Heat waves aging and human cardiovascular health

Medicine and Science in Sports and Exercise

Volumn 46, Issue 10, 2014, Pages 1891-1899

  Kenney, W Larry ^a   Craighead, Daniel H ^a   Alexander, Lacy M ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Age; Cardiovascular health; Cardiovascular strain; Climate change; Cutaneous blood Flow; Heat stress; Heat wave

Indexed keywords

AGED; AGING; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CAUSE OF DEATH; CLIMATE CHANGE; COMPLICATION; CUTANEOUS PARAMETERS; HEAT INJURY; HUMAN; MORTALITY; SPORTS MEDICINE; SWEATING; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CAUSE OF DEATH; CLIMATE CHANGE; HEAT STRESS DISORDERS; HUMANS; SKIN AGING; SPORTS MEDICINE; SWEATING;

EID: 84914691448     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0000000000000325     Document Type: Article

References (68)

1. A profile of older Americans: 2012 [cited 8/26/2013]. Available from: http://www.aoa.gov/AoARoot/Aging-Statistics/Profile/2012/2.aspx.
2. Anderson RK, Kenney WL. Effect of age on heat-activated sweat gland density and flow during exercise in dry heat. J Appl Physiol (1985). 1987;63(3):1089-94.
3. Baccini M, Biggeri A, Accetta G, et al. Heat effects on mortality in 15 European cities. Epidemiology. 2008;19(5):711-9.
4. Basu R, Malig B. High ambient temperature and mortality in California: exploring the roles of age, disease, and mortality displacement. Environ Res. 2011;111(8):1286-92.
5. Beckman JS. Oxidative damage and tyrosine nitration from peroxynitrite. Chem Res Toxicol. 1996;9(5):836-44.
6. Blagden C. Experiments and observations in a heated room. Philos Trans. 1775;65:111-23.
7. Braga AL, Zanobetti A, Schwartz J. The time course of weatherrelated deaths. Epidemiology. 2001;12(6):662-7.
8. Bustinza R, Lebel G, Gosselin P, Belanger D, Chebana F. Health impacts of the July 2010 heat wave in Quebec, Canada. BMC Public Health. 2013;13:56.
9. Carberry PA, Shepherd AM, Johnson JM. Resting and maximal forearm skin blood flows are reduced in hypertension. Hypertension. 1992;20(3):349-55.
10. Conti S, Meli P, Minelli G, et al. Epidemiologic study of mortality during the Summer 2003 heat wave in Italy. Environ Res. 2005; 98(3):390-9.
11. Crandall CG, Wilson TE, Marving J, et al. Effects of passive heating on central blood volume and ventricular dimensions in humans. J Physiol. 2008;586(1):293-301.
12. D'Ippoliti D, Michelozzi P, Marino C, et al. The impact of heat waves on mortality in 9 European cities: results from the EuroHEAT project. Environ Health. 2010;9:37.
13. Davido A, Patzak A, Dart T, et al. Risk factors for heat related death during the August 2003 heat wave in Paris, France, in patients evaluated at the emergency department of the Hospital Europeen Georges Pompidou. Emerg Med J. 2006;23(7): 515-8.
14. Dousset B, Gourmelon F, Laaidi K, et al. Satellite monitoring of summer heat waves in the Paris metropolitan area. Int J Climatol. 2011;31(2):313-23.
15. Ellis FP. Mortality from heat illness and heat-aggravated illness in the United States. Environ Res. 1972;5(1):1-58.
16. Ellis FP, Nelson F, Pincus L. Mortality during heat waves in New York City July, 1972 and August and September, 1973. Environ Res. 1975;10(1):1-13.
17. Fouillet A, Rey G, Laurent F, et al. Excess mortality related to the August 2003 heat wave in France. Int Arch Occup Environ Health. 2006;80(1):16-24.
18. Gillis J. Not Even Close: 2012 Was Hottest Ever in US. The New York Times. 2013. Sect. A:1.
19. Hansen J, Ruedy R, Sato M, Lo K. Global surface temperature change. Rev Geophys. 2010:48.
20. Hansen J, Sato M, Ruedy R. Perception of climate change. Proc Natl Acad Sci U S A. 2012;109(37):E2415-23.
21. Hansen JE. Climate change is here-and worse than we thought. Washington Post. 2012. Sect. A:14.
22. Hausfater P, Doumenc B, Chopin S, et al. Elevation of cardiac troponin I during non-exertional heat-related illnesses in the context of a heatwave. Crit Care. 2010;14(3):R99.
23. Hayhoe K, Sheridan S, Kalkstein L, Greene S. Climate change, heat waves, and mortality projections for Chicago. J Great Lakes Res. 2010;36:65-73.
