Comparison of biological properties of umbilical cord.derived mesenchymal stem cells from early and late passages: Immunomodulatory ability is enhanced in aged cells

Molecular Medicine Reports

Volumn 11, Issue 1, 2015, Pages 166-174

  Zhuang, Yong ^a   Li, Dong ^a   Fu, Jinqiu ^a   Shi, Qing ^a   Lu, Yuanyuan ^a   Ju, Xiuli ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Gene expression; Immunomodulatory ability; Mesenchymal stem cell; Senescence; Umbilical cord

Indexed keywords

5' NUCLEOTIDASE; BETA GALACTOSIDASE; ENDOGLIN; GAMMA INTERFERON; HERMES ANTIGEN; INDOLEAMINE 2,3 DIOXYGENASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MEMBRANE ANTIGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; THY 1 ANTIGEN; TRANSFORMING GROWTH FACTOR BETA1; VINCULIN; CYTOKINE;

ARTICLE; BIOLOGICAL ACTIVITY; CELL AGING; CELL PROLIFERATION; CELL SIZE; CELL STRUCTURE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME MECHANISM; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOMODULATION; IMMUNOREGULATION; MESENCHYMAL STEM CELL; PHENOTYPE; SENESCENCE; UMBILICAL CORD; BIOLOGY; CELL DIFFERENTIATION; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOPHENOTYPING; MESENCHYMAL STROMA CELL; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROCEDURES; ULTRASTRUCTURE;

ANTIGENS, SURFACE; BETA-GALACTOSIDASE; CELL AGING; CELL DIFFERENTIATION; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; CYTOKINES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; IMMUNOMODULATION; IMMUNOPHENOTYPING; MESENCHYMAL STROMAL CELLS; MOLECULAR SEQUENCE ANNOTATION; UMBILICAL CORD;

EID: 84916203926     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2755     Document Type: Article

References (49)

