Somatotropic and cardio-protective effects of ghrelin in experimental models of heart failure: A systematic review

Annals of Tropical Medicine and Public Health

Volumn 7, Issue 1, 2014, Pages 30-42

  Khatib, Mahalaqua Nazli ^a   Gode, Dilip ^a   Simkhada, Padam ^b   Agho, Kingsley ^c   Gaidhane, Shilpa ^a   Saxena, Deepak ^d   Unnikrishnan, B ^e   Raut, Yogesh ^a   Kawalkar, Umesh ^f   Gaidhane, Abhay ^a   Zahiruddin, Quazi Syed ^a  

^a DATTA MEGHE INSTITUTE OF MEDICAL SCIENCES   (India)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF WESTERN SYDNEY   (Australia)

^d IIPH   (India)

^e KASTURBA MEDICAL COLLEGE   (India)

^f SRTR Medical College   (India)

Author keywords

doxorubicin; Ghrelin; growth hormone secretagogue receptor; heart failure; isoprenaline

Indexed keywords

EID: 84915767572     PISSN: 17556783     EISSN: 09746005     Source Type: Journal    
DOI: 10.4103/1755-6783.145008     Document Type: Review

References (48)

1. Tsu tsui H, Tsuchihashi-Makaya M, Kinugawa S, Goto D, Takeshita A, JCARE-GENERAL Investigators. Characteristics and outcomes of patients with heart failure in general practices and hospitals. Circ J 2007;71:449-54.
2. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-60.
3. Akamizu T, Kangawa K. Ghrelin for cachexia. J Cachexia Sarcopenia Muscle 2010;1:169-76.
4. Costantini VJ, Vicentini E, Sabbatini FM, Valerio E, Lepore S, Tessari M, et al. GSK1614343, a novel ghrelin receptor antagonist, produces an unexpected increase of food intake and body weight in rodents and dogs. Neuroendocrinology 2011;94:158-68.
5. Müller TD, Perez-Tilve D, Tong J, Pfl uger PT, Tschöp MH. Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia. J Cachexia Sarcopenia Muscle 2010;1:159-67.
6. Oner-Iyidogan Y, Gurdol F, Kocak H, Oner P, Cetinalp-Demircan P, Caliskan Y, et al. Appetite-regulating hormones in chronic kidney disease patients. J Ren Nutr 2011;21:316-21.
7. Zhang L, Yagi M, Herzog H. The role of NPY and ghrelin in anorexia nervosa. Curr Pharm Des 2012;18:4766-78.
8. Zhang G, Yin X, Qi Y, Pendyala L, Chen J, Hou D, et al. Ghrelin and cardiovascular diseases. Curr Cardiol Rev 2010;6:62-70.
9. Nagaya N, Uematsu M, Kojima M, Ikeda Y, Yoshihara F, Shimizu W, et al. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 2001;104:1430-5.
10. Enomoto M, Nagaya N, Uematsu M, Okumura H, Nakagawa E, Ono F, et al. Cardiovascular and hormonal effects of subcutaneous administration of ghrelin, a novel growth hormone-releasing peptide, in healthy humans. Clin Sci (Lond) 2003;105:431-5.
11. Nagaya N, Kangawa K. Ghrelin, a novel growth hormone-releasing peptide, in the treatment of chronic heart failure. Regul Pept 2003;114:71-7.
12. Nagaya N, Kangawa K. Ghrelin improves left ventricular dysfunction and cardiac cachexia in heart failure. Curr Opin Pharmacol 2003;3:146-51.
13. Nagaya N, Moriya J, Yasumura Y, Uematsu M, Ono F, Shimizu W, et al. Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation 2004;110:3674-9.
14. Lund LH, Freda P, Williams JJ, LaManca JJ, LeJemtel TH, Mancini DM. Growth hormone resistance in severe heart failure resolves after cardiac transplantation. Eur J Heart Fail 2009;11:525-8.
15. Mao Y, Tokudome T, Otani K, Kishimoto I, Miyazato M, Kangawa K. Excessive sympathoactivation and deteriorated heart function after myocardial infarction in male ghrelin knockout mice. Endocrinology 2013;154:1854-63.
16. Soeki T, Niki T, Uematsu E, Bando S, Matsuura T, Kusunose K, et al. Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein. Heart Vessels 2013;28:795-801.
17. Waseem T, Duxbury M, Ito H, Ashley SW, Robinson MK. Exogenous ghrelin modulates release of pro-infl ammatory and anti-infl ammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways. Surgery 2008;143:334-42.
18. Zhang GG, Cai HQ, Li YH, Sui YB, Zhang JS, Chang JR, et al. Ghrelin protects heart against ERS-induced injury and apoptosis by activating AMP-activated protein kinase. Peptides 2013;48:156-65.
19. Zhao YT, Shao L, Yang HB, Li L, Teng LL. Effects of Ghrelin on hypertension and insulin resistance in fructose-fed rats. Zhonghua Yi Xue Za Zhi 2013;93:935-8.
20. Yano Y, Nakazato M, Toshinai K, Inokuchi T, Matsuda S, Hidaka T, et al. Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients. Am J Hypertens 2014;27:727-33.
21. Yang D, Liu Z, Luo Q. Plasma ghrelin and pro-infl ammatory markers in patients with obstructive sleep apnea and stable coronary heart disease. Med Sci Monit 2013;19:251-6.
22. Tong XX, Wu D, Wang X, Chen HL, Chen JX, Wang XX, et al. Ghrelin protects against cobalt chloride-induced hypoxic injury in cardiac H9c2 cells by inhibiting oxidative stress and inducing autophagy. Peptides 2012;38:217-27.
