Decreased active vasodilator sensitivity in aged skin

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 272, Issue 4 41-4, 1997, Pages

  Kenney, W L ^a   Morgan, A L ^a   Farquhar, W B ^a   Brooks, E M ^a   Pierzga, J M ^a   Derr, J A ^a   Meaker, K B ^b   Sanchez, M M ^b   Li, H ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b NONE

Author keywords

aging; bretylium; hyperthermia; peripheral circulation; skin blood flow; temperature regulation

Indexed keywords

ADULT; AGED; ARTICLE; CELL AGING; CONDUCTANCE; HEAT STRESS; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; LASER DOPPLER FLOWMETRY; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; PERFUSION; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; TEMPERATURE DEPENDENCE; VASODILATATION;

EID: 0031003786     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1997.272.4.h1609     Document Type: Article

References (27)

1. American College of Sports Medicine. ACSM's Guidelines for Exercise Testing and Prescription (5th ed.), edited by W. L. Kenney. Baltimore, MD: Williams and Wilkins, 1995, p. 373.
2. Braverman, I. M., and E. Fonferko. Studies in cutaneous aging. II. The microvasculature. J. Invest. Dermatol. 78: 444-448, 1982.
3. Brengelmann, G. L., J. M. Johnson, L. Hermansen, and L. B. Rowell. Altered control of skin blood flow during exercise at high internal temperatures. J. Appl. Physiol. 43: 790-794, 1977.
4. DeLean, A., P. J. Munson, and D. Rodbard. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am. J. Physiol. 235 (Endocrinol. Metab. Gastrointest. Physiol. 4): E97-E102, 1978.
5. DiPietro, L., C. J. Casperson, A. M. Ostfeld, and E. R. Nadel. A survey for assessing physical activity among older adults. Med. Sci. Sports Exercise 25: 628-642, 1993.
6. Docherty, J. R. Aging and the cardiovascular system. J. Auton. Pharmacol. 6: 77-84, 1986.
7. Evans, E., M. Rendell, J. Bartek, S. Connor, O. Bamisedun, D. Dovgan, and M. Gutter. Thermally-induced cutaneous vasodilatation in aging. J. Gerontol. 48: M53-M57, 1993.
8. Havenith, G., Y. Inoue, V. Luttikholt, and W. L. Kenney. Age predicts cardiovascular, but not thermoregulatory responses to humid heat stress. Eur. J. Appl. Physiol. 70: 88-96, 1995.
9. Johnson, J. M. Nonthermoregulatory control of human skin blood flow. J. Appl. Physiol. 61: 1613-1622, 1986.
10. Johnson, J. M., D. S. O'Leary, W. F. Taylor, and W. Kosiba. Effect of local warming on forearm reactive hyperaemia. Clin. Physiol. 6: 337-346, 1986.
11. Kellogg, D. L., J. M. Johnson, W. L. Kenney, P. Pergola, and W. A. Kosiba. Mechanisms of control of skin blood flow during prolonged exercise in humans. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H562-H568, 1993.
12. Kellogg, D. L., J. M. Johnson, and W. A. Kosiba. Selective abolition of adrenergic vasoconstrictor responses in skin by local iontophoresis of bretylium. Am. J. Physiol. 257 (Heart Circ. Physiol. 26): H1599-H1606, 1989.
13. Kellogg, D. L., J. M. Johnson, and W. A. Kosiba. Baroreflex control of the cutaneous active vasodilator system in humans. Circ. Res. 66: 1420-1426, 1990.
14. Kenney, W. L. Control of heat-induced vasodilation in relation to age. Eur. J.Appl. Physiol. 57: 120-125, 1988.
15. Kenney, W. L., and J. M. Johnson. Control of skin blood flow during exercise. Med. Sci. Sports Exercise 24: 303-312, 1992.
16. Kenney, W. L., C. G. Tankersley, D. L. Newswanger, D. E. Hyde, and S. M. Puhl. Age and hypohydration independently influence the peripheral vascular response to heat stress. J. Appl. Physiol. 68: 1902-1908, 1990.
17. 1-Adrenergic blockade does not alter control of skin blood flow during exercise. Am. J. Physiol. 260 (Heart Circ. Physiol. 29): H855-H861, 1991.
18. Lindstrom, M. J., and D. M. Bates. Nonlinear mixed effects models for repeated measures data. Biometrics 46: 673-687, 1990.
19. Martin, H. L., J. L. Loomis, and W. L. Kenney. Maximal skin vascular conductance in subjects aged 5 to 85 yr. J. Appl. Physiol. 79: 297-301, 1995.
20. Neilsen, B., J. R. S. Hales, S. Strange, N. J. Christensen, J. Warberg, and B. Saltin. Human circulatory and thermoregulatory adaptations with heat acclimation and exercise in a hot dry environment. J. Physiol. (Lond.) 460: 467-485, 1993.
21. Nose, H., G. W. Mack, X. Shi, K. Morimoto, and E. R. Nadel. Effect of saline infusion during exercise on thermal and circulatory regulation. J. Appl. Physiol. 69: 609-616, 1990.
22. Richardson, D. Effects of age on cutaneous circulatory response to direct heat on the forearm. J. Gerontol. 44: M189-M194, 1989.
23. Rooke, G. A., M. V. Savage, and G. L. Brengelmann. Maximal skin blood flow is decreased in elderly men. J. Appl. Physiol. 77: 11-14, 1994.
24. Rowe, J. W., and B. R. Troon. Sympathetic nervous system and aging in man. Endocr. Rev. 1: 167-179, 1980.
25. Veith, R. C., J. A. Fetherstone, O. A. Linares, and J. B. Halter. Age differences in plasma norepinephrine kinetics in humans. J. Gerontol. 41: 319-324, 1986.
26. Weiss, M., B. Milman, B. Rosen, Z. Eisenstein, and R. Zimlichman. Analysis of the diminished skin perfusion in elderly people by laser Doppler flowmetry. Age Ageing 21: 237-241, 1992.
27. Wenger, C. B., M. F. Roberts, J. A. J. Stolwijk, and E. R. Nadel. Forearm blood flow during body temperature transients produced by leg exercise. J. Appl. Physiol. 38: 58-63, 1975.