메뉴 건너뛰기




Volumn 68, Issue 8, 2014, Pages 911-916

Colon cancer: Cancer stem cells markers, drug resistance and treatment

Author keywords

Aldehyd dehydrogenase ALDH1; Cancer stem cells markers; Colon cancer; Multidrug resistance

Indexed keywords

ABC TRANSPORTER; ANTINEOPLASTIC AGENT; TUMOR MARKER;

EID: 84916230380     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2014.10.019     Document Type: Review
Times cited : (197)

References (84)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 84891759536 scopus 로고    scopus 로고
    • The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy
    • Marin J.J., Monte M.J., Blazquez A.G., Macias R.I., Serrano M.A., Briz O. The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy. Acta Pharmacol Sin 2014, 35:1-10.
    • (2014) Acta Pharmacol Sin , vol.35 , pp. 1-10
    • Marin, J.J.1    Monte, M.J.2    Blazquez, A.G.3    Macias, R.I.4    Serrano, M.A.5    Briz, O.6
  • 5
    • 37549034571 scopus 로고    scopus 로고
    • Non-invasive imaging correlates with histological and molecular characteristics of an osteosarcoma model: application for early detection and follow-up of MDR phenotype
    • Dutour A., Leclers D., Monteil J., Paraf F., Charissoux J.L., Rousseau R., et al. Non-invasive imaging correlates with histological and molecular characteristics of an osteosarcoma model: application for early detection and follow-up of MDR phenotype. Anticancer Res 2007, 27:4171-4178.
    • (2007) Anticancer Res , vol.27 , pp. 4171-4178
    • Dutour, A.1    Leclers, D.2    Monteil, J.3    Paraf, F.4    Charissoux, J.L.5    Rousseau, R.6
  • 6
    • 84872028852 scopus 로고    scopus 로고
    • The biology of brain metastasis
    • Langley R.R., Fidler I.J. The biology of brain metastasis. Clin Chem 2013, 59:180-189.
    • (2013) Clin Chem , vol.59 , pp. 180-189
    • Langley, R.R.1    Fidler, I.J.2
  • 7
    • 33847212780 scopus 로고    scopus 로고
    • Drug resistance in melanoma: new perspectives
    • La Porta C.A. Drug resistance in melanoma: new perspectives. Curr Med Chem 2007, 14:387-391.
    • (2007) Curr Med Chem , vol.14 , pp. 387-391
    • La Porta, C.A.1
  • 8
    • 84871509846 scopus 로고    scopus 로고
    • Intrinsic properties of tumour cells have a key impact on the bystander effect mediated by genetically engineered mesenchymal stromal cells
    • Matuskova M., Baranovicova L., Kozovska Z., Durinikova E., Pastorakova A., Hunakova L., et al. Intrinsic properties of tumour cells have a key impact on the bystander effect mediated by genetically engineered mesenchymal stromal cells. J Gene Med 2012, 14:776-787.
    • (2012) J Gene Med , vol.14 , pp. 776-787
    • Matuskova, M.1    Baranovicova, L.2    Kozovska, Z.3    Durinikova, E.4    Pastorakova, A.5    Hunakova, L.6
  • 9
    • 84859111006 scopus 로고    scopus 로고
    • Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase: uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma
    • Altanerova V., Cihova M., Babic M., Rychly B., Ondicova K., Mravec B., et al. Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase: uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma. Int J Cancer 2012, 130:2455-2463.
    • (2012) Int J Cancer , vol.130 , pp. 2455-2463
    • Altanerova, V.1    Cihova, M.2    Babic, M.3    Rychly, B.4    Ondicova, K.5    Mravec, B.6
  • 10
    • 84855280129 scopus 로고    scopus 로고
    • Increased proliferation and chemosensitivity of human mesenchymal stromal cells expressing fusion yeast cytosine deaminase
    • Kucerova L., Poturnajova M., Tyciakova S., Matuskova M. Increased proliferation and chemosensitivity of human mesenchymal stromal cells expressing fusion yeast cytosine deaminase. Stem Cell Res 2012, 8:247-258.
