Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure

Peptides

Volumn 31, Issue 12, 2010, Pages 2222-2228

  Beiras Fernandez, Andres ^a   Kreth, Simone ^a   Weis, Florian ^a   Ledderose, Carola ^b   Pöttinger, Thomas ^a   Dieguez, Carlos ^c   Beiras, Andres ^c   Reichart, Bruno ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Ghrelin; GHSR 1a; Heart failure; Immunohistochemistry; Myocardium

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GHRELIN; GHRELIN RECEPTOR; GHRELIN RECEPTOR 1A; GROWTH HORMONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ADULT; ANATOMICAL VARIATION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; GENE EXPRESSION; HEART ATRIUM; HEART FAILURE; HEART FUNCTION; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HEART VENTRICLE; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION;

ADULT; GHRELIN; HEART FAILURE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; MYOCARDIUM; RECEPTORS, GHRELIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 78049483949     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2010.08.019     Document Type: Article

References (24)

1. I. Bedendi, G. Alloatti, A. Marcantoni, D. Malan, F. Catapano, and C. Ghé Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin Eur J Pharmacol 476 2003 87 95
2. V. Bodart, M. Febbraio, A. Demers, N. McNicoll, P. Pohankova, and A. Perreault CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart Circ Res 90 2002 844 849
3. M. Enomoto, N. Nagaya, M. Uematsu, H. Okumura, E. Nakagawa, and F. Ono Cardiovascular and hormonal effects of subcutaneous administration of ghrelin, a novel growth hormone-releasing peptide, in healthy humans Clin Sci (Lond) 105 2003 431 435
4. S. Frascarelli, S. Ghelardoni, S. Ronca-Testoni, and R. Zucchi Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart Basic Res Cardiol 98 2003 401 405
5. S. Gnanapavan, B. Kola, S.A. Bustin, D.G. Morris, P. McGee, and P. Fairclough The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans J Clin Endocrinol Metab 87 2002 2988
6. C.X. Huang, M.J. Yuan, H. Huang, G. Wu, Y. Liu, and S.B. Yu Ghrelin inhibits post-infarct myocardial remodeling and improves cardiac function through anti-inflammation effect Peptides 30 2009 2286 2291
7. M.J. Iglesias, R. Piñeiro, M. Blanco, R. Gallego, C. Diéguez, and O. Gualillo Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes Cardiovasc Res 62 2004 481 488
8. P.L. Jeffery, A.C. Herington, and L.K. Chopin Expression and action of the growth hormone releasing peptide ghrelin and its receptor in prostate cancer cell lines J Endocrinol 172 2002 R7 11
9. M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660
10. M. Kojima, and K. Kangawa Ghrelin: more than endogenous growth hormone secretagogue Ann N Y Acad Sci 1200 2010 140 148
11. L. Li, L.K. Zhang, Y.Z. Pang, C.S. Pan, Y.F. Qi, and L. Chen Cardioprotective effects of ghrelin and des-octanoyl ghrelin on myocardial injury induced by isoproterenol in rats Acta Pharmacol Sin 27 2006 527 535
12. L.H. Lund, J.J. Williams, P. Freda, J.J. LaManca, T.H. LeJemtel, and D.M. Mancini Ghrelin resistance occurs in severe heart failure and resolves after heart transplantation Eur J Heart Fail 11 2009 789 794
13. N. Nagaya, J. Moriya, Y. Yasumura, M. Uematsu, F. Ono, and W. Shimizu Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure Circulation 110 2004 3674 3679
14. N. Nagaya, M. Uematsu, M. Kojima, Y. Ikeda, F. Yoshihara, and W. Shimizu Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure Circulation 104 2001 1430 1435
15. N. Nagaya, and K. Kangawa Ghrelin, a novel growth hormone-releasing peptide, in the treatment of chronic heart failure Regul Pept 114 2003 71 77
16. N. Nagaya, M. Uematsu, M. Kojima, Y. Date, M. Nakazato, and H. Okumura Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors Circulation 104 2001 2034 2038
17. M. Papotti, C. Ghe, P. Cassoni, F. Catapano, R. Deghenghi, and E. Ghigo Growth hormone secretagogue binding sites in peripheral human tissues J Clin Endocrinol Metab 85 2000 3803 3807
18. S. Perez, L.J. Royo, A. Astudillo, D. Escudero, F. Alvarez, and A. Rodriguez Identifying the most suitable endogenous control for determining gene expression in hearts from organ donors BMC Mol Biol 8 2007 114
19. K. Raghay, T. Garcia-Caballero, S. Bravo, C.V. Alvarez, R. Gonzalez, and C. Dieguez Ghrelin localization in the medulla of rat and human adrenal gland and in pheochromocytomas Histol Histopathol 23 2008 57 65
20. A. Rodriguez, J. Gomez-Ambrosi, V. Catalan, S. Becerril, N. Sainz, and M.J. Gil Association of plasma acylated ghrelin with blood pressure and left ventricular mass in patients with metabolic syndrome J Hypertens 28 2010 560 567
21. J.B. Soares, A. Rocha-Sousa, P. Castro-Chaves, T. Henriques-Coelho, and A.F. Leite-Moreira Inotropic and lusitropic effects of ghrelin and their modulation by the endocardial endothelium, NO, prostaglandins, GHS-R1a and KCa channels Peptides 27 2006 1616 1623
22. F. Weis, A. Beiras-Fernandez, R. Sodian, I. Kaczmarek, B. Reichart, and A. Beiras Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure J Mol Cell Cardiol 48 2010 1187 1193
23. K.E. Wiley, and A.P. Davenport Comparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin-1 Br J Pharmacol 136 2002 1146 1152
24. X.B. Xu, J.J. Pang, J.M. Cao, C. Ni, R.K. Xu, and X.Z. Peng GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure Am J Physiol Heart Circ Physiol 289 2005 H1643 H1651