Substrate- and cofactor-independent inhibition of histone demethylase KDM4C

ACS Chemical Biology

Volumn 9, Issue 9, 2014, Pages 2131-2138

  Leurs, Ulrike ^a   Lohse, Brian ^a   Rand, Kasper D ^a   Ming, Shonoi ^b   Riise, Erik S ^a   Cole, Philip A ^b   Kristensen, Jesper L ^a   Clausen, Rasmus P ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPEPTIDE; HISTONE DEMETHYLASE; HISTONE DEMETHYLASE KDM4C; OXYGENASE INHIBITOR; UNCLASSIFIED DRUG; COENZYME; ENZYME INHIBITOR; KDM1A PROTEIN, HUMAN; KDM4A PROTEIN, HUMAN; KDM4C PROTEIN, HUMAN; PEPTIDE LIBRARY;

ACETYLATION; ALKYLATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIOPHAGE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE PERMEABILITY; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; HISTONE DEMETHYLATION; HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY; IMMUNOFLUORESCENCE; LIGAND BINDING; MASS SPECTROMETRY; MICHAELIS MENTEN KINETICS; NONHUMAN; PEPTIDE LIBRARY; PHAGE DISPLAY; TRUNCATION; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; COENZYME; DRUG EFFECTS; HIGH THROUGHPUT SCREENING; HUMAN; IC50; METABOLISM; MOLECULAR GENETICS; PROCEDURES;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CELL LINE; COENZYMES; DEUTERIUM EXCHANGE MEASUREMENT; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HISTONE DEMETHYLASES; HUMANS; INHIBITORY CONCENTRATION 50; JUMONJI DOMAIN-CONTAINING HISTONE DEMETHYLASES; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY;

EID: 84912572636     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500374f     Document Type: Article

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