Characterization of constituents in Sini decoction and rat plasma by high-performance liquid chromatography with diode array detection coupled to time-of-flight mass spectrometry

Biomedical Chromatography

Volumn 25, Issue 8, 2011, Pages 913-924

  Tan, Guangguo ^a   Zhu, Zhenyu ^a   Jing, Jing ^a   Lv, Lei ^a   Lou, Ziyang ^a   Zhang, Guoqing ^a   Chai, Yifeng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Active components; HPLC DAD TOFMS; Sini decoction; Structural characterization

Indexed keywords

BODY FLUIDS; CHEMICAL DETECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONS; MASS SPECTROMETRY; RATS;

ACTIVE COMPONENTS; CHEMICAL COMPOSITIONS; FRAGMENT IONS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH DIODE ARRAY DETECTION; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH DIODE-ARRAY DETECTION COUPLED TO TIME-OF-FLIGHT MASS SPECTROMETRY; ORAL ADMINISTRATION; RAT PLASMA; SINI DECOCTION; STRUCTURAL CHARACTERIZATION; TIME OF FLIGHT MASS SPECTROMETRY;

METABOLITES;

CHINESE DRUG; DITERPENOID; FLAVONOID; GINGEROL; HERBACEOUS AGENT; SINI DECOCTION; TRITERPENOID; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DIODE; DIODE ARRAY DETECTION; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG QUALITY; DRUG STRUCTURE; ELECTRIC POTENTIAL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; ION TRANSPORT; MALE; MEASUREMENT ERROR; NONHUMAN; RAT; STRUCTURE ANALYSIS; TIME OF FLIGHT MASS SPECTROMETRY;

RATTUS;

EID: 79960014541     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1544     Document Type: Article

References (24)

