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Volumn 123, Issue , 2014, Pages 515-523

Spray-dried didanosine-loaded polymeric particles for enhanced oral bioavailability

Author keywords

Didanosine (ddI); Enhanced oral bioavailability; HIV therapy; Poly(epsilon caprolactone) microparticles; Spray drying

Indexed keywords

BIOCHEMISTRY; BIOCOMPATIBILITY; SPRAY DRYING;

EID: 84915750260     PISSN: 09277765     EISSN: 18734367     Source Type: Journal    
DOI: 10.1016/j.colsurfb.2014.09.055     Document Type: Article
Times cited : (19)

References (68)
  • 1
    • 84915808662 scopus 로고    scopus 로고
    • Updated October
    • World Health Organization, HIV/AIDS, Fact sheets. Updated October 2013. http://www.who.int/mediacentre/factsheets/fs360/es/.
    • (2013)
  • 2
    • 84915808661 scopus 로고    scopus 로고
    • Updated September
    • HIV 2013 Global Fact Sheet, UNAIDS, Updated September 2013. http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2013/gr2013/20130923_FactSheet_Global_en.pdf.
    • (2013)
  • 3
    • 84915808660 scopus 로고    scopus 로고
    • Updated October
    • World Health Organization, HIV/AIDS, Updated October 2013. http://www.who.int/features/qa/71/es/.
    • (2013)
  • 4
    • 61449189645 scopus 로고    scopus 로고
    • Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV
    • De Clercq E. Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int. J. Antimicrob. Ag. 2009, 33:307.
    • (2009) Int. J. Antimicrob. Ag. , vol.33 , pp. 307
    • De Clercq, E.1
  • 5
    • 67650177053 scopus 로고    scopus 로고
    • Drug delivery systems in HIV pharmacotherapy: what has been done and the challenges standing ahead
    • Sosnik A., Chiappetta D.A., Carcaboso A.M. Drug delivery systems in HIV pharmacotherapy: what has been done and the challenges standing ahead. J. Control. Release 2009, 138:2.
    • (2009) J. Control. Release , vol.138 , pp. 2
    • Sosnik, A.1    Chiappetta, D.A.2    Carcaboso, A.M.3
  • 6
    • 79952116301 scopus 로고    scopus 로고
    • Progress in antiretroviral drug delivery using nanotechnology
    • Mallipeddi R., Rohan L.C. Progress in antiretroviral drug delivery using nanotechnology. Int. J. Nanomed. 2010, 5:533.
    • (2010) Int. J. Nanomed. , vol.5 , pp. 533
    • Mallipeddi, R.1    Rohan, L.C.2
  • 8
    • 76849095367 scopus 로고    scopus 로고
    • Nanotechnology-based systems for the treatment and prevention of HIV/AIDS
    • das Neves J., Amiji M.M., Bahia M.F., Sarmento B. Nanotechnology-based systems for the treatment and prevention of HIV/AIDS. Adv. Drug Deliv. Rev. 2010, 62:458.
    • (2010) Adv. Drug Deliv. Rev. , vol.62 , pp. 458
    • das Neves, J.1    Amiji, M.M.2    Bahia, M.F.3    Sarmento, B.4
  • 9
    • 81255153957 scopus 로고    scopus 로고
    • The importance of the vaginal delivery route for antiretrovirals in HIV prevention
    • Ferguson L.M., Rohan L.C. The importance of the vaginal delivery route for antiretrovirals in HIV prevention. Ther. Deliv. 2011, 2:1535.
    • (2011) Ther. Deliv. , vol.2 , pp. 1535
    • Ferguson, L.M.1    Rohan, L.C.2
  • 10
    • 59849092368 scopus 로고    scopus 로고
    • Prodrug and conjugate drug delivery strategies for improving HIV/AIDS therapy
    • Palombo M.S., Singh Y., Sinko P.J. Prodrug and conjugate drug delivery strategies for improving HIV/AIDS therapy. J. Drug Deliv. Sci. Technol. 2009, 19:3.
    • (2009) J. Drug Deliv. Sci. Technol. , vol.19 , pp. 3
    • Palombo, M.S.1    Singh, Y.2    Sinko, P.J.3
  • 11
    • 54949136864 scopus 로고    scopus 로고
    • Exploring the use of novel drug delivery systems for antiretroviral drugs
    • Ojewole E., Mackraj I., Naidoo P., Govender T. Exploring the use of novel drug delivery systems for antiretroviral drugs. Eur. J. Pharm. Biopharm. 2008, 70:697.
