-
1
-
-
77953077420
-
A global protein kinase and phosphatase interaction network in yeast
-
A. Breitkreutz, H. Choi, J. R. Sharom, L. Boucher, V. Neduva, B. Larsen, Z. Y. Lin, B. J. Breitkreutz, C. Stark, G. Liu, J. Ahn, D. Dewar-Darch, T. Reguly, X. Tang, R. Almeida, Z. S. Qin, T. Pawson, A. C. Gingras, A. I. Nesvizhskii, M. Tyers, A global protein kinase and phosphatase interaction network in yeast. Science 328, 1043-1046 (2010).
-
(2010)
Science
, vol.328
, pp. 1043-1046
-
-
Breitkreutz, A.1
Choi, H.2
Sharom, J.R.3
Boucher, L.4
Neduva, V.5
Larsen, B.6
Lin, Z.Y.7
Breitkreutz, B.J.8
Stark, C.9
Liu, G.10
Ahn, J.11
Dewar-Darch, D.12
Reguly, T.13
Tang, X.14
Almeida, R.15
Qin, Z.S.16
Pawson, T.17
Gingras, A.C.18
Nesvizhskii, A.I.19
Tyers, M.20
more..
-
2
-
-
84878243037
-
Signalling change: Signal transduction through the decades
-
N. E. Hynes, P. W. Ingham, W. A. Lim, C. J. Marshall, J. Massagué, T. Pawson, Signalling change: Signal transduction through the decades. Nat. Rev. Mol. Cell Biol. 14, 393-398 (2013).
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 393-398
-
-
Hynes, N.E.1
Ingham, P.W.2
Lim, W.A.3
Marshall, C.J.4
Massagué, J.5
Pawson, T.6
-
3
-
-
0033768106
-
Analysis of yeast protein kinases using protein chips
-
H. Zhu, J. F. Klemic, S. Chang, P. Bertone, A. Casamayor, K. G. Klemic, D. Smith,M. Gerstein, M. A. Reed, M. Snyder, Analysis of yeast protein kinases using protein chips. Nat. Genet. 26, 283-289 (2000).
-
(2000)
Nat. Genet.
, vol.26
, pp. 283-289
-
-
Zhu, H.1
Klemic, J.F.2
Chang, S.3
Bertone, P.4
Casamayor, A.5
Klemic, K.G.6
Smithm. Gerstein, D.7
Reed, M.A.8
Snyder, M.9
-
4
-
-
84865066280
-
Evolution of the eukaryotic protein kinases as dynamic molecular switches
-
S. S. Taylor, M. M. Keshwani, J. M. Steichen, A. P. Kornev, Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philos. Trans. R. Soc. Lond. B Biol. Sci. 367, 2517-2528 (2012).
-
(2012)
Philos. Trans. R. Soc. Lond. B Biol. Sci.
, vol.367
, pp. 2517-2528
-
-
Taylor, S.S.1
Keshwani, M.M.2
Steichen, J.M.3
Kornev, A.P.4
-
5
-
-
84886629236
-
Deciphering the structural basis of eukaryotic protein kinase regulation
-
H. S. Meharena, P. Chang, M. M. Keshwani, K. Oruganty, A. K. Nene, N. Kannan, S. S. Taylor, A. P. Kornev, Deciphering the structural basis of eukaryotic protein kinase regulation. PLOS Biol. 11, e1001680 (2013).
-
(2013)
PLOS Biol.
, vol.11
, pp. e1001680
-
-
Meharena, H.S.1
Chang, P.2
Keshwani, M.M.3
Oruganty, K.4
Nene, A.K.5
Kannan, N.6
Taylor, S.S.7
Kornev, A.P.8
-
6
-
-
74949097227
-
Global identification of protein kinase substrates by protein microarray analysis
-
J. Mok, H. Im, M. Snyder, Global identification of protein kinase substrates by protein microarray analysis. Nat. Protoc. 4, 1820-1827 (2009).
-
(2009)
Nat. Protoc.
, vol.4
, pp. 1820-1827
-
-
Mok, J.1
Im, H.2
Snyder, M.3
-
7
-
-
78650632764
-
Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast
-
B. Bodenmiller, S. Wanka, C. Kraft, J. Urban, D. Campbell, P. G. Pedrioli, B. Gerrits, P. Picotti, H. Lam,O. Vitek, M. Y. Brusniak, B. Roschitzki, C. Zhang, K. M. Shokat, R. Schlapbach, A. Colman-Lerner, G. P. Nolan, A. I. Nesvizhskii, M. Peter, R. Loewith, C. von Mering, R. Aebersold, Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Sci. Signal. 3, rs4 (2010).
-
(2010)
Sci. Signal.
, vol.3
, pp. rs4
-
-
Bodenmiller, B.1
Wanka, S.2
Kraft, C.3
Urban, J.4
Campbell, D.5
Pedrioli, P.G.6
Gerrits, B.7
Picotti, P.8
Lamo. Vitek, H.9
Brusniak, M.Y.10
Roschitzki, B.11
Zhang, C.12
Shokat, K.M.13
Schlapbach, R.14
Colman-Lerner, A.15
Nolan, G.P.16
Nesvizhskii, A.I.17
Peter, M.18
Loewith, R.19
Von Mering, C.20
Aebersold, R.21
more..
