-
1
-
-
78049485263
-
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
-
Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893-2917, 2010.
-
(2010)
Int J Cancer
, vol.127
, pp. 2893-2917
-
-
Ferlay, J.1
Shin, H.R.2
Bray, F.3
Forman, D.4
Mathers, C.5
Parkin, D.M.6
-
2
-
-
36849061154
-
Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation
-
Lee WYW, Chiu LCM and Yeung JHK: Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation. Food Chem Toxicol 46: 328-338, 2008.
-
(2008)
Food Chem Toxicol
, vol.46
, pp. 328-338
-
-
Lee, W.Y.W.1
Chiu, L.C.M.2
Yeung, J.H.K.3
-
3
-
-
67449083388
-
Tanshinone IIA inhibits leukemia THP-1cell growth by induction of apoptosis
-
Liu JJ, Zhang Y, Lin DJ and Xiao RZ: Tanshinone IIA inhibits leukemia THP-1cell growth by induction of apoptosis. Oncol Rep 21: 1075-1081, 2009.
-
(2009)
Oncol Rep
, vol.21
, pp. 1075-1081
-
-
Liu, J.J.1
Zhang, Y.2
Lin, D.J.3
Xiao, R.Z.4
-
4
-
-
53049099464
-
Tanshinone IIA inhibits human breast cancer cells through increased Bax to Bcl-xL ratios
-
Su CC and Lin YH: Tanshinone IIA inhibits human breast cancer cells through increased Bax to Bcl-xL ratios. Int J Mol Med 22: 357-361, 2008.
-
(2008)
Int J Mol Med
, vol.22
, pp. 357-361
-
-
Su, C.C.1
Lin, Y.H.2
-
5
-
-
56249087235
-
Anticancer effects of tanshinone i in human non-small cell lung cancer
-
Lee CY, Sher HF, Chen HW, et al: Anticancer effects of tanshinone I in human non-small cell lung cancer. Mol Cancer Ther 7: 3527-3538, 2008.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3527-3538
-
-
Lee, C.Y.1
Sher, H.F.2
Chen, H.W.3
-
6
-
-
54849187400
-
Tanshinone i effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells
-
Nizamutdinova IT, Lee GW, Son KH, et al: Tanshinone I effectively induces apoptosis in estrogen receptor-positive (MCF-7) and estrogen receptor-negative (MDA-MB-231) breast cancer cells. Int J Oncol 33: 485-491, 2008.
-
(2008)
Int J Oncol
, vol.33
, pp. 485-491
-
-
Nizamutdinova, I.T.1
Lee, G.W.2
Son, K.H.3
-
7
-
-
27844511101
-
Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use
-
Zhou LM, Zuo Z and Chow MSS: Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol 45: 1345-1359, 2005.
-
(2005)
J Clin Pharmacol
, vol.45
, pp. 1345-1359
-
-
Zhou, L.M.1
Zuo, Z.2
Chow, M.S.S.3
-
8
-
-
84879463275
-
Bioactive tanshinone i inhibits the growth of lung cancer in part via downregulation of Aurora A function
-
Li YL, Gong Y, Li LL, Abdolmaleky HM and Zhou JR: Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function. Mol Carcinog 52: 535-543, 2012.
-
(2012)
Mol Carcinog
, vol.52
, pp. 535-543
-
-
Li, Y.L.1
Gong, Y.2
Li, L.L.3
Abdolmaleky, H.M.4
Zhou, J.R.5
-
9
-
-
0029085781
-
A checkpoint regulates the rate of progression through S phase in Saccharomyces cerevisiae in response to DNA damage
-
Paulovich AG and Hartwell LH: A checkpoint regulates the rate of progression through S phase in Saccharomyces cerevisiae in response to DNA damage. Cell 82: 841-847, 1995.
-
(1995)
Cell
, vol.82
, pp. 841-847
-
-
Paulovich, A.G.1
Hartwell, L.H.2
-
10
-
-
27644552168
-
Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression
-
Walker JL and Assoian RK: Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression. Cancer Metastasis Rev 24: 383-393, 2005.
-
(2005)
Cancer Metastasis Rev
, vol.24
, pp. 383-393
-
-
Walker, J.L.1
Assoian, R.K.2
-
11
-
-
0030561427
-
Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control
-
Lew DJ and Kornbluth S: Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control. Curr Opin Cell Biol 8: 795-804, 1996.
