Genetic activation of ERK5 MAP kinase enhances adult neurogenesis and extends hippocampus-dependent long-term memory

Journal of Neuroscience

Volumn 34, Issue 6, 2014, Pages 2130-2147

  Wang, Wenbin ^a   Pan, Yung Wei ^a   Zou, Junhui ^a   Li, Tan ^a,b   Abel, Glen M ^a   Palmiter, Richard D ^c   Storm, Daniel R ^d   Xia, Zhengui ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b ZHEJIANG UNIVERSITY   (China)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Adult neurogenesis; ERK5; MAP kinase; Memory persistence; Spatial learning

Indexed keywords

BETA ACTIN; BROXURIDINE; DIPHTHERIA TOXIN; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE 5; MYOCYTE ENHANCER FACTOR 2; NESTIN; NEURON SPECIFIC NUCLEAR PROTEIN; TAMOXIFEN; TRANSCRIPTION FACTOR GAL4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CELL SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITIC CELL; DENTATE GYRUS; FEMALE; FLUORESCENCE MICROSCOPY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LIMIT OF QUANTITATION; LOCOMOTION; LONG TERM MEMORY; MALE; MORRIS WATER MAZE TEST; MOUSE; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SOUTHERN BLOTTING; SPATIAL LEARNING; SPATIAL MEMORY; WESTERN BLOTTING;

ADULT NEUROGENESIS; ERK5; MAP KINASE; MEMORY PERSISTENCE; SPATIAL LEARNING;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; CELL DIFFERENTIATION; ENZYME ACTIVATION; GENE KNOCK-IN TECHNIQUES; HIPPOCAMPUS; MAZE LEARNING; MEMORY, LONG-TERM; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE 7; NEUROGENESIS;

EID: 84893479546     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3324-13.2014     Document Type: Article

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