Improved transplantation outcome through delivery of DNA encoding secretion signal peptide-linked glucagon-like peptide-1 into mouse islets

Transplant International

Volumn 26, Issue 4, 2013, Pages 443-452

  Chae, Hee Young ^a   Lee, Minhyung ^b   Hwang, Hyo Jeong ^a   Kim, Hyun Ah ^b   Kang, Jun Goo ^a   Kim, Chul Sik ^a   Lee, Seong Jin ^a   Ihm, Sung Hee ^a  

^a Hallym University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

glucagon like peptide 1; islet; transplantation

Indexed keywords

DNA; GLUCAGON LIKE PEPTIDE 1; INSULIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; DIABETES MELLITUS; GENE TARGETING; GENETIC TRANSFECTION; IN VITRO STUDY; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN SECRETION;

ANIMALS; CELL PROLIFERATION; GLUCAGON-LIKE PEPTIDE 1; GRAFT SURVIVAL; HYDROGEN PEROXIDE; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, INBRED BALB C; PROTEIN SORTING SIGNALS; TRANSFECTION; TREATMENT OUTCOME;

EID: 84875382430     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/tri.12052     Document Type: Article

References (39)

1. Ryan EA, Paty BW, Senior PA, et al,. Five-year follow-up after clinical islet transplantation. Diabetes 2005; 54: 2060.
2. Korsgren O, Lundgren T, Felldin M, et al,. Optimising islet engraftment is critical for successful clinical islet transplantation. Diabetologia 2008; 51: 227.
3. Mendola JF, Conget I, Manzanares JM, et al,. Follow-up study of the revascularization process of purified rat islet beta-cell grafts. Cell Transplant 1997; 6: 603.
4. Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GC,. Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes 1996; 45: 1161.
5. Biarnes M, Montolio M, Nacher V, Raurell M, Soler J, Montanya E,. Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia. Diabetes 2002; 51: 66.
6. Contreras JL, Bilbao G, Smyth CA, et al,. Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene. Transplantation 2001; 71: 1015.
7. Emamaullee JA, Rajotte RV, Liston P, et al,. XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes. Diabetes 2005; 54: 2541.
8. Plesner A, Liston P, Tan R, Korneluk RG, Verchere CB,. The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts. Diabetes 2005; 54: 2533.
9. Cheng K, Fraga D, Zhang C, et al,. Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets. Gene Ther 2004; 11: 1105.
10. Lee BW, Lee M, Chae HY, et al,. Effect of hypoxia-inducible VEGF gene expression on revascularization and graft function in mouse islet transplantation. Transplant Int 2010; 24: 307.
11. Wideman RD, Yu ILY, Webber TD, et al,. Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide-1 (GLP-1). Proc Natl Acad Sci U S A 2006; 103: 13468.
12. Drucker DJ,. The glucagon-like peptides. Endocrinology 2001; 142: 521.
13. Holst JJ,. The physiology of glucagon-like peptide 1. Physiol Rev 2007; 87: 1409.
14. Xu G, Stoffers DA, Habener JF, Bonner-Weir S,. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999; 48: 2270.
15. Zhou J, Wang X, Pineyro MA, Egan JM,. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 1999; 48: 2358.
16. Stoffers DA, Kieffer TJ, Hussain MA, et al,. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 2000; 49: 741.
17. Farilla L, Hui H, Bertolotto C, et al,. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology 2002; 143: 4397.
18. Drucker DJ,. Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis. Endocrinology 2003; 144: 5145.
19. Egan JM, Bulotta A, Hui H, Perfetti R,. GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells. Diabetes Metab Res Rev 2003; 19: 115.
20. Urusova IA, Farilla L, Hui H, D'Amico E, Perfetti R,. GLP-1 inhibition of pancreatic islet cell apoptosis. Trends Endocrinol Metab 2004; 15: 27.
21. Ghofaili KA, Fung M, Ao Z, et al,. Effect of exenatide on beta cell function after islet transplantation in type 1 diabetes. Transplantation 2007; 83: 24.
22. Froud T, Faradji RN, Pileggi A, et al,. The use of exenatide in islet transplant recipients with chronic allograft dysfunction: safety, efficacy, and metabolic effects. Transplantation 2008; 86: 36.
23. Faradji RN, Tharavanij T, Messinger S, et al,. Long-term insulin independence and improvement in insulin secretion after supplemental islet infusion under exenatide and etanercept. Transplantation 2008; 86: 1658.
24. Gangemi A, Salehi P, Hatipoglu B, et al,. Islet transplantation for brittle type 1 diabetes: the UIC protocol. Am J Transplant 2008; 8: 1250.
25. Chae HY, Kang JG, Kim CS, et al,. Effect of glucagon-like peptide-1 gene expression on graft function in mouse islet transplantation. Transplant Int 2012; 25: 242.
26. Lee BW, Kwon SJ, Chae HY, et al,. Dose-related cytoprotective effect of α-lipoic acid on hydrogen peroxide-induced oxidative stress to pancreatic beta cells. Free Rad Res 2009; 43: 68.
27. Castedo M, Ferri K, Roumier T, Metiyier D, Zamzami N, Kroemer G,. Quantitation of mitochondrial alterations associated with apoptosis. J Immunol Methods 2002; 265: 39.
28. Narang AS, Mahato RI,. Biological and biomaterial approaches for improved islet transplantation. Pharmacol Rev 2006; 58: 194.
29. Narang AS, Cheng K, Henry J, et al,. Vascular endothelial growth factor gene delivery for revascularization in transplanted human islets. Pharm Res 2004; 21: 15.
30. Mahato RI, Henry J, Narang AS, et al,. Cationic lipid and polymer-based gene delivery to human pancreatic islets. Mol Ther 2003; 7: 89.
31. Lee BW, Chae HY, Tuyen TT, et al,. A comparison of non-viral vectors for gene delivery to pancreatic β-cells: delivering a hypoxia-inducible vascular endothelial growth factor gene to rat islets. Int J Mol Med 2009; 23: 757.
32. Parsons GB, Souza DW, Wu H, et al,. Ectopic expression of glucagon-like peptide 1 for gene therapy of type II diabetes. Gene Ther 2007; 14: 38.
33. Kim HA, Lee S, Park JH, et al,. Enhanced protection of Ins-1 cells from apoptosis under hypoxia by delivery of DNA encoding secretion signal peptide-linked exendin-4. J Drug Target 2009; 17: 242.
34. Tian L, Gao J, Weng G, et al,. Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts. Transplant Int 2011; 24: 856.
35. Li Y, Hansotia T, Yusta B, Ris F, Halban PA, Drucker DJ,. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J Biol Chem 2003; 278: 471.
36. Ogawa N, List JF, Habener JF, Maki T,. Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4. Diabetes 2004; 53: 1700.
37. Drucker DJ,. Glucagon-like peptides: regulators of cell proliferation, differentiation and apoptosis. Mol Endocrinol 2005; 17: 161.
38. Farilla L, Bulotta A, Hirshberg B, et al,. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology 2003; 144: 5149.
39. Toso C, McCall M, Emamaullee J, et al,. Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture. Transplant Int 2009; 23: 259.