메뉴 건너뛰기




Volumn 9, Issue 12, 2014, Pages

Akt activation is required for TGF-β1-induced Osteoblast differentiation of MC3T3-E1 Pre-osteoblasts

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; MESSENGER RNA; OSTEOCALCIN; PROTEIN KINASE B; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA1; AKT1 PROTEIN, MOUSE; ATRNL1 PROTEIN, MOUSE; GENETIC MARKER; MEMBRANE PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

EID: 84916204802     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112566     Document Type: Article
Times cited : (53)

References (45)
  • 2
    • 84876323400 scopus 로고    scopus 로고
    • Regenerative periodontal therapy: 30 years of lessons learned and unlearned
    • Susin C, Wikesjö UME (2013) Regenerative periodontal therapy: 30 years of lessons learned and unlearned. Periodontol 2000 62: 232-242.
    • (2013) Periodontol , vol.2000 , Issue.62 , pp. 232-242
    • Susin, C.1    Wikesjö, U.M.E.2
  • 3
    • 84865536949 scopus 로고    scopus 로고
    • Growth and differentiation factors for periodontal regeneration: A review on factors with clinical testing
    • Stavropoulos A, Wikesjö UME (2012) Growth and differentiation factors for periodontal regeneration: a review on factors with clinical testing. J Periodontal Res 47: 545-553.
    • (2012) J Periodontal Res , vol.47 , pp. 545-553
    • Stavropoulos, A.1    Wikesjö, U.M.E.2
  • 4
    • 80052989439 scopus 로고    scopus 로고
    • Cell-and gene-based therapeutic strategies for periodontal regenerative medicine
    • Rios HF, Lin Z, Oh B, Park CH, Giannobile WV (2011) Cell-and gene-based therapeutic strategies for periodontal regenerative medicine. J Periodontol 82: 1223-1237.
    • (2011) J Periodontol , vol.82 , pp. 1223-1237
    • Rios, H.F.1    Lin, Z.2    Oh, B.3    Park, C.H.4    Giannobile, W.V.5
  • 5
    • 68849126246 scopus 로고    scopus 로고
    • Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity
    • Sanjabi S, Zenewicz LA, Kamanaka M, Flavell RA (2009) Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity. Curr Opin Pharmacol 9: 447-453.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 447-453
    • Sanjabi, S.1    Zenewicz, L.A.2    Kamanaka, M.3    Flavell, R.A.4
  • 6
    • 84884681701 scopus 로고    scopus 로고
    • TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts
    • Ota K, Quint P, Ruan M, Pederson L, Westendorf JJ, et al. (2013) TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts. Endocrinology 154: 3745-3752.
    • (2013) Endocrinology , vol.154 , pp. 3745-3752
    • Ota, K.1    Quint, P.2    Ruan, M.3    Pederson, L.4    Westendorf, J.J.5
  • 8
    • 0023664056 scopus 로고
    • Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone
    • Centrella M, McCarthy TL, Canalis E (1987) Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone. J Biol Chem 262: 2869-2874.
    • (1987) J Biol Chem , vol.262 , pp. 2869-2874
    • Centrella, M.1    McCarthy, T.L.2    Canalis, E.3
  • 10
    • 0029033910 scopus 로고
    • Independent changes in type i and type II receptors for transforming growth factor beta induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype
    • Centrella M, Casinghino S, Kim J, Pham T, Rosen V, et al. (1995) Independent changes in type I and type II receptors for transforming growth factor beta induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype. Mol Cell Biol 15: 3273-3281.
    • (1995) Mol Cell Biol , vol.15 , pp. 3273-3281
    • Centrella, M.1    Casinghino, S.2    Kim, J.3    Pham, T.4    Rosen, V.5
  • 11
    • 77049089562 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces osteogenic differentiation of murine bone marrow stromal cells
    • Zhao L, Jiang S, Hantash BM (2010) Transforming growth factor beta1 induces osteogenic differentiation of murine bone marrow stromal cells. Tissue Eng Part A 16: 725-733.
