NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection

Journal of Immunology

Volumn 181, Issue 8, 2008, Pages 5481-5489

  Wesselkamper, Scott C ^a   Eppert, Bryan L ^a   Motz, Gregory T ^a   Lau, Gee W ^b   Hassett, Daniel J ^a   Borchers, Michael T ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; GAMMA INTERFERON; LIPOPOLYSACCHARIDE; NATURAL KILLER CELL RECEPTOR NKG2D; RETINOIC ACID; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; NATURAL KILLER CELL ACTIVATING RECEPTORS; RAET1A PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL ISOLATION; CELL SURVIVAL; CYTOKINE PRODUCTION; EPITHELIUM CELL; EX VIVO STUDY; FEMALE; HOST RESISTANCE; IMMUNE RESPONSE; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG CLEARANCE; LYMPHOCYTE; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT INFECTION; TRANSGENIC MOUSE; ANIMAL; GENE EXPRESSION; GENETICS; GRAM NEGATIVE INFECTION; IMMUNOLOGY; LUNG; LYMPHOCYTE ACTIVATION; OPPORTUNISTIC INFECTION; RESPIRATORY TRACT MUCOSA;

ANIMALS; GENE EXPRESSION; INTERFERON TYPE II; KILLER CELLS, NATURAL; LIPOPOLYSACCHARIDES; LUNG; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; OPPORTUNISTIC INFECTIONS; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RECEPTORS, IMMUNOLOGIC; RESPIRATORY MUCOSA; RESPIRATORY TRACT INFECTIONS;

EID: 54049126920     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.8.5481     Document Type: Article

References (45)