    • (2012) Stem Cell Res , vol.8 , pp. 247-258
    • Kucerova, L.1    Poturnajova, M.2    Tyciakova, S.3    Matuskova, M.4
  • 12
    • 84901591109 scopus 로고    scopus 로고
    • Mesenchymal stromal cells retrovirally transduced with prodrug-converting genes are suitable vehicles for cancer gene therapy
    • Durinikova E., Kucerova L., Matuskova M. Mesenchymal stromal cells retrovirally transduced with prodrug-converting genes are suitable vehicles for cancer gene therapy. Acta Virol 2014, 58:1-13.
    • (2014) Acta Virol , vol.58 , pp. 1-13
    • Durinikova, E.1    Kucerova, L.2    Matuskova, M.3
  • 13
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E.R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990, 61:759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 14
    • 0018864610 scopus 로고
    • The pathogenesis of cancer metastasis
    • Poste G., Fidler I.J. The pathogenesis of cancer metastasis. Nature 1980, 283:139-146.
    • (1980) Nature , vol.283 , pp. 139-146
    • Poste, G.1    Fidler, I.J.2
  • 15
    • 33745612099 scopus 로고    scopus 로고
    • Stochastic cancer progression driven by non-clonal chromosome aberrations
    • Heng H.H., Stevens J.B., Liu G., Bremer S.W., Ye K.J., Reddy P.V., et al. Stochastic cancer progression driven by non-clonal chromosome aberrations. J Cell Physiol 2006, 208:461-472.
    • (2006) J Cell Physiol , vol.208 , pp. 461-472
    • Heng, H.H.1    Stevens, J.B.2    Liu, G.3    Bremer, S.W.4    Ye, K.J.5    Reddy, P.V.6
  • 16
  • 17
    • 84857671060 scopus 로고    scopus 로고
    • Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design
    • Diaz-Cano S.J. Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design. Int J Mol Sci 2012, 13:1951-2011.
    • (2012) Int J Mol Sci , vol.13 , pp. 1951-2011
    • Diaz-Cano, S.J.1
  • 19
    • 0021242388 scopus 로고
    • Tumor heterogeneity
    • Heppner G.H. Tumor heterogeneity. Cancer Res 1984, 44:2259-2265.
    • (1984) Cancer Res , vol.44 , pp. 2259-2265
    • Heppner, G.H.1
  • 21
    • 33947433676 scopus 로고    scopus 로고
    • Cancer stem cells: at the headwaters of tumor development
    • Ward R.J., Dirks P.B. Cancer stem cells: at the headwaters of tumor development. Annu Rev Pathol 2007, 2:175-189.
    • (2007) Annu Rev Pathol , vol.2 , pp. 175-189
    • Ward, R.J.1    Dirks, P.B.2
  • 22
    • 43749084585 scopus 로고    scopus 로고
    • Recent advances in cancer stem cells
    • Cho R.W., Clarke M.F. Recent advances in cancer stem cells. Curr Opin Genet Dev 2008, 18:48-53.
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 48-53
    • Cho, R.W.1    Clarke, M.F.2
  • 23
    • 33745600820 scopus 로고    scopus 로고
    • Asymmetric and symmetric stem-cell divisions in development and cancer
    • Morrison S.J., Kimble J. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 2006, 441:1068-1074.
    • (2006) Nature , vol.441 , pp. 1068-1074
    • Morrison, S.J.1    Kimble, J.2
  • 24
    • 0037080188 scopus 로고    scopus 로고
    • A genetic determinant that specifically regulates the frequency of hematopoietic stem cells
    • Morrison S.J., Qian D., Jerabek L., Thiel B.A., Park I.K., Ford P.S., et al. A genetic determinant that specifically regulates the frequency of hematopoietic stem cells. J Immunol 2002, 168:635-642.