    • (2010) Tissue Eng Part A , vol.16 , pp. 725-733
    • Zhao, L.1    Jiang, S.2    Hantash, B.M.3
  • 12
    • 0037126380 scopus 로고    scopus 로고
    • Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein
    • Lee K-S, Hong S-H, Bae S-C (2002) Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein. Oncogene 21: 7156-7163.
    • (2002) Oncogene , vol.21 , pp. 7156-7163
    • Lee, K.-S.1    Hong, S.-H.2    Bae, S.-C.3
  • 13
    • 0242669922 scopus 로고    scopus 로고
    • Effects of transforming growth factor-beta 1 (TGF-beta1) on in vitro mineralization of human osteoblasts on implant materials
    • Zhang H, Ahmad M, Gronowicz G (2003) Effects of transforming growth factor-beta 1 (TGF-beta1) on in vitro mineralization of human osteoblasts on implant materials. Biomaterials 24: 2013-2020.
    • (2003) Biomaterials , vol.24 , pp. 2013-2020
    • Zhang, H.1    Ahmad, M.2    Gronowicz, G.3
  • 14
    • 33645292061 scopus 로고    scopus 로고
    • Enhanced bone formation by transforming growth factor-beta1-releasing collagen/chitosan microgranules
    • Lee J-Y, Kim K-H, Shin S-Y, Rhyu I-C, Lee Y-M, et al. (2006) Enhanced bone formation by transforming growth factor-beta1-releasing collagen/chitosan microgranules. J Biomed Mater Res A 76: 530-539.
    • (2006) J Biomed Mater Res A , vol.76 , pp. 530-539
    • Lee, J.-Y.1    Kim, K.-H.2    Shin, S.-Y.3    Rhyu, I.-C.4    Lee, Y.-M.5
  • 15
    • 70349667771 scopus 로고    scopus 로고
    • Transforming growth factor-beta isoforms and the induction of bone formation: Implications for reconstructive craniofacial surgery
    • Ripamonti U, Ferretti C, Teare J, Blann L (2009) Transforming growth factor-beta isoforms and the induction of bone formation: implications for reconstructive craniofacial surgery. J Craniofac Surg 20: 1544-1555.
    • (2009) J Craniofac Surg , vol.20 , pp. 1544-1555
    • Ripamonti, U.1    Ferretti, C.2    Teare, J.3    Blann, L.4
  • 16
    • 0024535248 scopus 로고
    • Transcriptional regulation of osteocalcin production by transforming growth factor-beta in rat osteoblast-like cells
    • Noda M (1989) Transcriptional regulation of osteocalcin production by transforming growth factor-beta in rat osteoblast-like cells. Endocrinology 124: 612-617.
    • (1989) Endocrinology , vol.124 , pp. 612-617
    • Noda, M.1
  • 17
    • 0035341209 scopus 로고    scopus 로고
    • TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
    • Alliston T, Choy L, Ducy P, Karsenty G, Derynck R (2001) TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J 20: 2254-2272.
    • (2001) EMBO J , vol.20 , pp. 2254-2272
    • Alliston, T.1    Choy, L.2    Ducy, P.3    Karsenty, G.4    Derynck, R.5
  • 18
    • 33845364588 scopus 로고    scopus 로고
    • Smad3 differently affects osteoblast differentiation depending upon its differentiation stage
    • Kaji H, Naito J, Sowa H, Sugimoto T, Chihara K (2006) Smad3 differently affects osteoblast differentiation depending upon its differentiation stage. Horm Metab Res 38: 740-745.
    • (2006) Horm Metab Res , vol.38 , pp. 740-745
    • Kaji, H.1    Naito, J.2    Sowa, H.3    Sugimoto, T.4    Chihara, K.5
  • 19
    • 0035020950 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signalling pathways
    • Cantrell DA (2001) Phosphoinositide 3-kinase signalling pathways. J Cell Sci 114: 1439-1445.
