Design of sequence-specific DNA binding molecules for DNA methyltransferase inhibition

Journal of the American Chemical Society

Volumn 136, Issue 9, 2014, Pages 3687-3694

  Kang, Jeenjoo S ^a   Meier, Jordan L ^a   Dervan, Peter B ^a  

^a California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; AMINO ACIDS; DNA SEQUENCES;

BINDING ORIENTATION; DNA METHYLATION; DNA METHYLTRANSFERASES; HAIRPIN POLYAMIDES; NEXT-GENERATION SEQUENCING; PYRROLE-IMIDAZOLE POLYAMIDES; SEQUENCE SPECIFICITY; TRANSCRIPTIONAL REGULATION;

MOLECULES;

ALANINE; DNA METHYLTRANSFERASE; IMIDAZOLE DERIVATIVE; OLIGOMER; POLYAMIDE; PYRROLE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA BINDING; DNA METHYLATION; DNA SEQUENCE; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH THROUGHPUT SEQUENCING; HUMAN; MOLECULAR LIBRARY;

BASE SEQUENCE; CPG ISLANDS; DNA; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DRUG DESIGN; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; IMIDAZOLES; SUBSTRATE SPECIFICITY;

EID: 84897712536     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja500211z     Document Type: Article

References (41)

1. Jones, P. A.; Baylin, S. B. Nat. Rev. Genetics 2002, 3, 415-428
2. Rountree, M. R.; Bachman, K. E.; Herman, J. G.; Baylin, S. B. Oncogene 2001, 20, 3156-3165
3. Bird, A. P. Nature 1986, 321, 209-213
4. Ballestar, E.; Wolffe, A. P. Eur. J. Biochem. 2001, 268, 1-6
5. Merlo, A.; Herman, J. G.; Mao, L.; Lee, D. J.; Gabrielson, E.; Burger, P. C.; Baylin, S. B.; Sidransky, D. Nat. Med. 1995, 1, 686-692
6. Katzenellenbogen, R. A.; Baylin, S. B.; Herman, J. G. Blood 1999, 93, 4347-4353
7. Plumb, J. A.; Strathdee, G.; Sludden, J.; Kaye, S. B.; Brown, R. Cancer Res. 2000, 60, 6039-6044
8. Dammann, R.; Li, C.; Yoon, J. H.; Chin, P. L.; Bates, S.; Pfeifer, G. P. Nat. Genet. 2000, 25, 315-319
9. Christman, J. K. Oncogene 2002, 21, 5483-5495
10. Waring, M. J.; Wakelin, L. P. G. Nature 1974, 252, 653-657
11. Adams, R. L.; Rinaldi, A. FEBS Lett. 1987, 215, 266-268
12. Stresemann, C.; Brueckner, B.; Musch, T.; Stopper, H.; Lyko, F. Cancer Res. 2006, 66, 2794-2800
13. Fagan, R. L.; Cryderman, D. E.; Kopelovich, L.; Wallrath, L. L.; Brenner, C. J. Biol. Chem. 2013, 288, 23858-23867
14. Ceccaldi, A.; Rajavelu, A.; Ragozin, S.; Sénamaud-Beaufort, C.; Bashtrykov, P.; Testa, N.; Dali-Ali, H.; Maulay-Bailly, C.; Amand, S.; Guianvarch, D. ACS Chem. Biol. 2013, 8, 543-548
15. Wade, W. S.; Mrksich, M.; Dervan, P. B. J. Am. Chem. Soc. 1992, 114, 8783-8794
16. Trauger, J. W.; Baird, E. E.; Dervan, P. B. Nature 1996, 382, 559-561
17. White, S.; Baird, E. E.; Dervan, P. B. Chem. Biol. 1997, 4, 569-578
18. White, S.; Szewczyk, J. W.; Turner, J. M.; Baird, E. E.; Dervan, P. B. Nature 1998, 391, 468-471
19. Kielkopf, C. L.; Baird, E. E.; Dervan, P. B.; Rees, D. C. Nat. Struct. Biol. 1998, 5, 104-109
20. Kielkopf, C. L.; White, S.; Szewczyk, J. W.; Turner, J. M.; Baird, E. E.; Dervan, P. B.; Rees, D. C. Science 1998, 282, 111-115
21. Mrksich, M.; Parks, M. E.; Dervan, P. B. J. Am. Chem. Soc. 1994, 116, 7983-7988
22. Trauger, J. W.; Baird, E. E.; Mrksich, M.; Dervan, P. B. J. Am. Chem. Soc. 1996, 118, 6160-6166
23. Swalley, S. E.; Baird, E. E.; Dervan, P. B. Chem.-Eur. J. 1997, 3, 1600-1607
24. Trauger, J. W.; Baird, E. E.; Dervan, P. B. J. Am. Chem. Soc. 1998, 120, 3534-3535
25. Turner, J. M.; Swalley, S. E.; Baird, E. E.; Dervan, P. B. J. Am. Chem. Soc. 1998, 120, 6219-6226
26. Wang, C. C.; Ellervik, U.; Dervan, P. B. Bioorg. Med. Chem. 2001, 9, 653-657
27. White, S.; Baird, E. E.; Dervan, P. B. J. Am. Chem. Soc. 1997, 119, 8756-8765
28. Herman, D.; Baird, E.; Dervan, P. B. J. Am. Chem. Soc. 1998, 120, 1382-1391
29. Rucker, V.; Melander, C.; Dervan, P. Helv. Chim. Acta 2003, 86, 1839-1851
30. Meier, J. L.; Yu, A. S.; Korf, I.; Segal, D. J.; Dervan, P. B. J. Am. Chem. Soc. 2012, 134, 17814-17822
31. Swalley, S. E.; Baird, E. E.; Dervan, P. B. J. Am. Chem. Soc. 1997, 119, 6953-6961
32. Minoshima, M.; Bando, T.; Sasaki, S.; Fujimoto, J.; Sugiyama, H. Nucleic Acids Res. 2008, 36, 2889-2894
33. Chenoweth, D. M.; Dervan, P. B. Proc. Natl. Acad. Sci. U.S.A 2009, 106, 13175-13179
34. Chenoweth, D. M.; Dervan, P. B. J. Am. Chem. Soc. 2010, 132, 14521-14529
35. Pilch, D. S.; Poklar, N.; Gelfand, C. A.; Law, S. M.; Breslauer, K. J.; Baird, E. E.; Dervan, P. B. Proc. Natl. Acad. Sci. U.S.A 1996, 93, 8306-8311
36. Brueckner, B.; Garcia Boy, R.; Siedlecki, P.; Musch, T.; Kliem, H. C.; Zielenkiewicz, P.; Suhai, S.; Wiessler, M.; Lyko, F. Cancer Res. 2005, 65, 6305-6311
37. McClelland, M.; Nelson, M. Nucleic Acids Res. 1992, 20 (Suppl) 2145-2157
38. Darii, M. V.; Cherepanova, N. A.; Subach, O. M.; Kirsanova, O. V.; Raskó, T.; Slaska-Kiss, K.; Kiss, A.; Deville-Bonne, D.; Reboud-Ravaux, M.; Gromova, E. S. Biochim. Biophys. Acta 2009, 1794, 1654-1662
39. Song, J.; Teplova, M.; Ishibe-Murakami, S.; Patel, D. J. Science 2012, 335, 709-712
40. Baird, E. E.; Dervan, P. B. J. Am. Chem. Soc. 1996, 118, 6141-6146
41. Puckett, J. W.; Green, J. T.; Dervan, P. B. Org. Lett. 2012, 14, 2774-2777