Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair

Oncogene

Volumn 33, Issue 40, 2014, Pages 4803-4812

  Park, J Y ^a   Singh, T R ^a   Nassar, N ^a,b   Zhang, F ^a   Freund, M ^c   Hanenberg, H ^c,d,e   Meetei, A R ^a,b   Andreassen, P R ^a,b  

^a CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e INDIANA UNIVERSITY   (United States)

Author keywords

BRCA genes; BRCA2; DNA repair; Homologous recombination; PALB2; RAD51C

Indexed keywords

BRCA2 PROTEIN; DEOXYRIBONUCLEOPROTEIN; PALB2 WD40 PROTEIN; RAD51 PROTEIN; RAD51C PROTEIN; UNCLASSIFIED DRUG; BRCA2 PROTEIN, HUMAN; DNA BINDING PROTEIN; NUCLEAR PROTEIN; PALB2 PROTEIN, HUMAN; PROTEIN BINDING; RAD51 PROTEIN, HUMAN; RAD51C PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BREAST CANCER; CANCER PATIENT; CANCER SUSCEPTIBILITY; COMPLEX FORMATION; DNA REPAIR; DOUBLE STRANDED DNA BREAK; FANCONI ANEMIA; GENOMIC INSTABILITY; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; IONIZING RADIATION; LOSS OF FUNCTION MUTATION; MISSENSE MUTATION; OVARY CANCER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; BREAST TUMOR; CHEMISTRY; FEMALE; GENETICS; HEK293 CELL LINE; HELA CELL LINE; METABOLISM;

BRCA2 PROTEIN; BREAST NEOPLASMS; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; HEK293 CELLS; HELA CELLS; HUMANS; MUTATION, MISSENSE; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPS; RAD51 RECOMBINASE; TUMOR SUPPRESSOR PROTEINS;

EID: 84916202537     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.421     Document Type: Article

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