    • (2008) Eur. J. Pharm. Biopharm. , vol.70 , pp. 697
    • Ojewole, E.1    Mackraj, I.2    Naidoo, P.3    Govender, T.4
  • 12
    • 76849108225 scopus 로고    scopus 로고
    • Pure drug and polymer based nanotechnologies for the improved solubility, stability, bioavailability and targeting of anti-HIV drugs
    • Sharma P., Garg S. Pure drug and polymer based nanotechnologies for the improved solubility, stability, bioavailability and targeting of anti-HIV drugs. Adv. Drug Deliv. Rev. 2010, 62:491.
    • (2010) Adv. Drug Deliv. Rev. , vol.62 , pp. 491
    • Sharma, P.1    Garg, S.2
  • 13
    • 58949094512 scopus 로고    scopus 로고
    • Self-assembled drug delivery systems: Part 3. In vitro/in vivo studies of the self-assembled nanoparticulates of cholesteryl acyl didanosine
    • Jin Y., Ai P., Xin R., Tian Y., Dong J., Chen D., Wang W. Self-assembled drug delivery systems: Part 3. In vitro/in vivo studies of the self-assembled nanoparticulates of cholesteryl acyl didanosine. Int. J. Pharm. 2009, 368:207.
    • (2009) Int. J. Pharm. , vol.368 , pp. 207
    • Jin, Y.1    Ai, P.2    Xin, R.3    Tian, Y.4    Dong, J.5    Chen, D.6    Wang, W.7
  • 17
    • 84925835439 scopus 로고    scopus 로고
    • Preparation of gastro-resistant pellets containing chitosan microspheres for improvement of oral didanosine bioavailability
    • Severino P., de Oliveira G.G.G., Ferraz H.G., Souto E.B., Santana M.H.A. Preparation of gastro-resistant pellets containing chitosan microspheres for improvement of oral didanosine bioavailability. J. Pharm. Anal. 2012, 2:188.
    • (2012) J. Pharm. Anal. , vol.2 , pp. 188
    • Severino, P.1    de Oliveira, G.G.G.2    Ferraz, H.G.3    Souto, E.B.4    Santana, M.H.A.5
  • 19
    • 0036148655 scopus 로고    scopus 로고
    • Lack of effect of simultaneously administered didanosine encapsulated enteric bead formulation (Videx EC) on oral absorption of indinavir, ketoconazole, or ciprofloxacin
    • Damle B.D., Mummaneni V., Kaul S., Knupp C. Lack of effect of simultaneously administered didanosine encapsulated enteric bead formulation (Videx EC) on oral absorption of indinavir, ketoconazole, or ciprofloxacin. Antimicrob. Agents Chemother. 2002, 46:385.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 385
    • Damle, B.D.1    Mummaneni, V.2    Kaul, S.3    Knupp, C.4
  • 20
    • 41049091411 scopus 로고    scopus 로고
    • Mannan-coated gelatin nanoparticles for sustained and targeted delivery of didanosine: in vitro and in vivo evaluation
    • Kaur A., Jain S., Tiwary A.K. Mannan-coated gelatin nanoparticles for sustained and targeted delivery of didanosine: in vitro and in vivo evaluation. Acta Pharm. 2008, 58:61.
    • (2008) Acta Pharm. , vol.58 , pp. 61
    • Kaur, A.1    Jain, S.2    Tiwary, A.K.3
  • 21
    • 84915808659 scopus 로고    scopus 로고
    • Supplement to the 2013 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Recommendations for a public health approach. Updated March 2014.
    • World Health Organization, March 2014 Supplement to the 2013 consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. Recommendations for a public health approach. Updated March 2014. http://apps.who.int/iris/bitstream/10665/104264/1/9789241506830_eng.pdf.
    • (2014)
  • 24
    • 84898639755 scopus 로고    scopus 로고
    • In vitro comparative evaluation of monolayered multipolymeric films embedded with didanosine-loaded solid lipid nanoparticles: a potential buccal drug delivery system for ARV therapy
    • Jones E., Ojewole E., Kalhapure R., Govender T. In vitro comparative evaluation of monolayered multipolymeric films embedded with didanosine-loaded solid lipid nanoparticles: a potential buccal drug delivery system for ARV therapy. Drug Dev. Ind. Pharm. 2014, 40:669.