-
8
-
-
84859520339
-
Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs
-
S. Sharifpoor, D. van Dyk, M. Costanzo, A. Baryshnikova, H. Friesen, A. C. Douglas, J. Y. Youn, B. VanderSluis, C. L. Myers, B. Papp, C. Boone, B. J. Andrews, Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Genome Res. 22, 791-801 (2012).
-
(2012)
Genome Res.
, vol.22
, pp. 791-801
-
-
Sharifpoor, S.1
Van Dyk, D.2
Costanzo, M.3
Baryshnikova, A.4
Friesen, H.5
Douglas, A.C.6
Youn, J.Y.7
Vandersluis, B.8
Myers, C.L.9
Papp, B.10
Boone, C.11
Andrews, B.J.12
-
9
-
-
78649938122
-
Functional overlap and regulatory links shape genetic interactions between signaling pathways
-
S. vanWageningen, P. Kemmeren, P. Lijnzaad, T. Margaritis, J. J. Benschop, I. J. de Castro, D. van Leenen, M. J. A. Groot Koerkamp, C. W. Ko, A. J. Miles, N. Brabers, M. O. Brok, T. L. Lenstra, D. Fiedler, L. Fokkens, R. Aldecoa, E. Apweiler, V. Taliadouros, K. Sameith, L. A. L. van de Pasch, S. R. van Hooff, L. V. Bakker, N. J. Krogan, B. Snel, F. C. P. Holstege, Functional overlap and regulatory links shape genetic interactions between signaling pathways. Cell 143, 991-1004 (2010).
-
(2010)
Cell
, vol.143
, pp. 991-1004
-
-
Vanwageningen, S.1
Kemmeren, P.2
Lijnzaad, P.3
Margaritis, T.4
Benschop, J.J.5
De Castro, I.J.6
Van Leenen, D.7
Groot Koerkamp, M.J.A.8
Ko, C.W.9
Miles, A.J.10
Brabers, N.11
Brok, M.O.12
Lenstra, T.L.13
Fiedler, D.14
Fokkens, L.15
Aldecoa, R.16
Apweiler, E.17
Taliadouros, V.18
Sameith, K.19
De Van Pasch, L.L.A.20
Van Hooff, S.R.21
Bakker, L.V.22
Krogan, N.J.23
Snel, B.24
Holstege, F.C.P.25
more..
-
10
-
-
84869430619
-
Regulation of yeast central metabolism by enzyme phosphorylation
-
A. P. Oliveira, C. Ludwig, P. Picotti, M. Kogadeeva, R. Aebersold, U. Sauer, Regulation of yeast central metabolism by enzyme phosphorylation. Mol. Syst. Biol. 8, 623 (2012).
-
(2012)
Mol. Syst. Biol.
, vol.8
, pp. 623
-
-
Oliveira, A.P.1
Ludwig, C.2
Picotti, P.3
Kogadeeva, M.4
Aebersold, R.5
Sauer, U.6
-
11
-
-
48349138726
-
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle
-
H. Daub, J. V. Olsen, M. Bairlein, F. Gnad, F. S. Oppermann, R. Körner, Z. Greff, G. Kéri, O. Stemmann, M. Mann, Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell 31, 438-448 (2008).
-
(2008)
Mol. Cell
, vol.31
, pp. 438-448
-
-
Daub, H.1
Olsen, J.V.2
Bairlein, M.3
Gnad, F.4
Oppermann, F.S.5
Körner, R.6
Greff, Z.7
Kéri, G.8
Stemmann, O.9
Mann, M.10
-
12
-
-
78651296878
-
PhosphoGRID: A database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae
-
C. Stark, T. C. Su, A. Breitkreutz, P. Lourenco, M. Dahabieh, B. J. Breitkreutz, M. Tyers, I. Sadowski, PhosphoGRID: A database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae. Database J. Biol. Databases Curation 2010, bap026 (2010).
-
(2010)
Database J. Biol. Databases Curation
, vol.2010
, pp. bap026
-
-
Stark, C.1
Su, T.C.2
Breitkreutz, A.3
Lourenco, P.4
Dahabieh, M.5
Breitkreutz, B.J.6
Tyers, M.7
Sadowski, I.8
-
13
-
-
80052785690
-
High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry
-
T. Fuhrer, D. Heer, B. Begemann, N. Zamboni, High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry. Anal. Chem. 83, 7074-7080 (2011).
-
(2011)
Anal. Chem.
, vol.83
, pp. 7074-7080
-
-
Fuhrer, T.1
Heer, D.2
Begemann, B.3
Zamboni, N.4
-
14
-
-
77958597036
-
Further developments towards a genome-scale metabolic model of yeast
-
P. D. Dobson, K. Smallbone, D. Jameson, E. Simeonidis, K. Lanthaler, P. Pir, C. Lu, N. Swainston, W. B. Dunn, P. Fisher, D. Hull, M. Brown, O. Oshota, N. J. Stanford, D. B. Kell, R. D. King, S. G. Oliver, R. D. Stevens, P. Mendes, Further developments towards a genome-scale metabolic model of yeast. BMC Syst. Biol. 4, 145 (2010).
-
(2010)
BMC Syst. Biol.