    • (2002) J Immunol , vol.168 , pp. 635-642
    • Morrison, S.J.1    Qian, D.2    Jerabek, L.3    Thiel, B.A.4    Park, I.K.5    Ford, P.S.6
  • 25
    • 79952993517 scopus 로고    scopus 로고
    • Multidrug efflux pumps and cancer stem cells: insights into multidrug resistance and therapeutic development
    • Moitra K., Lou H., Dean M. Multidrug efflux pumps and cancer stem cells: insights into multidrug resistance and therapeutic development. Clin Pharmacol Ther 2011, 89:491-502.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 491-502
    • Moitra, K.1    Lou, H.2    Dean, M.3
  • 26
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O'Brien C.A., Pollett A., Gallinger S., Dick J.E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007, 445:106-110.
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 28
    • 65949112714 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis
    • Huang E.H., Hynes M.J., Zhang T., Ginestier C., Dontu G., Appelman H., et al. Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Res 2009, 69:3382-3389.
    • (2009) Cancer Res , vol.69 , pp. 3382-3389
    • Huang, E.H.1    Hynes, M.J.2    Zhang, T.3    Ginestier, C.4    Dontu, G.5    Appelman, H.6
  • 29
    • 84863843869 scopus 로고    scopus 로고
    • A subpopulation of CD24(+) cells in colon cancer cell lines possess stem cell characteristics
    • Ke J., Wu X., He X., Lian L., Zou Y., Wang H., et al. A subpopulation of CD24(+) cells in colon cancer cell lines possess stem cell characteristics. Neoplasma 2012, 59:282-288.
    • (2012) Neoplasma , vol.59 , pp. 282-288
    • Ke, J.1    Wu, X.2    He, X.3    Lian, L.4    Zou, Y.5    Wang, H.6
  • 32
    • 77649272778 scopus 로고    scopus 로고
    • CD133 expression predicts for non-response to chemotherapy in colorectal cancer
    • Ong C.W., Kim L.G., Kong H.H., Low L.Y., Iacopetta B., Soong R., et al. CD133 expression predicts for non-response to chemotherapy in colorectal cancer. Mod Pathol 2010, 23:450-457.
    • (2010) Mod Pathol , vol.23 , pp. 450-457
    • Ong, C.W.1    Kim, L.G.2    Kong, H.H.3    Low, L.Y.4    Iacopetta, B.5    Soong, R.6
  • 33
    • 58149269566 scopus 로고    scopus 로고
    • CD44 is of functional importance for colorectal cancer stem cells
    • Du L., Wang H., He L., Zhang J., Ni B., Wang X., et al. CD44 is of functional importance for colorectal cancer stem cells. Clin Cancer Res 2008, 14:6751-6760.
    • (2008) Clin Cancer Res , vol.14 , pp. 6751-6760
    • Du, L.1    Wang, H.2    He, L.3    Zhang, J.4    Ni, B.5    Wang, X.6
  • 34
    • 32444448861 scopus 로고    scopus 로고
    • Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family
    • Vasiliou V., Nebert D.W. Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family. Hum Genomics 2005, 2:138-143.
    • (2005) Hum Genomics , vol.2 , pp. 138-143
    • Vasiliou, V.1    Nebert, D.W.2
  • 36
    • 79955025420 scopus 로고    scopus 로고
    • The role of human aldehyde dehydrogenase in normal and cancer stem cells
    • Ma I., Allan A.L. The role of human aldehyde dehydrogenase in normal and cancer stem cells. Stem Cell Rev 2011, 7:292-306.
    • (2011) Stem Cell Rev , vol.7 , pp. 292-306
    • Ma, I.1    Allan, A.L.2
  • 38
    • 76149125786 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer
    • Su Y., Qiu Q., Zhang X., Jiang Z., Leng Q., Liu Z., et al. Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer. Cancer Epidemiol Biomarkers Prev 2010, 19:327-337.
