Improved islet transplantation outcome by the co-delivery of siRNAs for iNOS and 17β-estradiol using an R3V6 peptide carrier

Biomaterials

Volumn 38, Issue , 2015, Pages 36-42

  Hwang, Hyo Jeong ^a   Lee, Minhyung ^b   Park, Jin Hyeong ^b   Jung, Hye Seung ^c   Kang, Jun Goo ^a   Kim, Chul Sik ^a   Lee, Seong Jin ^a   Ihm, Sung Hee ^a  

^a Hallym University College of Medicine   (South Korea)

^b Hanyang University   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

Author keywords

17 Estradiol; INOS; Islet; R3V6 peptide micelles; SiRNA; Transplantation

Indexed keywords

ARGININE; CELL DEATH; CHEMICAL COMPOUNDS; DRUG THERAPY; HYDROPHOBICITY; LIPOSOMES; MAMMALS; MICELLES; NITRIC OXIDE; PEPTIDES; RNA; TRANSPLANTATION (SURGICAL);

ANTI-APOPTOTIC EFFECTS; APOPTOTIC CELL DEATH; DOUBLE-STRANDED RNA; INDUCIBLE NITRIC OXIDE SYNTHASE; INOS; ISLET; ISLET TRANSPLANTATION; SIRNA;

GENE THERAPY;

ARGININE; CARRIER PROTEIN; CYTOPROTECTIVE AGENT; ESTRADIOL; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOFECTAMINE; MESSENGER RNA; R3V6 PEPTIDE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VALINE; DRUG CARRIER; NOS2 PROTEIN, MOUSE; PEPTIDE; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AQUEOUS SOLUTION; ARTICLE; CELL DEATH; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DELIVERY SYSTEM; GENE SILENCING; IN VITRO STUDY; MALE; MICELLE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PANCREAS ISLET TRANSPLANTATION; PROTEIN EXPRESSION; SURFACE PROPERTY; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL SURVIVAL; CHEMICALLY INDUCED; CHEMISTRY; CYTOLOGY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; GRAFT SURVIVAL; PANCREAS ISLET; PATHOLOGY; PHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; ESTRADIOL; GENE SILENCING; GRAFT SURVIVAL; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, INBRED BALB C; NITRIC OXIDE SYNTHASE TYPE II; PEPTIDES; RNA, SMALL INTERFERING; STREPTOZOCIN; TRANSFECTION; TREATMENT OUTCOME;

EID: 84912141066     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.10.060     Document Type: Article

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