, vol.4
, pp. 145
-
-
Dobson, P.D.1
Smallbone, K.2
Jameson, D.3
Simeonidis, E.4
Lanthaler, K.5
Pir, P.6
Lu, C.7
Swainston, N.8
Dunn, W.B.9
Fisher, P.10
Hull, D.11
Brown, M.12
Oshota, O.13
Stanford, N.J.14
Kell, D.B.15
King, R.D.16
Oliver, S.G.17
Stevens, R.D.18
Mendes, P.19
-
15
-
-
0033982936
-
KEGG: Kyoto encyclopedia of genes and genomes
-
M. Kanehisa, S. Goto, KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 28, 27-30 (2000).
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 27-30
-
-
Kanehisa, M.1
Goto, S.2
-
16
-
-
33847172327
-
Clustering by passing messages between data points
-
B. J. Frey, D. Dueck, Clustering by passing messages between data points. Science 315, 972-976 (2007).
-
(2007)
Science
, vol.315
, pp. 972-976
-
-
Frey, B.J.1
Dueck, D.2
-
17
-
-
78651324347
-
The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored
-
D. Szklarczyk, A. Franceschini, M. Kuhn, M. Simonovic, A. Roth, P. Minguez, T. Doerks, M. Stark, J. Muller, P. Bork, L. J. Jensen, C. von Mering, The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 39, D561-D568 (2011).
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. D561-D568
-
-
Szklarczyk, D.1
Franceschini, A.2
Kuhn, M.3
Simonovic, M.4
Roth, A.5
Minguez, P.6
Doerks, T.7
Stark, M.8
Muller, J.9
Bork, P.10
Jensen, L.J.11
Von Mering, C.12
-
18
-
-
0025647113
-
Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes
-
A. A. Sneddon, P. T. Cohen, M. J. Stark, Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes. EMBO J. 9, 4339-4346 (1990).
-
(1990)
EMBO J.
, vol.9
, pp. 4339-4346
-
-
Sneddon, A.A.1
Cohen, P.T.2
Stark, M.J.3
-
19
-
-
0023658335
-
Three different genes in S. Cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase
-
T. Toda, S. Cameron, P. Sass, M. Zoller, M. Wigler, Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50, 277-287 (1987).
-
(1987)
Cell
, vol.50
, pp. 277-287
-
-
Toda, T.1
Cameron, S.2
Sass, P.3
Zoller, M.4
Wigler, M.5
-
20
-
-
44349170639
-
Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases
-
U. Gey, C. Czupalla, B. Hoflack, G. Rödel, U. Krause-Buchholz, Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. J. Biol. Chem. 283, 9759-9767 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 9759-9767
-
-
Gey, U.1
Czupalla, C.2
Hoflack, B.3
Rödel, G.4
Krause-Buchholz, U.5
-
21
-
-
67149107074
-
Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae
-
T. J. Westmoreland, S. M. Wickramasekara, A. Y. Guo, A. L. Selim, T. S. Winsor, A. L. Greenleaf, K. L. Blackwell, J. A. Olson, J. R. Marks, C. B. Bennett, Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae. PLOS One 4, e5830 (2009).
-
(2009)
PLOS One
, vol.4
, pp. e5830
-
-
Westmoreland, T.J.1
Wickramasekara, S.M.2
Guo, A.Y.3
Selim, A.L.4
Winsor, T.S.5
Greenleaf, A.L.6
Blackwell, K.L.7
Olson, J.A.8
Marks, J.R.9
Bennett, C.B.10
-
22
-
-
0026570843
-
Yeast casein kinase i homologues: An essential gene pair
-
L. C. Robinson, E. J. Hubbard, P. R. Graves, A. A. DePaoli-Roach, P. J. Roach, C. Kung, D. W. Haas, C. H. Hagedorn, M. Goebl, M. R. Culbertson, Yeast casein kinase I homologues: An essential gene pair. Proc. Natl. Acad. Sci. U.S.A. 89, 28-32 (1992).
-
(1992)
Proc. Natl. Acad. Sci. U.S.A.
, vol.89
, pp. 28-32
-
-
Robinson, L.C.1
Hubbard, E.J.2
Graves, P.R.3
Depaoli-Roach, A.A.4
Roach, P.J.5
Kung, C.6
Haas, D.W.7
Hagedorn, C.H.8
Goebl, M.9
Culbertson, M.R.10
-
23
-
-
9444277208
-
Pheromone signaling mechanisms in yeast: A prototypical sex machine
-
Y. Wang, H. G. Dohlman, Pheromone signaling mechanisms in yeast: A prototypical sex machine. Science 306, 1508-1509 (2004).
-
(2004)
Science
, vol.306
, pp. 1508-1509
-
-
Wang, Y.1
Dohlman, H.G.2
-
24
-
-
0030933899
-
Pheromone response in trehalose-6-phosphate synthase yeast mutants
-
P. M. B. Fernandes, A. D. Panek, Pheromone response in trehalose-6-phosphate synthase yeast mutants. Microbiology 143, 689-690 (1997).
-
(1997)
Microbiology
, vol.143
, pp. 689-690
-
-
Fernandes, P.M.B.1
Panek, A.D.2
-
25
-
-
84864805148
-
Integrated analysis of transcriptome and lipid profiling reveals the co-influences of inositol-choline and Snf1 in controlling lipid biosynthesis in yeast
-
P. Chumnanpuen, J. Zhang, I. Nookaew, J. Nielsen, Integrated analysis of transcriptome and lipid profiling reveals the co-influences of inositol-choline and Snf1 in controlling lipid biosynthesis in yeast. Mol. Genet. Genomics 287, 541-554 (2012).
