Metabolic Profiling Provides a System Understanding of Hypothyroidism in Rats and Its Application

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Wu, Si ^a,b   Tan, Guangguo ^a,c   Dong, Xin ^a   Zhu, Zhenyu ^a,b   Li, Wuhong ^a,b   Lou, Ziyang ^a   Chai, Yifeng ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI KEY LABORATORY FOR PHARMACEUTICAL METABOLITE RESEARCH   (China)

^c The 22nd Hospital of Chinese People's Liberation Army   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHINESE DRUG; LEVOTHYROXINE; SINI DECOCTION; THYROXINE; UNCLASSIFIED DRUG;

ACONTIUM CARMICHAELI; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; GINGER; GLYCYRRHIZA URALENSIS; HYPOTHYROIDISM; LIPID METABOLISM; MALE; MEDICINAL PLANT; METABOLIC REGULATION; METABOLOMICS; MOLECULAR DYNAMICS; NONHUMAN; PHYTOCHEMISTRY; PURINE METABOLISM; RAT; THYROXINE BLOOD LEVEL; TIME OF FLIGHT MASS SPECTROMETRY; TREATMENT OUTCOME; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS;

ANIMALS; ANTITHYROID AGENTS; BIOLOGICAL MARKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYPOTHYROIDISM; MASS SPECTROMETRY; METABOLOMICS; MULTIVARIATE ANALYSIS; RATS; THYROIDECTOMY;

EID: 84873598922     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055599     Document Type: Article

References (67)

