Next-generation sequencing studies guide the design of pyrrole-imidazole polyamides with improved binding specificity by the addition of β-alanine

ChemBioChem

Volumn 15, Issue 18, 2014, Pages 2647-2651

  Kumar, Chandran Anandha ^a   Li, Yue ^a   Kizaki, Seiichiro ^a   Pandian, Ganesh N ^b   Hashiya, Kaori ^a   Bando, Toshikazu ^a   Sugiyama, Hiroshi ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ALANINE; IMIDAZOLE DERIVATIVE; POLYAMIDE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; VORINOSTAT; VORINOSTAT PYRROLE IMIDAZOLE POLYAMIDE DERIVATIVE; DNA; IMIDAZOLE; NYLON;

ARTICLE; BINDING AFFINITY; COST EFFECTIVENESS ANALYSIS; DNA SEQUENCE; DRUG CONFORMATION; DRUG DESIGN; DRUG DNA BINDING; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; HIGH THROUGHPUT SEQUENCING; NEXT GENERATION SEQUENCING; BINDING SITE; CHEMISTRY; METABOLISM; NUCLEOTIDE SEQUENCE;

BASE SEQUENCE; BETA-ALANINE; BINDING SITES; DNA; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; IMIDAZOLES; NYLONS; PYRROLES;

EID: 84915752667     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201402497     Document Type: Article

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