-
(2012)
Mol. Genet. Genomics
, vol.287
, pp. 541-554
-
-
Chumnanpuen, P.1
Zhang, J.2
Nookaew, I.3
Nielsen, J.4
-
26
-
-
79953903501
-
A quantitative literaturecurated gold standard for kinase-substrate pairs
-
S. Sharifpoor, A. N. Nguyen Ba, J. Y. Young, D. van Dyk, H. Friesen, A. C. Douglas, C. F. Kurat, Y. T. Chong, K. Founk, A. M. Moses, B. J. Andrews, A quantitative literaturecurated gold standard for kinase-substrate pairs. Genome Biol. 12, R39 (2011).
-
(2011)
Genome Biol.
, vol.12
, pp. R39
-
-
Sharifpoor, S.1
Nguyen Ba, A.N.2
Young, J.Y.3
Van Dyk, D.4
Friesen, H.5
Douglas, A.C.6
Kurat, C.F.7
Chong, Y.T.8
Founk, K.9
Moses, A.M.10
Andrews, B.J.11
-
27
-
-
0027960808
-
The yeast translational allosuppressor, SAL6: A new member of the PP1-like phosphatase family with a long serine-rich N-terminal extension
-
A. Vincent, G. Newnam, S. W. Liebman, The yeast translational allosuppressor, SAL6: A new member of the PP1-like phosphatase family with a long serine-rich N-terminal extension. Genetics 138, 597-608 (1994).
-
(1994)
Genetics
, vol.138
, pp. 597-608
-
-
Vincent, A.1
Newnam, G.2
Liebman, S.W.3
-
28
-
-
0035168699
-
Identification of a Saccharomyces cerevisiae gene that is required for G1 arrest in response to the lipid oxidation product linoleic acid hydroperoxide
-
N. Alic, V. J. Higgins, I. W. Dawes, Identification of a Saccharomyces cerevisiae gene that is required for G1 arrest in response to the lipid oxidation product linoleic acid hydroperoxide. Mol. Biol. Cell 12, 1801-1810 (2001).
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 1801-1810
-
-
Alic, N.1
Higgins, V.J.2
Dawes, I.W.3
-
29
-
-
78649832864
-
Unraveling condition-dependent networks of transcription factors that control metabolic pathway activity in yeast
-
S. M. Fendt, A. P. Oliveira, S. Christen, P. Picotti, R. C. Dechant, U. Sauer, Unraveling condition-dependent networks of transcription factors that control metabolic pathway activity in yeast. Mol. Syst. Biol. 6, 432 (2010).
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 432
-
-
Fendt, S.M.1
Oliveira, A.P.2
Christen, S.3
Picotti, P.4
Dechant, R.C.5
Sauer, U.6
-
30
-
-
0031907161
-
An essential function of a phosphoinositide-specific phospholipase C is relieved by inhibition of a cyclin-dependent protein kinase in the yeast Saccharomyces cerevisiae
-
J. S. Flick, J. Thorner, An essential function of a phosphoinositide-specific phospholipase C is relieved by inhibition of a cyclin-dependent protein kinase in the yeast Saccharomyces cerevisiae. Genetics 148, 33-47 (1998).
-
(1998)
Genetics
, vol.148
, pp. 33-47
-
-
Flick, J.S.1
Thorner, J.2
-
31
-
-
0142180122
-
The Saccharomyces cerevisiae high affinity phosphate transporter encoded by PHO84 also functions in manganese homeostasis
-
L. T. Jensen, M. Ajua-Alemanji, V. C. Culotta, The Saccharomyces cerevisiae high affinity phosphate transporter encoded by PHO84 also functions in manganese homeostasis. J. Biol. Chem. 278, 42036-42040 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 42036-42040
-
-
Jensen, L.T.1
Ajua-Alemanji, M.2
Culotta, V.C.3
-
32
-
-
84876069749
-
Manganese complexes: Diverse metabolic routes to oxidative stress resistance in prokaryotes and yeast
-
V. C. Culotta, M. J. Daly, Manganese complexes: Diverse metabolic routes to oxidative stress resistance in prokaryotes and yeast. Antioxid. Redox Signal. 19, 933-944 (2013).
-
(2013)
Antioxid. Redox Signal.
, vol.19
, pp. 933-944
-
-
Culotta, V.C.1
Daly, M.J.2
-
33
-
-
0024391033
-
Intracellular Mn (II)-associated superoxide scavenging activity protects Cu,Zn superoxide dismutase-deficient Saccharomyces cerevisiae against dioxygen stress
-
E. C. Chang, D. J. Kosman, Intracellular Mn (II)-associated superoxide scavenging activity protects Cu,Zn superoxide dismutase-deficient Saccharomyces cerevisiae against dioxygen stress. J. Biol. Chem. 264, 12172-12178 (1989).
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 12172-12178
-
-
Chang, E.C.1
Kosman, D.J.2
-
34
-
-
84884238664
-
Mitochondrial DNA instability in cells lacking aconitase correlates with iron citrate toxicity
-
M. A. Farooq, T. M. Pracheil, Z. Dong, F. Xiao, Z. Liu, Mitochondrial DNA instability in cells lacking aconitase correlates with iron citrate toxicity. Oxid. Med. Cell. Longev. 2013, 493536 (2013).