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 327-337
    • Su, Y.1    Qiu, Q.2    Zhang, X.3    Jiang, Z.4    Leng, Q.5    Liu, Z.6
  • 39
    • 79958716191 scopus 로고    scopus 로고
    • ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma
    • Kim M.P., Fleming J.B., Wang H., Abbruzzese J.L., Choi W., Kopetz S., et al. ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. PLoS ONE 2011, 6:e20636.
    • (2011) PLoS ONE , vol.6 , pp. e20636
    • Kim, M.P.1    Fleming, J.B.2    Wang, H.3    Abbruzzese, J.L.4    Choi, W.5    Kopetz, S.6
  • 40
    • 77954351665 scopus 로고    scopus 로고
    • Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance
    • Honoki K., Fujii H., Kubo A., Kido A., Mori T., Tanaka Y., et al. Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. Oncol Rep 2010, 24:501-505.
    • (2010) Oncol Rep , vol.24 , pp. 501-505
    • Honoki, K.1    Fujii, H.2    Kubo, A.3    Kido, A.4    Mori, T.5    Tanaka, Y.6
  • 41
    • 84860347162 scopus 로고    scopus 로고
    • Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44(+) human breast cancer cells
    • Croker A.K., Allan A.L. Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44(+) human breast cancer cells. Breast Cancer Res Treat 2012, 133:75-87.
    • (2012) Breast Cancer Res Treat , vol.133 , pp. 75-87
    • Croker, A.K.1    Allan, A.L.2
  • 42
    • 84902332685 scopus 로고    scopus 로고
    • Association of aldehyde dehydrogenase 1 expression and biologically aggressive features in breast cancer
    • Kang E.J., Jung H., Woo O.H., Park K.H., Woo S.U., Yang D.S., et al. Association of aldehyde dehydrogenase 1 expression and biologically aggressive features in breast cancer. Neoplasma 2014, 61:352-362.
    • (2014) Neoplasma , vol.61 , pp. 352-362
    • Kang, E.J.1    Jung, H.2    Woo, O.H.3    Park, K.H.4    Woo, S.U.5    Yang, D.S.6
  • 43
    • 73949097562 scopus 로고    scopus 로고
    • Overexpression of aldehyde dehydrogenase 1A1 reduces oxidation-induced toxicity in SH-SY5Y neuroblastoma cells
    • Zhang M., Shoeb M., Goswamy J., Liu P., Xiao T.L., Hogan D., et al. Overexpression of aldehyde dehydrogenase 1A1 reduces oxidation-induced toxicity in SH-SY5Y neuroblastoma cells. J Neurosci Res 2010, 88:686-694.
    • (2010) J Neurosci Res , vol.88 , pp. 686-694
    • Zhang, M.1    Shoeb, M.2    Goswamy, J.3    Liu, P.4    Xiao, T.L.5    Hogan, D.6
  • 44
    • 44949179401 scopus 로고    scopus 로고
    • Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?
    • Lawenda B.D., Kelly K.M., Ladas E.J., Sagar S.M., Vickers A., Blumberg J.B. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy?. J Natl Cancer Inst 2008, 100:773-783.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 773-783
    • Lawenda, B.D.1    Kelly, K.M.2    Ladas, E.J.3    Sagar, S.M.4    Vickers, A.5    Blumberg, J.B.6
  • 45
    • 23044514578 scopus 로고    scopus 로고
    • Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis
    • Donnenberg V.S., Donnenberg A.D. Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis. J Clin Pharmacol 2005, 45:872-877.
    • (2005) J Clin Pharmacol , vol.45 , pp. 872-877
    • Donnenberg, V.S.1    Donnenberg, A.D.2
  • 47
    • 34047096557 scopus 로고    scopus 로고
    • Cancer stem cells: models and concepts
    • Dalerba P., Cho R.W., Clarke M.F. Cancer stem cells: models and concepts. Annu Rev Med 2007, 58:267-284.