1. Diekema, D. J., M. A. Pfaller, R. N. Jones, G. V. Doern, P. L. Winokur, A. C. Gales, H. S. Sader, K. Kugler, and M. Beach. 1999. Survey of bloodstream infections due to Gram-negative bacilli: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, and Latin America for the SENTRY Antimicrobial Surveillance Program, 1997. Clin. Infect. Dis. 29: 595-607. (Pubitemid 29439960)
2. Burns, J. L., R. L. Gibson, S. McNamara, D. Yim, J. Emerson, M. Rosenfeld, P. Hiatt, K. McCoy, R. Castile, A. L. Smith, and B. W. Ramsey. 2001. Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis. J. Infect. Dis. 183: 444-452. (Pubitemid 32105604)
3. Emerson, J., M. Rosenfeld, S. McNamara, B. Ramsey, and R. L. Gibson. 2002. Pseudomonas aeruginosa and other predictors of mortality and morbidity in young children with cystic fibrosis. Pediatr. Pulmonol. 34: 91-100. (Pubitemid 34809519)
4. West, S. E., L. Zeng, B. L. Lee, M. R. Kosorok, A. Laxova, M. J. Rock, M. J. Splaingard, and P. M. Farrell. 2002. Respiratory infections with Pseudomonas aeruginosa in children with cystic fibrosis: early detection by serology and assessment of risk factors. J. Am. Med. Assoc. 287: 2958-2967.
5. Cook, D. J., S. D. Walter, R. J. Cook, L. E. Griffith, G. H. Guyatt, D. Leasa, R. Z. Jaeschke, and C. Brun-Buisson. 1998. Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann. Intern. Med. 129: 433-440. (Pubitemid 28428078)
6. Murphy, T. F., A. L. Brauer, K. Eschberger, P. Lobbins, L. Grove, X. Cai, and S. Sethi. 2008. Pseudomonas aeruginosa in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 177: 853-860. (Pubitemid 351600663)
7. Hamerman, J. A., K. Ogasawara, and L. L. Lanier. 2005. NK cells in innate immunity. Curr. Opin. Immunol. 17: 29-35.
8. Orange, J. S. 2002. Human natural killer cell deficiencies and susceptibility to infection. Microbes Infect. 4: 1545-1558. (Pubitemid 36050824)
9. Byrne, P., P. McGuirk, S. Todryk, and K. H. Mills. 2004. Depletion of NK cells results in disseminating lethal infection with Bordetella pertussis associated with a reduction of antigen-specific Th1 and enhancement of Th2, but not Tr1 cells. Eur. J. Immunol. 34: 2579-2588. (Pubitemid 39302815)
10. Junqueira-Kipnis, A. P., A. Kipnis, A. Jamieson, M. G. Juarrero, A. Diefenbach, D. H. Raulet, J. Turner, and I. M. Orme. 2003. NK cells respond to pulmonary infection with Mycobacterium tuberculosis, but play a minimal role in protection. J. Immunol. 171: 6039-6045.
11. Le-Barillec, K., J. G. Magalhaes, E. Corcuff, A. Thuizat, P. J. Sansonetti, A. Phalipon, and J. P. Di Santo. 2005. Roles for T and NK cells in the innate immune response to Shigella flexneri. J. Immunol. 175: 1735-1740. (Pubitemid 41023077)
12. Bauer, S., V. Groh, J. Wu, A. Steinle, J. H. Phillips, L. L. Lanier, and T. Spies. 1999. Activation of NK cells and T cells by NKG2D, a receptor for stressinducible MICA. Science 285: 727-729. (Pubitemid 129505074)
13. Diefenbach, A., A. M. Jamieson, S. D. Liu, N. Shastri, and D. H. Raulet. 2000. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages. Nat. Immunol. 1: 119-126.
14. Jamieson, A. M., A. Diefenbach, C. W. McMahon, N. Xiong, J. R. Carlyle, and D. H. Raulet. 2002. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity 17: 19-29.
15. Cerwenka, A., and L. L. Lanier. 2001. Natural killer cells, viruses and cancer. Nat. Rev. Immunol. 1: 41-49. (Pubitemid 33741974)
16. Kubin, M., L. Cassiano, J. Chalupny, W. Chin, D. Cosman, W. Fanslow, J. Mullberg, A. M. Rousseau, D. Ulrich, and R. Armitage. 2001. ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells. Eur. J. Immunol. 31: 1428-1437. (Pubitemid 32454690)
17. Sutherland, C. L., N. J. Chalupny, and D. Cosman. 2001. The UL16-binding proteins, a novel family of MHC class I-related ligands for NKG2D, activate natural killer cell functions. Immunol. Rev. 181: 185-192.
18. McFarland, B. J., T. Kortemme, S. F. Yu, D. Baker, and R. K. Strong. 2003. Symmetry recognizing asymmetry: analysis of the interactions between the Ctype lectin-like immunoreceptor NKG2D and MHC class I-like ligands. Structure 11: 411-422.
19. Radaev, S., and P. D. Sun. 2003. Structure and function of natural killer cell surface receptors. Annu. Rev. Biophys. Biomol. Struct. 32: 93-114. (Pubitemid 37056223)
20. Cerwenka, A., A. B. Bakker, T. McClanahan, J. Wagner, J. Wu, J. H. Phillips, and L. L. Lanier. 2000. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Immunity 12: 721-727.
21. Raulet, D. H. 2003. Roles of the NKG2D immunoreceptor and its ligands. Nat. Rev. Immunol. 3: 781-790.
22. Kasahara, M., Y. Watanabe, M. Sumasu, and T. Nagata. 2002. A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex. Proc. Natl. Acad. Sci. USA 99: 13687-13692. (Pubitemid 35215442)
23. Borchers, M. T., N. L. Harris, S. C. Wesselkamper, M. Vitucci, and D. Cosman. 2006. NKG2D ligands are expressed on stressed human airway epithelial cells. Am. J. Physiol. 291: L222-L231.
