Acute exposure to 3-methylcholanthrene induces hepatic oxidative stress via activation of the Nrf2/ARE signaling pathway in mice

Environmental Toxicology

Volumn 29, Issue 12, 2014, Pages 1399-1408

  Jin, Yuanxiang ^a   Miao, Wenyu ^a   Lin, Xiaojian ^a   Pan, Xiuhong ^a   Ye, Yang ^a   Xu, Minjie ^a   Fu, Zhengwei ^a  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

3 methylcholanthrene; ICR mice; NQO1; Nrf2 pathway; Oxidative stress

Indexed keywords

ANTIOXIDANTS; ENZYMES; MAMMALS; OXIDATIVE STRESS; PEPTIDES; PLANTS (BOTANY); QUINONE;

3-METHYLCHOLANTHRENE; ARYL HYDROCARBON RECEPTOR; ICR MICE; INTRAPERITONEAL INJECTIONS; NQO1; NRF2 PATHWAY; POLYCYCLIC AROMATIC HYDROCARBONS (PAHS); TOTAL ANTIOXIDANT CAPACITY;

POLYCYCLIC AROMATIC HYDROCARBONS;

3 METHYLCHOLANTHRENE; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE; MALONALDEHYDE; OXIDOREDUCTASE; PROTEIN NQO1; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIOXIDANT; AROMATIC HYDROCARBON RECEPTOR; MESSENGER RNA;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ERK2 GENE; GENE; GPX GENE; GR GENE; GS GENE; LIVER LEVEL; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; NQO1 GENE; NRF2 GENE; OXIDATIVE STRESS; P38 GENE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SOD1 GENE; SOD2 GENE; ANIMAL; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER; METABOLISM; OXIDATION REDUCTION REACTION;

MUS;

ANIMALS; ANTIOXIDANTS; GLUTATHIONE; LIVER; MALE; MALONDIALDEHYDE; METHYLCHOLANTHRENE; MICE; MICE, INBRED ICR; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RECEPTORS, ARYL HYDROCARBON; RESPONSE ELEMENTS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 84911966105     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.21870     Document Type: Article

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