-
1
-
-
67650874081
-
Cancer statistics, 2009
-
Jemal A, Siegel R, Ward E, Hao Y, Xu J, et al. (2009) Cancer statistics, 2009. CA Cancer J Clin 59: 225-249.
-
(2009)
CA Cancer J Clin
, vol.59
, pp. 225-249
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
-
2
-
-
0024467516
-
-
Langdon WY, Hyland CD, Grumont RJ, Morse HC 3rd (1989) The c-cbl protooncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein. J Virol 63: 5420-5424.
-
Langdon WY, Hyland CD, Grumont RJ, Morse HC 3rd (1989) The c-cbl protooncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein. J Virol 63: 5420-5424.
-
-
-
-
3
-
-
33748196233
-
The Cbl family proteins: Ring leaders in regulation of cell signaling
-
Swaminathan G, Tsygankov AY (2006) The Cbl family proteins: ring leaders in regulation of cell signaling. J Cell Physiol 209: 21-43.
-
(2006)
J Cell Physiol
, vol.209
, pp. 21-43
-
-
Swaminathan, G.1
Tsygankov, A.Y.2
-
4
-
-
0038581265
-
Comparative genomic organization of the cbl genes
-
Nau MM, Lipkowitz S (2003) Comparative genomic organization of the cbl genes. Gene 308: 103-113.
-
(2003)
Gene
, vol.308
, pp. 103-113
-
-
Nau, M.M.1
Lipkowitz, S.2
-
5
-
-
34848888401
-
Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase
-
Kozlov G, Peschard P, Zimmerman B, Lin T, Moldoveanu T, et al. (2007) Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase. J Biol Chem 282: 27547-27555.
-
(2007)
J Biol Chem
, vol.282
, pp. 27547-27555
-
-
Kozlov, G.1
Peschard, P.2
Zimmerman, B.3
Lin, T.4
Moldoveanu, T.5
-
6
-
-
0033529537
-
The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor
-
Waterman H, Levkowitz G, Alroy I, Yarden Y (1999) The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor. J Biol Chem 274: 22151-22154.
-
(1999)
J Biol Chem
, vol.274
, pp. 22151-22154
-
-
Waterman, H.1
Levkowitz, G.2
Alroy, I.3
Yarden, Y.4
-
7
-
-
0031011155
-
EGF receptor binding and transformation by vcbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene
-
Thien CB, Langdon WY (1997) EGF receptor binding and transformation by vcbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene. Oncogene 14: 2239-2249.
-
(1997)
Oncogene
, vol.14
, pp. 2239-2249
-
-
Thien, C.B.1
Langdon, W.Y.2
-
8
-
-
0033523010
-
Cblmediated negative regulation of platelet-derived growth factor receptordependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain
-
Miyake S, Mullane-Robinson KP, Lill NL, Douillard P, Band H (1999) Cblmediated negative regulation of platelet-derived growth factor receptordependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain. J Biol Chem 274: 16619-16628.
-
(1999)
J Biol Chem
, vol.274
, pp. 16619-16628
-
-
Miyake, S.1
Mullane-Robinson, K.P.2
Lill, N.L.3
Douillard, P.4
Band, H.5
-
9
-
-
0034614652
-
The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance downregulation of the epidermal growth factor receptor
-
Lill NL, Douillard P, Awwad RA, Ota S, Lupher ML Jr, et al. (2000) The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance downregulation of the epidermal growth factor receptor. J Biol Chem 275: 367-377.
-
(2000)
J Biol Chem
, vol.275
, pp. 367-377
-
-
Lill, N.L.1
Douillard, P.2
Awwad, R.A.3
Ota, S.4
Lupher Jr, M.L.5
-
10
-
-
0033522219
-
Structure of the aminoterminal domain of Cbl complexed to its binding site on ZAP-70 kinase
-
Meng W, Sawasdikosol S, Burakoff SJ, Eck MJ (1999) Structure of the aminoterminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature 398: 84-90.