    • (2001) J Cell Sci , vol.114 , pp. 1439-1445
    • Cantrell, D.A.1
  • 20
    • 66149119052 scopus 로고    scopus 로고
    • Akt promotes BMP2-mediated osteoblast differentiation and bone development
    • Mukherjee A, Rotwein P (2009) Akt promotes BMP2-mediated osteoblast differentiation and bone development. J Cell Sci 122: 716-726.
    • (2009) J Cell Sci , vol.122 , pp. 716-726
    • Mukherjee, A.1    Rotwein, P.2
  • 21
    • 83455211711 scopus 로고    scopus 로고
    • The skeleton: A multi-functional complex organ: New insights into osteoblasts and their role in bone formation: The central role of PI3Kinase
    • Guntur AR, Rosen CJ (2011) The skeleton: a multi-functional complex organ: new insights into osteoblasts and their role in bone formation: the central role of PI3Kinase. J Endocrinol 211: 123-130.
    • (2011) J Endocrinol , vol.211 , pp. 123-130
    • Guntur, A.R.1    Rosen, C.J.2
  • 22
    • 0034653608 scopus 로고    scopus 로고
    • The PI3K-PDK1 connection: More than just a road to PKB
    • Vanhaesebroeck B, Alessi DR (2000) The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 346 Pt 3: 561-576.
    • (2000) Biochem J , vol.346 , pp. 561-576
    • Vanhaesebroeck, B.1    Alessi, D.R.2
  • 23
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296: 1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 24
    • 84863040008 scopus 로고    scopus 로고
    • TGF-β and BMP signaling in osteoblast differentiation and bone formation
    • Chen G, Deng C, Li Y (2012) TGF-β and BMP signaling in osteoblast differentiation and bone formation. Int J Biol Sci 8: 272-288.
    • (2012) Int J Biol Sci , vol.8 , pp. 272-288
    • Chen, G.1    Deng, C.2    Li, Y.3
  • 25
    • 0037031854 scopus 로고    scopus 로고
    • Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription
    • Ghosh-Choudhury N, Abboud SL, Nishimura R, Celeste A, Mahimainathan L, et al. (2002) Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription. J Biol Chem 277: 33361-33368.
    • (2002) J Biol Chem , vol.277 , pp. 33361-33368
    • Ghosh-Choudhury, N.1    Abboud, S.L.2    Nishimura, R.3    Celeste, A.4    Mahimainathan, L.5
  • 26
    • 3142707223 scopus 로고    scopus 로고
    • Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling
    • Fujita T, Azuma Y, Fukuyama R, Hattori Y, Yoshida C, et al. (2004) Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling. J Cell Biol 166: 85-95.
    • (2004) J Cell Biol , vol.166 , pp. 85-95
    • Fujita, T.1    Azuma, Y.2    Fukuyama, R.3    Hattori, Y.4    Yoshida, C.5
  • 27
    • 23044506069 scopus 로고    scopus 로고
    • Bone morphogenetic protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase signaling
    • Osyczka AM, Leboy PS (2005) Bone morphogenetic protein regulation of early osteoblast genes in human marrow stromal cells is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinase signaling. Endocrinology 146: 3428-3437.
    • (2005) Endocrinology , vol.146 , pp. 3428-3437
    • Osyczka, A.M.1    Leboy, P.S.2
  • 29
    • 83455211711 scopus 로고    scopus 로고
    • The skeleton: A multi-functional complex organ: New insights into osteoblasts and their role in bone formation: The central role of PI3Kinase
    • Guntur AR, Rosen CJ (2011) The skeleton: a multi-functional complex organ: new insights into osteoblasts and their role in bone formation: the central role of PI3Kinase. J Endocrinol 211: 123-130.
    • (2011) J Endocrinol , vol.211 , pp. 123-130
    • Guntur, A.R.1    Rosen, C.J.2
  • 30
    • 84863303408 scopus 로고    scopus 로고
    • Inhibition of insulin-like growth factor-1 (IGF-1) expression by prolonged transforming growth factor-β1 (TGF-β1) administration suppresses osteoblast differentiation
    • Ochiai H, Okada S, Saito A, Hoshi K, Yamashita H, et al. (2012) Inhibition of insulin-like growth factor-1 (IGF-1) expression by prolonged transforming growth factor-β1 (TGF-β1) administration suppresses osteoblast differentiation. J Biol Chem 287: 22654-22661.