    • (2014) Drug Dev. Ind. Pharm. , vol.40 , pp. 669
    • Jones, E.1    Ojewole, E.2    Kalhapure, R.3    Govender, T.4
  • 25
    • 33845712848 scopus 로고    scopus 로고
    • Spray drying conditions and encapsulating composition effects on formation and properties of sodium diclofenac microparticles
    • Ribeiro Rattes A.L., Pereira Oliveira W. Spray drying conditions and encapsulating composition effects on formation and properties of sodium diclofenac microparticles. Powder Technol. 2007, 171:7.
    • (2007) Powder Technol. , vol.171 , pp. 7
    • Ribeiro Rattes, A.L.1    Pereira Oliveira, W.2
  • 26
    • 34548696197 scopus 로고    scopus 로고
    • Applications of spray-drying in microencapsulation of food ingredients: an overview
    • Gharsallaoui A., Roudaut G., Chambin O., Voilley A., Saurel R. Applications of spray-drying in microencapsulation of food ingredients: an overview. Food Res. Int. 2007, 40:1107.
    • (2007) Food Res. Int. , vol.40 , pp. 1107
    • Gharsallaoui, A.1    Roudaut, G.2    Chambin, O.3    Voilley, A.4    Saurel, R.5
  • 27
    • 84860494497 scopus 로고    scopus 로고
    • Microencapsulation of Morinda citrifolia L. extract by spray-drying
    • Krishnaiah D., Sarbatly R., Nithyanandam R. Microencapsulation of Morinda citrifolia L. extract by spray-drying. Chem. Eng. Res. Des. 2012, 90:622.
    • (2012) Chem. Eng. Res. Des. , vol.90 , pp. 622
    • Krishnaiah, D.1    Sarbatly, R.2    Nithyanandam, R.3
  • 28
    • 77952698655 scopus 로고    scopus 로고
    • Electrospraying, spray drying and related techniques for production and formulation of drug nanoparticles
    • Peltonen L., Valo H., Kolakovic R., Laaksonen T., Hirvonen J. Electrospraying, spray drying and related techniques for production and formulation of drug nanoparticles. Expert Opin. Drug Deliv. 2010, 7:705.
    • (2010) Expert Opin. Drug Deliv. , vol.7 , pp. 705
    • Peltonen, L.1    Valo, H.2    Kolakovic, R.3    Laaksonen, T.4    Hirvonen, J.5
  • 29
    • 33645707180 scopus 로고    scopus 로고
    • Formulating drug delivery systems by spray drying
    • Ré M.I. Formulating drug delivery systems by spray drying. Dry. Technol. 2006, 24:433.
    • (2006) Dry. Technol. , vol.24 , pp. 433
    • Ré, M.I.1
  • 30
    • 33846496876 scopus 로고    scopus 로고
    • Preparation of redispersible dry nanocapsules by means of spray-drying: development and characterisation
    • Tewa-Tagne P., Briançon S., Fessi H. Preparation of redispersible dry nanocapsules by means of spray-drying: development and characterisation. Eur. J. Pharm. Sci. 2007, 30:124.
    • (2007) Eur. J. Pharm. Sci. , vol.30 , pp. 124
    • Tewa-Tagne, P.1    Briançon, S.2    Fessi, H.3
  • 31
    • 84908258289 scopus 로고    scopus 로고
    • Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method
    • in press
    • Tshweu L., Katata L., Kalombo L., Chiappetta D.A., Hocht C., Sosnik A., Swai H. Enhanced oral bioavailability of the antiretroviral efavirenz encapsulated in poly(epsilon-caprolactone) nanoparticles by a spray-drying method. Nanomedicine (Lond.) 2014, in press.
    • (2014) Nanomedicine (Lond.)
    • Tshweu, L.1    Katata, L.2    Kalombo, L.3    Chiappetta, D.A.4    Hocht, C.5    Sosnik, A.6    Swai, H.7
  • 32
    • 77957021388 scopus 로고    scopus 로고
    • Nanoparticles by spray drying using innovative new technology: the Büchi nano spray dryer B-90
    • Li X., Anton N., Arpagaus C., Belleteix F., Vandamme T.F. Nanoparticles by spray drying using innovative new technology: the Büchi nano spray dryer B-90. J. Control. Release 2010, 147:304.