1. Chan EC, Yap SL, Lau AJ, Leow PC, Toh DF and Koh HL. Ultra-performance liquid chromatography/time-of-flight mass spectrometry based metabolomics of raw and steamed Panax notoginseng. Rapid Communications in Mass Spectrometry 2007; 21(4): 519-528.
2. Chen Y, Koelliker S, Oehme M and Katz A. Isolation of diterpenoid alkaloids from herb and flowers of aconitum napellus ssp. vulgare and electrospray ion trap multiple MS study of these alkaloids. Journal of Natural Products 1999; 62(5): 701-704.
3. Chinese Pharmacopoeia Commission. Pharmacopoeia of the Peoples Republic of China, Vol. I. Beijing: Chemical Industry Press, 2005.
4. Guo Y, Yang X, Xiao S, Chong Z and Lin W. The regulating effect and mechanism of Sini decoction on vascular active substance in renovascular hypertensive rats. Chinese Pharmacological Bulletin 2008; 24(1): 79-83.
5. Hao H, Cui N, Wang G, Xiang B, Liang Y, Xu X, Zhang H, Yang J, Zheng C, Wu L, Gong P and Wang W. Global detection and identification of nontarget components from herbal preparations by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a strategy. Analytical Chemistry 2008; 80(21): 8187-8194.
6. He LP, Di B, Du YX, Yan F, Su MX, Liu HQ and You LJ. Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the rapid simultaneous quantification of aconitine, mesaconitine, and hypaconitine in rat plasma after oral administration of Sini decoction. Journal of Analytical Toxicology 2009; 33(9): 588-594.
7. Ibáñez M, Sancho JV, Hernández F, McMillan D and Rao R. Rapid non-target screening of organic pollutants in water by ultraperformance liquid chromatography coupled to time-of-light mass spectrometry. Trends in Analytical Chemistry 2008; 27(5): 481-489.
8. Kind T and Fiehn O. Metabolomic database annotations via query of elemental compositions: mass accuracy is insufficient even at less than 1ppm. BMC Bioinformatics 2006; 7: 234.
9. Konno C, Shirasaka M and Hikino H. Structure of senbusine A, B and C, diterpenie alkaloids of Aconitum carmichaeli roots From China. Journal of Natural Products 1982; 45(2): 128-133.
10. Liu X, Liu G, Chen Y, Li J and Hu J. Effects of Sini decoction against pulmonary injury induced by ex vivo ischemia-reperfusion in rats. Chinese Journal of Pathophysiology 2008; 24(4): 680-682.
11. Ohta H, Seto Y, Tsunoda N, Takahashi Y, Matsuura K and Ogasawara K. Determination of Aconitum alkaloids in blood and urine samples: II. Capillary liquid chromatographic-frit fast atom bombardment mass spectrometric analysis. Journal of Chromatography B 1998; 714(2): 215-221.
12. Ohtani K, Kasai R, Yang C-R, Yamasaki K, Zhou J and Tanaka O. Oleanane glycosides from roots of Glycyrrhiza yunnanensis. Phytochemistry 1994; 36(1): 139-145.
13. Simons R, Vincken JP, Bakx EJ, Verbruggen MA and Gruppen H. A rapid screening method for prenylated flavonoids with ultra-high-performance liquid chromatography/electrospray ionisation mass spectrometry in licorice root extracts. Rapid Communications in Mass Spectrometry 2009; 23(19): 3083-3093.
14. Suekawa M, Ishige A, Yuasa K, Sudo K, Aburada M and Hosoya E. Pharmacological studies on ginger. I. Pharmacological actions of pungent constitutents, (6)-gingerol and (6)-shogaol. Journal of Pharmacobiodyn 1984; 7(11): 836-848.
15. Sultankhodzhaev MN, Yunusov MS and Yu SY. Alkaloids of Aconitum karakolicum. Chemistry of Natural Compounds 1973; 9(1): 129-130.
16. Tang Q, Yang C, Ye W, Liu J and Zhao S. Preparative isolation and purification of chemical components from Aconitum coreanum by high-speed counter-current chromatography coupled with evaporative light scattering detection. Phytochemical Analysis 2008; 19(2): 155-159.
17. Wang W, Li C-Y, Wen X-D, Li P and Qi L-W. Plasma pharmacokinetics, tissue distribution and excretion study of 6-gingerol in rat by liquid chromatography-electrospray ionization time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2009; 49(4): 1070-1074.
18. Wang X, Sun W, Sun H, Lv H, Wu Z, Wang P, Liu L and Cao H. Analysis of the constituents in the rat plasma after oral administration of Yin Chen Hao Tang by UPLC/Q-TOF-MS/MS. Journal of Pharmaceutical and Biomedical Analysis 2008; 46(3): 477-490.
19. Yang L, Liu YL and Lin SQ. HPLC analysis of flavonoids in the root of six Glycyrrhiza species. Yao Xue Xue Bao 1990; 25(11): 840-848.
20. Ye M, Liu SH, Jiang Z, Lee Y, Tilton R and Cheng YC. Liquid chromatography/mass spectrometry analysis of PHY906, a Chinese medicine formulation for cancer therapy. Rapid Communications in Mass Spectrometry 2007; 21(22): 3593-3607.
21. Yue H, Pi Z, Song F, Liu Z, Cai Z and Liu S. Studies on the aconitine-type alkaloids in the roots of Aconitum Carmichaeli Debx. by HPLC/ESIMS/MSn. Talanta 2009; 77(5): 1800-1807.
22. Zhang H, Guo Z, Li W, Feng J, Xiao Y, Zhang F, Xue X and Liang X. Purification of flavonoids and triterpene saponins from the licorice extract using preparative HPLC under RP and HILIC mode. Journal of Separation Science 2009; 32(4): 526-535.
23. Zhang Q and Ye M. Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice). Journal of Chromatography A 2009; 1216(11): 1954-1969.
24. Zheng X, Shi P, Cheng Y and Qu H. Rapid analysis of a Chinese herbal prescription by liquid chromatography-time-of-flight tandem mass spectrometry. Journal of Chromatography A 2008; 1206(2): 140-146.