-
(1996)
Curr Opin Cell Biol
, vol.8
, pp. 795-804
-
-
Lew, D.J.1
Kornbluth, S.2
-
12
-
-
67651112149
-
The PI3K/Akt pathway as a target in the treatment of hematologic malignancies
-
Kawauchi K, Ogasawara T, Yasuyama M, Otsuka K and Yamada O: The PI3K/Akt pathway as a target in the treatment of hematologic malignancies. Anticancer Agents Med Chem 9: 550-559, 2009.
-
(2009)
Anticancer Agents Med Chem
, vol.9
, pp. 550-559
-
-
Kawauchi, K.1
Ogasawara, T.2
Yasuyama, M.3
Otsuka, K.4
Yamada, O.5
-
13
-
-
0032579532
-
Signal transduction-lipid-regulated kinases: Some common themes at last
-
Downward J: Signal transduction-lipid-regulated kinases: Some common themes at last. Science 279: 673-674, 1998.
-
(1998)
Science
, vol.279
, pp. 673-674
-
-
Downward, J.1
-
14
-
-
77952007543
-
Mammalian target of rapamycin (mTOR): Conducting the cellular signaling symphony
-
Foster KG and Fingar DC: Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony. J Biol Chem 285: 14071-14077, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 14071-14077
-
-
Foster, K.G.1
Fingar, D.C.2
-
16
-
-
84875748505
-
Targeting the PI3K/Akt/mTOR pathway for breast cancer therapy
-
Justin C and Ben Ho P: Targeting the PI3K/Akt/mTOR pathway for breast cancer therapy. J Mammary Gland Biol Neoplasia 17: 205-216, 2012.
-
(2012)
J Mammary Gland Biol Neoplasia
, vol.17
, pp. 205-216
-
-
Justin, C.1
Ben Ho, P.2
-
17
-
-
68949198785
-
MTOR signaling pathway is a target for the treatment of colorectal cancer
-
Zhang YJ, Dai Q, Sun DF, et al: mTOR signaling pathway is a target for the treatment of colorectal cancer. Ann Surg Oncol 6: 2617-2628, 2009.
-
(2009)
Ann Surg Oncol
, vol.6
, pp. 2617-2628
-
-
Zhang, Y.J.1
Dai, Q.2
Sun, D.F.3
-
18
-
-
39649122377
-
Class IA phosphatidylinositol 3-kinase: From their biologic implication in human cancers to drug discovery
-
Maira SM, Voliva C and Garcia-Echeverria C: Class IA phosphatidylinositol 3-kinase: from their biologic implication in human cancers to drug discovery. Expert Opin Ther Targets 12: 223-238, 2008.
-
(2008)
Expert Opin Ther Targets
, vol.12
, pp. 223-238
-
-
Maira, S.M.1
Voliva, C.2
Garcia-Echeverria, C.3
-
19
-
-
84869829578
-
MicroRNA-34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting notch1
-
Li XJ, Ji MH, Zhong SL, et al: MicroRNA-34a modulates chemosensitivity of breast cancer cells to adriamycin by targeting notch1. Arch Med Res 43: 514-521, 2012.
-
(2012)
Arch Med Res
, vol.43
, pp. 514-521
-
-
Li, X.J.1
Ji, M.H.2
Zhong, S.L.3
-
20
-
-
84886744759
-
Obesity associated alterations in the biology of adipose stem cells mediate enhanced tumorigenesis by estrogen dependent pathways
-
Strong AL, Strong TA, Rhodes LV, et al: Obesity associated alterations in the biology of adipose stem cells mediate enhanced tumorigenesis by estrogen dependent pathways. Breast Cancer Res 15:R102, 2013.
-
(2013)
Breast Cancer Res
, vol.15
, pp. R102
-
-
Strong, A.L.1
Strong, T.A.2
Rhodes, L.V.3
-
21
-
-
34250859393
-
Breast cancer in Iran: An epidemiological review
-
Mousavi M, Montazeri A, Mohagheghi MA,et al:Breast Cancer in Iran: An Epidemiological Review. Breast J 13:383-391, 2007.
-
(2007)
Breast J
, vol.13
, pp. 383-391
-
-
Mousavi, M.1
Montazeri, A.2
Mohagheghi, M.A.3
-
22
-
-
0344197546
-
Vitro cytotoxicity of tanshinones isolated from Salvia miltiorrhiza Bunge against P388 lymphocytic leukemia cells
-
Mosaddik MA: In vitro cytotoxicity of tanshinones isolated from Salvia miltiorrhiza Bunge against P388 lymphocytic leukemia cells. Phytomedicine 10: 682-685, 2003.