    • (2010) J. Control. Release , vol.147 , pp. 304
    • Li, X.1    Anton, N.2    Arpagaus, C.3    Belleteix, F.4    Vandamme, T.F.5
  • 33
    • 75149175575 scopus 로고    scopus 로고
    • Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery
    • Mishra B., Patel B.B., Tiwari S. Colloidal nanocarriers: a review on formulation technology, types and applications toward targeted drug delivery. Nanomed. Nanotechnol. Biol. Med. 2010, 6:9.
    • (2010) Nanomed. Nanotechnol. Biol. Med. , vol.6 , pp. 9
    • Mishra, B.1    Patel, B.B.2    Tiwari, S.3
  • 34
  • 35
    • 51649091116 scopus 로고    scopus 로고
    • Conversion of nanosuspensions into dry powders by spray drying: a case study
    • Chaubal M.V., Popescu C. Conversion of nanosuspensions into dry powders by spray drying: a case study. Pharm. Res. 2008, 25:2302.
    • (2008) Pharm. Res. , vol.25 , pp. 2302
    • Chaubal, M.V.1    Popescu, C.2
  • 36
    • 77957588918 scopus 로고    scopus 로고
    • The return of a forgotten polymer-polycaprolactone in the 21st century
    • Woodruff M.A., Hutmacher D.W. The return of a forgotten polymer-polycaprolactone in the 21st century. Prog. Polym. Sci. 2010, 35:1217.
    • (2010) Prog. Polym. Sci. , vol.35 , pp. 1217
    • Woodruff, M.A.1    Hutmacher, D.W.2
  • 37
    • 84867252809 scopus 로고    scopus 로고
    • Electrospraying of polymers with therapeutic molecules: state of the art
    • Bock N., Dargaville T.R., Woodruff M.A. Electrospraying of polymers with therapeutic molecules: state of the art. Prog. Polym. Sci. 2012, 37:1510.
    • (2012) Prog. Polym. Sci. , vol.37 , pp. 1510
    • Bock, N.1    Dargaville, T.R.2    Woodruff, M.A.3
  • 38
    • 0037027882 scopus 로고    scopus 로고
    • Biodegradable poly(e-caprolactone) nanoparticles for tumor-targeted delivery of tamoxifen
    • Chawla J.S., Amiji M.M. Biodegradable poly(e-caprolactone) nanoparticles for tumor-targeted delivery of tamoxifen. Int. J. Pharm. 2002, 249:127.
    • (2002) Int. J. Pharm. , vol.249 , pp. 127
    • Chawla, J.S.1    Amiji, M.M.2
  • 39
    • 28744438866 scopus 로고    scopus 로고
    • The in vivo degradation, absorption and excretion of PCL-based implant
    • Sun H., Mei L., Song C., Cui X., Wang P. The in vivo degradation, absorption and excretion of PCL-based implant. Biomaterials 2006, 27:1735.
    • (2006) Biomaterials , vol.27 , pp. 1735
    • Sun, H.1    Mei, L.2    Song, C.3    Cui, X.4    Wang, P.5
  • 40
    • 84866485610 scopus 로고    scopus 로고
    • Poly(e-caprolactone), Eudragit® RS 100 and poly(e-caprolactone)/Eudragit® RS 100 blend submicron particles for the sustained release of the antiretroviral efavirenz
    • Seremeta K.P., Chiappetta D.A., Sosnik A. Poly(e-caprolactone), Eudragit® RS 100 and poly(e-caprolactone)/Eudragit® RS 100 blend submicron particles for the sustained release of the antiretroviral efavirenz. Colloid. Surf. B Biointerfaces 2013, 102:441.
    • (2013) Colloid. Surf. B Biointerfaces , vol.102 , pp. 441
    • Seremeta, K.P.1    Chiappetta, D.A.2    Sosnik, A.3
  • 41
    • 79959264990 scopus 로고    scopus 로고
    • Fast and efficient synthesis of high molecular weight poly(epsilon-caprolactone) diols by microwave-assisted polymer synthesis
    • Gotelli G.A., Bonelli P., Abraham G.A., Sosnik A. Fast and efficient synthesis of high molecular weight poly(epsilon-caprolactone) diols by microwave-assisted polymer synthesis. J. Appl. Polym. Sci. 2011, 121:1321.