-
(2013)
Oxid. Med. Cell. Longev.
, vol.2013
, pp. 493536
-
-
Farooq, M.A.1
Pracheil, T.M.2
Dong, Z.3
Xiao, F.4
Liu, Z.5
-
35
-
-
0030943397
-
Inactivation of aconitase in yeast exposed to oxidative stress
-
K. Murakami, M. Yoshino, Inactivation of aconitase in yeast exposed to oxidative stress. Biochem. Mol. Biol. Int. 41, 481-486 (1997).
-
(1997)
Biochem. Mol. Biol. Int.
, vol.41
, pp. 481-486
-
-
Murakami, K.1
Yoshino, M.2
-
36
-
-
84874074958
-
Superoxide triggers an acid burst in Saccharomyces cerevisiae to condition the environment of glucose-starved cells
-
J. A. Baron, K. M. Laws, J. S. Chen, V. C. Culotta, Superoxide triggers an acid burst in Saccharomyces cerevisiae to condition the environment of glucose-starved cells. J. Biol. Chem. 288, 4557-4566 (2013).
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 4557-4566
-
-
Baron, J.A.1
Laws, K.M.2
Chen, J.S.3
Culotta, V.C.4
-
37
-
-
77951125481
-
Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity
-
S. M. Fendt, J. M. Buescher, F. Rudroff, P. Picotti, N. Zamboni, U. Sauer, Tradeoff between enzyme and metabolite efficiency maintains metabolic homeostasis upon perturbations in enzyme capacity. Mol. Syst. Biol. 6, 356 (2010).
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 356
-
-
Fendt, S.M.1
Buescher, J.M.2
Rudroff, F.3
Picotti, P.4
Zamboni, N.5
Sauer, U.6
-
38
-
-
0028070457
-
Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo
-
A. Woods, M. R. Munday, J. Scott, X. Yang, M. Carlson, D. Carling, Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo. J. Biol. Chem. 269, 19509-19515 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 19509-19515
-
-
Woods, A.1
Munday, M.R.2
Scott, J.3
Yang, X.4
Carlson, M.5
Carling, D.6
-
39
-
-
84868676090
-
Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress
-
Y. J. Lee, G. R. Jeschke, F. M. Roelants, J. Thorner, B. E. Turk, Reciprocal phosphorylation of yeast glycerol-3-phosphate dehydrogenases in adaptation to distinct types of stress. Mol. Cell. Biol. 32, 4705-4717 (2012).
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 4705-4717
-
-
Lee, Y.J.1
Jeschke, G.R.2
Roelants, F.M.3
Thorner, J.4
Turk, B.E.5
-
40
-
-
4043098376
-
MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction
-
M. Proft, K. Struhl, MAP kinase-mediated stress relief that precedes and regulates the timing of transcriptional induction. Cell 118, 351-361 (2004).
-
(2004)
Cell
, vol.118
, pp. 351-361
-
-
Proft, M.1
Struhl, K.2
-
41
-
-
22544467022
-
Phosphorylation of the yeast choline kinase by protein kinase C. Identification of Ser25 and Ser30 as major sites of phosphorylation
-
M. G. Choi, V. Kurnov, M. C. Kersting, A. Sreenivas, G. M. Carman, Phosphorylation of the yeast choline kinase by protein kinase C. Identification of Ser25 and Ser30 as major sites of phosphorylation. J. Biol. Chem. 280, 26105-26112 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26105-26112
-
-
Choi, M.G.1
Kurnov, V.2
Kersting, M.C.3
Sreenivas, A.4
Carman, G.M.5
-
42
-
-
0037144578
-
Phosphorylation of Saccharomyces cerevisiae choline kinase on Ser30 and Ser85 by protein kinase A regulates phosphatidylcholine synthesis by the CDP-choline pathway
-
Y. Yu, A. Sreenivas, D. B. Ostrander, G. M. Carman, Phosphorylation of Saccharomyces cerevisiae choline kinase on Ser30 and Ser85 by protein kinase A regulates phosphatidylcholine synthesis by the CDP-choline pathway. J. Biol. Chem. 277, 34978-34986 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 34978-34986
-
-
Yu, Y.1
Sreenivas, A.2
Ostrander, D.B.3
Carman, G.M.4
-
43
-
-
0027436392
-
Control of yeast glycogen synthase-2 by COOH-terminal phosphorylation
-
T. A. Hardy, P. J. Roach, Control of yeast glycogen synthase-2 by COOH-terminal phosphorylation. J. Biol. Chem. 268, 23799-23805 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 23799-23805
-
-
Hardy, T.A.1
Roach, P.J.2
-
44
-
-
58149308056
-
Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression
-
C. F. Kurat, H.Wolinski, J. Petschnigg, S. Kaluarachchi, B. Andrews, K. Natter, S. D. Kohlwein, Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol. Cell 33, 53-63 (2009).
