Tanshinones inhibit the growth of breast cancer cells through epigenetic modification of aurora a expression and function

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Gong, Yi ^a   Li, Yanli ^a,b   Abdolmaleky, Hamid M ^a   Li, Linglin ^a   Zhou, Jin Rong ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; BUTYRIC ACID; CRYPTOTANSHINONE; CYCLIN B; CYCLIN D; CYCLIN DEPENDENT KINASE 4; HISTONE H3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SMALL INTERFERING RNA; SURVIVIN; TANSHINONE I; TANSHINONE IIA; ABIETANE DERIVATIVE; ANTINEOPLASTIC AGENT; AURORA KINASE; BIRC5 PROTEIN, HUMAN; HISTONE; INHIBITOR OF APOPTOSIS PROTEIN; PARP1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; TANSHINONE;

ANTIANGIOGENIC ACTIVITY; APOPTOSIS; ARTICLE; AURORA A GENE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CONTROLLED STUDY; DNA METHYLATION; DNA MODIFICATION; DOSE RESPONSE; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; HISTONE ACETYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; ONCOGENE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SALVIA MILTIORRHIZA; TREATMENT RESPONSE; ACETYLATION; BREAST TUMOR; CELL CYCLE; CELL PROLIFERATION; DRUG EFFECT; GENE EXPRESSION; GENETIC EPIGENESIS; GENETICS; IC 50; METABOLISM; TUMOR CELL LINE;

SALVIA MILTIORRHIZA;

ACETYLATION; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DITERPENES, ABIETANE; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION; HISTONES; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INHIBITORY CONCENTRATION 50; POLY(ADP-RIBOSE) POLYMERASES; PROMOTER REGIONS, GENETIC; PROTEIN-SERINE-THREONINE KINASES;

EID: 84859248400     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033656     Document Type: Article

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