    • (2011) J. Appl. Polym. Sci. , vol.121 , pp. 1321
    • Gotelli, G.A.1    Bonelli, P.2    Abraham, G.A.3    Sosnik, A.4
  • 42
    • 77953915263 scopus 로고    scopus 로고
    • Molecular implications in the nanoencapsulation of the anti-tuberculosis drug rifampicin within flower-like polymeric micelles
    • Moretton M.A., Glisoni R.J., Chiappetta D.A., Sosnik A. Molecular implications in the nanoencapsulation of the anti-tuberculosis drug rifampicin within flower-like polymeric micelles. Colloid. Surf. B Biointerfaces 2010, 79:467.
    • (2010) Colloid. Surf. B Biointerfaces , vol.79 , pp. 467
    • Moretton, M.A.1    Glisoni, R.J.2    Chiappetta, D.A.3    Sosnik, A.4
  • 43
    • 13244260729 scopus 로고    scopus 로고
    • Preparation and characterization of 5-fluorouracil-loaded poly(e-caprolactone) microspheres for drug administration
    • Sastre R.L., Blanco M.D., Teijón C., Olmo R., Teijón J.M. Preparation and characterization of 5-fluorouracil-loaded poly(e-caprolactone) microspheres for drug administration. Drug Develop. Res. 2004, 63:41.
    • (2004) Drug Develop. Res. , vol.63 , pp. 41
    • Sastre, R.L.1    Blanco, M.D.2    Teijón, C.3    Olmo, R.4    Teijón, J.M.5
  • 45
    • 0024563628 scopus 로고
    • Stress effects on gastrointestinal transit in the rat
    • Enck P., Merlin V., Erckenbrecht J.F., Wienbeck M. Stress effects on gastrointestinal transit in the rat. Gut 1989, 30:455.
    • (1989) Gut , vol.30 , pp. 455
    • Enck, P.1    Merlin, V.2    Erckenbrecht, J.F.3    Wienbeck, M.4
  • 46
    • 79953825653 scopus 로고    scopus 로고
    • Bifunctional peptidomimetic prodrugs of didanosine for improved intestinal permeability and enhanced acidic stability: synthesis, transepithelial transport, chemical stability and pharmacokinetics
    • Yan Z., Sun J., Chang Y., Liu Y., Fu Q., Xu Y., Sun Y., Pu X., Zhang Y., Jing Y., Yin S., Zhu M., Wang Y., He Z. Bifunctional peptidomimetic prodrugs of didanosine for improved intestinal permeability and enhanced acidic stability: synthesis, transepithelial transport, chemical stability and pharmacokinetics. Mol. Pharmaceutics 2011, 8:319.
    • (2011) Mol. Pharmaceutics , vol.8 , pp. 319
    • Yan, Z.1    Sun, J.2    Chang, Y.3    Liu, Y.4    Fu, Q.5    Xu, Y.6    Sun, Y.7    Pu, X.8    Zhang, Y.9    Jing, Y.10    Yin, S.11    Zhu, M.12    Wang, Y.13    He, Z.14
  • 47
    • 78751705732 scopus 로고    scopus 로고
    • Oral pharmacokinetics of the anti-HIV efavirenz encapsulated within polymeric micelles
    • Chiappetta D.A., Hocht C., Taira C., Sosnik A. Oral pharmacokinetics of the anti-HIV efavirenz encapsulated within polymeric micelles. Biomaterials 2011, 32:2379.
    • (2011) Biomaterials , vol.32 , pp. 2379
    • Chiappetta, D.A.1    Hocht, C.2    Taira, C.3    Sosnik, A.4
  • 48
    • 0037381525 scopus 로고    scopus 로고
    • Droplet and particle size relationship and shell thickness of inhalable lactose particles during spray drying
    • Elversson J., Millqvist-Fureby A., Alderborn G., Elofsson U. Droplet and particle size relationship and shell thickness of inhalable lactose particles during spray drying. J. Pharm. Sci. 2003, 92:900.
    • (2003) J. Pharm. Sci. , vol.92 , pp. 900
    • Elversson, J.1    Millqvist-Fureby, A.2    Alderborn, G.3    Elofsson, U.4
  • 49
    • 28244494087 scopus 로고    scopus 로고
    • The influence of formulation components on the aerosolisation properties of spray-dried powders
    • Rabbani N.R., Seville P.C. The influence of formulation components on the aerosolisation properties of spray-dried powders. J. Control. Release 2005, 110:130.