1. Hulbert AJ, (2000) Thyroid hormones and their effects: a new perspective. Biol Rev Camb Philos Soc 75: 519-631.
2. Puzianowska-Kuznicka M, Pietrzak M, Turowska O, Nauman A, (2006) Thyroid hormones and their receptors in the regulation of cell proliferation. Acta Biochim Pol 53: 641-650.
3. Williams GR, (2009) Actions of thyroid hormones in bone. Endokrynol Pol 60: 380-388.
4. Ermantas N, Guldiken S, Demir M, Tugrul A, (2010) Thrombin-activatable fibrinolysis inhibitor (TAFI) antigen and activity assay in patients with primary hypothyroidism. Clin Appl Thromb Hemost 16: 568-573.
5. Stabouli S, Papakatsika S, Kotsis V, (2010) Hypothyroidism and hypertension. Expert Rev Cardiovasc Ther 8: 1559-1565.
6. Krassas GE, Poppe K, Glinoer D, (2010) Thyroid function and human reproductive health. Endocr Rev 31: 702-755.
7. Koromilas C, Liapi C, Schulpis KH, Kalafatakis K, Zarros A, et al. (2010) Structural and functional alterations in the hippocampus due to hypothyroidism. Metab Brain Dis 25: 339-354.
8. Wiersinga WM, (2001) Thyroid hormone replacement therapy. Horm Res 56 Suppl 1: 74-81.
9. Clarke N, Kabadi UM, (2004) Optimizing treatment of hypothyroidism. Treat Endocrinol 3: 217-221.
10. Flynn RW, Bonellie SR, Jung RT, MacDonald TM, Morris AD, et al. (2010) Serum thyroid-stimulating hormone concentration and morbidity from cardiovascular disease and fractures in patients on long-term thyroxine therapy. J Clin Endocrinol Metab 95: 186-193.
11. La Vignera S, Vicari E, Tumino S, Ciotta L, Condorelli R, et al. (2008) L-thyroxin treatment and post-menopausal osteoporosis: relevance of the risk profile present in clinical history. Minerva Ginecol 60: 475-484.
12. Beckett GJ, Kellett HA, Gow SM, Hussey AJ, Hayes JD, et al. (1985) Raised plasma glutathione S-transferase values in hyperthyroidism and in hypothyroid patients receiving thyroxine replacement: evidence for hepatic damage. Br Med J (Clin Res Ed) 291: 427-431.
13. Wang L, Zhou GB, Liu P, Song JH, Liang Y, et al. (2008) Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci U S A 105: 4826-4831.
14. Zhao J, Jiang P, Zhang W, (2010) Molecular networks for the study of TCM pharmacology. Brief Bioinform 11: 417-430.
15. Xiang N (2005) Hypothyroidism. Beijing: People's Education Press. 65 p.
16. Zha LL, (1993) Relation of hypothyroidism and deficiency of kidney yang. Chinese journal of integrated traditional and Western medicine 13: 195-202.
17. Ding WJ, Zeng YZ, Li WH, Zhang TE, Liu WW, et al. (2009) Identification of Linkage Disequilibrium SNPs from a Kidney-Yang Deficiency Syndrome Pedigree. Am J Chin Med 37: 427-438.
18. Lu X, Xiong Z, Li J, Zheng S, Huo T, et al. (2011) Metabonomic study on 'Kidney-Yang Deficiency syndrome' and intervention effects of Rhizoma Drynariae extracts in rats using ultra performance liquid chromatography coupled with mass spectrometry. Talanta 83: 700-708.
19. Cai D, Chen X, Liu Y, (1999) Effect of regulation of kidney-yin and kidney-yang on hypothalamus-pituitary-adrenal-thymus axis in monosodium L-glutamate rats. Zhongguo Zhong Xi Yi Jie He Za Zhi 19: 415-417.
20. Miaorong P, Xiaoying W, (2010) Study on effect of various extract of Sini Decoction on reproductive organ and sexual hormone of hypothyroidism rats with syndrome of yang deficiency. China Journal of Traditional Chinese Medicine and Pharmacy.
21. Chinese Pharmacopoeia Commission (2010) Pharmacopeia of the People's Republic of China. Beijing: People's Medicine Publishing House. 650 p.
22. Liu Y, Wu WK, Chen C, Duan XF, (2006) Effect of delayed preconditioning induced by Sini decoction on myocardial cell apoptosis and its mitochondrial mechanism. Zhongguo Zhong Yao Za Zhi 31: 1269-1272.
23. Zhao MQ, Wu WK, Zhao DY, Duan XF, Liu Y, (2009) Protective effects of sini decoction on adriamycin-induced heart failure and its mechanism. Zhong Yao Cai 32: 1860-1863.
24. Tan G, Lou Z, Liao W, Zhu Z, Dong X, et al. (2011) Potential biomarkers in mouse myocardium of doxorubicin-induced cardiomyopathy: a metabonomic method and its application. PLoS One 6: e27683.
