Docosahexaenoic acid induces M2 macrophage polarization through peroxisome proliferator-activated receptor γ activation

Life Sciences

Volumn 120, Issue , 2015, Pages 39-47

  Chang, Hae Yeun ^a   Lee, Ha Na ^a   Kim, Wonki ^a   Surh, Young Joon ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Docosahexaenoic acid; Efferocytosis; Omega 3 polyunsaturated fatty acid; Peroxisome proliferator activated receptor ; Resolution of inflammation

Indexed keywords

CD36 ANTIGEN; CYCLOOXYGENASE 2; DOCOSAHEXAENOIC ACID; INTERLEUKIN 10; LIPOXYGENASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSFORMING GROWTH FACTOR BETA; SMALL INTERFERING RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PHAGOCYTOSIS; CONTROLLED STUDY; DNA BINDING; ELECTROPHILICITY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INFLAMMATORY DISEASE; JURKAT CELL LINE; MACROPHAGE ACTIVATION; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; UPREGULATION; ACTIVE TRANSPORT; ANIMAL; ATHEROSCLEROSIS; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; INFLAMMATION; MACROPHAGE; METABOLISM; MOUSE; PATHOPHYSIOLOGY; PHENOTYPE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; ATHEROSCLEROSIS; CELL LINE; DOCOSAHEXAENOIC ACIDS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; JURKAT CELLS; MACROPHAGES; MICE; PHENOTYPE; PPAR GAMMA; RNA, SMALL INTERFERING;

EID: 84914171441     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2014.10.014     Document Type: Article

References (31)

1. V. Avettand-Fenoel, M. Kim, B. Antuna, A. Borjabad, U. Hazan, and E. Lanoy Macrophage recruitment in adipose tissue from HIV-infected patients under ART: concomitant presence of classically activated pro-inflammatory M1 and alternatively activated M2 macrophages Antivir. Ther. 12 2007 L12
2. N.G. Bazan Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection Curr. Opin. Clin. Nutr. Metab. Care 10 2007 136 141
3. A. Berry, P. Balard, A. Coste, D. Olagnier, C. Laganel, and H.N. Authier Interleukin-13 induces expression of CD36 in human monocytes through PPARγ activation Eur. J. Immunol. 37 2007 1642 1652
4. M. Borkman, L.H. Storlien, D.A. Pan, A.B. Jenkins, D.J. Chisholm, and L.V. Campbell The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids N. Engl. J. Med. 328 1993 238 244
5. M.A. Bouhlel, B. Derudas, E. Rigamonti, R. Dievart, J. Brozek, and S. Haulon PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties Cell Metab. 6 2007 137 143
6. J. Bystrom, I. Evans, J. Newson, M. Stables, I. Toor, and N. van Rooijen Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP Blood 112 2008 4117 4127
7. P.C. Calder Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases Mol. Nutr. Food Res. 52 2008 885 897
8. A. Chawla, Y. Barak, L. Nagy, D. Liao, P. Tontonoz, and R.M. Evans PPARγ-dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation Nat. Med. 7 2001 48 52
9. J. Dalli, M. Zhu, N.A. Vlasenko, B. Deng, J.Z. Haeggstrom, N.A. Petasis, and C.N. Serhan The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A(4) hydrolase (LTA(4)H), and shifts macrophage phenotype FASEB J. 27 2013 2573 2583
10. 2, and PAF J. Clin. Investig. 101 1998 890 898
11. D.W. Gilroy, T. Lawrence, M. Perretti, and A.G. Rossi Inflammatory resolution: new opportunities for drug discovery Nat. Rev. Drug Discov. 3 2004 401 416
12. J.T. Huang, J.S. Welch, M. Ricote, C.J. Binder, T.M. Willson, and C. Kelly Interleukin-4-dependent production of PPARγ ligands in macrophages by 12/15-lipoxygenase Nature 400 1999 378 382
13. I. Issemann, and S. Green Activation of a member of the steroid-hormone receptor superfamily by peroxisome proliferators Nature 347 1990 645 650
14. U. Kintscher, and R.E. Law PPARγ-mediated insulin sensitization: the importance of fat versus muscle Am. J. Physiol. Endocrinol. Metab. 288 2005 E287 E291
15. D.L. Laskin, V.R. Sunil, C.R. Gardner, and J.D. Laskin Macrophages and tissue injury: agents of defense or destruction? Annu. Rev. Pharmacol. Toxicol. 51 2011 267 288
16. C.H. Lee, and R.M. Evans Peroxisome proliferator-activated receptor-γ in macrophage lipid homeostasis Trends Endocrinol. Metab. 13 2002 331 335
17. H.N. Lee, J.K. Kundu, Y.N. Cha, and Y.J. Surh Resolvin D1 stimulates efferocytosis through p50/p50-mediated suppression of tumor necrosis factor-α expression J. Cell Sci. 126 2013 4037 4047
18. R. Medzhitov Inflammation 2010: new adventures of an old flame Cell 140 2010 771 776
19. P.J. Murray, and T.A. Wynn Protective and pathogenic functions of macrophage subsets Nat. Rev. Immunol. 11 2011 723 737
20. J.I. Odegaard, and A. Chawla Alternative macrophage activation and metabolism Ann. Rev. Pathol. Mech. Dis. 6 2011 275 297
21. D.Y. Oh, S. Talukdar, E.J. Bae, T. Imamura, H. Morinaga, W.Q. Fan, P.P. Li, W.J. Lu, S.M. Watkins, and J.M. Olefsky GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects Cell 142 2010 687 698
22. G. Schmitz, and J. Ecker The opposing effects of omega-3 and omega-6 fatty acids Prog. Lipid Res. 47 2008 147 155
23. C.N. Serhan Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways Annu. Rev. Immunol. 25 2007 101 137
24. C.N. Serhan, N. Chiang, and T.E. Van Dyke Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators Nat. Rev. Immunol. 8 2008 349 361
25. C.N. Serhan, and N.A. Petasis Resolvins and protectins in inflammation resolution Chem. Rev. 111 2011 5922 5943
26. C.N. Serhan, and J. Savill Resolution of inflammation: the beginning programs the end Nat. Immunol. 6 2005 1191 1197
27. I. Tabas Macrophage death and defective inflammation resolution in atherosclerosis Nat. Rev. Immunol. 10 2010 36 46
28. E. Titos, B. Rius, A. Gonzalez-Periz, C. Lopez-Vicario, E. Moran-Salvador, and M. Martinez-Clemente Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype J. Immunol. 187 2011 5408 5418
29. E.R. Tuller, C.T. Beavers, J.R. Lou, M.A. Ihnat, D.M. Benbrook, and W.Q. Ding Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of PPARα and HIF-2α signaling Mol. Pharmacol. 76 2009 588 595
30. K. Yu, W. Bayona, C.B. Kallen, H.P. Harding, C.P. Ravera, G. McMahon, M. Brown, and M.A. Lazar Differential activation of peroxisome proliferator-activated receptors by eicosanoids J. Biol. Chem. 270 1995 23975 23983
31. S. Zhang, Z. Shen, G. Hu, R. Liu, and X. Zhang Effects of endogenous glucocorticoids on allergic inflammation and Th1/Th2 balance in airway allergic disease Ann. Allergy Asthma Immunol. 103 2009 525 534