A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans

PLoS Genetics

Volumn 4, Issue 11, 2008, Pages

  Lucanic, Mark ^a,b   Cheng, Hwai Jong ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR KINASE INTERACTING PROTEIN; GUANOSINE TRIPHOSPHATASE; INTEGRIN RECEPTOR; P21 ACTIVATED KINASE; P21 ACTIVATED KINASE 1; PAK INTERACTING EXCHANGE FACTOR; PROTEIN CDC42; PROTEIN DERIVATIVE; PROTEIN MAX 2; RAC PROTEIN; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; CARRIER PROTEIN; GIT 1 PROTEIN, C ELEGANS; GIT-1 PROTEIN, C ELEGANS; MAX 2 PROTEIN, C ELEGANS; MAX-2 PROTEIN, C ELEGANS; PAK 1 PROTEIN, C ELEGANS; PAK-1 PROTEIN, C ELEGANS; PIX 1 PROTEIN, C ELEGANS; PIX-1 PROTEIN, C ELEGANS; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CAENORHABDITIS ELEGANS; CELL MIGRATION; CELL STRUCTURE; GONAD; IN VIVO STUDY; MORPHOGENESIS; NONHUMAN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; CELL MOTION; METABOLISM; PHYSIOLOGY;

CAENORHABDITIS ELEGANS; MAMMALIA; VERTEBRATA;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CARRIER PROTEINS; CDC42 GTP-BINDING PROTEIN; CELL MOVEMENT; MORPHOGENESIS; P21-ACTIVATED KINASES; PROTEIN-SERINE-THREONINE KINASES; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 57149102091     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000269     Document Type: Article

References (39)

1. Bagrodia S, Bailey D, Lenard Z, Hart M, Guan JL, et al. (1999) A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. J Biol Chem 274: 22393-22400.
2. Ku GM, Yablonski D, Manser E, Lim L, Weiss A (2001) A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. Embo J 20: 457-465.
3. Zhang H, Webb DJ, Asmussen H, Niu S, Horwitz AF (2005) A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC. J Neurosci 25: 3379-3388.
4. Allen KM, Gleeson JG, Bagrodia S, Partington MW, MacMillan JC, et al. (1998) PAK3 mutation in nonsyndromic X-linked mental retardation. Nat Genet 20: 25-30.
5. Kutsche K, Yntema H, Brandt A, Jantke I, Nothwang HG, et al. (2000) Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation. Nat Genet 26: 247-250.
6. Bokoch GM (2003) Biology of the p21-activated kinases. Annu Rev Biochem 72: 743-781.
7. Takai Y, Sasaki T, Matozaki T (2001) Small GTP-binding proteins. Physiol Rev 81: 153-208.
8. Zhao ZS, Manser E (2005) PAK and other Rho-associated kinases-effectors with surprisingly diverse mechanisms of regulation. Biochem J 386: 201-214.
9. Zhao ZS, Manser E, Loo TH, Lim L (2000) Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. Mol Cell Biol 20: 6354-6363.
10. Daniels RH, Zenke FT, Bokoch GM (1999) alphaPix stimulates p21-activated kinase activity through exchange factor-dependent and -independent mechanisms. J Biol Chem 274: 6047-6050.
11. Loo TH, Ng YW, Lim L, Manser E (2004) GIT1 activates p21-activated kinase through a mechanism independent of p21 binding. Mol Cell Biol 24: 3849-3859.
12. Hedgecock EM, Culotti JG, Hall DH (1990) The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4: 61-85.
13. Hedgecock EM, Culotti JG, Hall DH, Stern BD (1987) Genetics of cell and axon migrations in Caenorhabditis elegans. Development 100: 365-382.
14. Hubbard EJ, Greenstein D (2000) The Caenorhabditis elegans gonad: a test tube for cell and developmental biology. Dev Dyn 218: 2-22.
15. Baum PD, Garriga G (1997) Neuronal migrations and axon fasciculation are disrupted in ina-1 integrin mutants. Neuron 19: 51-62.
16. Walston T, Guo C, Proenca R, Wu M, Herman M, et al. (2006) mig-5/Dsh controls cell fate determination and cell migration in C. elegans. Dev Biol 298: 485-497.
17. Blelloch R, Kimble J (1999) Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans. Nature 399: 586-590.
18. Cram EJ, Shang H, Schwarzbauer JE (2006) A systematic RNA interference screen reveals a cell migration gene network in C. elegans. J Cell Sci 119: 4811-4818.
19. Kao G, Huang CC, Hedgecock EM, Hall DH, Wadsworth WG (2006) The role of the laminin beta subunit in laminin heterotrimer assembly and basement membrane function and development in C. elegans. Dev Biol 290: 211-219.
20. Merz DC, Alves G, Kawano T, Zheng H, Culotti JG (2003) UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling. Dev Biol 256: 173-186.
21. Nishiwaki K, Hisamoto N, Matsumoto K (2000) A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans. Science 288: 2205-2208.
22. Suzuki N, Toyoda H, Sano M, Nishiwaki K (2006) Chondroitin acts in the guidance of gonadal distal tip cells in C. elegans. Dev Biol 300: 635-646.
23. Lucanic M, Kiley M, Ashcroft N, L'Etoile N, Cheng HJ (2006) The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance. Development 133: 4549-4559.
24. Lundquist EA, Reddien PW, Hartwieg E, Horvitz HR, Bargmann CI (2001) Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development 128: 4475-4488.
25. Reddien PW, Horvitz HR (2000) CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat Cell Biol 2: 131-136.
26. Qadota H, Inoue M, Hikita T, Koppen M, Hardin JD, et al. (2007) Establishment of a tissue-specific RNAi system in C. elegans. Gene 400: 166-173.
27. Zhang H, Webb DJ, Asmussen H, Horwitz AF (2003) Synapse formation is regulated by the signaling adaptor GIT1. J Cell Biol 161: 131-142.
28. Premont RT, Perry SJ, Schmalzigaug R, Roseman JT, Xing Y, et al. (2004) The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors. Cell Signal 16: 1001-1011.
29. Webb DJ, Zhang H, Majumdar D, Horwitz AF (2007) alpha5 integrin signaling regulates the formation of spines and synapses in hippocampal neurons. J Biol Chem 282: 6929-6935.
30. Lee M, Cram EJ, Shen B, Schwarzbauer JE (2001) Roles for beta(pat-3) integrins in development and function of Caenorhabditis elegans muscles and gonads. J Biol Chem 276: 36404-36410.
31. Meighan CM, Schwarzbauer JE (2007) Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors. Genes Dev 21: 1615-1620.
32. Lehmann R (2001) Cell migration in invertebrates: clues from border and distal tip cells. Curr Opin Genet Dev 11: 457-463.
33. Phee H, Abraham RT, Weiss A (2005) Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1. Nat Immunol 6: 608-617.
34. Brown MC, West KA, Turner CE (2002) Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. Mol Biol Cell 13: 1550-1565.
35. Manabe R, Kovalenko M, Webb DJ, Horwitz AR (2002) GIT1 functions in a motile, multi-molecular signaling complex that regulates protrusive activity and cell migration. J Cell Sci 115: 1497-1510.
36. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77: 71-94.
37. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, et al. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811.
38. Fraser AG, Kamath RS, Zipperlen P, Martinez-Campos M, Sohrmann M, et al. (2000) Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408: 325-330.
39. Ogura K, Goshima Y (2006) The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans. Development 133: 3441-3450.