C-Cbl regulates αpix-mediated cell migration and invasion

Biochemical and Biophysical Research Communications

Volumn 455, Issue 3-4, 2014, Pages 153-158

  Seong, Min Woo ^a   Park, Ji Ho ^a   Yoo, Hee Min ^a   Yang, Seung Wook ^a   Oh, Kyu Hee ^a   Ka, Seung Hyeun ^a   Park, Dong Eun ^a   Lee, Soon Tae ^b   Chung, Chin Ha ^a  

^a Seoul National University   (South Korea)

^b Seoul National University Hospital   (South Korea)

Author keywords

c Cbl; Cell invasion; Cell migration; Glioma; Pix

Indexed keywords

ALPHAPIX PROTEIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETAPIX PROTEIN; CBL PROTEIN; PROTEASOME; PROTEIN; SHORT HAIRPIN RNA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ARHGEF6 PROTEIN, HUMAN; CBL PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; PROTEIN BINDING; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; CELL FUNCTION; CELL INVASION; CELL MIGRATION; COMPARATIVE STUDY; CONTROLLED STUDY; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; TUMOR INVASION; UBIQUITINATION; UPREGULATION; ANIMAL; CELL MOTION; GENETIC COMPLEMENTATION; GENETICS; GLIOMA; HEK293 CELL LINE; METABOLISM; MUTATION; MYELOID LEUKEMIA; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; GENETIC COMPLEMENTATION TEST; GLIOMA; HEK293 CELLS; HUMANS; LEUKEMIA, MYELOID; MUTATION; NEOPLASM INVASIVENESS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-CBL; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS; RNA, MESSENGER; RNA, SMALL INTERFERING; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION;

EID: 84914095527     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.10.129     Document Type: Article

References (37)

