Lipidomic profiling reveals significant alterations in lipid biochemistry in hypothyroid rat cerebellum and the therapeutic effects of Sini decoction

Journal of Ethnopharmacology

Volumn 159, Issue , 2015, Pages 262-273

  Wu, Si ^a,c   Chen, Si ^a   Dong, Xin ^a   Tan, Guangguo ^a,b   Li, Wuhong ^a   Lou, Ziyang ^a   Zhu, Zhenyu ^a   Chai, Yifeng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c MAX PLANCK INSTITUTE OF MOLECULAR PLANT PHYSIOLOGY   (Germany)

Author keywords

Cerebellum; Hypothyroidism; Lipidomic profiling; Sini decoction; Traditional Chinese medicine; Ultra high performance liquid chromatography mass spectrometry

Indexed keywords

ARACHIDONIC ACID; BIOLOGICAL MARKER; CERAMIDE; FATTY ACID; GLYCEROLIPID; GLYCEROPHOSPHOLIPID; LEVOTHYROXINE; LINOLEIC ACID; LIPID; LYSOPHOSPHATIDYLCHOLINE; PALMITIC ACID; PHOSPHATIDYLCHOLINE; PHYTOSPHINGOSINE; PLANT EXTRACT; SINI DECOCTION; SPHINGANINE; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOSINE; THYROID HORMONE; THYROMIMETIC AGENT; UNCLASSIFIED DRUG; HERBACEOUS AGENT; LIOTHYRONINE; SINI TANG; THYROTROPIN; THYROXINE;

ACONITUM CARMICHAELII; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CEREBELLUM; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FATTY ACID OXIDATION; GINGER; GLYCYRRHIZA URALENSIS; HYPOTHYROIDISM; LIPID ANALYSIS; LIPID BRAIN LEVEL; LIPIDOMICS; MALE; NONHUMAN; PATHOPHYSIOLOGY; PHOSPHOLIPID METABOLISM; RAT; SHAM PROCEDURE; SIMULATION; SPHINGOLIPID METABOLISM; THYROIDECTOMY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; BLOOD; LIPID METABOLISM; METABOLISM; METABOLOMICS; WISTAR RAT;

RATTUS;

ANIMALS; CEREBELLUM; DRUGS, CHINESE HERBAL; HYPOTHYROIDISM; LIPID METABOLISM; MALE; METABOLOMICS; RATS, WISTAR; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 84915747548     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.11.033     Document Type: Article

References (53)

