Growth hormone resistance in severe heart failure resolves after cardiac transplantation

European Journal of Heart Failure

Volumn 11, Issue 5, 2009, Pages 525-528

  Lund, Lars H ^a   Freda, Pamela ^b   Williams, Jill J ^b   Lamanca, John J ^c   Lejemtel, Thierry H ^d   Mancini, Donna M ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Columbia University ^*  (United States)

^c SALISBURY UNIVERSITY   (United States)

^d TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cachexia; Cardiac transplantation; Growth hormone; Heart failure; Insulin like growth factor 1

Indexed keywords

GROWTH HORMONE; IMMUNOSUPPRESSIVE AGENT; PREDNISONE; SOMATOMEDIN C;

ABDOMINAL FAT; ADULT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; CACHEXIA; CARDIAC GRAFT REJECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITOMETRY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HEART FAILURE; HEART TRANSPLANTATION; HORMONE RESISTANCE; HUMAN; IMAGING SYSTEM; IMMUNORADIOMETRIC ASSAY; MALE; OBESITY; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE; SKELETAL MUSCLE; WAIST CIRCUMFERENCE; WEIGHT GAIN;

ADULT; BODY COMPOSITION; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; GROWTH HORMONE; HEART FAILURE; HEART TRANSPLANTATION; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; PROGNOSIS; RADIOIMMUNOASSAY; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 66249109584     PISSN: 13889842     EISSN: 18790844     Source Type: Journal    
DOI: 10.1093/eurjhf/hfp044     Document Type: Article

References (12)

1. Anker SD, Ponikowski P, Varney S, Chua TP, Clark AL, Webb-Peploe KM, Harrington D, Kox WJ, Poole-Wilson PA, Coats AJ. Wasting as independent risk factor for mortality in chronic heart failure. Lancet 1997;349:1050-1053.
2. Clark AL, Knosalla C, Birks E, Loebe M, Davos CH, Tsang S, Negassa A, Yacoub M, Hetzer R, Coats AJ, Anker SD. Heart transplantation in heart failure: the prognostic importance of body mass index at time of surgery and subsequent weight changes. Eur J Heart fail 2007;9:839-844.
3. Pocock SJ, McMurray JJ, Dobson J, Yusuf S, Granger CB, Michelson EL, Ostergren J, Pfeffer MA, Solomon SD, Anker SD, Swedberg KB. Weight loss and mortality risk in patients with chronic heart failure in the candesartan in heart failure: assessment of reduction in mortality and morbidity (CHARM) programme. Eur Heart J 2008;29:2641-2650.
4. Williams JJ, Lund LH, LaManca J, Kunavarapu C, Cohen DJ, Heshka S, Heymsfield SB, Mancini DM. Excessive weight gain in cardiac transplant recipients. J Heart Lung Transplant 2006;25:36-41.
5. Anker SD, Chua TP, Ponikowski P, Harrington D, Swan JW, Kox WJ, Poole-Wilson PA, Coats AJ. Hormonal changes and catabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia. Circulation 1997; 96:526-534.
6. Anker SD, Volterrani M, Pflaum CD, Strasburger CJ, Osterziel KJ, Doehner W, Ranke MB, Poole-Wilson PA, Giustina A, Dietz R, Coats AJ. Acquired growth hormone resistance in patients with chronic heart failure: implications for therapy with growth hormone. J Am Coll Cardiol 2001;38:443-452.
7. Ibe W, Saraste A, Lindemann S, Bruder S, Buerke M, Darius H, Pulkki K, Voipio-Pulkki LM. Cardiomyocyte apoptosis is related to left ventricular dysfunction and remodelling in dilated cardiomyopathy, but is not affected by growth hormone treatment. Eur J Heart Fail 2007;9:160-167.
8. Bollano E, Bergh CH, Kjellstrom C, Omerovic E, Kujacic V, Caidahl K, Bengtsson BA, Waagstein F, Isgaard J. Growth hormone alone or combined with metoprolol preserves cardiac function after myocardial infarction in rats. Eur J Heart Fail 2001;3:651-660.
9. Cicoira M, Kalra PR, Anker SD. Growth hormone resistance in chronic heart failure and its therapeutic implications. J Card Fail 2003;9:219-226.
10. Hambrecht R, Schulze PC, Gielen S, Linke A, Mobius-Winkler S, Yu J, Kratzsch JJ, Baldauf G, Busse MW, Schubert A, Adams V, Schuler G. Reduction of insulin-like growth factor-l expression in the skeletal muscle of noncachectic patients with chronic heart failure. J Am Coll Cardiol 2002;39: 1175-1181.
11. Frost RA, Lang CH. Alteration of somatotropic function by proinflammatory cytokines. J Anim Sci 2004;82(Suppl. E):E100-E109.
12. Song YH, Li Y, Du J, Mitch WE, Rosenthal N, Delafontaine P. Muscle-specific expression of IGF-1 blocks angiotensin ll-induced skeletal muscle wasting. J Clin Invest 2005;115:451-458.