1. J.J. Bravo-Cordero, L. Hodgson, and J. Condeelis Directed cell invasion and migration during metastasis Curr. Opin. Cell Biol. 24 2012 277 283
2. M. Nakada, S. Nakada, T. Demuth, N.L. Tran, D.B. Hoelzinger, and M.E. Berens Molecular targets of glioma invasion Cell. Mol. Life Sci. 64 2007 458 478
3. D. Baird, Q. Feng, and R.A. Cerione The Cool-2/alpha-Pix protein mediates a Cdc42-Rac signaling cascade Curr. Biol. 15 2005 1 10
4. D. Baird, Q. Feng, and R.A. Cerione Biochemical characterization of the Cool (Cloned-out-of-Library)/Pix (Pak-interactive exchange factor) proteins Methods Enzymol. 406 2006 58 69
5. E. Manser, T.H. Loo, C.G. Koh, Z.S. Zhao, X.Q. Chen, L. Tan, I. Tan, T. Leung, and L. Lim PAK kinases are directly coupled to the PIX family of nucleotide exchange factors Mol. Cell 1 1998 183 192
6. A. Obermeier, S. Ahmed, E. Manser, S.C. Yen, C. Hall, and L. Lim PAK promotes morphological changes by acting upstream of Rac EMBO J. 17 1998 4328 4339
7. Z.S. Zhao, E. Manser, T.H. Loo, and L. Lim Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly Mol. Cell. Biol. 20 2000 6354 6363
8. M. Lucanic, and H.J. Cheng A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans PLoS Genet. 4 2008 e1000269
9. M. Meseke, G. Rosenberger, and E. Forster Reelin and the Cdc42/Rac1 guanine nucleotide exchange factor alphaPIX/Arhgef6 promote dendritic Golgi translocation in hippocampal neurons Eur. J. Neurosci. 37 2013 1404 1412
10. N.K. Singh, V. Kundumani-Sridharan, and G.N. Rao 12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation Blood 118 2013 5701 5712
11. Y. Mazaki, S. Hashimoto, T. Tsujimura, M. Morishige, A. Hashimoto, K. Aritake, A. Yamada, J.M. Nam, H. Kiyonari, K. Nakao, and H. Sabe Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2 Nat. Immunol. 7 2006 724 731
12. M. Santiago-Medina, K.A. Gregus, and T.M. Gomez PAK-PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowth J. Cell Sci. 126 2012 1122 1133
13. K. Missy, B. Hu, K. Schilling, A. Harenberg, V. Sakk, K. Kuchenbecker, K. Kutsche, and K.D. Fischer AlphaPIX Rho GTPase guanine nucleotide exchange factor regulates lymphocyte functions and antigen receptor signaling Mol. Cell. Biol. 28 2008 3776 3789
14. T. Yokota, J. Kouno, K. Adachi, H. Takahashi, A. Teramoto, K. Matsumoto, Y. Sugisaki, M. Onda, and T. Tsunoda Identification of histological markers for malignant glioma by genome-wide expression analysis: dynein, alpha-PIX and sorcin Acta Neuropathol. 111 2006 29 38
15. H.Y. Baek, J.W. Lim, and H. Kim Interaction between the Helicobacter pylori CagA and alpha-Pix in gastric epithelial AGS cells Ann. N. Y. Acad. Sci. 1096 2007 18 23
16. M.H. Schmidt, and I. Dikic The Cbl interactome and its functions Nat. Rev. Mol. Cell Biol. 6 2005 907 918
17. Y.H. Tan, S. Krishnaswamy, S. Nandi, R. Kanteti, S. Vora, K. Onel, R. Hasina, F.Y. Lo, E. El-Hashani, G. Cervantes, M. Robinson, H.S. Hsu, S.C. Kales, S. Lipkowitz, T. Karrison, M. Sattler, E.E. Vokes, Y.C. Wang, and R. Salgia CBL is frequently altered in lung cancers: its relationship to mutations in MET and EGFR tyrosine kinases PLoS ONE 5 2010 e8972
18. L. Truitt, T. Freywald, J. DeCoteau, N. Sharfe, and A. Freywald The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells Cancer Res. 70 2010 1141 1153
19. C. Huang Roles of E3 ubiquitin ligases in cell adhesion and migration Cell Adh. Migr. 4 2010 10 18
20. K. Rafiq, J. Guo, L. Vlasenko, X. Guo, M.A. Kolpakov, A. Sanjay, S.R. Houser, and A. Sabri C-Cbl ubiquitin ligase regulates focal adhesion protein turnover and myofibril degeneration induced by neutrophil protease cathepsin G J. Biol. Chem. 287 2011 5327 5339
21. S. Abbas, G. Rotmans, B. Lowenberg, and P.J. Valk Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias Haematologica 93 2008 1595 1597
22. S. Martinelli, A. De Luca, E. Stellacci, C. Rossi, S. Checquolo, F. Lepri, V. Caputo, M. Silvano, F. Buscherini, F. Consoli, G. Ferrara, M.C. Digilio, M.L. Cavaliere, J.M. van Hagen, G. Zampino, I. van der Burgt, G.B. Ferrero, L. Mazzanti, I. Screpanti, H.G. Yntema, W.M. Nillesen, R. Savarirayan, M. Zenker, B. Dallapiccola, B.D. Gelb, and M. Tartaglia Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype Am. J. Hum. Genet. 87 2010 250 257
23. M.R. McKeller, R.S. Robetorye, P.L. Dahia, and R.C. Aguiar Integrity of the CBL gene in mature B-cell malignancies Blood 114 2009 4321 4322
24. C.M. Niemeyer, M.W. Kang, D.H. Shin, I. Furlan, M. Erlacher, N.J. Bunin, S. Bunda, J.Z. Finklestein, K.M. Sakamoto, T.A. Gorr, P. Mehta, I. Schmid, G. Kropshofer, S. Corbacioglu, P.J. Lang, C. Klein, P.G. Schlegel, A. Heinzmann, M. Schneider, J. Stary, M.M. van den Heuvel-Eibrink, H. Hasle, F. Locatelli, D. Sakai, S. Archambeault, L. Chen, R.C. Russell, S.S. Sybingco, M. Ohh, B.S. Braun, C. Flotho, and M.L. Loh Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia Nat. Genet. 42 2010 794 800
25. C. Reindl, H. Quentmeier, K. Petropoulos, P.A. Greif, T. Benthaus, B. Argiropoulos, G. Mellert, S. Vempati, J. Duyster, C. Buske, S.K. Bohlander, K.R. Humphries, W. Hiddemann, and K. Spiekermann CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes Clin. Cancer Res. 15 2009 2238 2247
26. Q. Feng, D. Baird, and R.A. Cerione Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix EMBO J. 23 2004 3492 3504
27. J.A. Flanders, Q. Feng, S. Bagrodia, M.T. Laux, A. Singavarapu, and R.A. Cerione The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins FEBS Lett. 550 2003 119 123
28. D. Jozic, N. Cardenes, Y.L. Deribe, G. Moncalian, D. Hoeller, Y. Groemping, I. Dikic, K. Rittinger, and J. Bravo Cbl promotes clustering of endocytic adaptor proteins Nat. Struct. Mol. Biol. 12 2005 972 979
29. M.H. Schmidt, K. Husnjak, I. Szymkiewicz, K. Haglund, and I. Dikic Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix Oncogene 25 2006 3071 3078
30. W.J. Wu, S. Tu, and R.A. Cerione Activated Cdc42 sequesters c-Cbl and prevents EGF receptor degradation Cell 114 2003 715 725
31. K.T. Hua, C.T. Tan, G. Johansson, J.M. Lee, P.W. Yang, H.Y. Lu, C.K. Chen, J.L. Su, P.B. Chen, Y.L. Wu, C.C. Chi, H.J. Kao, H.J. Shih, M.W. Chen, M.H. Chien, P.S. Chen, W.J. Lee, T.Y. Cheng, G. Rosenberger, C.Y. Chai, C.J. Yang, M.S. Huang, T.C. Lai, T.Y. Chou, M. Hsiao, and M.L. Kuo N-alpha-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity Cancer Cell 19 2011 218 231
32. E.S. Wong, C.W. Fong, J. Lim, P. Yusoff, B.C. Low, W.Y. Langdon, and G.R. Guy Sprouty2 attenuates epidermal growth factor receptor ubiquitination and endocytosis, and consequently enhances Ras/ERK signalling EMBO J. 21 2002 4796 4808
33. J. Zhang, M.A. Antonyak, G. Singh, and R.A. Cerione A mechanism for the upregulation of EGF receptor levels in glioblastomas Cell Rep. 3 2013 2008 2020
34. H. Ohgaki, and P. Kleihues Epidemiology and etiology of gliomas Acta Neuropathol. 109 2005 93 108
35. W. Liu, G. Lv, Y. Li, L. Li, and B. Wang Downregulation of CDKN2A and suppression of cyclin D1 gene expressions in malignant gliomas J. Exp. Clin. Cancer Res. 30 2011 76 82
36. I. Dikic, and M.H. Schmidt Malfunctions within the Cbl interactome uncouple receptor tyrosine kinases from destructive transport Eur. J. Cell Biol. 86 2007 505 512
37. S.C. Kales, P.E. Ryan, M.M. Nau, and S. Lipkowitz Cbl and human myeloid neoplasms: the Cbl oncogene comes of age Cancer Res. 70 2010 4789 4794