    • (2012) J Biol Chem , vol.287 , pp. 22654-22661
    • Ochiai, H.1    Okada, S.2    Saito, A.3    Hoshi, K.4    Yamashita, H.5
  • 31
    • 0030443613 scopus 로고    scopus 로고
    • Signal transduction mechanism of insulin and insulin-like growth factor-1
    • Kadowaki T, Tobe K, Honda-Yamamoto R, Tamemoto H, Kaburagi Y, et al. (1996) Signal transduction mechanism of insulin and insulin-like growth factor-1. Endocr J 43 Suppl: S33-41.
    • (1996) Endocr J , vol.43 , pp. S33-41
    • Kadowaki, T.1    Tobe, K.2    Honda-Yamamoto, R.3    Tamemoto, H.4    Kaburagi, Y.5
  • 32
    • 17144438059 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover
    • Ogata N, Chikazu D, Kubota N, Terauchi Y, Tobe K, et al. (2000) Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. J Clin Invest 105: 935-943.
    • (2000) J Clin Invest , vol.105 , pp. 935-943
    • Ogata, N.1    Chikazu, D.2    Kubota, N.3    Terauchi, Y.4    Tobe, K.5
  • 33
    • 33746871738 scopus 로고    scopus 로고
    • Transforming growth factor beta1, bone connection
    • Kanaan RA, Kanaan LA (2006) Transforming growth factor beta1, bone connection. Med Sci Monit 12: RA164-9.
    • (2006) Med Sci Monit , vol.12 , pp. RA164-RA169
    • Kanaan, R.A.1    Kanaan, L.A.2
  • 34
    • 0037184053 scopus 로고    scopus 로고
    • Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells
    • Sowa H, Kaji H, Yamaguchi T, Sugimoto T, Chihara K (2002) Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells. J Biol Chem 277: 36024-36031.
    • (2002) J Biol Chem , vol.277 , pp. 36024-36031
    • Sowa, H.1    Kaji, H.2    Yamaguchi, T.3    Sugimoto, T.4    Chihara, K.5
  • 36
    • 67650985957 scopus 로고    scopus 로고
    • Critical roles of the TGFbeta type i receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development
    • Matsunobu T, Torigoe K, Ishikawa M, de Vega S, Kulkarni AB, et al. (2009) Critical roles of the TGFbeta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev Biol 332: 325-338.
    • (2009) Dev Biol , vol.332 , pp. 325-338
    • Matsunobu, T.1    Torigoe, K.2    Ishikawa, M.3    De Vega, S.4    Kulkarni, A.B.5
  • 37
    • 0034815142 scopus 로고    scopus 로고
    • Opposite effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on osteoblast differentiation
    • Spinella-Jaegle S, Roman-Roman S, Faucheu C, Dunn FW, Kawai S, et al. (2001) Opposite effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on osteoblast differentiation. Bone 29: 323-330.
    • (2001) Bone , vol.29 , pp. 323-330
    • Spinella-Jaegle, S.1    Roman-Roman, S.2    Faucheu, C.3    Dunn, F.W.4    Kawai, S.5
  • 38
    • 84883715714 scopus 로고    scopus 로고
    • PI3K/AKT pathway involvement in the osteogenic effects of osteoclast culture supernatants on preosteoblast cells
    • Chen L-L, Huang M, Tan J-Y, Chen X-T, Lei L-H, et al. (2013) PI3K/AKT pathway involvement in the osteogenic effects of osteoclast culture supernatants on preosteoblast cells. Tissue Eng Part A 19: 2226-2232.