    • (2005) J. Control. Release , vol.110 , pp. 130
    • Rabbani, N.R.1    Seville, P.C.2
  • 50
    • 77953544033 scopus 로고    scopus 로고
    • Spray drying formulation of hollow spherical aggregates of silica nanoparticles by experimental design
    • Cheow W.S., Li S., Hadinoto K. Spray drying formulation of hollow spherical aggregates of silica nanoparticles by experimental design. Chem. E. Res. Design 2010, 88:673.
    • (2010) Chem. E. Res. Design , vol.88 , pp. 673
    • Cheow, W.S.1    Li, S.2    Hadinoto, K.3
  • 52
    • 79651473099 scopus 로고    scopus 로고
    • Progress in developing spray-drying methods for the production of controlled morphology particles: from the nanometer to submicrometer size ranges
    • Nandiyanto A.B.D., Okuyama K. Progress in developing spray-drying methods for the production of controlled morphology particles: from the nanometer to submicrometer size ranges. Adv. Powder Technol. 2011, 22:1.
    • (2011) Adv. Powder Technol. , vol.22 , pp. 1
    • Nandiyanto, A.B.D.1    Okuyama, K.2
  • 55
    • 0347360189 scopus 로고    scopus 로고
    • Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung
    • Sham J.O.-H., Zhang Y., Finlay W.H., Roa W.H., Löbenberg R. Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung. Int. J. Pharm. 2004, 269:457.
    • (2004) Int. J. Pharm. , vol.269 , pp. 457
    • Sham, J.O.-H.1    Zhang, Y.2    Finlay, W.H.3    Roa, W.H.4    Löbenberg, R.5
  • 56
    • 0034712966 scopus 로고    scopus 로고
    • Parameters influencing the antigen release from spray-dried poly(DL-lactide) microparticles
    • Baras B., Benoit M.-A., Gillard J. Parameters influencing the antigen release from spray-dried poly(DL-lactide) microparticles. Int. J. Pharm. 2000, 200:133.
    • (2000) Int. J. Pharm. , vol.200 , pp. 133
    • Baras, B.1    Benoit, M.-A.2    Gillard, J.3
  • 57
    • 79953162179 scopus 로고    scopus 로고
    • Surfactant-free redispersible nanoparticles in fast-dissolving composite microcarriers for dry-powder inhalation
    • Lebhardt T., Roesler S., Uusitalo H.P., Kissel T. Surfactant-free redispersible nanoparticles in fast-dissolving composite microcarriers for dry-powder inhalation. Eur. J. Pharm. Biopharm. 2011, 78:90.
    • (2011) Eur. J. Pharm. Biopharm. , vol.78 , pp. 90
    • Lebhardt, T.1    Roesler, S.2    Uusitalo, H.P.3    Kissel, T.4
  • 58
    • 0343407048 scopus 로고    scopus 로고
    • Spray-drying of solid lipid nanoparticles (SLNTM)
    • Freitas C., Müller R.H. Spray-drying of solid lipid nanoparticles (SLNTM). Eur. J. Pharm. Biopharm. 1998, 46:145.
    • (1998) Eur. J. Pharm. Biopharm. , vol.46 , pp. 145
    • Freitas, C.1    Müller, R.H.2
  • 59
    • 0032078388 scopus 로고    scopus 로고
    • Recombinant human erythropoietin (rhEPO) loaded poly(lactide-co-glycolide) microspheres: influence of the encapsulation technique and polymer purity on microsphere characteristics
    • Bittner B., Morlock M., Koll H., Winter G., Kissel T. Recombinant human erythropoietin (rhEPO) loaded poly(lactide-co-glycolide) microspheres: influence of the encapsulation technique and polymer purity on microsphere characteristics. Eur. J. Pharm. Biopharm. 1998, 45:295.
    • (1998) Eur. J. Pharm. Biopharm. , vol.45 , pp. 295
    • Bittner, B.1    Morlock, M.2    Koll, H.3    Winter, G.4    Kissel, T.5
  • 60
    • 14844318092 scopus 로고    scopus 로고
    • Effects of process variables on the powder yield of spray-dried trehalose on a laboratory spray-dryer
    • Maury M., Murphy K., Kumar S., Shi L., Lee G. Effects of process variables on the powder yield of spray-dried trehalose on a laboratory spray-dryer. Eur. J. Pharm. Biopharm. 2005, 59:565.