-
(2009)
Mol. Cell
, vol.33
, pp. 53-63
-
-
Kurat, C.F.1
Wolinski, H.2
Petschnigg, J.3
Kaluarachchi, S.4
Andrews, B.5
Natter, K.6
Kohlwein, S.D.7
-
45
-
-
0027932717
-
Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase
-
K. I. Mitchelhill, D. Stapleton, G. Gao, C. House, B. Michell, F. Katsis, L. A.Witters, B. E. Kemp, Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase. J. Biol. Chem. 269, 2361-2364 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 2361-2364
-
-
Mitchelhill, K.I.1
Stapleton, D.2
Gao, G.3
House, C.4
Michell, B.5
Katsis, F.6
Witters, L.A.7
Kemp, B.E.8
-
46
-
-
0036272133
-
The proper folding of a long C-terminal segment of the yeast Lys14p regulator is required for activation of LYS genes in response to the metabolic effector
-
M. El Alami, A. Feller, A. Piérard, E. Dubois, The proper folding of a long C-terminal segment of the yeast Lys14p regulator is required for activation of LYS genes in response to the metabolic effector. Mol. Microbiol. 43, 1629-1639 (2002).
-
(2002)
Mol. Microbiol.
, vol.43
, pp. 1629-1639
-
-
El Alami, M.1
Feller, A.2
Piérard, A.3
Dubois, E.4
-
47
-
-
0028041491
-
Repression of the genes for lysine biosynthesis in Saccharomyces cerevisiae is caused by limitation of Lys14-dependent transcriptional activation
-
A. Feller, E. Dubois, F. Ramos, A. Piérard, Repression of the genes for lysine biosynthesis in Saccharomyces cerevisiae is caused by limitation of Lys14-dependent transcriptional activation. Mol. Cell. Biol. 14, 6411-6418 (1994).
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 6411-6418
-
-
Feller, A.1
Dubois, E.2
Ramos, F.3
Piérard, A.4
-
48
-
-
0023860007
-
Control of enzyme synthesis in the lysine biosynthetic pathway of Saccharomyces cerevisiae. Evidence for a regulatory role of gene LYS14
-
F. Ramos, E. Dubois, A. Piérard, Control of enzyme synthesis in the lysine biosynthetic pathway of Saccharomyces cerevisiae. Evidence for a regulatory role of gene LYS14. Eur. J. Biochem. 171, 171-176 (1988).
-
(1988)
Eur. J. Biochem.
, vol.171
, pp. 171-176
-
-
Ramos, F.1
Dubois, E.2
Piérard, A.3
-
49
-
-
0033118923
-
In Saccharomyces cerevisae, feedback inhibition of homocitrate synthase isoenzymes by lysine modulates the activation of LYS gene expression by Lys14p
-
A. Feller, F. Ramos, A. Piérard, E. Dubois, In Saccharomyces cerevisae, feedback inhibition of homocitrate synthase isoenzymes by lysine modulates the activation of LYS gene expression by Lys14p. Eur. J. Biochem. 261, 163-170 (1999).
-
(1999)
Eur. J. Biochem.
, vol.261
, pp. 163-170
-
-
Feller, A.1
Ramos, F.2
Piérard, A.3
Dubois, E.4
-
50
-
-
84871925048
-
Kynurenines in the CNS: Recent advances and new questions
-
L. Vécsei, L. Szalárdy, F. Fülöp, J. Toldi, Kynurenines in the CNS: Recent advances and new questions. Nat. Rev. Drug Discov. 12, 64-82 (2013).
-
(2013)
Nat. Rev. Drug Discov.
, vol.12
, pp. 64-82
-
-
Vécsei, L.1
Szalárdy, L.2
Fülöp, F.3
Toldi, J.4
-
51
-
-
18144406846
-
A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease
-
F. Giorgini, P. Guidetti, Q. Nguyen, S. C. Bennett, P. J. Muchowski, A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat. Genet. 37, 526-531 (2005).
-
(2005)
Nat. Genet.
, vol.37
, pp. 526-531
-
-
Giorgini, F.1
Guidetti, P.2
Nguyen, Q.3
Bennett, S.C.4
Muchowski, P.J.5
-
52
-
-
33745464129
-
Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate
-
L. Liu, P. Cundiff, G. Abel, Y. Wang, R. Faigle, H. Sakagami, M. Xu, Z. Xia, Extracellular signal-regulated kinase (ERK) 5 is necessary and sufficient to specify cortical neuronal fate. Proc. Natl. Acad. Sci. U.S.A. 103, 9697-9702 (2006).
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 9697-9702
-
-
Liu, L.1
Cundiff, P.2
Abel, G.3
Wang, Y.4
Faigle, R.5
Sakagami, H.6
Xu, M.7
Xia, Z.8
-
53
-
-
84893479546
-
Genetic activation of ERK5 MAP kinase enhances adult neurogenesis and extends hippocampus-dependent long-term memory
-
W. Wang, Y. W. Pan, J. Zou, T. Li, G. M. Abel, R. D. Palmiter, D. R. Storm, Z. Xia, Genetic activation of ERK5 MAP kinase enhances adult neurogenesis and extends hippocampus-dependent long-term memory. J. Neurosci. 34, 2130-2147 (2014).