    • (2013) Tissue Eng Part A , vol.19 , pp. 2226-2232
    • Chen, L.-L.1    Huang, M.2    Tan, J.-Y.3    Chen, X.-T.4    Lei, L.-H.5
  • 39
    • 0029984140 scopus 로고    scopus 로고
    • Expression patterns of bone-related proteins during osteoblastic differentiation in MC3T3-E1 cells
    • Choi JY, Lee BH, Song KB, Park RW, Kim IS, et al. (1996) Expression patterns of bone-related proteins during osteoblastic differentiation in MC3T3-E1 cells. J Cell Biochem 61: 609-618.
    • (1996) J Cell Biochem , vol.61 , pp. 609-618
    • Choi, J.Y.1    Lee, B.H.2    Song, K.B.3    Park, R.W.4    Kim, I.S.5
  • 40
    • 0038624395 scopus 로고    scopus 로고
    • Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
    • Peng X, Xu P, Chen M-L, Hahn-Windgassen A, Skeen J, et al. (2003) Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 17: 1352-1365.
    • (2003) Genes Dev , vol.17 , pp. 1352-1365
    • Peng, X.1    Xu, P.2    Chen, M.-L.3    Hahn-Windgassen, A.4    Skeen, J.5
  • 41
    • 70350231775 scopus 로고    scopus 로고
    • The role of Akt1 in terminal stages of endochondral bone formation: Angiogenesis and ossification
    • Ulici V, Hoenselaar KD, Agoston H, McErlain DD, Umoh J, et al. (2009) The role of Akt1 in terminal stages of endochondral bone formation: angiogenesis and ossification. Bone 45: 1133-1145.
    • (2009) Bone , vol.45 , pp. 1133-1145
    • Ulici, V.1    Hoenselaar, K.D.2    Agoston, H.3    McErlain, D.D.4    Umoh, J.5
  • 42
    • 84867800912 scopus 로고    scopus 로고
    • Transforming growth factor b suppresses osteoblast differentiation via the vimentin activating transcription factor 4 (ATF4) axis
    • Lian N, Lin T, Liu W, Wang W, Li L, et al. (2012) Transforming growth factor b suppresses osteoblast differentiation via the vimentin activating transcription factor 4 (ATF4) axis. J Biol Chem 287: 35975-35984.
    • (2012) J Biol Chem , vol.287 , pp. 35975-35984
    • Lian, N.1    Lin, T.2    Liu, W.3    Wang, W.4    Li, L.5
  • 43
    • 84893868549 scopus 로고    scopus 로고
    • PDGF-induced PI3K-mediated signaling enhances the TGF-β-induced osteogenic differentiation of human mesenchymal stem cells in a TGF-β-activated MEK-dependent manner
    • Yokota J, Chosa N, Sawada S, Okubo N, Takahashi N, et al. (2014) PDGF-induced PI3K-mediated signaling enhances the TGF-β-induced osteogenic differentiation of human mesenchymal stem cells in a TGF-β-activated MEK-dependent manner. Int J Mol Med 33: 534-542.
    • (2014) Int J Mol Med , vol.33 , pp. 534-542
    • Yokota, J.1    Chosa, N.2    Sawada, S.3    Okubo, N.4    Takahashi, N.5
  • 44
    • 2342647439 scopus 로고    scopus 로고
    • PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3
    • Remy I, Montmarquette A, Michnick SW (2004) PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3. Nat Cell Biol 6: 358-365.
    • (2004) Nat Cell Biol , vol.6 , pp. 358-365
    • Remy, I.1    Montmarquette, A.2    Michnick, S.W.3
  • 45
    • 84865161633 scopus 로고    scopus 로고
    • Immunohistochemical analysis of TGF-β1 and VEGF in gingival and periodontal tissues: A role of these biomarkers in the pathogenesis of scleroderma and periodontal disease
    • Matarese G, Isola G, Anastasi GP, Favaloro A, Milardi D, et al. (2012) Immunohistochemical analysis of TGF-β1 and VEGF in gingival and periodontal tissues: a role of these biomarkers in the pathogenesis of scleroderma and periodontal disease. Int J Mol Med 30: 502-508.
    • (2012) Int J Mol Med , vol.30 , pp. 502-508
    • Matarese, G.1    Isola, G.2    Anastasi, G.P.3    Favaloro, A.4    Milardi, D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.