Serum metabonomics coupled with Ingenuity Pathway Analysis characterizes metabolic perturbations in response to hypothyroidism induced by propylthiouracil in rats

Journal of Pharmaceutical and Biomedical Analysis

Volumn 72, Issue , 2013, Pages 109-114

  Wu, Si ^a,b   Gao, Yue ^a   Dong, Xin ^a   Tan, Guangguo ^a,b   Li, Wuhong ^a,b   Lou, Ziyang ^a   Chai, Yifeng ^a,b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI KEY LABORATORY FOR PHARMACEUTICAL METABOLITE RESEARCH   (China)

Author keywords

Hypothyroidism; Ingenuity Pathway Analysis; Metabonomics; Propylthiouracil; Ultra performance liquid chromatography mass spectrometry

Indexed keywords

ARACHIDONIC ACID; BIOLOGICAL MARKER; BUTYRYLCARNITINE; CARNITINE; FATTY ACID; LIOTHYRONINE; METHIONINE; PHENYLALANINE; PHOSPHOLIPID; PHYTOSPHINGOSINE; PIPECOLIC ACID; PROPYLTHIOURACIL; SPHINGOLIPID; SPHINGOSINE; THYROXINE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMICS; CONTROLLED STUDY; FATTY ACID TRANSPORT; HYPOTHYROIDISM; INGENUITY PATHWAY ANALYSIS; MALE; METABONOMICS; MICROARRAY ANALYSIS; NONHUMAN; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; RAT; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; BODY WEIGHT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FATTY ACIDS; HYPOTHYROIDISM; MALE; MASS SPECTROMETRY; METABOLOMICS; PHENYLALANINE; PHOSPHOLIPIDS; PROPYLTHIOURACIL; RATS; RATS, WISTAR; SPHINGOLIPIDS;

EID: 84869053376     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.09.030     Document Type: Article

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