Development of multi-electrode array screening for anticonvulsants in acute rat brain slices

Journal of Neuroscience Methods

Volumn 185, Issue 2, 2010, Pages 246-256

  Hill, Andrew J ^a   Jones, Nicholas A ^a   Williams, Claire M ^a   Stephens, Gary J ^a   Whalley, Benjamin J ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

Anticonvulsant; Epilepsy; Hippocampus; MEA; Multi electrode array; Slice

Indexed keywords

4 AMINOPYRIDINE; ANTICONVULSIVE AGENT; FELBAMATE; MAGNESIUM ION; PHENOBARBITAL;

ACTION POTENTIAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ANTICONVULSANT THERAPY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; ELECTROSTIMULATION THERAPY; EXPERIMENTAL TEST; FEMALE; HIPPOCAMPUS; MALE; MICROELECTRODE; NONHUMAN; PHARMACOLOGICAL PROCEDURES; PRIORITY JOURNAL; RAT; VALIDATION PROCESS;

4-AMINOPYRIDINE; ANIMALS; ANIMALS, NEWBORN; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ELECTRODES; ELECTROPHYSIOLOGY; EPILEPSY; FEMALE; HIPPOCAMPUS; MAGNESIUM DEFICIENCY; MEMBRANE POTENTIALS; PHENOBARBITAL; PHENYLCARBAMATES; PROPYLENE GLYCOLS; RATS; RATS, WISTAR; TIME FACTORS;

EID: 72249085155     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2009.10.007     Document Type: Article

References (38)