24. Borchers, M. T., N. L. Harris, S. C. Wesselkamper, S. Zhang, Y. Chen, L. Young, and G. W. Lau. 2006. The NKG2D-activating receptor mediates pulmonary clearance of Pseudomonas aeruginosa. Infect. Immun. 74: 2578-2586. (Pubitemid 43672965)
25. Tichelaar, J. W., W. Lu, and J. A. Whitsett. 2000. Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J. Biol. Chem. 275: 11858-11864. (Pubitemid 30237754)
26. Holloway, B. W., V. Krishnapillai, and A. F. Morgan. 1979. Chromosomal genetics of Pseudomonas. Microbiol. Rev. 43: 73-102.
27. Ogasawara, K., J. A. Hamerman, H. Hsin, S. Chikuma, H. Bour-Jordan, T. Chen, T. Pertel, C. Carnaud, J. A. Bluestone, and L. L. Lanier. 2003. Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity 18: 41-51. (Pubitemid 36120686)
28. Ogasawara, K., J. A. Hamerman, L. R. Ehrlich, H. Bour-Jordan, P. Santamaria, J. A. Bluestone, and L. L. Lanier. 2004. NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity 20: 757-767. (Pubitemid 38757445)
29. Skerrett, S. J., C. B. Wilson, H. D. Liggitt, and A. M. Hajjar. 2007. Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa. Am. J. Physiol. 292: L312-L322.
30. Hamerman, J. A., K. Ogasawara, and L. L. Lanier. 2004. Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J. Immunol. 172: 2001-2005. (Pubitemid 38182343)
31. Schaber, J. A., N. L. Carty, N. A. McDonald, E. D. Graham, R. Cheluvappa, J. A. Griswold, and A. N. Hamood. 2004. Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa. J. Med. Microbiol. 53: 841-853. (Pubitemid 39238389)
32. Passador, L., J. M. Cook, M. J. Gambello, L. Rust, and B. H. Iglewski. 1993. Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication. Science 260: 1127-1130. (Pubitemid 23186788)
33. Yahr, T. L., and M. C. Wolfgang. 2006. Transcriptional regulation of the Pseudomonas aeruginosa type III secretion system. Mol. Microbiol. 62: 631-640. (Pubitemid 44571590)
34. Holder, I. A., A. N. Neely, and D. W. Frank. 2001. PcrV immunization enhances survival of burned Pseudomonas aeruginosa-infected mice. Infect. Immun. 69: 5908-5910.
35. Holder, I. A., A. N. Neely, and D. W. Frank. 2001. Type III secretion/intoxication system important in virulence of Pseudomonas aeruginosa infections in burns. Burns 27: 129-130.
36. Walzer, T., M. Blery, J. Chaix, N. Fuseri, L. Chasson, S. H. Robbins, S. Jaeger, P. Andre, L. Gauthier, L. Daniel, et al. 2007. Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46. Proc. Natl. Acad. Sci. USA 104: 3384-3389. (Pubitemid 46364168)
37. Moser, C., P. O. Jensen, O. Kobayashi, H. P. Hougen, Z. Song, J. Rygaard, A. Kharazmi, and N. Hoiby. 2002. Improved outcome of chronic Pseudomonas aeruginosa lung infection is associated with induction of a Th1-dominated cytokine response. Clin. Exp. Immunol. 127: 206-213. (Pubitemid 34233924)
38. Lei, D., J. R. Lancaster, Jr., M. S. Joshi, S. Nelson, D. Stoltz, G. J. Bagby, G. Odom, J. E. Shellito, and J. K. Kolls. 1997. Activation of alveolar macrophages and lung host defenses using transfer of the interferon-γ gene. Am. J. Physiol. 272: L852-L859. (Pubitemid 27241932)
39. Johansen, H. K., H. P. Hougen, J. Rygaard, and N. Hoiby. 1996. Interferon-γ (IFN-γ) treatment decreases the inflammatory response in chronic Pseudomonas aeruginosa pneumonia in rats. Clin. Exp. Immunol. 103: 212-218.
40. Wojnarowski, C., T. Frischer, E. Hofbauer, C. Grabner, W. Mosgoeller, I. Eichler, and R. Ziesche. 1999. Cytokine expression in bronchial biopsies of cystic fibrosis patients with and without acute exacerbation. Eur. Respir. J. 14: 1136-1144.
41. Moser, C., H. P. Hougen, Z. Song, J. Rygaard, A. Kharazmi, and N. Hoiby. 1999. Early immune response in susceptible and resistant mice strains with chronic Pseudomonas aeruginosa lung infection determines the type of T-helper cell response. APMIS 107: 1093-1100. (Pubitemid 30016634)
42. Cerwenka, A., J. L. Baron, and L. L. Lanier. 2001. Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits natural killer cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc. Natl. Acad. Sci. USA 98: 11521-11526. (Pubitemid 32928761)
43. Lodoen, M., K. Ogasawara, J. A. Hamerman, H. Arase, J. P. Houchins, E. S. Mocarski, and L. L. Lanier. 2003. NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules. J. Exp. Med. 197: 1245-1253. (Pubitemid 36617771)
44. Vankayalapati, R., A. Garg, A. Porgador, D. E. Griffith, P. Klucar, H. Safi, W. M. Girard, D. Cosman, T. Spies, and P. F. Barnes. 2005. Role of NK cellactivating receptors and their ligands in the lysis of mononuclear phagocytes infected with an intracellular bacterium. J. Immunol. 175: 4611-4617. (Pubitemid 41362000)
45. Fang, M., L. L. Lanier, and L. J. Sigal. 2008. A role for NKG2D in NK cellmediated resistance to poxvirus disease. PLoS Pathog. 4: e30. (Pubitemid 351340717)