-
(1999)
Nature
, vol.398
, pp. 84-90
-
-
Meng, W.1
Sawasdikosol, S.2
Burakoff, S.J.3
Eck, M.J.4
-
11
-
-
0035930341
-
Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
-
Peschard P, Fournier TM, Lamorte L, Naujokas MA, Band H, et al. (2001) Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol Cell 8: 995-1004.
-
(2001)
Mol Cell
, vol.8
, pp. 995-1004
-
-
Peschard, P.1
Fournier, T.M.2
Lamorte, L.3
Naujokas, M.A.4
Band, H.5
-
12
-
-
0034682718
-
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases
-
Zheng N, Wang P, Jeffrey PD, Pavletich NP (2000) Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell 102: 533-539.
-
(2000)
Cell
, vol.102
, pp. 533-539
-
-
Zheng, N.1
Wang, P.2
Jeffrey, P.D.3
Pavletich, N.P.4
-
13
-
-
17544365654
-
Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins
-
Fukazawa T, Miyake S, Band V, Band H (1996) Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. J Biol Chem 271: 14554-14559.
-
(1996)
J Biol Chem
, vol.271
, pp. 14554-14559
-
-
Fukazawa, T.1
Miyake, S.2
Band, V.3
Band, H.4
-
14
-
-
0028885860
-
Coupling of the proto-oncogene product c-Cbl to the epidermal growth factor receptor
-
Meisner H, Czech MP (1995) Coupling of the proto-oncogene product c-Cbl to the epidermal growth factor receptor. J Biol Chem 270: 25332-25335.
-
(1995)
J Biol Chem
, vol.270
, pp. 25332-25335
-
-
Meisner, H.1
Czech, M.P.2
-
15
-
-
0033545668
-
cbl-b inhibits epidermal growth factor receptor signaling
-
Ettenberg SA, Keane MM, Nau MM, Frankel M, Wang LM, et al. (1999) cbl-b inhibits epidermal growth factor receptor signaling. Oncogene 18: 1855-1866.
-
(1999)
Oncogene
, vol.18
, pp. 1855-1866
-
-
Ettenberg, S.A.1
Keane, M.M.2
Nau, M.M.3
Frankel, M.4
Wang, L.M.5
-
16
-
-
0034714277
-
Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome
-
Bao J, Alroy I, Waterman H, Schejter ED, Brodie C, et al. (2000) Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome. J Biol Chem 275: 26178-26186.
-
(2000)
J Biol Chem
, vol.275
, pp. 26178-26186
-
-
Bao, J.1
Alroy, I.2
Waterman, H.3
Schejter, E.D.4
Brodie, C.5
-
17
-
-
0035162703
-
Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking
-
Burke P, Schooler K, Wiley HS (2001) Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Mol Biol Cell 12: 1897-1910.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 1897-1910
-
-
Burke, P.1
Schooler, K.2
Wiley, H.S.3
-
18
-
-
0034794184
-
The interface of receptor trafficking and signalling
-
Clague MJ, Urbe S (2001) The interface of receptor trafficking and signalling. J Cell Sci 114: 3075-3081.
-
(2001)
J Cell Sci
, vol.114
, pp. 3075-3081
-
-
Clague, M.J.1
Urbe, S.2
-
19
-
-
35549013373
-
Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling
-
Shtiegman K, Kochupurakkal BS, Zwang Y, Pines G, Starr A, et al. (2007) Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling. Oncogene 26: 6968-6978.
-
(2007)
Oncogene
, vol.26
, pp. 6968-6978
-
-
Shtiegman, K.1
Kochupurakkal, B.S.2
Zwang, Y.3
Pines, G.4
Starr, A.5
-
20
-
-
34547946211
-
Flt3-dependent transformation by inactivating c-Cbl mutations in AML
-
Sargin B, Choudhary C, Crosetto N, Schmidt MH, Grundler R, et al. (2007) Flt3-dependent transformation by inactivating c-Cbl mutations in AML. Blood 110: 1004-1012.
