2006) Aging is no longer an unsolved problem in biology. Ann NY Acad Sci 1067:1-9
14. Ishii N, Suzuki N, Hartman PS, Suzuki K (1994) The effects of temperature on the longevity of a radiation-sensitive mutant rad-8 of the nematode Caenorhabditis elegans. J Gerontol 49:B117-B120
15. Johnson TE (1990) Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science 249:908-912
16. Kenyon CJ (2010) The genetics of ageing. Nature 464:504-512
17. Kirkwood TBL (2005) Understanding the odd science of aging. Cell 120:437-447
18. Kirkwood TB, Shanley DP (2005) Food restricticon, evolution and ageing. Mech Ageing Dev 126:1011-1016
19. Le Bourg E, Rattan SIS (2006) Special issue: can dietary restriction increase longevity in all species, particularly in human beings? Introduction to a debate among experts. Biogerontology 7:123-125
20. Longo VD (2009) Linking sirtuins, IGF-I signaling, and starvation. Exp Gerontol 44:70-74
21. Luckinbill LS (1998) Selection for longevity confers resistance to low-temperature stress in Drosophila melanogster. J Gerontol Biol Sci 53A:B147-B153
22. Norry FM, Loeschcke V (2002) Temperature-induced shifts in associations of longevity with body size in Drosophila melanogster. Evolution 56:299-306
23. North BJ, Sinclair DA (2007) Sirtuins: a conserved key unlocking AceCS activity. Trends Biochem Sci 32:1-4
24. Olsen A, Vantipalli MC, Lithgow GJ (2006) Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans. Science 312:1381-1385
25. Olshansky SJ, Rattan SIS (2005) At the heart of aging: is it metabolic rate or stability? Biogerontology 6:291-295
26. Panowski SH, Wolff S, Aguilaniu H, Durieux J, Dillin A (2007) PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans. Nature 447:550-555
27. Partridge L (2010) The new biology of ageing. Philos Trans R Soc Lond B Biol Sci 365:147-154
28. Rattan SIS (2005) Anti-ageing strategies: prevention or therapy? EMBO Reports 6:S25-S29
29. Rattan SIS (2006) Theories of biological aging: genes, proteins and free radicals. Free Rad Res 40:1230-1238
30. Rattan SIS (2007) Homeostasis, homeodynamics, and aging. In: Birren J (ed) Encyclopedia of gerontology. Elsevier Inc, UK, pp 696-699
31. Rattan SIS (2008a) Hormesis in aging. Ageing Res Rev 7:63-78
32. Rattan SIS (2008b) Increased molecular damage and heterogeneity as the basis of aging. Biol Chem 389:267-272
33. Rattan SIS, Singh R (2009) Gene therapy in aging. Gene Ther 16:3-9
34. Rincon M, Muzumdar R, Altmon G, Barzilai N (2004) The paradox of the insulin/IGF-1 signaling pathway in longevity. Mech Age Dev 125:397-403
35. Rose MR (1991) Evolutionary biology of aging. Oxford University Press, New York
36. Schriner SE, Linford NJ (2006) Extension of mouse lifespan by overexpression of catalase. Age 28:209-218
37. Shanley DP, Kirkwood TB (2006) Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans. Biogerontology 7:165-168
38. Turturro A, Hart RW (1991) Longevity assurance mechanisms and calorie restriction. Ann NY Acad Sci 621:363-372
39. Unger RH (2006) Klotho-induced insulin resistance: a blessing in disguise? Nat Med 12:56-57
40. Van Voorhies WA, Curtsinger JW, Rose MR (2006) Do longevity mutants always show trade-offs? Exp Gerontol 41:1055-1058
41. Vijg J, Campisi J (2008) Puzzles, promises and a cure for ageing. Nature 454:1065-1071
42. Yashin AI, De Benedictis G et al (2000) Genes and longevity: lessons from studies of centenarians. J Gerontol Biol Sci 55A:B319-B328