Esculetin suppresses lipopolysaccharide-induced inflammatory mediators and cytokines by inhibiting nuclear factor-κB translocation in RAW 264.7 macrophages

Molecular Medicine Reports

Volumn 10, Issue 6, 2014, Pages 3241-3246

  Hong, Su Hyun ^a   Jeong, Hui Kyung ^a   Han, Min Ho ^a   Park, Cheol ^a   Choi, Yung Hyun ^a  

^a Dong Eui University   (South Korea)

Author keywords

Esculetin; Inflammation; Nuclear factor kappa B; RAW 264.7 macrophages; Reactive oxygen species

Indexed keywords

MURINAE;

ANTIINFLAMMATORY AGENT; AUTACOID; CYCLOOXYGENASE 2; ESCULETIN; I KAPPA B; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NF-KAPPAB INHIBITOR ALPHA; NITRIC OXIDE; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; UMBELLIFERONE DERIVATIVE;

ANIMAL; CELL LINE; DRUG EFFECTS; INFLAMMATION; MACROPHAGE; METABOLISM; MOUSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; I-KAPPA B PROTEINS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; REACTIVE OXYGEN SPECIES; UMBELLIFERONES;

EID: 84914163777     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2613     Document Type: Article

References (42)

1. Vendramini-Costa DB and Carvalho JE: Molecular link mechanisms between inflammation and cancer. Curr Pharm Des 18: 3831-3852, 2012.
2. Ma A, Qi S and Chen H: Antioxidant therapy for prevention of inflammation, ischemic reperfusion injuries and allograft rejection. Cardiovasc Hematol Agents Med Chem 6: 20-43, 2008.
3. Carreira PE: Pulmonary hypertension in autoimmune rheumatic diseases. Autoimmun Rev 313-320, 2004.
4. Fialkow L, Wang Y and Downey GP: Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med 42: 153-164, 2007.
5. Geronikaki AA and Gavalas AM: Antioxidants and inflammatory disease: synthetic and natural antioxidants with anti-inflammatory activity. Comb Chem High Throughput Screen 9: 425-442, 2006.
6. Gasparini C and Feldmann M: NF-κB as a target for modulating inflammatory responses. Curr Pharm Des 18: 5735-5745, 2012.
7. Lawrence T: The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1: a001651, 2009.
8. Siomek A: NF-κB signaling pathway and free radical impact. Acta Biochim Pol 59: 323-331, 2012.
9. Temkin V and Karin M: From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey. Immunol Rev 220: 8-21, 2007.
10. Morgan MJ and Liu ZG: Crosstalk of reactive oxygen species and NF-κB signaling. Cell Res 21: 103-115, 2011.
11. Gloire G, Legrand-Poels S and Piette J: NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 72: 1493-1505, 2006.
12. Fylaktakidou KC, Hadjipavlou-Litina DJ, Litinas KE and Nicolaides DN: Natural and synthetic coumarin derivatives with anti-inflammatory/antioxidant activities. Curr Pharm Des 10: 3813-3833, 2004.
13. Witaicenis A, Seito LN and Di Stasi LC: Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis. Chem Biol Interact 186: 211-218, 2010.
14. Kwon OS, Choi JS, Islam MN, Kim YS and Kim HP: Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents. Arch Pharm Res 34: 1561-1569, 2011.
15. Prabakaran D and Ashokkumar N: Protective effect of esculetin on hyperglycemia-mediated oxidative damage in the hepatic and renal tissues of experimental diabetic rats. Biochimie 95: 366-373, 2013.
16. Subramaniam SR and Ellis EM: Esculetin-induced protection of human hepatoma HepG2 cells against hydrogen peroxide is associated with the Nrf2-dependent induction of the NAD(P)H: Quinone oxidoreductase 1 gene. Toxicol Appl Pharmacol 250: 130-136, 2011.
17. Kim SH, Kang KA, Zhang R, et al: Protective effect of esculetin against oxidative stress-induced cell damage via scavenging reactive oxygen species. Acta Pharmacol Sin 29: 1319-1326, 2008.