1. K.H. Alzoubi, N.Z. Gerges, A.M. Aleisa, and K.A. Alkadhi Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: behavioral, electrophysiological, and molecular studies Hippocampus 19 2009 66 78
2. G.W. Anderson Thyroid hormone and cerebellar development (London, England) Cerebellum 7 2008 60 74
3. G.W. Anderson, R.J. Larson, D.R. Oas, C.R. Sandhofer, H.L. Schwartz, C.N. Mariash, and J.H. Oppenheimer Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) modulates expression of the Purkinje cell protein-2 gene. A potential role for COUP-TF in repressing premature thyroid hormone action in the developing brain The Journal of Biological Chemistry 273 1998 16391 16399
4. Alex H. Brown Lipidomics: when apocrypha becomes canonical Current Opinion in Chemical Biology 16 2012 221 226
5. N.A. Babenko Long- and short-term effects of thyroxine on sphingolipid metabolism in rat liver Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 11 2005 BR131 BR138
6. N.A. Babenko, and Y.A. Natarova Role of thyroid hormones in regulation of sphingomyelin metabolism in the liver Biochemistry (Biokhimiia) 64 1999 912 915
7. S. Bijlsma, I. Bobeldijk, E.R. Verheij, R. Ramaker, S. Kochhar, I.A. Macdonald, B. van Ommen, and A.K. Smilde Large-scale human metabolomics studies: a strategy for data (pre-) processing and validation Analytical Chemistry 78 2006 567 574
8. H. Birbes, S. El Bawab, L.M. Obeid, and Y.A. Hannun Mitochondria and ceramide: intertwined roles in regulation of apoptosis Advances in Enzyme Regulation 42 2002 113 129
9. N.A. Bourbon, L. Sandirasegarane, and M. Kester Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest The Journal of Biological Chemistry 277 2002 3286 3292
10. Y. Cai, Y. Gao, G. Tan, S. Wu, X. Dong, Z. Lou, Z. Zhu, and Y. Chai Myocardial lipidomics profiling delineate the toxicity of traditional chinese medicine aconiti lateralis radix praeparata Journal of Ethnopharmacology 2013
11. F. Chantoux, and J. Francon Thyroid hormone regulates the expression of NeuroD/BHF1 during the development of rat cerebellum Molecular and Cellular Endocrinology 194 2002 157 163
12. F. Chatonnet, F. Picou, T. Fauquier, and F. Flamant Thyroid hormone action in cerebellum and cerebral cortex development Journal of Thyroid Research 2011 2011 145762
13. J.W. Choi, and H.S. Choi The regulatory effects of thyroid hormone on the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase Endocrine research 26 2000 1 21
14. C. Constantinou, P.K. Chrysanthopoulos, M. Margarity, and M.I. Klapa GC-MS metabolomic analysis reveals significant alterations in cerebellar metabolic physiology in a mouse model of adult onset hypothyroidism Journal of Proteome Research 10 2011 869 879
15. A.Q. Dang, F.H. Faas, and W.J. Carter Influence of hypo- and hyperthyroidism on rat liver glycerophospholipid metabolism Lipids 20 1985 897 902
16. L.H. Duntas, and G. Brenta The effect of thyroid disorders on lipid levels and metabolism The Medical clinics of North America 96 2012 269 281
17. A.N. Fonteh, J. Chiang, M. Cipolla, J. Hale, F. Diallo, A. Chirino, X. Arakaki, and M.G. Harrington Alterations in cerebrospinal fluid glycerophospholipids and phospholipase A2 activity in Alzheimer's disease Journal of Lipid Research 54 2013 2884 2897
18. J. Gao, V.G. Tarcea, A. Karnovsky, B.R. Mirel, T.E. Weymouth, C.W. Beecher, J.D. Cavalcoli, B.D. Athey, G.S. Omenn, C.F. Burant, and H.V. Jagadish Metscape: a Cytoscape plug-in for visualizing and interpreting metabolomic data in the context of human metabolic networks (Oxford, England) Bioinformatics 26 2010 971 973
19. C.R. Gault, L.M. Obeid, and Y.A. Hannun An overview of sphingolipid metabolism: from synthesis to breakdown Advances in Experimental Medicine and Biology 688 2010 1 23
20. A. Garcia, and C. Barbas Gas chromatography-mass spectrometry (GC-MS)-based metabolomics (Clifton, N.J.) Methods in Molecular Biology 708 2011 191 204
21. H.G. Gika, G.A. Theodoridis, J.E. Wingate, and I.D. Wilson Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: application to human urine Journal of Proteome Research 6 2007 3291 3303
22. M. Gorska, A. Dobrzyn, J. Langfort, and J. Gorski Effect of hypothyreosis on the content of ceramides in rat tissues Journal of Physiology and Pharmacology: an Official Journal of the Polish Physiological Society 54 2003 89 97
23. T. Hao, H.W. Ma, X.M. Zhao, and I. Goryanin The reconstruction and analysis of tissue specific human metabolic networks Molecular bioSystems 8 2012 663 670
24. M. Heilmann, and I. Heilmann Mass measurement of polyphosphoinositides by thin-layer and gas chromatography (Clifton, N.J.) Methods in Molecular Biology 1009 2013 25 32
25. W.L. Holland, E.C. Stauter, and B.J. Stith Quantification of phosphatidic acid and lysophosphatidic acid by HPLC with evaporative light-scattering detection Journal of Lipid Research 44 2003 854 858
26. J. Ji, A.E. Kline, A. Amoscato, A.K. Samhan-Arias, L.J. Sparvero, V.A. Tyurin, Y.Y. Tyurina, B. Fink, M.D. Manole, A.M. Puccio, D.O. Okonkwo, J.P. Cheng, H. Alexander, R.S. Clark, P.M. Kochanek, P. Wipf, V.E. Kagan, and H. Bayir Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury Nature Neuroscience 15 2012 1407 1413
27. L. Johansson, M. Rudling, T.S. Scanlan, T. Lundasen, P. Webb, J. Baxter, B. Angelin, and P. Parini Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice Proceedings of the National Academy of Sciences of the United States of America 102 2005 10297 10302
