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The crystal structure of granulysin indicates that it folds similar to other saposin family members and suggests that binding to the cell surface facilitates a scissors motion tunneling granulysin into the fracturing target membrane
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Dieli F., Troye-Blomberg M., Ivanyi J., Fournie J.J., Krensky A.M., Bonneville M., Peyrat M.A., Caccamo N., Sireci G., Salerno A. Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2 T lymphocytes. J. Infect. Dis. 184:2001;1082-1085.
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Kida Y., Shimizu T., Kuwano K. Opposing roles of activator protein-1 and CCAAT/enhancer binding protein beta in the regulation of inducible granulysin gene expression in a human monocytic cell line, THP-1. Immunology. 107:2002;507-516.
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0037111316
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CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15
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+ T cells. This is the first demonstration that silencing granulysin gene expression in intact cells abrogates target cell lysis.
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Dieli F., Sireci G., Caccamo N., Di Sano C., Titone L., Romano A., Di Carlo P., Barera A., Accardo-Palumbo A., Krensky A.M.et al. Selective depression of interferon-gamma and granulysin production with increase of proliferative response by Vgamma9/Vdelta2 T cells in children with tuberculosis. J. Infect. Dis. 186:2002;1835-1839.
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T-cell release of granulysin contributes to host defense in leprosy
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Ochoa M.T., Stenger S., Sieling P.A., Thoma-Uszynski S., Sabet S., Cho S., Krensky A.M., Rollinghoff M., Nunes Sarno E., Burdick A.E.et al. T-cell release of granulysin contributes to host defense in leprosy. Nat. Med. 7:2001;174-179.
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27
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Role of granulysin in immunity to leprosy
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0035168317
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Acholeplasma laidlawii up-regulates granulysin gene expression via transcription factor activator protein-1 in a human monocytic cell line, THP-1
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Kida Y., Kuwano K., Zhang Y., Arai S. Acholeplasma laidlawii up-regulates granulysin gene expression via transcription factor activator protein-1 in a human monocytic cell line, THP-1. Immunology. 104:2001;324-332.
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Hata A., Zerboni L., Sommer M., Kaspar A.A., Clayberger C., Krensky A.M., Arvin A.M. Granulysin blocks replication of varicella-zoster virus and triggers apoptosis of infected cells. Viral. Immunol. 14:2001;125-133.
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0035678917
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Differential expression of granulysin and perforin by NK cells in cancer patients and correlation of impaired granulysin expression with progression of cancer
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Examination of granulysin and perforin expression in NK cells from cancer patients and healthy controls revealed that tumor-free cancer patients and healthy controls exhibited equally high levels of granulysin and perforin, although tumor-bearing cancer patients expressed remarkably lower levels of granulysin, but not perforin. They conclude that impaired expression of granulysin correlates with progression of cancer.
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Kishi A., Takamori Y., Ogawa K., Takano S., Tomita S., Tanigawa M., Niman M., Kishida T., Fujita S. Differential expression of granulysin and perforin by NK cells in cancer patients and correlation of impaired granulysin expression with progression of cancer. Cancer Immunol. Immunother. 50:2002;604-614 Examination of granulysin and perforin expression in NK cells from cancer patients and healthy controls revealed that tumor-free cancer patients and healthy controls exhibited equally high levels of granulysin and perforin, although tumor-bearing cancer patients expressed remarkably lower levels of granulysin, but not perforin. They conclude that impaired expression of granulysin correlates with progression of cancer.
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34
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0036332063
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Adenovirus vector-mediated transfer of 9 kDa granulysin induces DNA fragmentation in HuD antigen-expressing small cell lung cancer murine model cells
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Adenovirus vector-mediated transfer of 9 kDa granulysin into an adenocarcinoma cell line suppressed cell growth and increased DNA fragmentation
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Sekiya M., Ohwada A., Katae M., Dambara T., Nagaoka I., Fukuchi Y. Adenovirus vector-mediated transfer of 9 kDa granulysin induces DNA fragmentation in HuD antigen-expressing small cell lung cancer murine model cells. Respirology. 7:2002;29-35 Adenovirus vector-mediated transfer of 9 kDa granulysin into an adenocarcinoma cell line suppressed cell growth and increased DNA fragmentation.
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35
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0035116493
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Granulysin expression is a marker for acute rejection and steroid resistance in human renal transplantation
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Sarwal M.M., Jani A., Chang S., Huie P., Wang Z., Salvatierra O. Jr., Clayberger C., Sibley R., Krensky A.M., Pavlakis M. Granulysin expression is a marker for acute rejection and steroid resistance in human renal transplantation. Hum. Immunol. 62:2001;21-31.
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36
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Quantification of cytotoxic T-cell gene transcripts in human lung transplantation
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37
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0037209152
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Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis
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Ericson K.G., Fadeel B., Andersson M., Gudmundsson G.H., Gurgey A., Yalman N., Janka G., Nordenskjold M., Henter J.I. Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis. Hum. Genet. 112:2003;98-99.
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Fadeel, B.2
Andersson, M.3
Gudmundsson, G.H.4
Gurgey, A.5
Yalman, N.6
Janka, G.7
Nordenskjold, M.8
Henter, J.I.9
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