18. Lee CR, Shin EJ, Kim HC, et al: Esculetin inhibits N-methyl-D-aspartate neurotoxicity via glutathione preservation in primary cortical cultures. Lab Anim Res 27: 259-263, 2011.
19. Leung KN, Leung PY, Kong LP and Leung PK: Immunomodulatory effects of esculetin (6, 7-dihydroxycoumarin) on murine lymphocytes and peritoneal macrophages. Cell Mol Immunol 2: 181-188, 2005.
20. Park C, Jin CY, Kim GY, et al: Induction of apoptosis by esculetin in human leukemia U937 cells through activation of JNK and ERK. Toxicol Appl Pharmacol 227: 219-228, 2008.
21. Park C, Jin CY, Kwon HJ, et al: Induction of apoptosis by esculetin in human leukemia U937 cells: roles of Bcl-2 and extracellular-regulated kinase signaling. Toxicol In Vitro 24: 486-494, 2010.
22. Kyung J, Kim D, Park D, et al: Synergistic anti-inflammatory effects of Laminaria japonica fucoidan and Cistanche tubulosa extract. Lab Anim Res 28: 91-97, 2012.
23. Lee SH, Kim DW, Eom SA, et al: Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein. BMB Rep 45: 354-359, 2012.
24. Sekiya K, Okuda H and Arichi S: Selective inhibition of platelet lipoxygenase by esculetin. Biochim Biophys Acta 713: 68-72, 1982.
25. Yang CS, Yuk JM and Jo EK: The role of nitric oxide in mycobacterial infections. Immune Netw 9: 46-52, 2009.
26. Rimoldi JM and Chimote SS: Inhibition on inducible nitric oxide synthase. Curr Opin Drug Discov Devel 1: 183-191, 1998.
27. Murakami A and Ohigashi H: Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals. Int J Cancer 121: 2357-2363, 2007.
28. Wadleigh DJ, Reddy ST, Kopp E, Ghosh S and Herschman HR: Transcriptional activation of the cyclooxygenase-2 gene in endotoxin-treated RAW 264-7 macrophages. J Biol Chem 275: 6259-6266, 2000.
29. Kanno S, Shouji A, Tomizawa A, et al: Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264-7 macrophages. Life Sci 78: 673-681, 2006.
30. Lin WJ and Yeh WC: Implication of Toll-like receptor and tumor necrosis factor alpha signaling in septic shock. Shock 24: 206-209, 2005.
31. Dayer JM: The process of identifying and understanding cytokines: from basic studies to treating rheumatic diseases. Best Pract Res Clin Rheumatol 18: 31-45, 2004.
32. Guha M and Mackman N: LPS induction of gene expression in human monocytes. Cell Signal 13: 85-94, 2001.
33. Pearlman DS: Pathophysiology of the inflammatory response. J Allergy Clin Immunol 104: S132-S137, 1999.
34. Beutler B and Cerami A: The biology of cachectin/TNF-α primary mediator of the host response. Annu Rev Immunol 7: 625-655, 1989.
35. Blatteis CM, Li S, Li Z, Perlik V and Feleder C: Signaling the brain in systemic inflammation: the role of complement. Front Biosci 9: 915-931, 2004.
36. Aggarwal BB and Natarajan K: Tumor necrosis factors: developments during the last decade. Eur Cytokine Netw 7: 93-124, 1996.
37. Moynagh PN: The NF-kappaB pathway. J Cell Sci 118: 4589-4592, 2005.
38. Sarkar FH, Li Y, Wang Z and Kong D: NF-kappaB signaling pathway and its therapeutic implications in human diseases. Int Rev Immunol 27: 293-319, 2008.
39. Makarov SS: NF-kappaB as a therapeutic target in chronic inflammation: recent advances. Mol Med Today 6: 441-448, 2000.
40. Islam MN, Choi RJ, Jin SE, et al: Mechanism of anti-inflammatory activity of umbelliferone 6-carboxylic acid isolated from Angelica decursiva. J Ethnopharmacol 144: 175-181 2012.
41. Jung WK, Choi I, Lee DY, et al: Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264-7 macrophages via the p38/ERK and NF-kappaB pathways. Int J Biochem Cell Biol 40: 2572-2582, 2008.
42. J Immunol 177: 2527-2535, 2006. Harris J, Olière S, Sharma S, et al: Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.