1. Abramoff M.D., Magelhaes P.J., and Ram S.J. Image processing with imageJ. Biophotonics Int 11 (2004) 36-42
2. Avoli M., Louvel J., Kurcewicz I., Pumain R., and Barbarosie M. Extracellular free potassium and calcium during synchronous activity induced by 4-aminopyridine in the juvenile rat hippocampus. J Physiol 493 (1996) 707-717
3. Avoli M., Nagao T., Köhling R., Lücke A., and Mattia D. Synchronization of rat hippocampal neurons in the absence of excitatory amino acid-mediated transmission. Brain Res 735 (1996) 188-196
4. Blair R.E., Deshpande L.S., Sombati S., Falenski K.W., Martin B.R., and DeLorenzo R.J. Activation of the cannabinoid Type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus. JPET 317 3 (2006) 1072-1078
5. Brown S.P., Safo P.K., and Regehr W.G. Endocannabinoids inhibit transmission at granule cell to Purkinje cell synapses by modulating three types of presynaptic calcium channels. J Neurosci 24 24 (2004) 5623-5631
6. Bruckner C., and Heinemann U. Effects of standard anticonvulsant drugs on different patterns of epileptiform discharges induced by 4-aminopyridine in combined entorhinal cortex-hippocampal slices. Brain Res 859 (2000) 15-20
7. Cascino G.D. When drugs and surgery don't work. Epilepsia 49 Suppl. 9 (2008) 79-84
8. Curia G., Longo D., Biagini G., Jones R.S.G., and Avoli M. The pilocarpine model of temporal lobe epilepsy. J Neurosci Methods 172 2 (2008) 143-157
9. D'Antuono M., Kawasaki H., Palmieri C., Curia G., Biagini G., and Avoli M. Antiepileptic drugs and muscarinic receptor-dependent excitation in the rat subiculum. Neuropharmacology 52 (2007) 1291-1302
10. Domenici M.R., Marinelli S., and Sagratella S. Effects of felbamate, kynurenic acid derivatives and nmda antagonists on in vitro kainate-induced epileptiform activity. Life Sci 58 (1996) PL391-PL396
11. Domenici M.R., Sagratella S., Ongini E., Longo R., and Scotti de Carolis A. Felbamate displays in vitro antiepileptic effects as a broad spectrum excitatory amino acid receptor antagonist. Eur J Pharmacol 271 (1994) 259-263
12. Egert U., Heck D., and Aertsen A. Two-dimensional monitoring of spiking networks in acute brain slices. Experimental brain research. Experimentelle Hirnforschung 142 (2002) 268-274
13. Egert U., Knott T., Schwarz C., Nawrot M., Brandt A., Rotter S., et al. MEA-tools: an open source toolbox for the analysis of multi-electrode data with. J Neurosci Methods 117 (2002) 33-42
14. 2+ in cultured rat hippocampal slices. Brain Res 815 (1999) 294-303
15. Heinemann U., Buchheim K., Gabriel S., Kann O., Kovacs R., and Schuchmann S. Cell death and metabolic activity during epileptiform discharges and status epilepticus in the hippocampus. Prog Brain Res 135 (2002) 197-210
16. Heinemann U., Buchheim K., Gabriel S., Kann O., Kovacs R., and Schuchmann S. Coupling of electrical and metabolic activity during epileptiform discharges. Epilepsia 43 Suppl. 5 (2002) 168-173
17. Jones NA, Hill AJ, Smith I, Bevan S, William CM, Whalley BJ, et al. Cannabidiol displays anti-epileptiform and anti-seizure properties in vitro and in vivo; in press.
18. 2+ in rat hippocampal slices depends on gap junctional coupling. Neuroscience 105 (2001) 579-587
19. Korn S.J., Giacchino J.L., Chamberlin N.L., and Dingledine R. Epileptiform burst activity induced by potassium in the hippocampus and its regulation by GABA-mediated inhibition. J Neurophysiol 57 (1987) 325-340
20. 2+-induced epileptiform activity in organotypic hippocampal slice cultures. Neuroreport 10 (1999) 207-213
21. Kovacs R., Kardos J., Heinemann U., and Kann O. Mitochondrial calcium ion and membrane potential transients follow the pattern of epileptiform discharges in hippocampal slice cultures. J Neuorsci 25 17 (2005) 4260-4269
22. Kovacs R., Rabanus A., Otahal J., Patzak A., Kardos J., Albus K., et al. Endogenous nitric oxide is a key promoting factor for initiation of seizure-like events in hippocampal and entorhinal cortex slices. J Neurosci 29 (2009) 8565-8577
23. Luhmann H.J., Dzhala V.I., and Ben-Ari Y. Generation and propagation of 4-AP-induced epileptiform activity in neonatal intact limbic structures in vitro. Eur J Neurosci 12 (2000) 2757-2768
24. Ma Y.L., Weston S.E., Whalley B.J., and Stephens G.J. The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum. Br J Pharmacol 154 1 (2008) 204-215
25. Mapelli J., and D'Angelo E. The spatial organization of long-term synaptic plasticity at the input stage of cerebellum. J Neurosci 27 (2007) 1285-1296
26. McCutcheon J.E., and Marinelli M. Age matters. Eur J Neurosci 29 5 (2009) 997-1014
27. 2+ channels. J Neurophysiol 78 (1997) 2467-2474
28. Panuccio G., Curia G., Colosimo A., Cruccu G., and Avoli M. Epileptiform synchronization in the cingulate cortex. Epilepsia 50 (2009) 521-536
29. Perreault P., and Avoli M. 4-Aminopyridine-induced epileptiform activity and a GABA-mediated long-lasting depolarization in the rat hippocampus. J Neurosci 12 1 (1992) 104-115
30. Perreault P., and Avoli M. Physiology and pharmacology of epileptiform activity induced by 4-aminopyridine in rat hippocampal slices. J Neurophysiol 65 4 (1991) 771-785
31. In: Pitkanen A., Schwartzkroin P.A., and Moshe S.L. (Eds). Models of seizures and epilepsy (2006), Elsevier Academic Press, San Diego
32. Pomper J.K., Hoffmann U., Kovács R., Gabriel S., and Heinemann U. Hyperoxia is not an essential condition for status epilepticus induced cell death in organotypic hippocampal slice cultures. Epilepsy Res 59 (2004) 61-65
33. Sagratella S. Characterization of the in vitro antiepileptic activity of new and old anticonvulsant drugs. Gen Pharmacol-Vasc S 30 (1998) 153-160
34. Scott R.A., Lhatoo S.D., and Sander J.W. The treatment of epilepsy in developing countries: where do we go from here?. Bull World Health Organ 79 (2001) 344-351
35. Steidl E.-M., Neveu E., Bertrand D., and Buisson B. The adult rat hippocampal slice revisited with multi-electrode arrays. Brain Res 1096 (2006) 70-84
36. Tancredi V., Hwa G.G.C., Zona C., Brancati A., and Avoli M. Low magnesium epileptogenesis in the rat hippocampal slice: electrophysiological and pharmacological features. Brain Res 511 (1990) 280-290
37. 2+ in the rat hippocampal slice. J Physiol 478 Pt 3 (1994) 379-393
38. Trevelyan A.J., Sussillo D., and Yuste R. Feedforward inhibition contributes to the control of epileptiform propagation speed. J Neurosci 27 13 (2007) 3383-3387