-
(2007)
Blood
, vol.110
, pp. 1004-1012
-
-
Sargin, B.1
Choudhary, C.2
Crosetto, N.3
Schmidt, M.H.4
Grundler, R.5
-
21
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J, Brennan C, Shih JY, Riely G, Viale A, et al. (2007) MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 104: 20932-20937.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
Riely, G.4
Viale, A.5
-
22
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, et al. (2007) MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316: 1039-1043.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
-
23
-
-
34547950568
-
Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia
-
Caligiuri MA, Briesewitz R, Yu J, Wang L, Wei M, et al. (2007) Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia. Blood 110: 1022-1024.
-
(2007)
Blood
, vol.110
, pp. 1022-1024
-
-
Caligiuri, M.A.1
Briesewitz, R.2
Yu, J.3
Wang, L.4
Wei, M.5
-
24
-
-
67650401377
-
Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms
-
Grand FH, Hidalgo-Curtis CE, Ernst T, Zoi K, Zoi C, et al. (2009) Frequent CBL mutations associated with 11q acquired uniparental disomy in myeloproliferative neoplasms. Blood 113: 6182-6192.
-
(2009)
Blood
, vol.113
, pp. 6182-6192
-
-
Grand, F.H.1
Hidalgo-Curtis, C.E.2
Ernst, T.3
Zoi, K.4
Zoi, C.5
-
25
-
-
57749114621
-
250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies
-
Dunbar AJ, Gondek LP, O'Keefe CL, Makishima H, Rataul MS, et al. (2008) 250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies. Cancer Res 68: 10349-10357.
-
(2008)
Cancer Res
, vol.68
, pp. 10349-10357
-
-
Dunbar, A.J.1
Gondek, L.P.2
O'Keefe, C.L.3
Makishima, H.4
Rataul, M.S.5
-
26
-
-
68949124841
-
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
-
Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, et al. (2009) Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature 460: 904-908.
-
(2009)
Nature
, vol.460
, pp. 904-908
-
-
Sanada, M.1
Suzuki, T.2
Shih, L.Y.3
Otsu, M.4
Kato, M.5
-
27
-
-
65249132999
-
CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes
-
Reindl C, Quentmeier H, Petropoulos K, Greif PA, Benthaus T, et al. (2009) CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes. Clin Cancer Res 15: 2238-2247.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2238-2247
-
-
Reindl, C.1
Quentmeier, H.2
Petropoulos, K.3
Greif, P.A.4
Benthaus, T.5
-
28
-
-
0035316576
-
Cbl: Many adaptations to regulate protein tyrosine kinases
-
Thien CB, Langdon WY (2001) Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol 2: 294-307.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 294-307
-
-
Thien, C.B.1
Langdon, W.Y.2
-
29
-
-
65249132999
-
CBL Exon 8/9 Mutants Activate the FLT3 Pathway and Cluster in Core Binding Factor/11q Deletion Acute Myeloid Leukemia/Myelodysplastic Syndrome Subtypes
-
Reindl C, Quentmeier H, Petropoulos K, Greif PA, Benthaus T, et al. (2009) CBL Exon 8/9 Mutants Activate the FLT3 Pathway and Cluster in Core Binding Factor/11q Deletion Acute Myeloid Leukemia/Myelodysplastic Syndrome Subtypes. Clin Cancer Res 15: 2238-2247.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2238-2247
-
-
Reindl, C.1
Quentmeier, H.2
Petropoulos, K.3
Greif, P.A.4
Benthaus, T.5
-
31
-
-
70349443680
-
Ethnic differences and functional analysis of MET mutations in lung cancer
-
Krishnaswamy S, Kanteti R, Duke-Cohan JS, Loganathan S, Liu W, et al. (2009) Ethnic differences and functional analysis of MET mutations in lung cancer. Clin Cancer Res 15: 5714-5723.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5714-5723
-
-
Krishnaswamy, S.1
Kanteti, R.2
Duke-Cohan, J.S.3
Loganathan, S.4
Liu, W.5
-
32
-
-
34248379575
-
Ubiquitin and ubiquitin-like proteins in protein regulation
-
Herrmann J, Lerman LO, Lerman A (2007) Ubiquitin and ubiquitin-like proteins in protein regulation. Circ Res 100: 1276-1291.