    • (2005) Eur. J. Pharm. Biopharm. , vol.59 , pp. 565
    • Maury, M.1    Murphy, K.2    Kumar, S.3    Shi, L.4    Lee, G.5
  • 61
    • 12344290280 scopus 로고    scopus 로고
    • Spray-drying of proteins: effects of sorbitol and trehalose on aggregation and FT-IR amide I spectrum of an immunoglobulin G
    • Maury M., Murphy K., Kumar S., Mauerer A., Lee G. Spray-drying of proteins: effects of sorbitol and trehalose on aggregation and FT-IR amide I spectrum of an immunoglobulin G. Eur. J. Pharm. Biopharm. 2005, 59:251.
    • (2005) Eur. J. Pharm. Biopharm. , vol.59 , pp. 251
    • Maury, M.1    Murphy, K.2    Kumar, S.3    Mauerer, A.4    Lee, G.5
  • 62
    • 0037148657 scopus 로고    scopus 로고
    • The effect of process variables on the degradation and physical properties of spray dried insulin intended for inhalation
    • Ståhl K., Claesson M., Lilliehorn P., Lindén H., Bäckström K. The effect of process variables on the degradation and physical properties of spray dried insulin intended for inhalation. Int. J. Pharm. 2002, 233:227.
    • (2002) Int. J. Pharm. , vol.233 , pp. 227
    • Ståhl, K.1    Claesson, M.2    Lilliehorn, P.3    Lindén, H.4    Bäckström, K.5
  • 63
    • 78650179651 scopus 로고    scopus 로고
    • Nano spray drying: a novel method for preparing protein nanoparticles for protein therapy
    • Lee S.H., Heng D., Ng W.K., Chan H.-K., Tan R.B.H. Nano spray drying: a novel method for preparing protein nanoparticles for protein therapy. Int. J. Pharm. 2011, 403:192.
    • (2011) Int. J. Pharm. , vol.403 , pp. 192
    • Lee, S.H.1    Heng, D.2    Ng, W.K.3    Chan, H.-K.4    Tan, R.B.H.5
  • 65
    • 0141919789 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-poly(epsilon-caprolactone) block oligomers as injectable materials
    • Sosnik A., Cohn D. Poly(ethylene glycol)-poly(epsilon-caprolactone) block oligomers as injectable materials. Polymer 2003, 44:7033.
    • (2003) Polymer , vol.44 , pp. 7033
    • Sosnik, A.1    Cohn, D.2
  • 66
    • 28744454127 scopus 로고    scopus 로고
    • PEO-PPO-PEO-based poly(ether ester urethane)s as degradable reverse thermo-responsive multiblock copolymers
    • Cohn D., Lando G., Sosnik A., Garty S., Levi A. PEO-PPO-PEO-based poly(ether ester urethane)s as degradable reverse thermo-responsive multiblock copolymers. Biomaterials 2006, 27:1718.
    • (2006) Biomaterials , vol.27 , pp. 1718
    • Cohn, D.1    Lando, G.2    Sosnik, A.3    Garty, S.4    Levi, A.5
  • 67
    • 79953252586 scopus 로고    scopus 로고
    • Formulation development and in vitro evaluation of didanosine-loaded nanostructured lipid carriers for the potential treatment of AIDS dementia complex
    • Kasongo K.W., Shegokar R., Müller R.H., Walker R.B. Formulation development and in vitro evaluation of didanosine-loaded nanostructured lipid carriers for the potential treatment of AIDS dementia complex. Drug Dev. Ind. Pharm. 2011, 37:396.
    • (2011) Drug Dev. Ind. Pharm. , vol.37 , pp. 396
    • Kasongo, K.W.1    Shegokar, R.2    Müller, R.H.3    Walker, R.B.4
  • 68
    • 84861651995 scopus 로고    scopus 로고
    • Poly-e-caprolactone based formulations for drug delivery and tissue engineering: A review
    • Dash T.K., Konkimalla V.B. Poly-e-caprolactone based formulations for drug delivery and tissue engineering: A review. J. Control. Release 2012, 158:15.
    • (2012) J. Control. Release , vol.158 , pp. 15
    • Dash, T.K.1    Konkimalla, V.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.