NK cells kill mycobacteria directly by releasing perforin and granulysin

Journal of Leukocyte Biology

Volumn 96, Issue 6, 2014, Pages 1119-1129

  Lu, Chia Chen ^a   Wu, Ting Shu ^b,c   Hsu, Ya Jing ^c   Chang, Chih Jung ^d   Lin, Chuan Sheng ^c   Chia, Ju Hsin ^b   Wu, Tsu Lan ^b   Huang, Tsung Teng ^c   Martel, Jan ^c   Ojcius, David M ^c,e   Young, John D ^c,f,g   Lai, Hsin Chih ^c  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f ROCKEFELLER UNIVERSITY   (United States)

^g MING CHI UNIVERSITY OF TECHNOLOGY   (Taiwan)

Author keywords

Antibacterial activity; Innate immunity; NCR; NKG2D; Tuberculosis

Indexed keywords

CELL SURFACE RECEPTOR; GRANULYSIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NATURAL KILLER CELL RECEPTOR NKG2D; PERFORIN; STRESS ACTIVATED PROTEIN KINASE; GNLY PROTEIN, HUMAN; KLRK1 PROTEIN, HUMAN; NANOTUBE; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 2; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K; NCR2 PROTEIN, HUMAN; NCR3 PROTEIN, HUMAN; PRF1 PROTEIN, HUMAN; SMALL INTERFERING RNA; T LYMPHOCYTE ANTIGEN;

ARTICLE; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; CELL ORGANELLE; CONTROLLED STUDY; HOST CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNE SYSTEM; INTRACELLULAR SIGNALING; MYCOBACTERIOSIS; MYCOBACTERIUM KANSASII; MYCOBACTERIUM TUBERCULOSIS; NATURAL KILLER CELL; PROTEIN SECRETION; ANTAGONISTS AND INHIBITORS; BACTERIOLYSIS; BIOSYNTHESIS; CELL WALL; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; PHYSIOLOGY; RNA INTERFERENCE; SECRETION (PROCESS); SIGNAL TRANSDUCTION; TUMOR CELL LINE; ULTRASTRUCTURE;

CORYNEBACTERINEAE;

ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BACTERIOLYSIS; CELL LINE, TUMOR; CELL WALL; HUMANS; KILLER CELLS, NATURAL; MAP KINASE SIGNALING SYSTEM; MYCOBACTERIUM KANSASII; MYCOBACTERIUM TUBERCULOSIS; NANOTUBES; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 2; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; PERFORIN; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC;

EID: 84914115520     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.4A0713-363RR     Document Type: Article

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