28. M. Jove, V. Ayala, O. Ramirez-Nunez, J.C. Serrano, A. Cassanye, L. Arola, A. Caimari, J.M. Del Bas, A. Crescenti, R. Pamplona, and M. Portero-Otin Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters Cardiovascular Research 97 2013 642 652
29. A. Karnovsky, T. Weymouth, T. Hull, V.G. Tarcea, G. Scardoni, C. Laudanna, M.A. Sartor, K.A. Stringer, H.V. Jagadish, C. Burant, B. Athey, and G.S. Omenn Metscape 2 bioinformatics tool for the analysis and visualization of metabolomics and gene expression data (Oxford, England) Bioinformatics 28 2012 373 380
30. N. Koibuchi, and W.W. Chin ROR alpha gene expression in the perinatal rat cerebellum: ontogeny and thyroid hormone regulation Endocrinology 139 1998 2335 2341
31. N. Koibuchi, H. Jingu, T. Iwasaki, and W.W. Chin Current perspectives on the role of thyroid hormone in growth and development of cerebellum (London, England) Cerebellum 2 2003 279 289
32. P. Miaorong, and W. Xiaoying Study on effect of various extract of Sini Decoction on reproductive organ and sexual hormone of hypothyroidism rats with syndrome of yang deficiency China Journal of Traditional Chinese Medicine and Pharmacy 2010
33. C. Mulder, L.O. Wahlund, T. Teerlink, M. Blomberg, R. Veerhuis, G.J. van Kamp, P. Scheltens, and P.G. Scheffer Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer's disease (Vienna, Austria: 1996) Journal of Neural Transmission 110 2003 949 955
34. I. Neveu, and E. Arenas Neurotrophins promote the survival and development of neurons in the cerebellum of hypothyroid rats in vivo The Journal of Cell Biology 133 1996 631 646
35. PR China, and E.C.o.P.o.M.o.H The Pharmacopoeia of People's Republic of China 2010 Chinese Medical Science and Technology Press Beijing, China
36. A.D. Patterson, O. Maurhofer, D. Beyoglu, C. Lanz, K.W. Krausz, T. Pabst, F.J. Gonzalez, J.F. Dufour, and J.R. Idle Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling Cancer Research 71 2011 6590 6600
37. G.J. Patti, O. Yanes, and G. Siuzdak Innovation: metabolomics: the Apogee of the Omics Trilogy Nature Reviews: Molecular Cell Biology 13 2012 263 269
38. O. Quehenberger, A.M. Armando, and E.A. Dennis High sensitivity quantitative lipidomics analysis of fatty acids in biological samples by gas chromatography-mass spectrometry Biochimica et Biophysica Acta 1811 2011 648 656
39. M.E. Rubio-Gozalbo, J.A. Bakker, H.R. Waterham, and R.J. Wanders Carnitine-acylcarnitine translocase deficiency, clinical, biochemical and genetic aspects Molecular Aspects of Medicine 25 2004 521 532
40. T. Sangster, H. Major, R. Plumb, A.J. Wilson, and I.D. Wilson A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis The Analyst 131 2006 1075 1078
41. D.J. Shin, and T.F. Osborne Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2) The Journal of Biological Chemistry 278 2003 34114 34118
42. C.A. Smith, E.J. Want, G. O'Maille, R. Abagyan, and G. Siuzdak XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification Analytical Chemistry 78 2006 779 787
43. E. Szymanska, E. Saccenti, A.K. Smilde, and J.A. Westerhuis Double-check: validation of diagnostic statistics for PLS-DA models in metabolomics studies Metabolomics: Official Journal of the Metabolomic Society 8 2012 3 16
44. G. Tan, W. Liao, X. Dong, G. Yang, Z. Zhu, W. Li, Y. Chai, and Z. Lou Metabonomic profiles delineate the effect of traditional Chinese medicine sini decoction on myocardial infarction in rats PloS One 7 2012 e34157
45. G. Tan, Z. Zhu, J. Jing, L. Lv, Z. Lou, G. Zhang, and Y. Chai Characterization of constituents in Sini decoction and rat plasma by high-performance liquid chromatography with diode array detection coupled to time-of-flight mass spectrometry Biomedical Chromatography: BMC 25 2011 913 924
46. A.E. Thumser, J.B. Moore, and N.J. Plant Fatty acid binding proteins: tissue-specific functions in health and disease Current Opinion in Clinical Nutrition and Metabolic Care 17 2014 124 129
47. J.E. Vance, and D.E. Vance Metabolic insights into phospholipid function using gene-targeted mice The Journal of Biological Chemistry 280 2005 10877 10880
48. M.R. Wenk The emerging field of lipidomics Nature reviews: Drug Discovery 4 2005 594 610
49. J. Westerhuis, E.J. van Velzen, H.J. Hoefsloot, and A. Smilde Discriminant Q2 (DQ2) for improved discrimination in PLSDA models Metabolomics: Official Journal of the Metabolomic Society 4 2008 293 296
50. S. Wu, Y. Gao, X. Dong, G. Tan, W. Li, Z. Lou, and Y. Chai Serum metabonomics coupled with Ingenuity Pathway Analysis characterizes metabolic perturbations in response to hypothyroidism induced by propylthiouracil in rats Journal of Pharmaceutical and Biomedical Analysis 72 2013 109 114
51. S. Wu, G. Tan, X. Dong, Z. Zhu, W. Li, Z. Lou, and Y. Chai Metabolic profiling provides a system understanding of hypothyroidism in rats and its application PloS One 8 2013 e55599
52. N.B. Zelinskaia The significance of studying phospholipids in the diagnosis of hypothyroidism Vrachebnoe Delo 1989 79 81
53. X. Zhou, J. Mao, J. Ai, Y. Deng, M.R. Roth, C. Pound, J. Henegar, R. Welti, and S.A. Bigler Identification of plasma lipid biomarkers for prostate cancer by lipidomics and bioinformatics PloS One 7 2012 e48889