메뉴 건너뛰기




Volumn 63, Issue 1, 2014, Pages 122-131

Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors

Author keywords

[No Author keywords available]

Indexed keywords

ACYL GHRELIN; DES ACYL GHRELIN; GHRELIN; GHRELIN RECEPTOR; GLUCOSE; UNCLASSIFIED DRUG;

EID: 84891803238     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0414     Document Type: Article
Times cited : (96)

References (44)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402:656-660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 2
    • 0035843183 scopus 로고    scopus 로고
    • A role for ghrelin in the central regulation of feeding
    • Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409:194-198
    • (2001) Nature , vol.409 , pp. 194-198
    • Nakazato, M.1    Murakami, N.2    Date, Y.3
  • 3
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000;407:908-913
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschöp, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 5
    • 67650423944 scopus 로고    scopus 로고
    • GOAT links dietary lipids with the endocrine control of energy balance
    • Kirchner H, Gutierrez JA, Solenberg PJ, et al. GOAT links dietary lipids with the endocrine control of energy balance. Nat Med 2009;15:741-745
    • (2009) Nat Med , vol.15 , pp. 741-745
    • Kirchner, H.1    Gutierrez, J.A.2    Solenberg, P.J.3
  • 6
    • 43249089526 scopus 로고    scopus 로고
    • Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men
    • Liu J, Prudom CE, Nass R, et al. Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men. J Clin Endocrinol Metab 2008;93:1980-1987
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1980-1987
    • Liu, J.1    Prudom, C.E.2    Nass, R.3
  • 7
    • 0034676324 scopus 로고    scopus 로고
    • Structure-function studies on the new growth hormone-releasing peptide, ghrelin: Minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
    • Bednarek MA, Feighner SD, Pong SS, et al. Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a. J Med Chem 2000;43:4370-4376
    • (2000) J Med Chem , vol.43 , pp. 4370-4376
    • Bednarek, M.A.1    Feighner, S.D.2    Pong, S.S.3
  • 8
    • 22344435662 scopus 로고    scopus 로고
    • Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats
    • Chen CY, Inui A, Asakawa A, et al. Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology 2005;129:8-25
    • (2005) Gastroenterology , vol.129 , pp. 8-25
    • Chen, C.Y.1    Inui, A.2    Asakawa, A.3
  • 9
    • 33645857375 scopus 로고    scopus 로고
    • Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor
    • Toshinai K, Yamaguchi H, Sun Y, et al. Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology 2006;147:2306-2314
    • (2006) Endocrinology , vol.147 , pp. 2306-2314
    • Toshinai, K.1    Yamaguchi, H.2    Sun, Y.3
  • 10
    • 84872402645 scopus 로고    scopus 로고
    • Central and peripheral des-acyl ghrelin regulates body temperature in rats
    • Inoue Y, Nakahara K, Maruyama K, et al. Central and peripheral des-acyl ghrelin regulates body temperature in rats. Biochem Biophys Res Commun 2013;430;278-283
    • (2013) Biochem Biophys Res Commun , vol.430 , pp. 278-283
    • Inoue, Y.1    Nakahara, K.2    Maruyama, K.3
  • 11
    • 84873367527 scopus 로고    scopus 로고
    • Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice
    • Porporato PE, Filigheddu N, Reano S, et al. Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice. J Clin Invest 2013;123:611-622
    • (2013) J Clin Invest , vol.123 , pp. 611-622
    • Porporato, P.E.1    Filigheddu, N.2    Reano, S.3
  • 12
    • 84862104269 scopus 로고    scopus 로고
    • Metabolic effects of overnight continuous infusion of unacylated ghrelin in humans
    • Benso A, St-Pierre DH, Prodam F, et al. Metabolic effects of overnight continuous infusion of unacylated ghrelin in humans. Eur J Endocrinol 2012;166:911-916