-
(2014)
J. Neurosci.
, vol.34
, pp. 2130-2147
-
-
Wang, W.1
Pan, Y.W.2
Zou, J.3
Li, T.4
Abel, G.M.5
Palmiter, R.D.6
Storm, D.R.7
Xia, Z.8
-
54
-
-
35648972123
-
The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels
-
P. Daran-Lapujade, S. Rossell, W. M. van Gulik, M. A. H. Luttik, M. J. L. de Groot, M. Slijper, A. J. R. Heck, J. M. Daran, J. H. de Winde, H. V. Westerhoff, J. T. Pronk, B. M. Bakker, The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels. Proc. Natl. Acad. Sci. U.S.A. 104, 15753-15758 (2007).
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 15753-15758
-
-
Daran-Lapujade, P.1
Rossell, S.2
Van Gulik, W.M.3
Luttik, M.A.H.4
De Groot, M.J.L.5
Slijper, M.6
Heck, A.J.R.7
Daran, J.M.8
De Winde, J.H.9
Westerhoff, H.V.10
Pronk, J.T.11
Bakker, B.M.12
-
55
-
-
0347033256
-
Role of duplicate genes in genetic robustness against null mutations
-
Z. Gu, L. M. Steinmetz, X. Gu, C. Scharfe, R. W. Davis, W. H. Li, Role of duplicate genes in genetic robustness against null mutations. Nature 421, 63-66 (2003).
-
(2003)
Nature
, vol.421
, pp. 63-66
-
-
Gu, Z.1
Steinmetz, L.M.2
Gu, X.3
Scharfe, C.4
Davis, R.W.5
Li, W.H.6
-
56
-
-
84872184195
-
Phosphorylation network dynamics in the control of cell cycle transitions
-
D. Fisher, L. Krasinska, D. Coudreuse, B. Novák, Phosphorylation network dynamics in the control of cell cycle transitions. J. Cell Sci. 125, 4703-4711 (2012).
-
(2012)
J. Cell Sci.
, vol.125
, pp. 4703-4711
-
-
Fisher, D.1
Krasinska, L.2
Coudreuse, D.3
Novák, B.4
-
57
-
-
84883362218
-
Ultrasensitivity in phosphorylation-dephosphorylation cycles with little substrate
-
B. M. C. Martins, P. S. Swain, Ultrasensitivity in phosphorylation-dephosphorylation cycles with little substrate. PLOS Comput. Biol. 9, e1003175 (2013).
-
(2013)
PLOS Comput. Biol.
, vol.9
, pp. e1003175
-
-
Martins, B.M.C.1
Swain, P.S.2
-
58
-
-
84876593243
-
Heinemann Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast
-
G. G. Zampar, A. Kümmel, J. Ewald, S. Jol, B. Niebel, P. Picotti, R. Aebersold, U. Sauer, N. Zamboni, M. Heinemann, Temporal system-level organization of the switch from glycolytic to gluconeogenic operation in yeast. Mol. Syst. Biol. 9, 651 (2013).
-
(2013)
Mol. Syst. Biol.
, vol.9
, pp. 651
-
-
Zampar, G.G.1
Kümmel, A.2
Ewald, J.3
Jol, S.4
Niebel, B.5
Picotti, P.6
Aebersold, R.7
Sauer, U.8
Zamboni, M.N.9
-
59
-
-
0015240158
-
The mechanism of aconitase action. II. Magnetic resonance studies of the complexes of enzyme, manganese(II), iron(II) and substrates
-
J. J. Villafranca, A. S. Mildvan, The mechanism of aconitase action. II. Magnetic resonance studies of the complexes of enzyme, manganese(II), iron(II) and substrates. J. Biol. Chem. 246, 5791-5798 (1971).
-
(1971)
J. Biol. Chem.
, vol.246
, pp. 5791-5798
-
-
Villafranca, J.J.1
Mildvan, A.S.2
-
60
-
-
84859976622
-
Battles with iron: Manganese in oxidative stress protection
-
J. D. Aguirre, V. C. Culotta, Battles with iron: Manganese in oxidative stress protection. J. Biol. Chem. 287, 13541-13548 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 13541-13548
-
-
Aguirre, J.D.1
Culotta, V.C.2
-
61
-
-
77956505339
-
Central role of manganese in regulation of stress responses, physiology, and metabolism in Streptococcus pneumoniae
-
A.D.Ogunniyi, L. K. Mahdi, M.P. Jennings, A. G. McEwan, C. A. McDevitt, M. B. V. derHoek, C. J. Bagley, P. Hoffmann, K. A. Gould, J. C. Paton, Central role of manganese in regulation of stress responses, physiology, and metabolism in Streptococcus pneumoniae. J. Bacteriol. 192, 4489-4497 (2010).
-
(2010)
J. Bacteriol.
, vol.192
, pp. 4489-4497
-
-
Ogunniyi, A.D.1
Mahdi, L.K.2
Jennings, M.P.3
McEwan, A.G.4
McDevitt, C.A.5
Derhoek, M.B.V.6
Bagley, C.J.7
Hoffmann, P.8
Gould, K.A.9
Paton, J.C.10
-
62
-
-
0032551697
-
Manganese inhibits mitochondrial aconitase: A mechanism of manganese neurotoxicity
-
W. Zheng, S. Ren, J. H. Graziano, Manganese inhibits mitochondrial aconitase: A mechanism of manganese neurotoxicity. Brain Res. 799, 334-342 (1998).
-
(1998)
Brain Res.
