-
1
-
-
64849099456
-
Fostamatinib disodium (FosD), an oral inhibitor of Syk, is well-tolerated and has significant clinical activity in diffuse large B cell lymphoma (DLBCL) and chronic lymphocytic leukemia (SLL/CLL)
-
abstract Abstract 3
-
Friedberg JW, Sharman J, Schaefer-Cutillo J, et al. Fostamatinib disodium (FosD), an oral inhibitor of Syk, is well-tolerated and has significant clinical activity in diffuse large B cell lymphoma (DLBCL) and chronic lymphocytic leukemia (SLL/CLL) [abstract]. Blood. 2008;112(11):3a. Abstract 3.
-
(2008)
Blood
, vol.112
, Issue.11
-
-
Friedberg, J.W.1
Sharman, J.2
Schaefer-Cutillo, J.3
-
2
-
-
67649425382
-
Syk and pTyr'd: Signaling through the B cell antigen receptor
-
Geahlen RL. Syk and pTyr'd: Signaling through the B cell antigen receptor. Biochim Biophys Acta. 2009;1793(7):1115-1127.
-
(2009)
Biochim Biophys Acta
, vol.1793
, Issue.7
, pp. 1115-1127
-
-
Geahlen, R.L.1
-
3
-
-
33748196233
-
The Cbl family proteins: Ring leaders in regulation of cell signaling
-
Swaminathan G, Tsygankov AY. The Cbl family proteins: ring leaders in regulation of cell signaling. J Cell Physiol. 2006;209(1):21-43.
-
(2006)
J Cell Physiol.
, vol.209
, Issue.1
, pp. 21-43
-
-
Swaminathan, G.1
Tsygankov, A.Y.2
-
4
-
-
41349110211
-
SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma
-
Chen L, Monti S, Juszczynski P, et al. SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood. 2008;111(4):2230-2237.
-
(2008)
Blood
, vol.111
, Issue.4
, pp. 2230-2237
-
-
Chen, L.1
Monti, S.2
Juszczynski, P.3
-
5
-
-
67650458526
-
Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia
-
Buchner M, Fuchs S, Prinz G, et al. Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia. Cancer Res. 2009;69(13):5424-5432.
-
(2009)
Cancer Res.
, vol.69
, Issue.13
, pp. 5424-5432
-
-
Buchner, M.1
Fuchs, S.2
Prinz, G.3
-
6
-
-
34248512113
-
Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b
-
Kitaura Y, Jang IK, Wang Y, et al. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity. 2007;26(5):567-578.
-
(2007)
Immunity
, vol.26
, Issue.5
, pp. 567-578
-
-
Kitaura, Y.1
Jang, I.K.2
Wang, Y.3
-
7
-
-
34547950568
-
Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia
-
Caligiuri MA, Briesewitz R, Yu J, et al. Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia. Blood. 2007;110(3):1022-1024.
-
(2007)
Blood
, vol.110
, Issue.3
, pp. 1022-1024
-
-
Caligiuri, M.A.1
Briesewitz, R.2
Yu, J.3
-
8
-
-
34547946211
-
Flt3-dependent transformation by inactivating c-Cbl mutations in AML
-
Sargin B, Choudhary C, Crosetto N, et al. Flt3-dependent transformation by inactivating c-Cbl mutations in AML. Blood. 2007;110(3):1004-1012.
-
(2007)
Blood
, vol.110
, Issue.3
, pp. 1004-1012
-
-
Sargin, B.1
Choudhary, C.2
Crosetto, N.3
-
9
-
-
54349105660
-
Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias
-
Abbas S, Rotmans G, Lowenberg B, Valk PJ. Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias. Haematologica. 2008;93(10):1595-1597.
-
(2008)
Haematologica
, vol.93
, Issue.10
, pp. 1595-1597
-
-
Abbas, S.1
Rotmans, G.2
Lowenberg, B.3
Valk, P.J.4
-
10
-
-
57749114621
-
250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies
-
Dunbar AJ, Gondek LP, O'Keefe CL, et al. 250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies. Cancer Res. 2008;68(24):10349-10357.
-
(2008)
Cancer Res.
, vol.68
, Issue.24
, pp. 10349-10357
-
-
Dunbar, A.J.1
Gondek, L.P.2
O'Keefe, C.L.3
-
11
-
-
67650401377
-
Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms
-
Grand FH, Hidalgo-Curtis CE, Ernst T, et al. Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Blood. 2009;113(24):6182-6192.
-
(2009)
Blood
, vol.113
, Issue.24
, pp. 6182-6192
-
-
Grand, F.H.1
Hidalgo-Curtis, C.E.2
Ernst, T.3
-
12
-
-
70349249988
-
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia
-
Loh ML, Sakai DS, Flotho C, et al. Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. Blood. 2009;114(9):1859-1863.
-
(2009)
Blood
, vol.114
, Issue.9
, pp. 1859-1863
-
-
Loh, M.L.1
Sakai, D.S.2
Flotho, C.3
-
13
-
-
65249132999
-
CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes
-
Reindl C, Quentmeier H, Petropoulos K, et al. CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes. Clin Cancer Res. 2009;15(7): 2238-2247.
-
(2009)
Clin Cancer Res.
, vol.15
, Issue.7
, pp. 2238-2247
-
-
Reindl, C.1
Quentmeier, H.2
Petropoulos, K.3
-
14
-
-
68949124841
-
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
-
Sanada M, Suzuki T, Shih LY, et al. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature. 2009;460(7257):904-908.
-
(2009)
Nature
, vol.460
, Issue.7257
, pp. 904-908
-
-
Sanada, M.1
Suzuki, T.2
Shih, L.Y.3
-
15
-
-
52249091511
-
Whole-genome scanning by array comparative genomic hybridization as a clinical tool for risk assessment in chronic lymphocytic leukemia
-
Gunn SR, Mohammed MS, Gorre ME, et al. Whole-genome scanning by array comparative genomic hybridization as a clinical tool for risk assessment in chronic lymphocytic leukemia. J Mol Diagn. 2008;10(5):442-451.
-
(2008)
J Mol Diagn.
, vol.10
, Issue.5
, pp. 442-451
-
-
Gunn, S.R.1
Mohammed, M.S.2
Gorre, M.E.3
-
16
-
-
68249144342
-
Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma
-
Li C, Kim SW, Rai D, et al. Copy number abnormalities, MYC activity, and the genetic fingerprint of normal B cells mechanistically define the microRNA profile of diffuse large B-cell lymphoma. Blood. 2009;113(26):6681-6690.
-
(2009)
Blood
, vol.113
, Issue.26
, pp. 6681-6690
-
-
Li, C.1
Kim, S.W.2
Rai, D.3
-
17
-
-
66649112854
-
Frequent inactivation of A20 in B-cell lymphomas
-
Kato M, Sanada M, Kato I, et al. Frequent inactivation of A20 in B-cell lymphomas. Nature. 2009;459(7247):712-716.
-
(2009)
Nature
, vol.459
, Issue.7247
, pp. 712-716
-
-
Kato, M.1
Sanada, M.2
Kato, I.3
|