-
(2003)
Phytomedicine
, vol.10
, pp. 682-685
-
-
Mosaddik, M.A.1
-
23
-
-
53349127298
-
Tanshinone i suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules
-
Nizamutdinova IT, Lee GW, Lee JS, et al: Tanshinone I suppresses growth and invasion of human breast cancer cells, MDA-MB-231, through regulation of adhesion molecules. Carcinogenesis 29 :1885-1892, 2008.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1885-1892
-
-
Nizamutdinova, I.T.1
Lee, G.W.2
Lee, J.S.3
-
24
-
-
17044420921
-
NK cells inhibit T cell proliferation via p21-mediated cell cycle arrest
-
Trivedi PP, Roberts PC, Wolf NA and Swanborg RH: NK cells inhibit T cell proliferation via p21-mediated cell cycle arrest. J Immunol 174: 4590-4597, 2005.
-
(2005)
J Immunol
, vol.174
, pp. 4590-4597
-
-
Trivedi, P.P.1
Roberts, P.C.2
Wolf, N.A.3
Swanborg, R.H.4
-
25
-
-
84859248400
-
Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of aurora A expression and function
-
Gong Y, Li Y, Abdolmaleky HM, Li L and Zhou JR: Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of aurora A expression and function. PLoS One 7: e33656, 2012.
-
(2012)
PLoS One
, vol.7
, pp. e33656
-
-
Gong, Y.1
Li, Y.2
Abdolmaleky, H.M.3
Li, L.4
Zhou, J.R.5
-
26
-
-
79959767855
-
Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice
-
Gong Y, Li Y, Lu Y, et al: Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice. Int J Cancer 129: 1042-1052, 2011.
-
(2011)
Int J Cancer
, vol.129
, pp. 1042-1052
-
-
Gong, Y.1
Li, Y.2
Lu, Y.3
-
27
-
-
47149101600
-
Antrodia camphorata inhibits proliferation of human breast cancer cells in vitro and in vivo
-
Hseu YC, Chen S C, Chen HC, Liao JW and Yang HL: Antrodia camphorata inhibits proliferation of human breast cancer cells in vitro and in vivo. Food Chem Toxicol 46: 2680-2688, 2008.
-
(2008)
Food Chem Toxicol
, vol.46
, pp. 2680-2688
-
-
Hseu, Y.C.1
Chen, S.C.2
Chen, H.C.3
Liao, J.W.4
Yang, H.L.5
-
28
-
-
1942434712
-
Cip/Kip proteins: More than just CDKs inhibitors
-
Denicourt C and Dowdy SF: Cip/Kip proteins: more than just CDKs inhibitors. Genes Dev 18: 851-855, 2004.
-
(2004)
Genes Dev
, vol.18
, pp. 851-855
-
-
Denicourt, C.1
Dowdy, S.F.2
-
29
-
-
0036594890
-
The role of the cyclin-dependent kinase inhibitor p21 in apoptosis
-
Gartel AL and Tyner AL: The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 1: 639-649, 2002.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 639-649
-
-
Gartel, A.L.1
Tyner, A.L.2
-
30
-
-
18044382891
-
Anti-proliferative A549 human activity of Bupleurum scrozonerifolium in lung cancer cells in vitro and in vivo
-
Cheng YL, Lee SC, Lin SZ, et al: Anti-proliferative A549 human activity of Bupleurum scrozonerifolium in lung cancer cells in vitro and in vivo. Cancer Lett 222: 183-193, 2005.
-
(2005)
Cancer Lett
, vol.222
, pp. 183-193
-
-
Cheng, Y.L.1
Lee, S.C.2
Lin, S.Z.3
-
32
-
-
34250788809
-
AKT/PKB signaling: Navigating downstream
-
Manning BD and Cantley LC: AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274, 2007.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
34
-
-
79952006399
-
PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation
-
Deng R, Tang J, Ma JG, et al: PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation. Oncogene 30: 944-955, 2011.
-
(2011)
Oncogene
, vol.30
, pp. 944-955
-
-
Deng, R.1
Tang, J.2
Ma, J.G.3
-
35
-
-
35548972342
-
Increased phosphorylation of Akt in triple-negative breast cancers
-
Umemura S, Yoshida S, Ohta Y, Naito K, Osamura RY and Tokuda Y: Increased phosphorylation of Akt in triple-negative breast cancers. Cancer Sci 98: 1889-1892, 2007.
-
(2007)
Cancer Sci
, vol.98
, pp. 1889-1892
-
-
Umemura, S.1
Yoshida, S.2
Ohta, Y.3
Naito, K.4
Osamura, R.Y.5
Tokuda, Y.6
-
36
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco I and Sawyers CL: The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501, 2002.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
37
-
-
0036729867
-
Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy
-
Krystal GW, Sulanke G and Litz J: Inhibition of phosphatidylinositol 3-kinase-Akt signaling blocks growth, promotes apoptosis, and enhances sensitivity of small cell lung cancer cells to chemotherapy. Mol Cancer Ther 1: 913-922, 2002.