23. Meriç C, Aydogdu A, Tasçi I, Deniz F, Baysan O, Serdar M, et al. Effects of valsartan treatment on serum ghrelin level and left ventricular mass index in patients with untreated primary hypertension. Anadolu Kardiyol Derg 2014;14:234-8.
24. Zhao YT, Yang HB, Li L, Gao K, Li PF, Xie WW. Reciprocal relationship between plasma ghrelin level and arterial stiffness in hypertensive subjects. Clin Exp Pharmacol Physiol 2013;40:735-9.
25. Invernizzi M, Carda S, Cisari C, Societ Italiana per lo Studio della Sarcopenia e della Disabilit Muscolo-Scheletrica (SISDIM). Possible synergism of physical exercise and ghrelin-agonists in patients with cachexia associated with chronic heart failure. Aging Clin Exp Res 2014;26:341-51.
26. Chang L, Zhao J, Li GZ, Geng B, Pan CS, Qi YF, et al. Ghrelin protects myocardium from isoproterenol-induced injury in rats. Acta Pharmacol Sin 2004;25:1131-7.
27. Schwenke DO, Tokudome T, Kishimoto I, Horio T, Cragg PA, Shirai M, et al. One dose of ghrelin prevents the acute and sustained increase in cardiac sympathetic tone after myocardial infarction. Endocrinology 2012;153:2436-43.
28. Mao Y, Tokudome T, Kishimoto I, Otani K, Hosoda H, Nagai C, et al. Hexarelin treatment in male ghrelin knockout mice after myocardial infarction. Endocrinology 2013;154:3847-54.
29. Mao Y, Tokudome T, Kishimoto I, Otani K, Miyazato M, Kangawa K. One dose of oral hexarelin protects chronic cardiac function after myocardial infarction. Peptides 2014;56:156-62.
30. Palus S, Schur R, Akashi YJ, Bockmeyer B, Datta R, Halem H, et al. Ghrelin and its analogues, BIM-28131 and BIM-28125, improve body weight and regulate the expression of MuRF-1 and MAFbx in a rat heart failure model. PLoS One 2011;6:e26865.
31. Lenk K, Palus S, Schur R, Datta R, Dong J, Culler MD, et al. Effect of ghrelin and its analogues, BIM-28131 and BIM-28125, on the expression of myostatin in a rat heart failure model. J Cachexia Sarcopenia Muscle 2013;4:63-9.
32. Akashi YJ, Palus S, Datta R, Halem H, Taylor JE, Thoene-Reineke C, et al. No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure. Int J Cardiol 2009;137:267-75.
33. Pei XM, Yung BY, Yip SP, Ying M, Benzie IF, Siu PM. Desacyl ghrelin prevents doxorubicin-induced myocardial fi brosis and apoptosis via the GHSR-independent pathway. Am J Physiol Endocrinol Metab 2014;306:E311-23.
34. Matsumura K, Tsuchihashi T, Fujii K, Abe I, Iida M. Central ghrelin modulates sympathetic activity in conscious rabbits. Hypertension 2002;40:694-9.
35. Heppner KM, Piechowski CL, Müller A, Ottaway N, Sisley S, Smiley DL, et al. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes 2014;63:122-31.
36. Al Massadi O, Lear PV, Müller TD, Lopez M, Dieguez C, Tschop MH, et al. Review of Novel Aspects of the Regulation of Ghrelin Secretion. Curr Drug Metab 2014.
37. Beiras-Fernandez A, Kreth S, Weis F, Ledderose C, Pöttinger T, Dieguez C, et al. Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure. Peptides 2010;31:2222-8.
38. Lund LH, Williams JJ, Freda P, LaManca JJ, LeJemtel TH, Mancini DM. Ghrelin resistance occurs in severe heart failure and resolves after heart transplantation. Eur J Heart Fail 2009;11:789-94.
39. Otto B, Cuntz U, Fruehauf E, Wawarta R, Folwaczny C, Riepl RL, et al. Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol 2001;145:669-73.
40. Freeman JN, do Carmo JM, Adi AH, da Silva AA. Chronic central ghrelin infusion reduces blood pressure and heart rate despite increasing appetite and promoting weight gain in normotensive and hypertensive rats. Peptides 2013;42:35-42.
41. Kang PM, Izumo S. Apoptosis and heart failure: A critical review of the literature. Circ Res 2000;86:1107-13.
42. Nishida K, Otsu K. Cell death in heart failure. Circ J 2008;72 Suppl A:A17-21.
43. Wencker D, Chandra M, Nguyen K, Miao W, Garantziotis S, Factor SM, et al. A mechanistic role for cardiac myocyte apoptosis in heart failure. J Clin Invest 2003;111:1497-504.
44. van Empel VP, Bertrand AT, Hofstra L, Crijns HJ, Doevendans PA, De Windt LJ. Myocyte apoptosis in heart failure. Cardiovasc Res 2005;67:21-9.
45. Zhang YJ, Duan Y, Zheng XF. Targeting the mTOR kinase domain: the second generation of mTOR inhibitors. Drug Discov Today 2011;16:325-31.
46. Xu X, Jhun BS, Ha CH, Jin ZG. Molecular mechanisms of ghrelinmediated endothelial nitric oxide synthase activation. Endocrinology 2008;149:4183-92.
47. Mihaylova MM, Shaw RJ. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol 2011;13:1016-23.
48. Wang X, Wang XL, Chen HL, Wu D, Chen JX, Wang XX, et al. Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK. Biochem Pharmacol 2014;88:334-50.