HSV-tk expressing mesenchymal stem cells exert bystander effect on human glioblastoma cells

Cancer Letters

Volumn 290, Issue 1, 2010, Pages 58-67

  Matuskova, Miroslava ^a   Hlubinova, Kristina ^a   Pastorakova, Andrea ^a   Hunakova, Luba ^a   Altanerova, Veronika ^a   Altaner, Cestmir ^a   Kucerova, Lucia ^a  

^a CANCER RESEARCH INSTITUTE   (Slovakia)

Author keywords

Cellular delivery; Gap junctions; Herpes simplex virus thymidine kinase; Human glioblastoma; Mesenchymal stem cells

Indexed keywords

GANCICLOVIR; THYMIDINE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BYSTANDER EFFECT; CANCER CELL; CANCER GENE THERAPY; CELL ACTIVITY; CELL COMMUNICATION; CELL VIABILITY; COCULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; GAP JUNCTION; GENE DELIVERY SYSTEM; GLIOBLASTOMA; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL;

ANIMALS; ANTIVIRAL AGENTS; BYSTANDER EFFECT; CELL LINE, TUMOR; CELL SEPARATION; CELL SURVIVAL; COCULTURE TECHNIQUES; FLOW CYTOMETRY; GANCICLOVIR; GAP JUNCTIONS; GENE THERAPY; GENETIC VECTORS; GLIOBLASTOMA; HUMANS; MESENCHYMAL STEM CELLS; MICE; MICE, NUDE; SIMPLEXVIRUS; THYMIDINE KINASE; TRANSDUCTION, GENETIC; XENOGRAFT MODEL ANTITUMOR ASSAYS;

SIMPLEXVIRUS;

EID: 77249122967     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.08.028     Document Type: Article

References (33)