25. Tan G, Liao W, Dong X, Yang G, Zhu Z, et al. (2012) Metabonomic profiles delineate the effect of traditional chinese medicine sini decoction on myocardial infarction in rats. PLoS One 7: e34157.
26. Nicholson JK, Lindon JC, Holmes E, (1999) 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29: 1181-1189.
27. Ma T, Tan C, Zhang H, Wang M, Ding W, et al. (2010) Bridging the gap between traditional Chinese medicine and systems biology: the connection of Cold Syndrome and NEI network. Mol Biosyst 6: 613-619.
28. Liang X, Chen X, Liang Q, Zhang H, Hu P, et al. (2011) Metabonomic study of Chinese medicine Shuanglong formula as an effective treatment for myocardial infarction in rats. J Proteome Res 10: 790-799.
29. Wei J, Xie G, Ge S, Qiu Y, Liu W, et al. (2012) Metabolic transformation of DMBA-induced carcinogenesis and inhibitory effect of salvianolic acid b and breviscapine treatment. J Proteome Res 11: 1302-1316.
30. van Ravenzwaay B, Cunha GC, Leibold E, Looser R, Mellert W, et al. (2007) The use of metabolomics for the discovery of new biomarkers of effect. Toxicol Lett 172: 21-28.
31. Fegert I, Billington R, Botham P, Carney E, Fitzgerald RE, et al. (2012) Feasibility of the extended one-generation reproductive toxicity study (OECD 443). Reprod Toxicol 34: 331-339.
32. van Ravenzwaay B, Herold M, Kamp H, Kapp MD, Fabian E, et al. (2012) Metabolomics: a tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals-from QSAR to QBAR. Mutat Res 746: 144-150.
33. Constantinou C, Chrysanthopoulos PK, Margarity M, Klapa MI, (2011) GC-MS metabolomic analysis reveals significant alterations in cerebellar metabolic physiology in a mouse model of adult onset hypothyroidism. J Proteome Res 10: 869-879.
34. Sangster T, Major H, Plumb R, Wilson AJ, Wilson ID, (2006) A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis. Analyst 131: 1075-1078.
35. Chen J, Wang W, Lv S, Yin P, Zhao X, et al. (2009) Metabonomics study of liver cancer based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations. Anal Chim Acta 650: 3-9.
36. Wang X, Zhao T, Qiu Y, Su M, Jiang T, et al. (2008) Metabonomics Approach to Understanding Acute and Chronic stress in rat models. J Proteome Res 8 (5) (): 2511-8.
37. Xie G, Zheng X, Qi X, Cao Y, Chi Y, et al. (2010) Metabonomic evaluation of melamine-induced acute renal toxicity in rats. J Proteome Res 9: 125-133.
38. Zhang A, Sun H, Wang Z, Sun W, Wang P, et al. (2010) Metabolomics: towards understanding traditional Chinese medicine. Planta Med 76: 2026-2035.
39. Briere JJ, Favier J, Gimenez-Roqueplo AP, Rustin P, (2006) Tricarboxylic acid cycle dysfunction as a cause of human diseases and tumor formation. Am J Physiol Cell Physiol 291: C1114-1120.
40. Martinez B, Rodrigues TB, Gine E, Kaninda JP, Perez-Castillo A, et al. (2009) Hypothyroidism decreases the biogenesis in free mitochondria and neuronal oxygen consumption in the cerebral cortex of developing rats. Endocrinology 150: 3953-3959.
41. Yao Z, Yin P, Su D, Peng Z, Zhou L, et al. (2011) Serum metabolic profiling and features of papillary thyroid carcinoma and nodular goiter. Mol Biosyst 7: 2608-2614.
42. Gault CR, Obeid LM, Hannun YA, (2010) An overview of sphingolipid metabolism: from synthesis to breakdown. Adv Exp Med Biol 688: 1-23.
43. Babenko NA, Natarova YA, (1999) Role of thyroid hormones in regulation of sphingomyelin metabolism in the liver. Biochemistry (Mosc) 64: 912-915.
44. Gorska M, Dobrzyn A, Langfort J, Gorski J, (2003) Effect of hypothyreosis on the content of ceramides in rat tissues. J Physiol Pharmacol 54: 89-97.
45. Lyman EM, Dove JL, Sribney M, (1976) Effect of propylthiouracil-induced hypothyroidism on phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin synthesis in chick liver microsomes. Can J Biochem 54: 15-21.
46. Fernstrom JD, Fernstrom MH, (2007) Tyrosine, phenylalanine, and catecholamine synthesis and function in the brain. J Nutr 137: 1539S-1547S discussion 1548S.