24. Hemon D, Jougla E. The heat wave in France in August 2003 [in French]. Rev Epidemiol Sante Publique. 2004;52(1):3-5.
25. Holowatz LA, Houghton BL, Wong BJ, et al. Nitric oxide and attenuated reflex cutaneous vasodilation in aged skin. Am J Physiol Heart Circ Physiol. 2003;284(5):H1662-7.
26. Holowatz LA, Jennings JD, Lang JA, Kenney WL. Systemic lowdose aspirin and clopidogrel independently attenuate reflex cutaneous vasodilation in middle-aged humans. J Appl Physiol (1985). 2010;108(6):1575-81.
27. Holowatz LA, Kenney WL. Acute localized administration of tetrahydrobiopterin and chronic systemic atorvastatin treatment restore cutaneous microvascular function in hypercholesterolaemic humans. J Physiol. 2011;589(Pt 19):4787-97.
28. Holowatz LA, Kenney WL. Chronic low-dose aspirin therapy attenuates reflex cutaneous vasodilation in middle-aged humans. J Appl Physiol (1985). 2009;106(2):500-5.
29. Holowatz LA, Santhanam L, Webb A, Berkowitz DE, Kenney WL. Oral atorvastatin therapy restores cutaneous microvascular function by decreasing arginase activity in hypercholesterolaemic humans. J Phys. 2011;589(Pt 8):2093-103.
30. Holowatz LA, Thompson CS, Kenney WL. Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin. Am J Physiol Heart Circ Physiol. 2006;291(6):H2965-70.
31. L-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin. J Physiol. 2006;574(Pt 2):573-81.
32. Holowatz LA, Thompson CS, Minson CT, Kenney WL. Mechanisms of acetylcholine-mediated vasodilatation in young and aged human skin. J Physiol. 2005;563(Pt 3):965-73.
33. Huynen MM, Martens P, Schram D, Weijenberg MP, Kunst AE. The impact of heat waves and cold spells on mortality rates in the Dutch population. Environ Health Perspect. 2001;109(5):463-70.
34. Intergovernmental Panel on Climate Change. Climate Change 2007: Synthesis Report. Contribution of Working Groups I, II, and III to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change. Pachauri, RK and Resinger, A, editors. Geneva (Switzerland): Intergovernmental Panel on Climate Change; 2007. p. 104.
35. Kaiser R, Le Tertre A, Schwartz J, Gotway CA, Daley WR, Rubin CH. The effect of the 1995 heat wave in Chicago on all-cause and cause-specific mortality. Am J Public Health. 2007;97(1 Suppl): S158-62.
36. Karl TR, Knight RW. The 1995 Chicago heat wave: how likely is a recurrence? B Am Meteorol Soc. 1997;78(6):1107-19.
37. Keatinge WR, Coleshaw SR, Easton JC, Cotter F, Mattock MB, Chelliah R. Increased platelet and red cell counts, blood viscosity, and plasma cholesterol levels during heat stress, and mortality from coronary and cerebral thrombosis. Am J Med. 1986;81(5):795-800.
38. Kellogg DL, Crandall CG, Liu Y, Charkoudian N, Johnson JM. Nitric oxide and cutaneous active vasodilation during heat stress in humans. J Appl Physiol (1985). 1998;85(3):824-9.
39. Kenney WL, Morgan AL, Farquhar WB, Brooks EM, Pierzga JM, Derr JA. Decreased active vasodilator sensitivity in aged skin. Am J Physiol. 1997;272(4 Pt 2):H1609-14.
40. Kenney WL, Tankersley CG, Newswanger DL, Hyde DE, Puhl SM, Turner NL. Age and hypohydration independently influence the peripheral vascular response to heat stress. J Appl Physiol (1985). 1990;68(5):1902-8.
41. Larose J, Wright HE, Sigal RJ, Boulay P, Hardcastle S, Kenny GP. Do older females store more heat than younger females during exercise in the heat? Med Sci Sports Exercise. 2013;45(12): 2265-76.
42. Larose J, Wright HE, Stapleton J, et al. Whole body heat loss is reduced in older males during short bouts of intermittent exercise. Am J Physiol Regul Integr Comp Physiol. 2013;305(6): R619-29.
43. Lazzeri C, Bonizzoli M, Cianchi G, Gensini GF, Peris A. Troponin I in the intensive care unit setting: from the heart to the heart. Intern Emerg Med. 2008;3(1):9-16.
44. McCord GR, Cracowski JL, Minson CT. Prostanoids contribute to cutaneous active vasodilation in humans. Am J Physiol Regul Integr Comp Physiol. 2006;291(3):R596-602.
45. Meehl GA, Tebaldi C. More intense, more frequent, and longer lasting heat waves in the 21st century. Science. 2004;305(5686): 994-7.