    • (2007) Annu Rev Med , vol.58 , pp. 267-284
    • Dalerba, P.1    Cho, R.W.2    Clarke, M.F.3
  • 48
    • 79955938811 scopus 로고    scopus 로고
    • Neoadjuvant vs adjuvant pelvic radiotherapy for locally advanced rectal cancer: Which is superior?
    • Popek S., Tsikitis V.L. Neoadjuvant vs adjuvant pelvic radiotherapy for locally advanced rectal cancer: Which is superior?. World J Gastroenterol 2011, 17:848-854.
    • (2011) World J Gastroenterol , vol.17 , pp. 848-854
    • Popek, S.1    Tsikitis, V.L.2
  • 49
    • 4344587783 scopus 로고    scopus 로고
    • American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer
    • Benson A.B., Schrag D., Somerfield M.R., Cohen A.M., Figueredo A.T., Flynn P.J., et al. American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J Clin Oncol 2004, 22:3408-3419.
    • (2004) J Clin Oncol , vol.22 , pp. 3408-3419
    • Benson, A.B.1    Schrag, D.2    Somerfield, M.R.3    Cohen, A.M.4    Figueredo, A.T.5    Flynn, P.J.6
  • 50
    • 0019277437 scopus 로고
    • Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells
    • Wohlhueter R.M., McIvor R.S., Plagemann P.G. Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells. J Cell Physiol 1980, 104:309-319.
    • (1980) J Cell Physiol , vol.104 , pp. 309-319
    • Wohlhueter, R.M.1    McIvor, R.S.2    Plagemann, P.G.3
  • 51
    • 0025362969 scopus 로고
    • Role for cytosolic folate-binding proteins in the compartmentation of endogenous tetrahydrofolates and the 5-formyl tetrahydrofolate-mediated enhancement of 5-fluoro-2'-deoxyuridine antitumor activity in vitro
    • Matherly L.H., Czajkowski C.A., Muench S.P., Psiakis J.T. Role for cytosolic folate-binding proteins in the compartmentation of endogenous tetrahydrofolates and the 5-formyl tetrahydrofolate-mediated enhancement of 5-fluoro-2'-deoxyuridine antitumor activity in vitro. Cancer Res 1990, 50:3262-3269.
    • (1990) Cancer Res , vol.50 , pp. 3262-3269
    • Matherly, L.H.1    Czajkowski, C.A.2    Muench, S.P.3    Psiakis, J.T.4
  • 52
    • 0024227210 scopus 로고
    • Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines
    • Park J.G., Collins J.M., Gazdar A.F., Allegra C.J., Steinberg S.M., Greene R.F., et al. Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines. J Natl Cancer Inst 1988, 80:1560-1564.
    • (1988) J Natl Cancer Inst , vol.80 , pp. 1560-1564
    • Park, J.G.1    Collins, J.M.2    Gazdar, A.F.3    Allegra, C.J.4    Steinberg, S.M.5    Greene, R.F.6
  • 53
    • 0024267939 scopus 로고
    • In vivo potentiation of 5-fluorouracil by leucovorin in murine colon carcinoma
    • Nadal J.C., Van Groeningen C.J., Pinedo H.M., Peters G.J. In vivo potentiation of 5-fluorouracil by leucovorin in murine colon carcinoma. Biomed Pharmacother 1988, 42:387-393.
    • (1988) Biomed Pharmacother , vol.42 , pp. 387-393
    • Nadal, J.C.1    Van Groeningen, C.J.2    Pinedo, H.M.3    Peters, G.J.4
  • 54
    • 0024413891 scopus 로고
    • Selective expansion of 5,10-methylenetetrahydrofolate pools and modulation of 5-fluorouracil antitumor activity by leucovorin in vivo
    • Wright J.E., Dreyfuss A., el-Magharbel I., Trites D., Jones S.M., Holden S.A., et al. Selective expansion of 5,10-methylenetetrahydrofolate pools and modulation of 5-fluorouracil antitumor activity by leucovorin in vivo. Cancer Res 1989, 49:2592-2596.
