Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS)

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 30, 2012, Pages 12017-12021

  Zhang, Zi Chao ^a,b   Chook, Yuh Min ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b SOUTHEAST UNIVERSITY   (China)

Author keywords

Lou Gehrig's disease; Nucleocytoplasmic transport

Indexed keywords

EPITOPE; FUSED IN SARCOMA PROTEIN; KARYOPHERIN BETA; KARYOPHERIN BETA2; MUTANT PROTEIN; PROLINE; PROTEIN VARIANT; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CONTROLLED STUDY; DISEASE SEVERITY; HUMAN; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; MUTATION; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN STRUCTURE; THERMODYNAMICS; WILD TYPE;

ACTIVE TRANSPORT, CELL NUCLEUS; AMYOTROPHIC LATERAL SCLEROSIS; BETA KARYOPHERINS; CRYSTALLIZATION; ESCHERICHIA COLI; HUMANS; MODELS, MOLECULAR; NUCLEAR LOCALIZATION SIGNALS; PROLINE; PROTEIN CONFORMATION; RNA-BINDING PROTEIN FUS; THERMODYNAMICS; TYROSINE;

EID: 84864366184     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1207247109     Document Type: Article

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