Inhibition of insulin-like growth factor-1 (IGF-1) expression by prolonged transforming growth factor-β1 (TGF-β1) administration suppresses osteoblast differentiation

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 22654-22661

  Ochiai, Hiromi ^a   Okada, Shoko ^a   Saito, Akiko ^a   Hoshi, Kazuto ^b   Yamashita, Haruto ^a   Takato, Tsuyoshi ^b   Azuma, Toshifumi ^a  

^a TOKYO DENTAL COLLEGE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AKT PHOSPHORYLATION; ALKALINE PHOSPHATASE ACTIVITY; BONE REGENERATION; BONE SIALOPROTEINS; DOWN-REGULATION; HIGH-DOSE TREATMENT; HUMAN MESENCHYMAL STEM CELLS; HUMAN PERIODONTAL LIGAMENT CELLS; INFLAMMATORY DISEASE; INSULIN RECEPTOR SUBSTRATE-1; INSULIN-LIKE GROWTH FACTOR-1; LOW DOSE; MC3T3-E1 CELL; MRNA EXPRESSION; OSTEOBLAST DIFFERENTIATION; PROTEIN LEVEL; SIGNALING PATHWAYS; SMALL INTERFERING RNA (SIRNA); TRANSFORMING GROWTH FACTORS;

INSULIN; PEPTIDES; PHOSPHATASES; PHOSPHORYLATION; RNA; STEM CELLS;

GENE EXPRESSION;

ALKALINE PHOSPHATASE; BONE SIALOPROTEIN; INSULIN RECEPTOR SUBSTRATE 1; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; SOMATOMEDIN C; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA1;

ALP GENE; ARTICLE; BONE SIALOPROTEIN GENE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; MARKER GENE; MESENCHYMAL STEM CELL; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PERIODONTAL LIGAMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RUNX2 GENE;

BIOLOGICAL MARKERS; BONE DISEASES; CELL DIFFERENTIATION; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-LIKE GROWTH FACTOR I; MESENCHYMAL STEM CELLS; OSTEOBLASTS; PERIODONTAL LIGAMENT; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

MURINAE;

EID: 84863303408     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.279091     Document Type: Article

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