Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling

Journal of Proteome Research

Volumn 13, Issue 12, 2014, Pages 5685-5694

  Boehm, Martin E ^a   Adlung, Lorenz ^a   Schilling, Marcel ^a   Roth, Susanne ^a,b   Klingmüller, Ursula ^a   Lehmann, Wolf D ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

dimerization; Epo stimulation; mathematical modeling; phosphorylation; relative isoform quantification; STAT5

Indexed keywords

ERYTHROPOIETIN; HETERODIMER; ISOPROTEIN; STAT5A PROTEIN; STAT5B PROTEIN; ERYTHROPOIETIN RECEPTOR; STAT5 PROTEIN; STAT5A PROTEIN, MOUSE; STAT5B PROTEIN, MOUSE;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOPLASM; DIMERIZATION; DYNAMICS; EMBRYO; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MATHEMATICAL MODEL; MOUSE; NONHUMAN; NUCLEAR IMPORT; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ALGORITHM; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL NUCLEUS; CHEMISTRY; DRUG EFFECTS; GENETICS; IMMUNOBLOTTING; KINETICS; LIQUID CHROMATOGRAPHY; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PROCEDURES; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY; THEORETICAL MODEL;

ALGORITHMS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL NUCLEUS; CHROMATOGRAPHY, LIQUID; CYTOPLASM; ERYTHROPOIETIN; IMMUNOBLOTTING; KINETICS; MASS SPECTROMETRY; MICE; MODELS, THEORETICAL; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; RECEPTORS, ERYTHROPOIETIN; SEQUENCE HOMOLOGY, AMINO ACID; STAT5 TRANSCRIPTION FACTOR;

EID: 84915746093     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr5006923     Document Type: Article

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