-
(2002)
Mol Cancer Ther
, vol.1
, pp. 913-922
-
-
Krystal, G.W.1
Sulanke, G.2
Litz, J.3
-
38
-
-
77956975737
-
Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro
-
Liu JJ, Liu WD, Yang HZ, et al: Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro. Ann Hematol 89: 1089-1097, 2010.
-
(2010)
Ann Hematol
, vol.89
, pp. 1089-1097
-
-
Liu, J.J.1
Liu, W.D.2
Yang, H.Z.3
-
39
-
-
84894577484
-
PI3K/AKT/mTOR signaling pathway inhibitors in proliferation of retinal pigment epithelial cells
-
Cai N, Dai SD, Liu NN, Liu LM, Zhao N and Chen L: PI3K/AKT/mTOR signaling pathway inhibitors in proliferation of retinal pigment epithelial cells. Int J Ophthalmol 5: 675-680, 2012.
-
(2012)
Int J Ophthalmol
, vol.5
, pp. 675-680
-
-
Cai, N.1
Dai, S.D.2
Liu, N.N.3
Liu, L.M.4
Zhao, N.5
Chen, L.6
-
40
-
-
29844452617
-
Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by antrodiacamphorata
-
Yang HL, Chen CS, Chang WH, et al: Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by antrodiacamphorata. Cancer Lett 231: 215-227, 2006.
-
(2006)
Cancer Lett
, vol.231
, pp. 215-227
-
-
Yang, H.L.1
Chen, C.S.2
Chang, W.H.3
-
41
-
-
0037181167
-
Caspase 3 regulates phosphatidylserine externalization and phagocytosis of oxidatively stressed erythrocytes
-
Mandal D, Moitra PK, Saha S and Basu J: Caspase 3 regulates phosphatidylserine externalization and phagocytosis of oxidatively stressed erythrocytes. FEBS Lett 513: 184-188, 2002.
-
(2002)
FEBS Lett
, vol.513
, pp. 184-188
-
-
Mandal, D.1
Moitra, P.K.2
Saha, S.3
Basu, J.4
-
42
-
-
33749359393
-
Mammalian target of rapamycin regulates the growth of mammary epithelial cells through the inhibitor of deoxyribonucleic acid binding Id1 and their functional differentiation through Id2
-
Jankiewicz M, Groner B and Desrivieres S: Mammalian target of rapamycin regulates the growth of mammary epithelial cells through the inhibitor of deoxyribonucleic acid binding Id1 and their functional differentiation through Id2. Mol Endocrinol 20: 2369-2381, 2006.
-
(2006)
Mol Endocrinol
, vol.20
, pp. 2369-2381
-
-
Jankiewicz, M.1
Groner, B.2
Desrivieres, S.3
-
43
-
-
4544315354
-
New targets for therapy in breast cancer: Mammalian target of rapamycin (mTOR) antagonists
-
Carraway H and Hidalgo M: New targets for therapy in breast cancer: mammalian target of rapamycin (mTOR) antagonists. Breast Cancer Res 6: 219-224, 2004.
-
(2004)
Breast Cancer Res
, vol.6
, pp. 219-224
-
-
Carraway, H.1
Hidalgo, M.2
-
44
-
-
78349277366
-
Target of rapamycin signaling in leukemia and lymphoma
-
Vu C and Fruman DA: Target of rapamycin signaling in leukemia and lymphoma. Clin Cancer Res 16: 5374-5380, 2010.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5374-5380
-
-
Vu, C.1
Fruman, D.A.2
-
46
-
-
42949133285
-
Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo
-
Johnsen JI, Segerstrom L, Orrego A, et al: Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo. Oncogene 27: 2910-2922, 2008.
-
(2008)
Oncogene
, vol.27
, pp. 2910-2922
-
-
Johnsen, J.I.1
Segerstrom, L.2
Orrego, A.3
-
47
-
-
33748068792
-
Inhibition of phosphatidylinositol 3-kinase destabilizes MYCN protein and blocks malignant progression in neuroblastoma
-
Chesler L, Schlieve C, Goldenberg DD, et al: Inhibition of phosphatidylinositol 3-kinase destabilizes MYCN protein and blocks malignant progression in neuroblastoma. Cancer Res 66: 8139-8146, 2006.
-
(2006)
Cancer Res
, vol.66
, pp. 8139-8146
-
-
Chesler, L.1
Schlieve, C.2
Goldenberg, D.D.3
|