1. Williams AR and Hare JM: Mesenchymal stem cells: biology, pathophysiology, translational fndings, and therapeutic implications for cardiac disease. Circ Res 109: 923-940, 2011.
2. Musumeci G, Lo Furno D, Loreto C, et al: Mesenchymal stem cells from adipose tissue which have been differentiated into chondrocytes in three-dimensional culture express lubricin. Exp Biol Med (Maywood) 236: 1333-1341, 2011.
3. Matsushita K, Morello F, Wu Y, et al: Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. J Biol Chem 285: 11974-11982, 2010.
4. Johnson T V, Bull ND, Hunt DP, et al: Neuroprotective effects of intravitreal mesenchymal stem cell transplantation in experimental glaucoma. Invest Ophthalmol Vis Sci 51: 2051-2059, 2010.
5. Weiss ML, Medicetty S, Bledsoe AR, et al: Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease. Stem Cells 24: 781-792, 2006.
6. Tsai PC, Fu T W, Chen YM, et al: The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fbrosis. Liver Transpl 15: 484-495, 2009.
7. Lund RD, Wang S, Lu B, et al: Cells isolated from umbilical cord tissue rescue photoreceptors and visual functions in a rodent model of retinal disease. Stem Cells 25: 602-611, 2007.
8. Liao W, Xie J, Zhong J, et al: Therapeutic effect of human umbilical cord multipotent mesenchymal stromal cells in a rat model of stroke. Transplantation 87: 350-359, 2009.
9. Boregowda SV and Phinney DG: Therapeutic applications of mesenchymal stem cells: current outlook. BioDrugs 26: 201-208, 2012.
10. Atoui R, Shum-Tim D and Chiu RC: Myocardial regenerative therapy: immunologic basis for the potential 'universal donor cells'. Ann Thorac Surg 86: 327-334, 2008.
11. Aggarwal S and Pittenger MF: Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105: 1815-1822, 2005.
12. Chen YT, Sun CK, Lin YC, et al: Adipose-derived mesenchymal stem cell protects kidneys against ischemia-reperfusion injury through suppressing oxidative stress and infammatory reaction. J Transl Med 9: 51, 2011.
13. Subbanna PK: Mesenchymal stem cells for treating GVHD: in-vivo fate and optimal dose. Med Hypotheses 69: 469-470, 2007.
14. Laschober GT, Brunauer R, Jamnig A, et al: Age-specific changes of mesenchymal stem cells are paralleled by upregu-lation of CD106 expression as a response to an infammatory environment. Rejuvenation Res 14: 119-131, 2011.
15. Lee OK, Kuo TK, Chen WM, et al: Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood 103: 1669-1675, 2004.
16. Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinfor-matics resources. Nat Protoc 4: 44-57, 2009.
17. Li J, Li D, Liu X, Tang S and Wei F: Human umbilical cord mesenchymal stem cells reduce systemic inflammation and attenuate LPS-induced acute lung injury in rats. J Inflamm (Lond) 9: 33, 2012.
18. Justesen J, Stenderup K, Eriksen EF and Kassem M: Maintenance of osteoblastic and adipocytic differentiation potential with age and osteoporosis in human marrow stromal cell cultures. Calcif Tissue Int 71: 36-44, 2002.
19. Stenderup K, Justesen J, Clausen C and Kassem M: Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone 33: 919-926, 2003.
20. Tokalov SV, Gruener S, Schindler S, et al: A number of bone marrow mesenchymal stem cells but neither phenotype nor differentiation capacities changes with age of rats. Mol Cells 24: 255-260, 2007.
21. von Zglinicki T and Martin-Ruiz CM: Telomeres as biomarkers for ageing and age-related diseases. Curr Mol Med 5: 197-203, 2005.
22. Olovnikov AM: A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleo tides and biological signifcance of the phenomenon. J Theor Biol 41: 181-190, 1973.
23. Hayfick L: Mortality and immortality at the cellular level. A review. Biochemistry (Mosc) 62: 1180-1190, 1997.
24. Campisi J and d'Adda di Fagagna F: Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8: 729-740, 2007.
25. Toussaint O, Medrano EE and von Zglinicki T: Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol 35: 927-945, 2000.
26. Serrano M and Blasco MA: Putting the stress on senescence. Curr Opin Cell Biol 13: 748-753, 2001.
27. Banfi A, Muraglia A, Dozin B, et al: Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy. Exp Hematol 28: 707-715, 2000.
28. Baxter MA, Wynn RF, Jowitt SN, et al: Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion. Stem Cells 22: 675-682, 2004.
29. Hall A and Nobes CD: Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeleton. Philos Trans R Soc Lond B Biol Sci 355: 965-970, 2000.
30. Kao G, Huang CC, Hedgecock EM, Hall DH and Wadsworth WG: The role of the laminin beta subunit in laminin heterotrimer assembly and basement membrane function and development in C. elegans. Dev Biol 290: 211-219, 2006.
31. Kadler KE, Hill A and Canty-Laird EG: Collagen fbrillogenesis: fbronectin, integrins, and minor collagens as organizers and nucleators. Curr Opin Cell Biol 20: 495-501, 2008.
32. Meisel R, Zibert A, Laryea M, et al: Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2, 3-dioxygenase-mediated tryptophan degradation. Blood 103: 4619-4621, 2004.
33. Sato K, Ozaki K, Oh I, et al: Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 109: 228-234, 2007.
34. Batten P, Sarathchandra P, Antoniw JW, et al: Human mesen-chymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves. Tissue Eng 12: 2263-2273, 2006.
35. Groh ME, Maitra B, Szekely E and Koç ON: Human mesen-chymal stem cells require monocyte-mediated activation to suppress alloreactive T cells. Exp Hematol 33: 928-934, 2005.
36. Bunnell BA, Betancourt AM and Sullivan DE: New concepts on the immune modulation mediated by mesenchymal stem cells. Stem Cell Res Ther 1: 34, 2010.
37. Zhang Q, Shi S, Liu Y, et al: Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate infammation-related tissue destruction in experimental colitis. J Immunol 183: 7787-7798, 2009.
38. Niedbala W, Cai B and Liew FY: Role of nitric oxide in the regulation of T cell functions. Ann Rheum Dis 65 (Suppl 3): iii37-iii40, 2006.
39. Couper KN, Blount DG and Riley EM: IL-10: the master regulator of immunity to infection. J Immunol 180: 5771-5777, 2008.
40. Otterbein LE and Choi AM: Heme oxygenase: colors of defense against cellular stress. Am J Physiol Lung Cell Mol Physiol 279: L1029-1037, 2000.
41. Chauveau C, Rémy S, Royer PJ, et al: Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflam-matory function but conserves IL-10 expression. Blood 106: 1694-1702, 2005.
42. Chabannes D, Hill M, Merieau E, et al: A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells. Blood 110: 3691-3694, 2007.
43. Bach FH: Heme oxygenase-1: a therapeutic amplifcation funnel. FASEB J 19: 1216-1219, 2005.
44. Toussaint O, Remacle J, Dierick J F, et al: From the Hayfick mosaic to the mosaics of ageing. Role of stress-induced premature senescence in human ageing. Int J Biochem Cell Biol 34: 1415-1429, 2002.
45. Derynck R, Akhurst RJ and Balmain A: TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 29: 117-129, 2001.
46. Djouad F, Charbonnier LM, Bouff C, et al: Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleukin-6-dependent mechanism. Stem Cells 25: 2025-2032, 2007.
47. Singh T and Newman AB: Infammatory markers in population studies of aging. Ageing Res Rev 10: 319-329, 2011.
48. Ryu E, Hong S, Kang J, et al: Identifcation of senescence-asso-ciated genes in human bone marrow mesenchymal stem cells. Biochem Biophys Res Commun 371: 431-436, 2008.
49. Zhan Q, Lord KA, Alamo I Jr, et al: The gadd and MyD genes defne a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Mol Cell Biol 14: 2361-2371, 1994.