    • (2012) Eur J Endocrinol , vol.166 , pp. 911-916
    • Benso, A.1    St-Pierre, D.H.2    Prodam, F.3
  • 13
    • 34548457203 scopus 로고    scopus 로고
    • Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions
    • Gauna C, Kiewiet RM, Janssen JA, et al. Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions. Am J Physiol Endocrinol Metab 2007;293:E697-E704
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Gauna, C.1    Kiewiet, R.M.2    Janssen, J.A.3
  • 14
    • 35649027860 scopus 로고    scopus 로고
    • Ghrelin gene-related peptides modulate rat white adiposity
    • Giovambattista A, Gaillard RC, Spinedi E. Ghrelin gene-related peptides modulate rat white adiposity. Vitam Horm 2008;77:171-205
    • (2008) Vitam Horm , vol.77 , pp. 171-205
    • Giovambattista, A.1    Gaillard, R.C.2    Spinedi, E.3
  • 15
    • 1042275336 scopus 로고    scopus 로고
    • Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor
    • Thompson NM, Gill DA, Davies R, et al. Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 2004;145: 234-242
    • (2004) Endocrinology , vol.145 , pp. 234-242
    • Thompson, N.M.1    Gill, D.A.2    Davies, R.3
  • 16
    • 84880288160 scopus 로고    scopus 로고
    • Hypothalamic glucagon signaling inhibits hepatic glucose production
    • Mighiu PI, Yue JT, Filippi BM, et al. Hypothalamic glucagon signaling inhibits hepatic glucose production. Nat Med 2013;19:766-772
    • (2013) Nat Med , vol.19 , pp. 766-772
    • Mighiu, P.I.1    Yue, J.T.2    Filippi, B.M.3
  • 17
    • 79955584321 scopus 로고    scopus 로고
    • Leptin and the central nervous system control of glucose metabolism
    • Morton GJ, Schwartz MW. Leptin and the central nervous system control of glucose metabolism. Physiol Rev 2011;91:389-411
    • (2011) Physiol Rev , vol.91 , pp. 389-411
    • Morton, G.J.1    Schwartz, M.W.2
  • 18
    • 0036913187 scopus 로고    scopus 로고
    • Hypothalamic insulin signaling is required for inhibition of glucose production
    • Obici S, Zhang BB, Karkanias G, Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 2002;8:1376-1382
    • (2002) Nat Med , vol.8 , pp. 1376-1382
    • Obici, S.1    Zhang, B.B.2    Karkanias, G.3    Rossetti, L.4
  • 19
    • 50949094723 scopus 로고    scopus 로고
    • Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake
    • Sandoval DA, Bagnol D, Woods SC, D'Alessio DA, Seeley RJ. Arcuate glucagon-like peptide 1 receptors regulate glucose homeostasis but not food intake. Diabetes 2008;57:2046-2054
    • (2008) Diabetes , vol.57 , pp. 2046-2054
    • Sandoval, D.A.1    Bagnol, D.2    Woods, S.C.3    D'Alessio, D.A.4    Seeley, R.J.5
  • 20
    • 9444264700 scopus 로고    scopus 로고
    • Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: Implication in the glycemic control in rodents
    • Dezaki K, Hosoda H, Kakei M, et al. Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in beta-cells: implication in the glycemic control in rodents. Diabetes 2004;53:3142-3151
    • (2004) Diabetes , vol.53 , pp. 3142-3151
    • Dezaki, K.1    Hosoda, H.2    Kakei, M.3
  • 21
    • 77956357163 scopus 로고    scopus 로고
    • Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans
    • Tong J, Prigeon RL, Davis HW, et al. Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes 2010;59:2145-2151
    • (2010) Diabetes , vol.59 , pp. 2145-2151
    • Tong, J.1    Prigeon, R.L.2    Davis, H.W.3
  • 23
    • 6344231416 scopus 로고    scopus 로고
    • Chronic central administration of ghrelin reverses the effects of leptin
    • Kim MS, Namkoong C, Kim HS, et al. Chronic central administration of ghrelin reverses the effects of leptin. Int J Obes Relat Metab Disord 2004; 28:1264-1271
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. 1264-1271
    • Kim, M.S.1    Namkoong, C.2    Kim, H.S.3
  • 24
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • Cowley MA, Smith RG, Diano S, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003;37:649-661