46. Meehl GA, Tebaldi C, Walton G, Easterling D, McDaniel L. Relative increase of record high maximum temperatures compared to record low minimum temperatures in the U S. Geophys Res Lett. 2009;36:23.
47. Minson CT, Wladkowski SL, Cardell AF, Pawelczyk JA, Kenney WL. Age alters the cardiovascular response to direct passive heating. J Appl Physiol (1985). 1998;84(4):1323-32.
48. Nakano M, Matsueda M, Sugi M. Future projections of heat waves around Japan simulated by CMIP3 and high-resolution Meteorological Research Institute atmospheric climate models. J Geophys Res Atmos. 2013;118(8):3097-109.
49. Naughton MP, Henderson A, Mirabelli MC, et al. Heat-related mortality during a 1999 heat wave in Chicago. Am J Prev Med. 2002;22(4):221-7.
50. NOAA National Climatic Data Center SotCGAfO. 2012 [cited 2013 August 26]. Available from: http://www.ncdc.noaa.gov/sotc/gobal/2012/10.
51. NOAA Office of Climate W, and Weather Services. Natural Hazard Statistics [cited 2013 August 20]. Available from: http://www.nws. noaa.gov/om/hazstats.shtml.
52. Palecki MA, Changnon SA, Kunkel KE. The nature and impacts of the July 1999 heat wave in the midwestern United States: learning from the lessons of 1995. B Am Meteorol Soc. 2001; 82(7):1353-67.
53. Perkins SE, Alexander LV, Nairn JR. Increasing frequency, intensity and duration of observed global heatwaves and warm spells. Geophys Res Lett. 2012;39:20.
54. Raman CS, Li H, Martasek P, Kral V, Masters BS, Poulos TL. Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center. Cell. 1998;95(7):939-50.
55. Rey G, Fouillet A, Bessemoulin P, et al. Heat exposure and socioeconomic vulnerability as synergistic factors in heat-wave-related mortality. Eur J Epidemiol. 2009;24(9):495-502.
56. Robine JM, Cheung SL, Le Roy S, et al. Death toll exceeded 70,000 in Europe during the summer of 2003. C R Biol. 2008; 331(2):171-8.
57. Rowell LB. Human cardiovascular adjustments to exercise and thermal stress. Physiol Rev. 1974;54(1):75-159.
58. Semenza JC, McCullough JE, Flanders WD, McGeehin MA, Lumpkin JR. Excess hospital admissions during the July 1995 heat wave in Chicago. Am J Prev Med. 1999;16(4):269-77.
59. Semenza JC, Rubin CH, Falter KH, et al. Heat-related deaths during the July 1995 heat wave in Chicago. New Engl J Med. 1996; 335(2):84-90.
60. Smith CJ, Alexander LM, Kenney WL. Nonuniform, age-related decrements in regional sweating and skin blood flow. Am J Physiol Regul Integr Comp Physiol. 2013;305(8):R877-85.
61. Stanhewicz AE, Alexander LM, Kenney WL. Oral sapropterin acutely augments reflex vasodilation in aged human skin through nitric oxide-dependent mechanisms. J Appl Physiol (1985). 2013; 115(7):972-8.
62. Stanhewicz AE, Bruning RS, Smith CJ, Kenney WL, Holowatz LA. Local tetrahydrobiopterin administration augments reflex cutaneous vasodilation through nitric oxide-dependent mechanisms in aged human skin. J Appl Physiol (1985). 2012;112(5):791-7.
63. Toulemon L, Barbieri M. The mortality impact of the August 2003 heat wave in France: investigating the 'harvesting' effect and other long-term consequences. Popul Stud. 2008;62(1):39-53.
64. United Nations Department of Economic and Social Affairs, Population Division. World Population Ageing, 1950-2050. New York (NY): United Nations; 2002. xlix, p. 483.
65. Vandentorren S, Bretin P, Zeghnoun A, et al. August 2003 heat wave in France: risk factors for death of elderly people living at home. Eur J Public Health. 2006;16(6):583-91.
66. Weisskopf MG, Anderson HA, Foldy S, et al. Heat wave morbidity and mortality, Milwaukee, Wis, 1999 vs 1995: an improved response? Am J Public Health. 2002;92(5): 830-3.
67. Whitman S, Good G, Donoghue ER, Benbow N, Shou W, Mou S. Mortality in Chicago attributed to the July 1995 heat wave. Am J Public Health. 1997;87(9):1515-8.
68. Zhu BL, Ishikawa T, Michiue T, et al. Postmortem cardiac troponin I and creatine kinase MB levels in the blood and pericardial fluid as markers of myocardial damage in medicolegal autopsy. Leg Med (Tokyo). 2007;9(5):241-50.