    • (1989) Cancer Res , vol.49 , pp. 2592-2596
    • Wright, J.E.1    Dreyfuss, A.2    el-Magharbel, I.3    Trites, D.4    Jones, S.M.5    Holden, S.A.6
  • 55
    • 0032127244 scopus 로고    scopus 로고
    • Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue
    • Miwa M., Ura M., Nishida M., Sawada N., Ishikawa T., Mori K., et al. Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. Eur J Cancer 1998, 34:1274-1281.
    • (1998) Eur J Cancer , vol.34 , pp. 1274-1281
    • Miwa, M.1    Ura, M.2    Nishida, M.3    Sawada, N.4    Ishikawa, T.5    Mori, K.6
  • 56
    • 0037089505 scopus 로고    scopus 로고
    • Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines
    • Cao D., Russell R.L., Zhang D., Leffert J.J., Pizzorno G. Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines. Cancer Res 2002, 62:2313-2317.
    • (2002) Cancer Res , vol.62 , pp. 2313-2317
    • Cao, D.1    Russell, R.L.2    Zhang, D.3    Leffert, J.J.4    Pizzorno, G.5
  • 57
    • 0038387494 scopus 로고    scopus 로고
    • 5-fluorouracil: mechanisms of action and clinical strategies
    • Longley D.B., Harkin D.P., Johnston P.G. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer 2003, 3:330-338.
    • (2003) Nat Rev Cancer , vol.3 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 58
    • 0022340594 scopus 로고
    • Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
    • Hsiang Y.H., Hertzberg R., Hecht S., Liu L.F. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 1985, 260:14873-14878.
    • (1985) J Biol Chem , vol.260 , pp. 14873-14878
    • Hsiang, Y.H.1    Hertzberg, R.2    Hecht, S.3    Liu, L.F.4
  • 59
  • 60
    • 67650759744 scopus 로고    scopus 로고
    • Evolving treatment of advanced colon cancer
    • Segal N.H., Saltz L.B. Evolving treatment of advanced colon cancer. Annu Rev Med 2009, 60:207-219.
    • (2009) Annu Rev Med , vol.60 , pp. 207-219
    • Segal, N.H.1    Saltz, L.B.2
  • 61
    • 0020524876 scopus 로고
    • Characterization of the adducts produced in DNA by cis-diamminedichloroplatinum(II) and cis-dichloro(ethylenediamine)platinum(II)
    • Eastman A. Characterization of the adducts produced in DNA by cis-diamminedichloroplatinum(II) and cis-dichloro(ethylenediamine)platinum(II). Biochemistry 1983, 22:3927-3933.
    • (1983) Biochemistry , vol.22 , pp. 3927-3933
    • Eastman, A.1
  • 62
    • 10644245994 scopus 로고    scopus 로고
    • Recognition and processing of cisplatin- and oxaliplatin-DNA adducts
    • Chaney S.G., Campbell S.L., Bassett E., Wu Y. Recognition and processing of cisplatin- and oxaliplatin-DNA adducts. Crit Rev Oncol Hematol 2005, 53:3-11.
    • (2005) Crit Rev Oncol Hematol , vol.53 , pp. 3-11
    • Chaney, S.G.1    Campbell, S.L.2    Bassett, E.3    Wu, Y.4
  • 64
    • 18244379333 scopus 로고    scopus 로고
    • Cellular processing of platinum anticancer drugs
    • Wang D., Lippard S.J. Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov 2005, 4:307-320.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 307-320
    • Wang, D.1    Lippard, S.J.2
  • 66
    • 0023628351 scopus 로고
    • The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes
    • Eastman A. The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes. Pharmacol Ther 1987, 34:155-166.