47. Sjoberg S, Eriksson M, Nordin C, (1998) L-thyroxine treatment and neurotransmitter levels in the cerebrospinal fluid of hypothyroid patients: a pilot study. Eur J Endocrinol 139: 493-497.
48. Vaccari A, Rossetti ZL, de Montis G, Stefanini E, Martino E, et al. (1990) Neonatal hypothyroidism induces striatal dopaminergic dysfunction. Neuroscience 35: 699-706.
49. Carew LB Jr, Alster FA, Foss DC, Scanes CG, (1983) Effect of a tryptophan deficiency on thyroid gland, growth hormone and testicular functions in chickens. J Nutr 113: 1756-1765.
50. Kulikov A, Moreau X, Jeanningros R, (1999) Effects of experimental hypothyroidism on 5-HT1A, 5-HT2A receptors, 5-HT uptake sites and tryptophan hydroxylase activity in mature rat brain1. Neuroendocrinology 69: 453-459.
51. Mannisto PT, Ranta T, (1978) Neurotransmitter control of thyrotrophin secretion in hypothyroid rats. Acta Endocrinol (Copenh) 89: 100-107.
52. Dirican M, Tas S, Sarandol E, (2007) High-dose taurine supplementation increases serum paraoxonase and arylesterase activities in experimental hypothyroidism. Clin Exp Pharmacol Physiol 34: 833-837.
53. Tas S, Dirican M, Sarandol E, Serdar Z, (2006) The effect of taurine supplementation on oxidative stress in experimental hypothyroidism. Cell Biochem Funct 24: 153-158.
54. Liu Y, Qian XX, Wu WK, Zhou B, Chen L, et al. (2006) [Effects of Sini decoction on vascular stenosis after iliac artery balloon injury and oxidative stress in rabbits]. Nan Fang Yi Ke Da Xue Xue Bao 26: 1559-1562.
55. Zhao DY, Zhao MQ, Wu WK, (2008) Study on activity and mechanism of Sini Decoction anti-mitochondrial oxidation injury caused by myocardial ischemia/reperfusion. Zhong Yao Cai 31: 1681-1685.
56. He LP, Di B, Du YX, Yan F, Su MX, et al. (2009) Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the rapid simultaneous quantification of aconitine, mesaconitine, and hypaconitine in rat plasma after oral administration of Sini decoction. J Anal Toxicol 33: 588-594.
57. Singhuber J, Zhu M, Prinz S, Kopp B, (2009) Aconitum in traditional Chinese medicine: a valuable drug or an unpredictable risk? J Ethnopharmacol 126: 18-30.
58. Min Z, (2006) The comparative studies between Chinese medicine and western medicines (Zhongxi Bijiao Yiyaoxue Gailun). Higher Education Press pp. 75-90.
59. Baliga MS, Haniadka R, Pereira MM, D'Souza JJ, Pallaty PL, et al. (2011) Update on the chemopreventive effects of ginger and its phytochemicals. Crit Rev Food Sci Nutr 51: 499-523.
60. Yu Z, Guiyan X, Yujuan C, Yulian L, (1996) Altertion in effective constituents in the Sini Tang oral liquor before and after the combination of Radix Aconiti lateralis preparata and rhizoma zingberis. Heilongjiang Medicine and Pharmacy 19: 13-15.
61. Tan G, Zhu Z, Jing J, Lv L, Lou Z, et al. (2011) Characterization of constituents in Sini decoction and rat plasma by high-performance liquid chromatography with diode array detection coupled to time-of-flight mass spectrometry. Biomed Chromatogr 25: 913-924.
62. Rahimpour S, Nezami BG, Karimian N, Sotoudeh-Anvari M, Ebrahimi F, et al. (2012) Hypothyroidism improves random-pattern skin flap survival in rats. J Surg Res.
63. Jena S, Chainy GB, Dandapat J, (2012) Expression of antioxidant genes in renal cortex of PTU-induced hypothyroid rats: effect of vitamin E and curcumin. Mol Biol Rep 39: 1193-1203.
64. Sanchez-Huerta KB, Montes S, Perez-Severiano F, Alva-Sanchez C, Rios C, et al. (2012) Hypothyroidism reduces glutamate-synaptic release by ouabain depolarization in rat CA3-hippocampal region. J Neurosci Res 90: 905-912.
65. Alzoubi KH, Gerges NZ, Aleisa AM, Alkadhi KA, (2009) Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: Behavioral, electrophysiological, and molecular studies. Hippocampus 19: 66-78.
66. Smith CA, Want EJ, O'Maille G, Abagyan R, Siuzdak G, (2006) XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem 78: 779-787.
67. Bijlsma S, Bobeldijk I, Verheij ER, Ramaker R, Kochhar S, et al. (2006) Large-scale human metabolomics studies: a strategy for data (pre-) processing and validation. Anal Chem 78: 567-574.