-
(2007)
Circ Res
, vol.100
, pp. 1276-1291
-
-
Herrmann, J.1
Lerman, L.O.2
Lerman, A.3
-
33
-
-
39049159657
-
Drosophila cbl is essential for control of cell death and cell differentiation during eye development
-
Wang Y, Werz C, Xu D, Chen Z, Li Y, et al. (2008) Drosophila cbl is essential for control of cell death and cell differentiation during eye development. PLoS One 3: e1447.
-
(2008)
PLoS One
, vol.3
-
-
Wang, Y.1
Werz, C.2
Xu, D.3
Chen, Z.4
Li, Y.5
-
34
-
-
33645742736
-
Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of Cdc42
-
Hirsch DS, Shen Y, Wu WJ (2006) Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of Cdc42. Cancer Res 66: 3523-3530.
-
(2006)
Cancer Res
, vol.66
, pp. 3523-3530
-
-
Hirsch, D.S.1
Shen, Y.2
Wu, W.J.3
-
35
-
-
0036587680
-
The Cbl family of ubiquitin ligases: Critical negative regulators of tyrosine kinase signaling in the immune system
-
Rao N, Dodge I, Band H (2002) The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J Leukoc Biol 71: 753-763.
-
(2002)
J Leukoc Biol
, vol.71
, pp. 753-763
-
-
Rao, N.1
Dodge, I.2
Band, H.3
-
36
-
-
0032438114
-
Altered thymic positive selection and intracellular signals in Cbl-deficient mice
-
Naramura M, Kole HK, Hu RJ, Gu H (1998) Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc Natl Acad Sci U S A 95: 15547-15552.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 15547-15552
-
-
Naramura, M.1
Kole, H.K.2
Hu, R.J.3
Gu, H.4
-
37
-
-
0031858649
-
Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice
-
Murphy MA, Schnall RG, Venter DJ, Barnett L, Bertoncello I, et al. (1998) Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice. Mol Cell Biol 18: 4872-4882.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 4872-4882
-
-
Murphy, M.A.1
Schnall, R.G.2
Venter, D.J.3
Barnett, L.4
Bertoncello, I.5
-
38
-
-
61549138135
-
Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
-
Onozato R, Kosaka T, Kuwano H, Sekido Y, Yatabe Y, et al. (2009) Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J Thorac Oncol 4: 5-11.
-
(2009)
J Thorac Oncol
, vol.4
, pp. 5-11
-
-
Onozato, R.1
Kosaka, T.2
Kuwano, H.3
Sekido, Y.4
Yatabe, Y.5
-
39
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, et al. (2008) Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455: 1069-1075.
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
Mardis, E.R.4
McLellan, M.D.5
-
40
-
-
77749324327
-
Novel Mutations in c-Cbl Ubiquitin Ligase Gene in Taiwanese Lung Cancer
-
Tan Y-H, Salgia R, Hsieh-Li H-M, Wang Y-C (2009) Novel Mutations in c-Cbl Ubiquitin Ligase Gene in Taiwanese Lung Cancer. BioFormosa 44: 1-10.
-
(2009)
BioFormosa
, vol.44
, pp. 1-10
-
-
Tan, Y.-H.1
Salgia, R.2
Hsieh-Li, H.-M.3
Wang, Y.-C.4
|