    • (1987) Pharmacol Ther , vol.34 , pp. 155-166
    • Eastman, A.1
  • 67
    • 0345256652 scopus 로고    scopus 로고
    • Cisplatin: mode of cytotoxic action and molecular basis of resistance
    • Siddik Z.H. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 2003, 22:7265-7279.
    • (2003) Oncogene , vol.22 , pp. 7265-7279
    • Siddik, Z.H.1
  • 68
    • 0031974420 scopus 로고    scopus 로고
    • Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins
    • Shen D., Pastan I., Gottesman M.M. Cross-resistance to methotrexate and metals in human cisplatin-resistant cell lines results from a pleiotropic defect in accumulation of these compounds associated with reduced plasma membrane binding proteins. Cancer Res 1998, 58:268-275.
    • (1998) Cancer Res , vol.58 , pp. 268-275
    • Shen, D.1    Pastan, I.2    Gottesman, M.M.3
  • 69
    • 0034036384 scopus 로고    scopus 로고
    • Preclinical perspectives on platinum resistance
    • [discussion 37-38]
    • Kelland L.R. Preclinical perspectives on platinum resistance. Drugs 2000, 59(Suppl. 4):1-8. [discussion 37-38].
    • (2000) Drugs , vol.59 , pp. 1-8
    • Kelland, L.R.1
  • 70
    • 0033621774 scopus 로고    scopus 로고
    • Decreased accumulation of [14C]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake
    • Shen D.W., Goldenberg S., Pastan I., Gottesman M.M. Decreased accumulation of [14C]carboplatin in human cisplatin-resistant cells results from reduced energy-dependent uptake. J Cell Physiol 2000, 183:108-116.
    • (2000) J Cell Physiol , vol.183 , pp. 108-116
    • Shen, D.W.1    Goldenberg, S.2    Pastan, I.3    Gottesman, M.M.4
  • 71
    • 0036176510 scopus 로고    scopus 로고
    • Mechanisms of cancer drug resistance
    • Gottesman M.M. Mechanisms of cancer drug resistance. Annu Rev Med 2002, 53:615-627.
    • (2002) Annu Rev Med , vol.53 , pp. 615-627
    • Gottesman, M.M.1
  • 72
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: role of ATP-dependent transporters
    • Gottesman M.M., Fojo T., Bates S.E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2002, 2:48-58.
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 73
    • 0035079539 scopus 로고    scopus 로고
    • Ceramide glycosylation potentiates cellular multidrug resistance
    • Liu Y.Y., Han T.Y., Giuliano A.E., Cabot M.C. Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J 2001, 15:719-730.
    • (2001) FASEB J , vol.15 , pp. 719-730
    • Liu, Y.Y.1    Han, T.Y.2    Giuliano, A.E.3    Cabot, M.C.4
  • 74
    • 0035038919 scopus 로고    scopus 로고
    • The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
    • Synold T.W., Dussault I., Forman B.M. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 2001, 7:584-590.
    • (2001) Nat Med , vol.7 , pp. 584-590
    • Synold, T.W.1    Dussault, I.2    Forman, B.M.3
  • 75
    • 0034917716 scopus 로고    scopus 로고
    • The human ATP-binding cassette (ABC) transporter superfamily
    • Dean M., Rzhetsky A., Allikmets R. The human ATP-binding cassette (ABC) transporter superfamily. Genome Res 2001, 11:1156-1166.
    • (2001) Genome Res , vol.11 , pp. 1156-1166
    • Dean, M.1    Rzhetsky, A.2    Allikmets, R.3
  • 76
    • 14644444547 scopus 로고    scopus 로고
    • ABC transporters in the balance: is there a role in multidrug resistance?
    • Polgar O., Bates S.E. ABC transporters in the balance: is there a role in multidrug resistance?. Biochem Soc Trans 2005, 33:241-245.
    • (2005) Biochem Soc Trans , vol.33 , pp. 241-245
    • Polgar, O.1    Bates, S.E.2
  • 77
    • 34249679271 scopus 로고    scopus 로고
    • ABC transporters and drug resistance in leukemia: was P-gp nothing but the first head of the Hydra?