1. Fillat C., Carrió M., Cascante A., and Sangro B. Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application. Curr. Gene Ther. 3 (2003) 13-26
2. van Dillen I.J., Mulder N.H., Vaalburg W., de Vries E.F., and Hospers G.A. Influence of the bystander effect on HSV-tk/GCV gene therapy. Curr. Gene Ther. 3 (2002) 307-322
3. Fick J., Barker II F.G., Dazin P., Westphale E.M., Beyer E.C., and Israel M.A. The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro. Proc. Natl. Acad. Sci. USA 92 (1995) 11071-11075
4. Nicholas T.W., Read S.B., Burrows F.J., and Kruse C.A. Suicide gene therapy with Herpes simplex virus thymidine kinase and ganciclovir is enhanced with connexins to improve gap junctions and bystander effects. Histol. Histopathol. 18 (2003) 495-507
5. Freeman S.M., Abboud C.N., Whartenby K.A., Packman C.H., Koeplin D.S., Moolten F.L., and Abraham G.N. The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res. 53 (1993) 5274-5283
6. Portsmouth D., Hlavaty J., and Renner M. Suicide genes for cancer therapy. Mol. Aspects Med. 28 (2007) 4-41
7. Immonen A., Vapalahti M., Tyynelä K., Hurskainen H., Sandmair A., Vanninen R., Langford G., Murray N., and Ylä-Herttuala S. AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study. Mol. Ther. 10 (2004) 967-972
8. Aboody K.S., Najbauer J., and Danks M.K. Stem and progenitor cell-mediated tumor selective gene therapy. Gene Ther. 15 (2008) 739-752
9. Altaner C. Prodrug cancer gene therapy. Cancer Lett. 270 (2008) 191-201
10. Danks M.K., Yoon K.J., Bush R.A., Remack J.S., Wierdl M., Tsurkan L., et al. Cancer Res. 67 (2007) 22-25
11. Wei J., Blum S., Unger M., Jarmy G., Lamparter M., and Geishauser A. Embryonic endothelial progenitor cells armed with a suicide gene target hypoxic lung metastases after intravenous delivery. Cancer Cell 5 (2004) 477-488
12. Aboody K.S., Najbauer J., Schmidt N.O., Yang W., Wu J.K., Zhuge Y., Przylecki W., Carroll R., Black P.M., and Perides G. Targeting of melanoma brain metastases using engineered neural stem/progenitor cells. Neuro Oncol. 8 (2006) 119-126
13. Kim S.K., Kim S.U., Park I.H., Bang J.H., Aboody K.S., Wang K.C., Cho B.K., Kim M., Menon L.G., Black P.M., and Carroll R.S. Human neural stem cells target experimental intracranial medulloblastoma and deliver a therapeutic gene leading to tumor regression. Clin. Cancer Res. 12 (2006) 5550-5556
14. Kucerova L., Altanerova V., Matuskova M., Tyciakova S., and Altaner C. Adipose tissue-derived human mesenchymal stem cells mediated prodrug cancer gene therapy. Cancer Res. 67 (2007) 6304-6313
15. Kucerova L., Matuskova M., Pastorakova A., Tyciakova S., Jakubikova J., Bohovic R., Altanerova V., and Altaner C. Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice. J. Gene Med. 10 (2008) 1071-1082
16. Miletic H., Fischer Y., Litwak S., Giroglou T., Waerzeggers Y., Winkeler A., Li H., Himmelreich U., Lange C., Stenzel W., Deckert M., Neumann H., Jacobs A.H., and von Laer D. Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide gene. Mol. Ther. 15 (2007) 1373-1381
17. Li S., Gao Y., Tokuyama T., Yamamoto J., Yokota N., Yamamoto S., Terakawa S., Kitagawa M., and Namba H. Genetically engineered neural stem cells migrate and suppress glioma cell growth at distant intracranial sites. Cancer Lett. 251 (2007) 220-227
18. Hlavaty J., Hlubinova K., Altanerova V., Liska J., and Altaner C. Treatment of rat gliomas with recombinant retrovirus harboring Herpes simplex virus thymidine kinase suicide gene. Neoplasma 44 (1997) 342-347
19. Azzam E.I., de Toledo S.M., and Little J.B. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc. Natl. Acad. Sci. USA 98 (2001) 473-478
20. Trosko J.E. Gap junctional intercellular communication as a biological "Rosetta stone" in understanding, in a systems biological manner, stem cell behavior, mechanisms of epigenetic toxicology, chemoprevention and chemotherapy. J. Membr. Biol. 218 (2007) 93-100
21. King T.J., and Bertram J.S. Connexins as targets for cancer chemoprevention and chemotherapy. Biochim. Biophys. Acta 1791 (2005) 146-160
22. Vine A.L., and Bertram J.S. Cancer chemoprevention by connexins. Cancer Metast. Rev. 21 (2002) 199-216
23. Morizono K., de Ugarte D.A., Zhu M., Zuk P., Elbarbary A., Ashjian P., Benhaim P., Chen I.S.Y., and Hedrick M.H. Multilineage cells from adipose tissue as gene delivery vehicles. Hum. Gene Ther. 14 (2003) 59-66
24. Pereboeva L., Komarova S., Mikheeva G., Krasnykh V., and Curiel D.T. Approaches to utilize mesenchymal progenitor cells as cellular vehicles. Stem Cells 21 (2003) 389-404
25. Hung S.C., Deng W.P., Yang W.K., Liu R.S., Lee C.C., Su T.C., Lin R.J., Yang D.M., Chang C.W., Chen W.H., Wei H.J., and Gelovani J.G. Mesenchymal stem cell targeting of microscopic tumors and tumor stroma development monitored by noninvasive in vivo positron emission tomography imaging. Clin. Cancer Res. 11 (2005) 7749-7756
26. Fareed M.U., and Moolten F.L. Suicide gene transduction sensitizes murine embryonic and human mesenchymal stem cells to ablation on demand - a fail-safe protection against cellular misbehaviour. Gene Ther. 9 (2002) 955-962
27. Pastorakova A., Hlubinova K., Jakubikova J., and Altaner C. Combine cancer gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and Herpes simplex thymidine kinase suicide gene. Neoplasma 53 (2006) 353-362
28. Hlubinova K., Hlavaty J., and Altaner C. Human glioma cells expressing herpes simplex virus thymidine kinase gene treated with acyclovir, ganciclovir and bromovinyldeoxyuridine. Evaluation of their activity in vitro and in nude mice. Neoplasma 48 (2001) 398-406
29. Hahn J.Y., Cho H.J., Kang H.J., Kim T.S., Kim M.H., Chung J.H., Bae J.W., Oh B.H., Park Y.B., and Kim H.S. Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction. J. Am. Coll. Cardiol. 51 (2008) 933-943
30. Wong R.C., Pera M.F., and Pébay A. Role of gap junctions in embryonic and somatic stem cells. Stem Cell Rev. 4 (2008) 283-292
31. Altaner C. Glioblastoma and stem cells. Neoplasma 55 (2008) 369-374
32. Uchibori R., Okada T., Ito T., Urabe M., Mizukami H., Kume A., and Ozawa K. Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy. J. Gene Med. 11 (2009) 373-381
33. J. Luetzkendorf, L.P. Mueller, T. Mueller, H. Caysa, K. Nerger, H.J. Schmoll, Growth-inhibition of colorectal carcinoma by lentiviral TRAIL-transgenic human mesenchymal stem cells requires their substantial intratumoral presence. J. Cell. Mol. Med. (2009) (Epub ahead of print).