, vol.799
, pp. 334-342
-
-
Zheng, W.1
Ren, S.2
Graziano, J.H.3
-
63
-
-
0035448662
-
Differential cytotoxicity of Mn(II) and Mn(III): Special reference to mitochondrial [Fe-S] containing enzymes. Toxicol
-
J. Y. Chen, G. C. Tsao, Q. Zhao, W. Zheng, Differential cytotoxicity of Mn(II) and Mn(III): Special reference to mitochondrial [Fe-S] containing enzymes. Toxicol. Appl. Pharmacol. 175, 160-168 (2001).
-
(2001)
Appl. Pharmacol.
, vol.175
, pp. 160-168
-
-
Chen, J.Y.1
Tsao, G.C.2
Zhao, Q.3
Zheng, W.4
-
64
-
-
34249805092
-
Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells
-
D. R. Crooks, M. C. Ghosh, M. Braun-Sommargren, T. A. Rouault, D. R. Smith, Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J. Neurosci. Res. 85, 1797-1809 (2007).
-
(2007)
J. Neurosci. Res.
, vol.85
, pp. 1797-1809
-
-
Crooks, D.R.1
Ghosh, M.C.2
Braun-Sommargren, M.3
Rouault, T.A.4
Smith, D.R.5
-
65
-
-
84860798289
-
Biologically relevant mechanism for catalytic superoxide removal by simple manganese compounds
-
K. Barnese, E. B. Gralla, J. S. Valentine, D. E. Cabelli, Biologically relevant mechanism for catalytic superoxide removal by simple manganese compounds. Proc. Natl. Acad. Sci. U.S.A. 109, 6892-6897 (2012).
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 6892-6897
-
-
Barnese, K.1
Gralla, E.B.2
Valentine, J.S.3
Cabelli, D.E.4
-
66
-
-
0042009669
-
Modulation of citrate metabolism alters aluminum tolerance in yeast and transgenic canola overexpressing a mitochondrial citrate synthase
-
V. M. Anoop, U. Basu, M. T. McCammon, L. McAlister-Henn, G. J. Taylor, Modulation of citrate metabolism alters aluminum tolerance in yeast and transgenic canola overexpressing a mitochondrial citrate synthase. Plant Physiol. 132, 2205-2217 (2003).
-
(2003)
Plant Physiol.
, vol.132
, pp. 2205-2217
-
-
Anoop, V.M.1
Basu, U.2
McCammon, M.T.3
McAlister-Henn, L.4
Taylor, G.J.5
-
67
-
-
0026710123
-
Effect of benzoic acid on metabolic fluxes in yeasts: A continuous-culture study on the regulation of respiration and alcoholic fermentation
-
C. Verduyn, E. Postma, W. A. Scheffers, J. P. Van Dijken, Effect of benzoic acid on metabolic fluxes in yeasts: A continuous-culture study on the regulation of respiration and alcoholic fermentation. Yeast 8, 501-517 (1992).
-
(1992)
Yeast
, vol.8
, pp. 501-517
-
-
Verduyn, C.1
Postma, E.2
Scheffers, W.A.3
Van Dijken, J.P.4
-
68
-
-
84858588614
-
Saccharomyces genome database: The genomics resource of budding yeast
-
J.M. Cherry, E. L. Hong, C. Amundsen, R. Balakrishnan, G. Binkley, E. T. Chan, K. R. Christie, M. C. Costanzo, S. S. Dwight, S. R. Engel, D. G. Fisk, J. E. Hirschman, B. C. Hitz, K. Karra, C. J. Krieger, S. R. Miyasato, R. S. Nash, J. Park, M. S. Skrzypek, M. Simison, S. Weng, E. D. Wong, Saccharomyces Genome Database: The genomics resource of budding yeast. Nucleic Acids Res. 40, D700-D705 (2012).
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. D700-D705
-
-
Cherry, J.M.1
Hong, E.L.2
Amundsen, C.3
Balakrishnan, R.4
Binkley, G.5
Chan, E.T.6
Christie, K.R.7
Costanzo, M.C.8
Dwight, S.S.9
Engel, S.R.10
Fisk, D.G.11
Hirschman, J.E.12
Hitz, B.C.13
Karra, K.14
Krieger, C.J.15
Miyasato, S.R.16
Nash, R.S.17
Park, J.18
Skrzypek, M.S.19
Simison, M.20
Weng, S.21
Wong, E.D.22
more..
-
69
-
-
77952985821
-
Ultrahigh performance liquid chromatography-tandem mass spectrometry method for fast and robust quantification of anionic and aromatic metabolites
-
J. M. Buescher, S. Moco, U. Sauer, N. Zamboni, Ultrahigh performance liquid chromatography-tandem mass spectrometry method for fast and robust quantification of anionic and aromatic metabolites. Anal. Chem. 82, 4403-4412 (2010).
-
(2010)
Anal. Chem.
, vol.82
, pp. 4403-4412
-
-
Buescher, J.M.1
Moco, S.2
Sauer, U.3
Zamboni, N.4
-
70
-
-
0036020892
-
A direct approach to false discovery rates
-
J. D. Storey, A direct approach to false discovery rates. J. R. Stat. Soc. Ser. B 64, 479-498 (2002).
-
(2002)
J. R. Stat. Soc. Ser. B.
, vol.64
, pp. 479-498
-
-
Storey, J.D.1
|