    • Steinbach D., Legrand O. ABC transporters and drug resistance in leukemia: was P-gp nothing but the first head of the Hydra?. Leukemia 2007, 21:1172-1176.
    • (2007) Leukemia , vol.21 , pp. 1172-1176
    • Steinbach, D.1    Legrand, O.2
  • 78
    • 0025007511 scopus 로고
    • Pharmacology of drugs that alter multidrug resistance in cancer
    • Ford J.M., Hait W.N. Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol Rev 1990, 42:155-199.
    • (1990) Pharmacol Rev , vol.42 , pp. 155-199
    • Ford, J.M.1    Hait, W.N.2
  • 79
    • 2542491777 scopus 로고    scopus 로고
    • The role of ABC transporters in drug resistance, metabolism and toxicity
    • Glavinas H., Krajcsi P., Cserepes J., Sarkadi B. The role of ABC transporters in drug resistance, metabolism and toxicity. Curr Drug Deliv 2004, 1:27-42.
    • (2004) Curr Drug Deliv , vol.1 , pp. 27-42
    • Glavinas, H.1    Krajcsi, P.2    Cserepes, J.3    Sarkadi, B.4
  • 80
    • 84900433657 scopus 로고    scopus 로고
    • Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting
    • Ye P., Zhang W., Yang T., Lu Y., Lu M., Gai Y., et al. Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting. Int J Nanomedicine 2014, 9:2167-2178.
    • (2014) Int J Nanomedicine , vol.9 , pp. 2167-2178
    • Ye, P.1    Zhang, W.2    Yang, T.3    Lu, Y.4    Lu, M.5    Gai, Y.6
  • 81
    • 84902489807 scopus 로고    scopus 로고
    • DrugComboRanker: drug combination discovery based on target network analysis
    • Huang L., Li F., Sheng J., Xia X., Ma J., Zhan M., et al. DrugComboRanker: drug combination discovery based on target network analysis. Bioinformatics 2014, 30:i228-i236.
    • (2014) Bioinformatics , vol.30 , pp. i228-i236
    • Huang, L.1    Li, F.2    Sheng, J.3    Xia, X.4    Ma, J.5    Zhan, M.6
  • 82
    • 80053500284 scopus 로고    scopus 로고
    • Stem cell based cancer gene therapy
    • Cihova M., Altanerova V., Altaner C. Stem cell based cancer gene therapy. Mol Pharm 2011, 8:1480-1487.
    • (2011) Mol Pharm , vol.8 , pp. 1480-1487
    • Cihova, M.1    Altanerova, V.2    Altaner, C.3
  • 83
    • 34848866647 scopus 로고    scopus 로고
    • Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
    • Todaro M., Alea M.P., Di Stefano A.B., Cammareri P., Vermeulen L., Iovino F., et al. Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell 2007, 1:389-402.
    • (2007) Cell Stem Cell , vol.1 , pp. 389-402
    • Todaro, M.1    Alea, M.P.2    Di Stefano, A.B.3    Cammareri, P.4    Vermeulen, L.5    Iovino, F.6
  • 84
    • 84896778994 scopus 로고    scopus 로고
    • In vivo 5FU-exposed human medullary thyroid carcinoma cells contain a chemoresistant CD133+ tumor-initiating cell subset
    • Kucerova L., Feketeova L., Kozovska Z., Poturnajova M., Matuskova M., Nencka R., et al. In vivo 5FU-exposed human medullary thyroid carcinoma cells contain a chemoresistant CD133+ tumor-initiating cell subset. Thyroid 2014, 24:520-532.
    • (2014) Thyroid , vol.24 , pp. 520-532
    • Kucerova, L.1    Feketeova, L.2    Kozovska, Z.3    Poturnajova, M.4    Matuskova, M.5    Nencka, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.