    • (2003) Neuron , vol.37 , pp. 649-661
    • Cowley, M.A.1    Smith, R.G.2    Diano, S.3
  • 25
    • 11144310116 scopus 로고    scopus 로고
    • Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus
    • Mondal MS, Date Y, Yamaguchi H, et al. Identification of ghrelin and its receptor in neurons of the rat arcuate nucleus. Regul Pept 2005;126:55-59
    • (2005) Regul Pept , vol.126 , pp. 55-59
    • Mondal, M.S.1    Date, Y.2    Yamaguchi, H.3
  • 26
    • 18844421372 scopus 로고    scopus 로고
    • Molecular forms of hypothalamic ghrelin and its regulation by fasting and 2-deoxy-d-glucose administration
    • Sato T, Fukue Y, Teranishi H, Yoshida Y, Kojima M. Molecular forms of hypothalamic ghrelin and its regulation by fasting and 2-deoxy-d-glucose administration. Endocrinology 2005;146:2510-2516
    • (2005) Endocrinology , vol.146 , pp. 2510-2516
    • Sato, T.1    Fukue, Y.2    Teranishi, H.3    Yoshida, Y.4    Kojima, M.5
  • 27
    • 84875746147 scopus 로고    scopus 로고
    • Des-acyl ghrelin analogs prevent high-fat-diet-induced dysregulation of glucose homeostasis
    • Delhanty PJ, Huisman M, Baldeon-Rojas LY, et al. Des-acyl ghrelin analogs prevent high-fat-diet-induced dysregulation of glucose homeostasis. FASEB J 2013;27:1690-1700
    • (2013) FASEB J , vol.27 , pp. 1690-1700
    • Delhanty, P.J.1    Huisman, M.2    Baldeon-Rojas, L.Y.3
  • 28
    • 33646582986 scopus 로고    scopus 로고
    • Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor
    • Gauna C, Delhanty PJ, van Aken MO, et al. Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor. Mol Cell Endocrinol 2006;251:103-111
    • (2006) Mol Cell Endocrinol , vol.251 , pp. 103-111
    • Gauna, C.1    Delhanty, P.J.2    Van Aken, M.O.3
  • 29
    • 41549110998 scopus 로고    scopus 로고
    • Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure
    • Pfluger PT, Kirchner H, Günnel S, et al. Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. Am J Physiol Gastrointest Liver Physiol 2008;294:G610-G618
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294
    • Pfluger, P.T.1    Kirchner, H.2    Günnel, S.3
  • 30
    • 84866769521 scopus 로고    scopus 로고
    • Acylation type determines ghrelin's effects on energy homeostasis in rodents
    • Heppner KM, Chaudhary N, Müller TD, et al. Acylation type determines ghrelin's effects on energy homeostasis in rodents. Endocrinology 2012; 153:4687-4695
    • (2012) Endocrinology , vol.153 , pp. 4687-4695
    • Heppner, K.M.1    Chaudhary, N.2    Müller, T.D.3
  • 31
    • 2342625391 scopus 로고    scopus 로고
    • Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis
    • Tinsley FC, Taicher GZ, Heiman ML. Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis. Obes Res 2004;12:150-160
    • (2004) Obes Res , vol.12 , pp. 150-160
    • Tinsley, F.C.1    Taicher, G.Z.2    Heiman, M.L.3
  • 33
    • 34047094881 scopus 로고    scopus 로고
    • Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice
    • Ayala JE, Bracy DP, Julien BM, Rottman JN, Fueger PT, Wasserman DH. Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Diabetes 2007;56:1025-1033
    • (2007) Diabetes , vol.56 , pp. 1025-1033
    • Ayala, J.E.1    Bracy, D.P.2    Julien, B.M.3    Rottman, J.N.4    Fueger, P.T.5    Wasserman, D.H.6
  • 34
    • 34547157499 scopus 로고    scopus 로고
    • Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R)
    • Gauna C, van de Zande B, van Kerkwijk A, Themmen AP, van der Lely AJ, Delhanty PJ. Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R). Mol Cell Endocrinol 2007;274:30-34
    • (2007) Mol Cell Endocrinol , vol.274 , pp. 30-34
    • Gauna, C.1    Van De Zande, B.2    Van Kerkwijk, A.3    Themmen, A.P.4    Van Der Lely, A.J.5    Delhanty, P.J.6
  • 35
    • 80053456531 scopus 로고    scopus 로고
    • Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity
    • Pfluger PT, Castañeda TR, Heppner KM, et al. Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity. Physiol Behav 2011;105:52-61
    • (2011) Physiol Behav , vol.105 , pp. 52-61
    • Pfluger, P.T.1    Castañeda, T.R.2    Heppner, K.M.3
  • 36
    • 80051691117 scopus 로고    scopus 로고
    • Ghrelin-induced adiposity is independent of orexigenic effects
    • Perez-Tilve D, Heppner K, Kirchner H, et al. Ghrelin-induced adiposity is independent of orexigenic effects. FASEB J 2011;25:2814-2822
    • (2011) FASEB J , vol.25 , pp. 2814-2822
    • Perez-Tilve, D.1    Heppner, K.2    Kirchner, H.3
  • 37
    • 33745834734 scopus 로고    scopus 로고
    • Ghrelin action in the brain controls adipocyte metabolism
    • Theander-Carrillo C, Wiedmer P, Cettour-Rose P, et al. Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest 2006;116:1983-1993
    • (2006) J Clin Invest , vol.116 , pp. 1983-1993
    • Theander-Carrillo, C.1    Wiedmer, P.2    Cettour-Rose, P.3
  • 38
    • 84863010954 scopus 로고    scopus 로고
    • Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism
    • Kern A, Albarran-Zeckler R, Walsh HE, Smith RG. Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism. Neuron 2012;73:317-332
    • (2012) Neuron , vol.73 , pp. 317-332
    • Kern, A.1    Albarran-Zeckler, R.2    Walsh, H.E.3    Smith, R.G.4
  • 39
    • 84869210746 scopus 로고    scopus 로고
    • Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release
    • Park S, Jiang H, Zhang H, Smith RG. Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release. Proc Natl Acad Sci USA 2012;109:19003-19008
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 19003-19008
    • Park, S.1    Jiang, H.2    Zhang, H.3    Smith, R.G.4
  • 40
    • 80655149447 scopus 로고    scopus 로고
    • Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors
    • Rediger A, Piechowski CL, Yi CX, et al. Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors. J Biol Chem 2011;286:39623-39631
    • (2011) J Biol Chem , vol.286 , pp. 39623-39631
    • Rediger, A.1    Piechowski, C.L.2    Yi, C.X.3
  • 41
    • 84872064517 scopus 로고    scopus 로고
    • Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signalling
    • Schellekens H, van Oeffelen WE, Dinan TG, Cryan JF. Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signalling. J Biol Chem 2013;288:181-191
    • (2013) J Biol Chem , vol.288 , pp. 181-191
    • Schellekens, H.1    Van Oeffelen, W.E.2    Dinan, T.G.3    Cryan, J.F.4
  • 42
    • 37349009036 scopus 로고    scopus 로고
    • Visualization of ghrelinproducing neurons in the hypothalamic arcuate nucleus using ghrelin-EGFP transgenic mice
    • Kageyama H, Kitamura Y, Hosono T, et al. Visualization of ghrelinproducing neurons in the hypothalamic arcuate nucleus using ghrelin-EGFP transgenic mice. Regul Pept 2008;145:116-121
    • (2008) Regul Pept , vol.145 , pp. 116-121
    • Kageyama, H.1    Kitamura, Y.2    Hosono, T.3
  • 43
    • 33751539311 scopus 로고    scopus 로고
    • Distribution of ghrelinimmunoreactive neuronal networks in the human hypothalamus
    • Menyhért J, Wittmann G, Hrabovszky E, et al. Distribution of ghrelinimmunoreactive neuronal networks in the human hypothalamus. Brain Res 2006;1125:31-36
    • (2006) Brain Res , vol.1125 , pp. 31-36
    • Menyhért, J.1    Wittmann, G.2    Hrabovszky, E.3
  • 44
    • 84878477768 scopus 로고    scopus 로고
    • Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans
    • Tong J, Prigeon RL, Davis HW, Bidlingmaier M, Tschöp MH, D'Alessio D. Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans. J Clin Endocrinol Metab 2013;98:2536-2543
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 2536-2543
    • Tong, J.1    Prigeon, R.L.2    Davis, H.W.3    Bidlingmaier, M.4    Tschöp, M.H.5    D'Alessio, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.